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Illumina Body Map 2 (GSE30611)

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Results for SPIC

Z-value: 3.88

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Transcription factors associated with SPIC

Gene Symbol Gene ID Gene Info
ENSG00000166211.8 Spi-C transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIChg38_v1_chr12_+_101475319_1014753400.336.6e-02Click!

Activity profile of SPIC motif

Sorted Z-values of SPIC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_8577405 19.78 ENST00000596675.1
ENST00000644032.2
ENST00000613525.4
myosin IF
chr19_+_41877267 19.17 ENST00000221972.8
ENST00000597454.1
ENST00000444740.2
CD79a molecule
chr1_-_160711803 15.38 ENST00000368045.3
ENST00000368046.8
ENST00000613788.1
CD48 molecule
chr12_+_54498766 15.32 ENST00000545638.2
NCK associated protein 1 like
chr16_+_30183595 13.56 ENST00000219150.10
ENST00000570045.5
ENST00000565497.5
ENST00000570244.5
coronin 1A
chr17_-_74712911 13.39 ENST00000326165.11
ENST00000583937.5
ENST00000301573.13
ENST00000469092.5
CD300 molecule like family member f
chr4_-_73988179 13.03 ENST00000296028.4
pro-platelet basic protein
chr19_+_49335396 13.02 ENST00000598095.5
ENST00000426897.6
ENST00000323906.9
ENST00000535669.6
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr1_+_159802346 12.75 ENST00000368106.4
ENST00000339348.9
ENST00000392235.7
Fc receptor like 6
chrX_-_47629845 12.71 ENST00000469388.1
ENST00000396992.8
ENST00000377005.6
complement factor properdin
chr6_+_31587002 12.65 ENST00000376090.6
leukocyte specific transcript 1
chr1_+_192158448 12.41 ENST00000367460.4
regulator of G protein signaling 18
chr6_+_31587049 12.38 ENST00000376089.6
ENST00000396112.6
leukocyte specific transcript 1
chrX_+_78945332 12.10 ENST00000544091.1
ENST00000171757.3
P2Y receptor family member 10
chr11_-_59212869 11.81 ENST00000361050.4
macrophage expressed 1
chr19_-_51372640 11.61 ENST00000600427.5
ENST00000221978.10
natural killer cell granule protein 7
chr6_-_132757883 11.44 ENST00000525289.5
ENST00000326499.11
vanin 2
chr17_-_74623730 11.38 ENST00000392619.2
CD300e molecule
chr14_+_88005128 11.23 ENST00000267549.5
G protein-coupled receptor 65
chr22_+_36913620 11.23 ENST00000403662.8
ENST00000262825.9
colony stimulating factor 2 receptor subunit beta
chr22_-_37244417 10.97 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
Rac family small GTPase 2
chr7_+_74773962 10.85 ENST00000289473.10
neutrophil cytosolic factor 1
chr17_-_31314040 10.65 ENST00000330927.5
ecotropic viral integration site 2B
chr6_-_159044980 10.53 ENST00000367066.8
T cell activation RhoGTPase activating protein
chr6_-_159045104 10.42 ENST00000326965.7
T cell activation RhoGTPase activating protein
chr1_-_157777124 10.41 ENST00000361516.8
ENST00000368181.4
Fc receptor like 2
chr7_+_150685693 10.33 ENST00000223293.10
ENST00000474605.1
GTPase, IMAP family member 2
chr1_+_161707244 10.31 ENST00000349527.8
ENST00000294796.8
ENST00000309691.10
ENST00000367953.7
ENST00000367950.2
Fc receptor like A
chr19_-_38617928 10.28 ENST00000396857.7
ENST00000586296.5
mitogen-activated protein kinase kinase kinase kinase 1
chr2_-_89222461 10.26 ENST00000482769.1
immunoglobulin kappa variable 2-28
chr19_-_10339610 10.26 ENST00000589261.5
ENST00000160262.10
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr17_-_31314066 10.25 ENST00000577894.1
ecotropic viral integration site 2B
chr5_-_67196791 10.25 ENST00000256447.5
CD180 molecule
chr2_+_89959979 10.12 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr19_-_54281145 9.92 ENST00000434421.5
ENST00000391749.4
leukocyte immunoglobulin like receptor B2
chr13_-_46182136 9.81 ENST00000323076.7
lymphocyte cytosolic protein 1
chr9_+_273026 9.69 ENST00000682249.1
ENST00000453981.5
ENST00000487230.5
ENST00000469391.5
dedicator of cytokinesis 8
chr22_+_36860973 9.66 ENST00000447071.5
ENST00000397147.7
ENST00000248899.11
neutrophil cytosolic factor 4
chr17_+_74466627 9.62 ENST00000360141.8
ENST00000392625.7
ENST00000310828.9
ENST00000361933.7
CD300a molecule
chr6_-_159045010 9.48 ENST00000338313.5
T cell activation RhoGTPase activating protein
chr9_+_214843 9.34 ENST00000432829.7
dedicator of cytokinesis 8
chr19_+_1067144 9.08 ENST00000313093.7
Rho GTPase activating protein 45
chr12_-_9733292 9.07 ENST00000621400.4
ENST00000327839.3
C-type lectin like 1
chr12_-_14961610 9.07 ENST00000542276.1
Rho GDP dissociation inhibitor beta
chr19_+_1067272 9.02 ENST00000590214.5
Rho GTPase activating protein 45
chr1_+_110873135 8.91 ENST00000271324.6
CD53 molecule
chr12_-_14961559 8.89 ENST00000228945.9
ENST00000541546.5
Rho GDP dissociation inhibitor beta
chr2_-_88857582 8.89 ENST00000390237.2
immunoglobulin kappa constant
chr1_+_161706949 8.88 ENST00000350710.3
ENST00000367949.6
ENST00000367959.6
ENST00000540521.5
ENST00000546024.5
ENST00000674251.1
ENST00000674323.1
Fc receptor like A
chr7_+_128937917 8.83 ENST00000357234.10
ENST00000613821.4
ENST00000477535.5
ENST00000479582.5
ENST00000464557.5
ENST00000402030.6
interferon regulatory factor 5
chr17_+_74466386 8.73 ENST00000648095.1
CD300a molecule
chr6_+_106086316 8.69 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr17_-_8965674 8.65 ENST00000447110.6
ENST00000611902.4
ENST00000616147.4
ENST00000623421.3
phosphoinositide-3-kinase regulatory subunit 5
chr16_+_30473946 8.56 ENST00000569725.1
integrin subunit alpha L
chr12_-_51324091 8.55 ENST00000604560.6
bridging integrator 2
chr19_+_1067493 8.50 ENST00000586866.5
Rho GTPase activating protein 45
chr19_-_54281082 8.50 ENST00000314446.10
leukocyte immunoglobulin like receptor B2
chr11_-_67437670 8.39 ENST00000326294.4
protein tyrosine phosphatase receptor type C associated protein
chr14_-_22815801 8.28 ENST00000397532.9
solute carrier family 7 member 7
chr19_-_38617912 8.25 ENST00000591517.5
mitogen-activated protein kinase kinase kinase kinase 1
chr22_+_22369601 8.19 ENST00000390295.3
immunoglobulin lambda variable 7-46
chr6_+_391743 8.17 ENST00000380956.9
interferon regulatory factor 4
chr5_-_39270623 8.13 ENST00000512138.1
ENST00000646045.2
FYN binding protein 1
chr8_+_27311471 8.11 ENST00000397501.5
protein tyrosine kinase 2 beta
chr6_+_31586835 8.10 ENST00000211921.11
leukocyte specific transcript 1
chr1_-_183590876 8.09 ENST00000367536.5
neutrophil cytosolic factor 2
chr1_-_157820060 8.09 ENST00000491942.1
ENST00000358292.7
Fc receptor like 1
chr14_-_22815856 8.08 ENST00000554758.1
ENST00000397528.8
solute carrier family 7 member 7
chr12_+_6946468 7.98 ENST00000543115.5
ENST00000399448.5
protein tyrosine phosphatase non-receptor type 6
chr19_-_51372686 7.95 ENST00000595217.1
natural killer cell granule protein 7
chr12_+_54497712 7.93 ENST00000293373.11
NCK associated protein 1 like
chr16_-_88651015 7.87 ENST00000568278.1
ENST00000569359.5
ENST00000567174.5
ENST00000261623.8
cytochrome b-245 alpha chain
chr19_-_10335773 7.86 ENST00000592439.1
intercellular adhesion molecule 3
chr19_+_54630410 7.83 ENST00000396327.7
ENST00000324602.12
leukocyte immunoglobulin like receptor B1
chr16_-_21652598 7.81 ENST00000569602.1
ENST00000268389.6
immunoglobulin superfamily member 6
chr2_+_201260510 7.79 ENST00000673742.1
caspase 8
chr3_+_32391694 7.74 ENST00000349718.8
CKLF like MARVEL transmembrane domain containing 7
chr14_+_20955484 7.71 ENST00000304625.3
ribonuclease A family member 2
chr3_-_121660892 7.70 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chr2_+_233059838 7.70 ENST00000359570.9
inositol polyphosphate-5-phosphatase D
chr19_+_35449584 7.67 ENST00000246549.2
free fatty acid receptor 2
chr6_+_116461364 7.67 ENST00000368606.7
ENST00000368605.3
calcium homeostasis modulator family member 6
chr14_-_22815493 7.60 ENST00000555911.1
solute carrier family 7 member 7
chr12_-_8066331 7.51 ENST00000546241.1
ENST00000307637.5
complement C3a receptor 1
chr1_-_150765735 7.51 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
cathepsin S
chr20_-_64079479 7.39 ENST00000395042.2
regulator of G protein signaling 19
chr1_-_30757767 7.32 ENST00000294507.4
lysosomal protein transmembrane 5
chr9_+_215157 7.30 ENST00000479404.5
dedicator of cytokinesis 8
chr7_+_150567382 7.24 ENST00000255945.4
ENST00000479232.1
GTPase, IMAP family member 4
chr1_+_40344844 7.22 ENST00000435168.6
small ArfGAP2
chr17_-_74531467 7.19 ENST00000314401.3
ENST00000392621.6
CD300 molecule like family member b
chr19_+_6772699 7.13 ENST00000602142.6
ENST00000304076.6
ENST00000596764.5
vav guanine nucleotide exchange factor 1
chr1_-_160579439 7.11 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84 molecule
chr17_+_44345291 7.06 ENST00000593167.5
ENST00000585512.5
ENST00000591740.5
ENST00000592783.5
ENST00000587387.5
ENST00000588237.5
ENST00000053867.8
ENST00000589265.5
granulin precursor
chr1_-_161549793 7.03 ENST00000443193.6
Fc fragment of IgG receptor IIIa
chr7_+_150567347 7.02 ENST00000461940.5
GTPase, IMAP family member 4
chr3_+_32391871 6.98 ENST00000465248.1
CKLF like MARVEL transmembrane domain containing 7
chrX_-_71618455 6.96 ENST00000373691.4
ENST00000373693.4
C-X-C motif chemokine receptor 3
chr8_+_27311620 6.95 ENST00000522338.5
protein tyrosine kinase 2 beta
chr16_+_31259922 6.94 ENST00000648685.1
ENST00000544665.9
integrin subunit alpha M
chr15_-_79971164 6.92 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2 related protein A1
chr6_-_41154326 6.89 ENST00000426005.6
ENST00000437044.2
ENST00000373127.8
triggering receptor expressed on myeloid cells like 1
chr6_+_31586124 6.82 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
leukocyte specific transcript 1
chr6_-_132763424 6.78 ENST00000532012.1
ENST00000525270.5
ENST00000530536.5
ENST00000524919.5
vanin 2
chr11_-_118212885 6.78 ENST00000524477.5
junction adhesion molecule like
chr13_+_30713477 6.70 ENST00000617770.4
arachidonate 5-lipoxygenase activating protein
chr17_+_7579491 6.65 ENST00000380498.10
ENST00000584502.1
ENST00000250092.11
CD68 molecule
chr16_+_81779279 6.63 ENST00000564138.6
phospholipase C gamma 2
chr12_+_25052732 6.63 ENST00000547044.5
inositol 1,4,5-triphosphate receptor associated 2
chr3_+_32391841 6.60 ENST00000334983.10
CKLF like MARVEL transmembrane domain containing 7
chr1_-_183590596 6.60 ENST00000418089.5
ENST00000413720.5
neutrophil cytosolic factor 2
chr1_+_161707205 6.59 ENST00000367957.7
Fc receptor like A
chr2_+_143129379 6.57 ENST00000295095.11
Rho GTPase activating protein 15
chr21_-_14546297 6.56 ENST00000400566.6
ENST00000400564.5
SAM domain, SH3 domain and nuclear localization signals 1
chr1_-_161549892 6.54 ENST00000426740.7
Fc fragment of IgG receptor IIIa
chr19_+_45507470 6.54 ENST00000245932.11
ENST00000592139.1
ENST00000590603.1
vasodilator stimulated phosphoprotein
chr5_-_150086511 6.53 ENST00000675795.1
colony stimulating factor 1 receptor
chr1_+_161581339 6.51 ENST00000543859.5
ENST00000611236.1
Fc fragment of IgG receptor IIc (gene/pseudogene)
chr12_-_110450298 6.50 ENST00000426440.5
ENST00000228825.12
actin related protein 2/3 complex subunit 3
chr19_+_54572971 6.45 ENST00000439534.5
leukocyte immunoglobulin like receptor A2
chr5_-_150086427 6.42 ENST00000543093.1
colony stimulating factor 1 receptor
chr20_+_44966478 6.40 ENST00000499879.6
ENST00000372806.8
ENST00000372801.5
serine/threonine kinase 4
chr1_-_183590439 6.38 ENST00000367535.8
neutrophil cytosolic factor 2
chr19_-_18397596 6.36 ENST00000595840.1
ENST00000339007.4
leucine rich repeat containing 25
chr19_+_51225059 6.30 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr1_+_161707222 6.28 ENST00000236938.12
Fc receptor like A
chr4_+_73740541 6.27 ENST00000401931.1
ENST00000307407.8
C-X-C motif chemokine ligand 8
chr7_+_142592928 6.24 ENST00000616518.1
T cell receptor beta variable 15
chr6_+_31586680 6.17 ENST00000339530.8
leukocyte specific transcript 1
chr5_-_139482285 6.17 ENST00000652110.1
stimulator of interferon response cGAMP interactor 1
chr19_+_54630497 6.15 ENST00000396332.8
ENST00000427581.6
leukocyte immunoglobulin like receptor B1
chr19_-_6481769 6.14 ENST00000381480.7
ENST00000543576.5
ENST00000590173.5
DENN domain containing 1C
chr7_-_150632333 6.12 ENST00000493969.2
ENST00000328902.9
GTPase, IMAP family member 6
chr1_+_161505438 6.12 ENST00000271450.12
Fc fragment of IgG receptor IIa
chrX_-_130110679 6.10 ENST00000335997.11
E74 like ETS transcription factor 4
chr1_-_157820113 6.09 ENST00000368176.8
Fc receptor like 1
chr19_-_51417619 6.07 ENST00000441969.7
ENST00000339313.10
ENST00000525998.5
ENST00000436984.6
sialic acid binding Ig like lectin 10
chr13_+_30735523 6.05 ENST00000380490.5
arachidonate 5-lipoxygenase activating protein
chr19_+_54593619 6.04 ENST00000251372.8
ENST00000453777.1
leukocyte immunoglobulin like receptor A1
chr19_-_14776756 6.03 ENST00000596991.6
ENST00000594294.5
ENST00000594076.5
ENST00000595839.5
ENST00000392965.7
ENST00000601345.5
adhesion G protein-coupled receptor E2
chr2_+_181457198 5.98 ENST00000339307.8
integrin subunit alpha 4
chr6_+_31586269 5.91 ENST00000438075.7
leukocyte specific transcript 1
chr7_+_142554828 5.91 ENST00000611787.1
T cell receptor beta variable 11-3
chr2_+_233060295 5.88 ENST00000445964.6
inositol polyphosphate-5-phosphatase D
chr6_+_31615215 5.87 ENST00000337917.11
ENST00000376059.8
allograft inflammatory factor 1
chr2_+_201260496 5.86 ENST00000323492.11
caspase 8
chr6_+_37005630 5.84 ENST00000274963.13
FYVE, RhoGEF and PH domain containing 2
chr2_-_112836702 5.75 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
interleukin 1 beta
chr20_-_1657762 5.73 ENST00000303415.7
ENST00000381583.6
signal regulatory protein gamma
chr5_+_96875978 5.72 ENST00000510373.5
endoplasmic reticulum aminopeptidase 2
chr1_-_150765785 5.70 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chrX_-_130110479 5.69 ENST00000308167.10
E74 like ETS transcription factor 4
chr1_+_241532121 5.66 ENST00000366558.7
kynurenine 3-monooxygenase
chr19_-_35742431 5.65 ENST00000592537.5
ENST00000246532.6
ENST00000588992.5
IGF like family receptor 1
chr21_-_14546351 5.64 ENST00000619120.4
SAM domain, SH3 domain and nuclear localization signals 1
chr21_-_44920892 5.63 ENST00000397846.7
ENST00000652462.1
ENST00000302347.10
ENST00000524251.1
integrin subunit beta 2
chr15_+_76995118 5.63 ENST00000558012.6
ENST00000379595.7
proline-serine-threonine phosphatase interacting protein 1
chr22_+_22395005 5.62 ENST00000390298.2
immunoglobulin lambda variable 7-43
chr17_+_64449037 5.60 ENST00000615220.4
ENST00000619286.5
ENST00000612535.4
ENST00000616498.4
mast cell immunoglobulin like receptor 1
chr1_+_40396766 5.58 ENST00000539317.2
small ArfGAP2
chr12_+_6951345 5.58 ENST00000318974.14
ENST00000541698.5
ENST00000542462.1
protein tyrosine phosphatase non-receptor type 6
chr10_+_88759997 5.58 ENST00000404459.2
lipase family member N
chr17_-_5234801 5.57 ENST00000571800.5
ENST00000574081.6
ENST00000399600.8
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr16_+_28494634 5.57 ENST00000564831.6
ENST00000431282.2
apolipoprotein B receptor
chr17_-_30824665 5.56 ENST00000324238.7
cytokine receptor like factor 3
chr17_-_44389594 5.55 ENST00000262407.6
integrin subunit alpha 2b
chr11_-_72752376 5.54 ENST00000393609.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr16_+_66579448 5.50 ENST00000379486.6
ENST00000268595.3
CKLF like MARVEL transmembrane domain containing 2
chr7_+_142328282 5.48 ENST00000390353.2
T cell receptor beta variable 6-1
chr4_-_102760914 5.48 ENST00000505239.1
ENST00000647097.2
mannosidase beta
chr1_+_111473972 5.46 ENST00000369718.4
chromosome 1 open reading frame 162
chr1_+_111473792 5.45 ENST00000343534.9
chromosome 1 open reading frame 162
chr4_+_67558719 5.43 ENST00000265404.7
ENST00000396225.1
signal transducing adaptor family member 1
chr2_+_218129277 5.43 ENST00000428565.1
C-X-C motif chemokine receptor 2
chr11_+_1853049 5.38 ENST00000311604.8
lymphocyte specific protein 1
chr12_+_105330835 5.31 ENST00000549934.2
chromosome 12 open reading frame 75
chr4_-_102760976 5.31 ENST00000644159.1
ENST00000642252.1
mannosidase beta
chr4_-_163613505 5.31 ENST00000339875.9
membrane associated ring-CH-type finger 1
chrY_+_12904860 5.31 ENST00000336079.8
DEAD-box helicase 3 Y-linked
chr18_-_63422377 5.28 ENST00000591519.1
vacuolar protein sorting 4 homolog B
chr14_-_106154113 5.24 ENST00000390603.2
immunoglobulin heavy variable 3-15
chr7_-_150632644 5.19 ENST00000618759.4
GTPase, IMAP family member 6
chr19_+_13150386 5.15 ENST00000292433.4
ENST00000587885.1
immediate early response 2
chr19_+_1026566 5.11 ENST00000562015.5
ENST00000263097.9
ENST00000348419.7
ENST00000565096.6
ENST00000562958.6
ENST00000568865.3
ENST00000606983.5
ENST00000562075.6
ENST00000607102.1
calponin 2
chr12_+_6951271 5.09 ENST00000456013.5
protein tyrosine phosphatase non-receptor type 6
chr3_+_122077850 5.08 ENST00000482356.5
ENST00000393627.6
CD86 molecule
chr12_-_14961256 5.07 ENST00000541380.5
Rho GDP dissociation inhibitor beta
chr21_-_44920855 5.03 ENST00000397854.7
integrin subunit beta 2
chr20_-_1657714 5.02 ENST00000216927.4
ENST00000344103.8
signal regulatory protein gamma
chr19_-_51417581 4.99 ENST00000442846.7
ENST00000530476.1
sialic acid binding Ig like lectin 10
chr16_-_68000549 4.89 ENST00000575510.5
dipeptidase 2
chrY_+_2841864 4.85 ENST00000430575.1
ribosomal protein S4 Y-linked 1
chr5_+_58491427 4.84 ENST00000396776.6
ENST00000502276.6
ENST00000511930.2
GRB2 binding adaptor protein, transmembrane
chr2_+_68365274 4.83 ENST00000234313.8
pleckstrin
chr19_-_51804104 4.82 ENST00000594900.1
formyl peptide receptor 1
chr16_-_88785210 4.80 ENST00000301015.14
piezo type mechanosensitive ion channel component 1
chr7_-_116159886 4.72 ENST00000484212.5
transcription factor EC
chr20_-_1588632 4.71 ENST00000262929.9
ENST00000567028.5
signal regulatory protein beta 1
novel protein, SIRPB1-SIRPD readthrough
chr20_+_59163810 4.71 ENST00000371030.4
zinc finger protein 831
chr10_+_26438404 4.69 ENST00000356785.4
amyloid beta precursor protein binding family B member 1 interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 31.7 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125)
8.8 26.3 GO:0061485 memory T cell proliferation(GO:0061485)
7.7 23.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
5.3 21.3 GO:0002337 B-1a B cell differentiation(GO:0002337)
4.6 36.6 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
4.4 17.8 GO:0045404 positive regulation of interleukin-4 biosynthetic process(GO:0045404)
4.4 13.2 GO:0034769 basement membrane disassembly(GO:0034769)
4.1 20.5 GO:0052053 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
3.9 23.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
3.8 23.0 GO:0071461 cellular response to redox state(GO:0071461)
3.8 11.3 GO:0002316 follicular B cell differentiation(GO:0002316)
3.4 13.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
3.2 22.6 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
3.1 31.4 GO:0000821 regulation of arginine metabolic process(GO:0000821)
2.9 8.7 GO:1990654 sebum secreting cell proliferation(GO:1990654)
2.7 13.6 GO:0032796 uropod organization(GO:0032796)
2.7 13.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
2.6 7.9 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
2.6 7.8 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
2.6 2.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
2.6 7.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
2.5 15.1 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
2.2 8.8 GO:1903722 regulation of centriole elongation(GO:1903722)
1.9 5.7 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
1.8 5.4 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
1.8 5.3 GO:0019085 early viral transcription(GO:0019085)
1.7 3.4 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.6 13.0 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
1.5 12.3 GO:0050904 diapedesis(GO:0050904)
1.5 4.6 GO:0006679 glucosylceramide biosynthetic process(GO:0006679)
1.5 10.6 GO:0010266 response to vitamin B1(GO:0010266)
1.4 12.9 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
1.4 7.0 GO:0019086 late viral transcription(GO:0019086)
1.4 9.6 GO:0033625 positive regulation of integrin activation(GO:0033625)
1.4 23.1 GO:0015939 pantothenate metabolic process(GO:0015939)
1.4 5.4 GO:0005986 sucrose biosynthetic process(GO:0005986)
1.3 2.6 GO:0036369 transcription factor catabolic process(GO:0036369)
1.3 7.7 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
1.3 57.1 GO:0045730 respiratory burst(GO:0045730)
1.2 3.7 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.1 3.4 GO:0071810 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
1.1 5.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
1.1 28.9 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.1 13.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.1 11.8 GO:0001866 NK T cell proliferation(GO:0001866)
1.1 6.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.0 9.4 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.0 3.1 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
1.0 8.8 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.9 4.7 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.9 5.5 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.9 5.4 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.9 7.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.9 4.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.8 3.4 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.8 6.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.8 5.9 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.8 3.1 GO:0036071 N-glycan fucosylation(GO:0036071)
0.8 3.1 GO:0043335 protein unfolding(GO:0043335)
0.8 4.5 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.8 6.8 GO:0035696 monocyte extravasation(GO:0035696)
0.7 12.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.7 10.5 GO:2001300 lipoxin metabolic process(GO:2001300)
0.7 3.0 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.7 12.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.7 4.2 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.7 4.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.7 2.0 GO:0000967 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.6 3.9 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.6 7.7 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.6 8.8 GO:0032494 response to peptidoglycan(GO:0032494)
0.6 5.6 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.6 3.7 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.6 8.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.6 6.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.6 4.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.6 8.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.6 6.1 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.6 13.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.5 12.2 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.5 4.2 GO:0006710 androgen catabolic process(GO:0006710)
0.5 3.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.5 10.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.5 1.5 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.5 1.5 GO:0071529 cementum mineralization(GO:0071529)
0.5 18.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 1.4 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.5 1.8 GO:0021569 rhombomere 3 development(GO:0021569)
0.4 9.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 5.0 GO:0090168 Golgi reassembly(GO:0090168)
0.4 1.7 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.4 45.6 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.4 1.2 GO:0001546 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.4 0.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.4 1.2 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.4 1.6 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.4 2.7 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.4 2.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.4 3.3 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.4 0.7 GO:0090135 actin filament branching(GO:0090135)
0.4 3.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.4 2.2 GO:0035063 nuclear speck organization(GO:0035063)
0.3 3.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.3 1.4 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.3 78.6 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.3 1.7 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.3 7.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.3 1.0 GO:0098583 mastication(GO:0071626) learned vocalization behavior(GO:0098583)
0.3 2.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.3 1.9 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.3 6.4 GO:0001955 blood vessel maturation(GO:0001955)
0.3 5.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.3 5.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.3 3.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 1.8 GO:0001692 histamine metabolic process(GO:0001692)
0.3 5.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.3 1.7 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.3 2.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 2.6 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.3 0.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.3 6.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 0.9 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.3 3.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 12.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 1.1 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.3 0.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.3 1.6 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.3 1.3 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.3 1.3 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.3 41.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 3.6 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 3.8 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 1.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 1.5 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 8.6 GO:0097320 membrane tubulation(GO:0097320)
0.2 4.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 4.3 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 2.6 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 3.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 2.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.2 8.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 0.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 0.9 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.2 1.8 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 9.3 GO:0006266 DNA ligation(GO:0006266)
0.2 0.9 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.2 1.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.9 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.2 0.8 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.2 2.5 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 1.5 GO:1903376 neuron intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0036480) regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903376)
0.2 7.0 GO:0043101 purine-containing compound salvage(GO:0043101)
0.2 5.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.2 1.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.2 24.4 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.2 1.9 GO:0061042 vascular wound healing(GO:0061042)
0.2 2.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 0.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.2 2.0 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 4.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 1.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 0.7 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 0.5 GO:0070077 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine(GO:0018395) histone arginine demethylation(GO:0070077) histone H3-R2 demethylation(GO:0070078) histone H4-R3 demethylation(GO:0070079)
0.2 2.7 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 5.1 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.2 2.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2 6.0 GO:0043304 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.2 0.5 GO:0071314 negative regulation of epinephrine secretion(GO:0032811) negative regulation of luteinizing hormone secretion(GO:0033685) negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) negative regulation of glucagon secretion(GO:0070093) cellular response to cocaine(GO:0071314)
0.2 1.4 GO:0080009 mRNA methylation(GO:0080009)
0.2 4.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 3.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 6.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.6 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.1 2.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 3.6 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.1 2.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.7 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.1 1.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.8 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.4 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.1 1.9 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 0.7 GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.1 2.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.7 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.1 3.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.1 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 1.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 5.0 GO:0007035 vacuolar acidification(GO:0007035)
0.1 5.7 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 3.1 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 3.1 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 5.6 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.1 1.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 4.6 GO:0070206 protein trimerization(GO:0070206)
0.1 0.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 2.0 GO:0006983 ER overload response(GO:0006983)
0.1 2.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 3.5 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.1 1.8 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 7.4 GO:0006968 cellular defense response(GO:0006968)
0.1 1.9 GO:0007220 Notch receptor processing(GO:0007220)
0.1 2.0 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 7.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 1.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 3.5 GO:0050832 defense response to fungus(GO:0050832)
0.1 2.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 5.3 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.2 GO:0051665 membrane raft localization(GO:0051665)
0.1 8.7 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.4 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.7 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 53.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 8.0 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.4 GO:0051382 kinetochore assembly(GO:0051382)
0.1 1.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.8 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349)
0.1 0.4 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.1 1.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.9 GO:0022417 protein maturation by protein folding(GO:0022417)
0.1 0.1 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.1 2.6 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 3.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.7 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 2.5 GO:0000732 strand displacement(GO:0000732)
0.1 0.7 GO:0070995 NADPH oxidation(GO:0070995)
0.1 4.0 GO:0006953 acute-phase response(GO:0006953)
0.1 0.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 1.2 GO:0019388 galactose catabolic process(GO:0019388)
0.1 5.5 GO:0097192 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.1 2.7 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.6 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 1.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.1 GO:0097421 liver regeneration(GO:0097421)
0.1 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.1 9.7 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 0.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.8 GO:0015866 ADP transport(GO:0015866)
0.1 0.2 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.1 0.2 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.1 0.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 0.6 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.1 3.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.7 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 7.9 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.1 0.6 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 35.8 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.2 GO:0061580 colon epithelial cell migration(GO:0061580)
0.0 0.4 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
0.0 1.5 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 0.4 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.5 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 1.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 1.8 GO:0007143 female meiotic division(GO:0007143)
0.0 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 1.0 GO:0016180 snRNA processing(GO:0016180)
0.0 0.4 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 2.9 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 2.8 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.7 GO:0031297 replication fork processing(GO:0031297)
0.0 1.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 2.2 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.4 GO:0009838 abscission(GO:0009838)
0.0 2.5 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.0 2.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 1.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 1.1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 2.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.9 GO:0006853 carnitine shuttle(GO:0006853)
0.0 3.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.6 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 1.4 GO:0042220 response to cocaine(GO:0042220)
0.0 1.2 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 1.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.6 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 4.3 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.3 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 17.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.8 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 0.1 GO:0048627 myoblast development(GO:0048627)
0.0 2.4 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.2 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 0.4 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 1.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682) protein lipoylation(GO:0009249)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.5 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.8 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 19.2 GO:0019815 B cell receptor complex(GO:0019815)
3.8 41.6 GO:0032010 phagolysosome(GO:0032010)
3.7 11.2 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
3.3 13.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.9 8.6 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
2.7 21.9 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
1.9 23.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.9 30.1 GO:0031209 SCAR complex(GO:0031209)
1.6 11.5 GO:0036021 endolysosome lumen(GO:0036021)
1.6 12.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.5 17.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.3 3.8 GO:0016590 ACF complex(GO:0016590)
1.3 8.8 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.2 6.0 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
1.2 8.2 GO:0000788 nuclear nucleosome(GO:0000788)
1.1 6.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.1 3.4 GO:0032002 interleukin-28 receptor complex(GO:0032002)
1.1 6.4 GO:1902560 GMP reductase complex(GO:1902560)
0.8 4.2 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.8 2.5 GO:0031251 PAN complex(GO:0031251)
0.8 20.6 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.8 19.8 GO:0016461 unconventional myosin complex(GO:0016461)
0.8 31.4 GO:0001891 phagocytic cup(GO:0001891)
0.8 3.0 GO:0071920 cleavage body(GO:0071920)
0.7 7.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.6 8.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.6 7.0 GO:0016589 NURF complex(GO:0016589)
0.6 14.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.6 13.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.5 2.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.5 9.1 GO:0090543 Flemming body(GO:0090543)
0.4 4.7 GO:0042101 T cell receptor complex(GO:0042101)
0.4 9.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 47.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.4 3.1 GO:0070435 Shc-EGFR complex(GO:0070435)
0.4 2.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 1.4 GO:0071001 U4/U6 snRNP(GO:0071001)
0.3 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.3 1.7 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.3 1.7 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.3 2.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 26.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 48.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 10.8 GO:0042629 mast cell granule(GO:0042629)
0.3 1.4 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.3 19.1 GO:0001772 immunological synapse(GO:0001772)
0.3 1.7 GO:0032807 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.3 1.9 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.3 118.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 0.8 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.2 1.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 5.1 GO:0042588 zymogen granule(GO:0042588)
0.2 11.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 6.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.4 GO:0043203 axon hillock(GO:0043203)
0.2 2.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 24.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.8 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.2 15.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 3.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 5.4 GO:0042627 chylomicron(GO:0042627)
0.2 1.5 GO:0005683 U7 snRNP(GO:0005683)
0.2 15.7 GO:0035580 specific granule lumen(GO:0035580)
0.2 3.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 1.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 1.1 GO:0097149 centralspindlin complex(GO:0097149)
0.2 1.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 2.7 GO:0032039 integrator complex(GO:0032039)
0.1 19.1 GO:0031091 platelet alpha granule(GO:0031091)
0.1 8.8 GO:0031201 SNARE complex(GO:0031201)
0.1 11.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.7 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 1.6 GO:0033269 internode region of axon(GO:0033269)
0.1 1.5 GO:0042382 paraspeckles(GO:0042382)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 13.6 GO:0005811 lipid particle(GO:0005811)
0.1 2.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 2.6 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 22.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 1.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 19.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.4 GO:0044754 autolysosome(GO:0044754)
0.1 0.7 GO:1990031 pinceau fiber(GO:1990031)
0.1 1.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 0.5 GO:0043196 varicosity(GO:0043196)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 6.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0000801 central element(GO:0000801)
0.1 1.5 GO:0070938 contractile ring(GO:0070938)
0.1 1.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 7.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 11.6 GO:0016605 PML body(GO:0016605)
0.1 0.2 GO:0071817 MMXD complex(GO:0071817)
0.1 1.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 15.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 0.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 4.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.4 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 1.8 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 1.2 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 127.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 19.5 GO:0031252 cell leading edge(GO:0031252)
0.0 0.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 11.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 4.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 6.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.2 GO:0031904 endosome lumen(GO:0031904)
0.0 3.4 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 3.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 23.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 100.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.6 GO:0060205 vesicle lumen(GO:0031983) secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 7.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 3.5 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 2.8 GO:0000922 spindle pole(GO:0000922)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 6.3 GO:0031410 cytoplasmic vesicle(GO:0031410)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 36.6 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
4.6 18.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
3.3 13.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
3.2 12.9 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
3.0 15.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
3.0 41.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
2.9 20.5 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
2.9 8.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
2.7 13.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
2.3 23.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.1 23.5 GO:0030369 ICAM-3 receptor activity(GO:0030369)
2.1 10.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
2.1 10.5 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
1.9 13.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
1.7 30.9 GO:0019864 IgG binding(GO:0019864)
1.6 13.0 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.5 4.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
1.5 4.6 GO:0050405 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
1.4 7.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.4 5.4 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.3 7.7 GO:0004522 ribonuclease A activity(GO:0004522)
1.3 30.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.2 3.7 GO:0042008 interleukin-18 receptor activity(GO:0042008)
1.2 10.6 GO:0005497 androgen binding(GO:0005497)
1.2 18.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.2 6.9 GO:0001851 complement component C3b binding(GO:0001851)
1.1 5.5 GO:0070051 fibrinogen binding(GO:0070051)
1.1 6.4 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.0 8.3 GO:0004974 leukotriene receptor activity(GO:0004974)
1.0 3.1 GO:0004730 pseudouridylate synthase activity(GO:0004730)
1.0 18.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.9 12.3 GO:0004875 complement receptor activity(GO:0004875)
0.9 5.4 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.8 6.8 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.8 2.5 GO:0005139 interleukin-7 receptor binding(GO:0005139)
0.8 4.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.8 3.1 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.7 6.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.7 18.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.7 6.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.7 5.6 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.7 3.4 GO:0048030 disaccharide binding(GO:0048030)
0.7 14.9 GO:0051400 BH domain binding(GO:0051400)
0.7 5.4 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.7 4.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.7 3.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.7 6.0 GO:1990405 protein antigen binding(GO:1990405)
0.6 2.6 GO:0042282 hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282)
0.6 7.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.6 16.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.6 49.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 1.8 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.6 4.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.6 2.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.6 13.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.5 11.8 GO:0005537 mannose binding(GO:0005537)
0.5 13.5 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.5 3.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.5 2.5 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.5 2.9 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.5 3.4 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.5 1.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.5 5.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.5 1.9 GO:0055100 adiponectin binding(GO:0055100)
0.5 3.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 1.7 GO:0070012 oligopeptidase activity(GO:0070012)
0.4 4.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 6.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 1.2 GO:0031753 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
0.4 1.9 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.4 3.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 5.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 4.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.3 2.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 1.7 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.3 1.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.3 1.0 GO:0035375 zymogen binding(GO:0035375)
0.3 2.6 GO:0050815 phosphoserine binding(GO:0050815)
0.3 1.9 GO:0008518 reduced folate carrier activity(GO:0008518)
0.3 1.6 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.3 1.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.2 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.3 1.5 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.3 1.1 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.3 6.5 GO:0005522 profilin binding(GO:0005522)
0.3 3.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 11.5 GO:0043394 proteoglycan binding(GO:0043394)
0.3 4.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 0.8 GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699)
0.3 0.8 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.2 2.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 60.3 GO:0003823 antigen binding(GO:0003823)
0.2 1.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2 3.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 2.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 5.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 5.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 0.9 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 1.8 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 5.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.2 1.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 7.3 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.8 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.2 1.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 6.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.2 4.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 7.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 6.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 5.2 GO:0043422 protein kinase B binding(GO:0043422)
0.2 1.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 112.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 6.8 GO:0005123 death receptor binding(GO:0005123)
0.2 1.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 1.7 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 2.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 3.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 2.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.2 0.5 GO:0033749 histone demethylase activity (H3-R2 specific)(GO:0033746) histone demethylase activity (H4-R3 specific)(GO:0033749)
0.2 6.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 1.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 7.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 4.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 3.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 0.8 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.4 GO:0052835 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.1 1.5 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 3.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 4.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 8.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 12.0 GO:0019843 rRNA binding(GO:0019843)
0.1 2.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.4 GO:0090422 thiamine pyrophosphate transporter activity(GO:0090422)
0.1 3.6 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 3.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 2.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.7 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.1 0.8 GO:0089720 caspase binding(GO:0089720)
0.1 7.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 1.1 GO:0043426 MRF binding(GO:0043426)
0.1 1.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 2.0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 1.6 GO:0004985 opioid receptor activity(GO:0004985)
0.1 33.3 GO:0005125 cytokine activity(GO:0005125)
0.1 0.5 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.4 GO:0090541 MIT domain binding(GO:0090541)
0.1 0.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 2.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 2.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 2.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 9.5 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.1 1.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 5.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.9 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 3.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.4 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 5.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.2 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039)
0.1 0.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.4 GO:0010857 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.1 6.4 GO:0019894 kinesin binding(GO:0019894)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.6 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 6.3 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.4 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 29.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 12.6 GO:0005178 integrin binding(GO:0005178)
0.1 1.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.8 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.2 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.1 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 19.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 3.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 7.0 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 23.6 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 3.0 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 30.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.9 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 4.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.1 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.0 0.9 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 1.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 6.8 GO:0051015 actin filament binding(GO:0051015)
0.0 1.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.5 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 5.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 8.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 31.8 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 3.6 GO:0004518 nuclease activity(GO:0004518)
0.0 0.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.9 60.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.6 14.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.6 84.0 PID BCR 5PATHWAY BCR signaling pathway
0.6 21.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.6 19.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 7.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 58.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.5 15.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 6.4 PID IL5 PATHWAY IL5-mediated signaling events
0.4 8.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 25.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 17.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.3 13.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 6.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.3 19.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.3 11.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 10.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.3 13.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 6.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 31.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 7.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 10.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 9.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 12.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 3.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.2 3.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 8.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 4.9 PID IL1 PATHWAY IL1-mediated signaling events
0.1 6.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 4.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 6.4 PID ENDOTHELIN PATHWAY Endothelins
0.1 6.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 5.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 5.1 PID RAS PATHWAY Regulation of Ras family activation
0.1 2.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 3.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 23.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 6.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.8 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 3.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.5 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 54.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
1.2 13.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.9 104.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.9 22.7 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.7 18.4 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.7 16.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.7 39.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.6 16.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.6 6.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.6 6.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.6 33.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.5 10.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.5 7.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.5 30.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.4 9.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 12.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 24.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.4 3.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.4 13.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.4 6.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 2.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 8.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 10.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 12.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 3.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 26.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 6.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 2.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.3 46.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.3 7.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 74.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 7.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 1.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 3.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 23.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 5.0 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.2 3.3 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.2 6.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 7.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 1.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 6.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 36.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.1 5.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 8.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 4.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 3.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.6 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 1.5 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 18.1 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 3.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 1.7 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 2.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 4.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 0.2 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 2.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 13.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 4.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.5 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 0.8 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 5.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.9 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 4.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.8 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 1.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.9 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)