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Illumina Body Map 2 (GSE30611)

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Results for SRF

Z-value: 3.96

Motif logo

Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
ENSG00000112658.8 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg38_v1_chr6_+_43171260_431712810.691.3e-05Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_45322867 57.00 ENST00000221476.4
creatine kinase, M-type
chr15_-_34795541 44.24 ENST00000290378.6
actin alpha cardiac muscle 1
chr1_-_229434086 37.31 ENST00000366684.7
ENST00000684723.1
ENST00000366683.4
actin alpha 1, skeletal muscle
chr20_+_36541484 34.33 ENST00000346786.2
myosin light chain 9
chr20_+_36541511 34.06 ENST00000279022.7
myosin light chain 9
chr2_+_73892967 32.07 ENST00000409731.7
ENST00000409918.5
ENST00000442912.5
ENST00000345517.8
ENST00000409624.1
actin gamma 2, smooth muscle
chr19_+_11539894 29.57 ENST00000586059.5
calponin 1
chr19_-_35757009 24.95 ENST00000587965.1
ENST00000004982.6
heat shock protein family B (small) member 6
chr14_-_93976550 21.75 ENST00000555019.6
ankyrin repeat and SOCS box containing 2
chr14_-_93976719 18.74 ENST00000555287.1
ankyrin repeat and SOCS box containing 2
chr10_-_29634964 17.89 ENST00000375398.6
ENST00000355867.8
supervillin
chr8_+_85438850 16.47 ENST00000285381.3
carbonic anhydrase 3
chr10_+_86668501 15.58 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LIM domain binding 3
chr17_+_35147807 15.52 ENST00000394570.7
ENST00000268876.9
unc-45 myosin chaperone B
chr10_-_129964240 15.43 ENST00000440978.2
ENST00000355311.10
EBF transcription factor 3
chr3_-_52452828 15.40 ENST00000496590.1
troponin C1, slow skeletal and cardiac type
chr1_-_207911384 15.25 ENST00000356522.4
CD34 molecule
chr6_-_123636997 13.61 ENST00000546248.5
triadin
chr1_-_207911027 13.51 ENST00000310833.12
CD34 molecule
chr2_+_88067818 13.41 ENST00000444564.2
ENST00000419482.7
SET and MYND domain containing 1
chr2_-_105398978 13.40 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
four and a half LIM domains 2
chr11_+_117199363 12.80 ENST00000392951.9
ENST00000525531.5
ENST00000278968.10
transgelin
chr6_-_123636979 12.35 ENST00000662930.1
triadin
chr2_-_105438503 12.22 ENST00000393352.7
ENST00000607522.1
four and a half LIM domains 2
chr18_-_3219849 12.12 ENST00000261606.11
myomesin 1
chr19_-_4518465 11.84 ENST00000633942.1
perilipin 4
chr3_-_46863435 11.78 ENST00000395869.5
ENST00000653454.1
ENST00000292327.6
myosin light chain 3
chr2_-_127675065 11.74 ENST00000545738.6
ENST00000409808.6
LIM zinc finger domain containing 2
chr18_-_3219961 11.58 ENST00000356443.9
myomesin 1
chr6_-_123636923 11.48 ENST00000334268.9
triadin
chr3_-_99876104 10.82 ENST00000471562.1
ENST00000495625.2
filamin A interacting protein 1 like
chr7_-_80919017 10.80 ENST00000265361.8
semaphorin 3C
chr2_-_127675459 10.43 ENST00000355119.9
LIM zinc finger domain containing 2
chr14_-_23408265 10.28 ENST00000405093.9
myosin heavy chain 6
chr16_+_30372291 10.27 ENST00000568749.5
myosin light chain, phosphorylatable, fast skeletal muscle
chr3_-_99876193 9.85 ENST00000383694.3
filamin A interacting protein 1 like
chr10_-_17617326 9.42 ENST00000326961.6
ENST00000361271.8
3-hydroxyacyl-CoA dehydratase 1
chr10_-_88952763 8.82 ENST00000224784.10
actin alpha 2, smooth muscle
chr10_+_122163426 8.77 ENST00000360561.7
transforming acidic coiled-coil containing protein 2
chr6_-_123636906 8.62 ENST00000628709.2
triadin
chr12_+_52051402 8.43 ENST00000243050.5
ENST00000550763.1
ENST00000394825.6
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4 group A member 1
chr2_+_88067849 8.04 ENST00000438570.1
SET and MYND domain containing 1
chr1_+_15758768 7.79 ENST00000483633.6
ENST00000502739.5
ENST00000375766.8
ENST00000431771.6
filamin binding LIM protein 1
chr15_-_65067938 7.64 ENST00000421977.7
ENST00000220062.9
RAS like family 12
chr19_+_13024573 7.54 ENST00000358552.7
ENST00000360105.8
ENST00000588228.5
ENST00000676441.1
ENST00000591028.1
nuclear factor I X
chr15_+_96330691 7.48 ENST00000394166.8
nuclear receptor subfamily 2 group F member 2
chr17_-_29622893 7.30 ENST00000345068.9
ENST00000584602.1
ENST00000388767.8
ENST00000580212.6
coronin 6
chr10_-_17617235 7.19 ENST00000466335.1
3-hydroxyacyl-CoA dehydratase 1
chrX_-_32412220 7.15 ENST00000619831.5
dystrophin
chr7_-_27143672 6.96 ENST00000222726.4
homeobox A5
chr10_+_73998104 6.94 ENST00000372755.7
ENST00000211998.10
vinculin
chr8_+_2045058 6.79 ENST00000523438.1
myomesin 2
chr4_+_87006988 6.75 ENST00000307808.10
AF4/FMR2 family member 1
chr1_+_19644284 6.70 ENST00000375136.8
NBL1, DAN family BMP antagonist
chr7_-_44141285 6.63 ENST00000458240.5
ENST00000223364.7
myosin light chain 7
chr7_-_44141074 6.51 ENST00000457314.5
ENST00000447951.1
ENST00000431007.1
myosin light chain 7
chr5_-_170389634 6.20 ENST00000521859.1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr6_-_123636966 6.07 ENST00000542443.5
triadin
chr4_+_185143258 5.98 ENST00000281456.11
solute carrier family 25 member 4
chr5_+_151025343 5.97 ENST00000521632.1
glutathione peroxidase 3
chr16_+_66379225 5.92 ENST00000563425.2
cadherin 5
chr3_+_188212931 5.41 ENST00000618621.4
ENST00000640853.1
LIM domain containing preferred translocation partner in lipoma
chr7_-_108003122 5.40 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
laminin subunit beta 1
chr4_+_87006736 5.38 ENST00000544085.6
AF4/FMR2 family member 1
chr3_+_188212703 5.29 ENST00000443217.5
LIM domain containing preferred translocation partner in lipoma
chr1_-_11847772 5.27 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr19_+_13023958 5.17 ENST00000587760.5
ENST00000585575.5
nuclear factor I X
chr7_+_114414997 5.12 ENST00000462331.5
ENST00000393491.7
ENST00000403559.8
ENST00000408937.7
ENST00000393498.6
ENST00000393495.7
ENST00000378237.7
forkhead box P2
chr10_+_31321152 4.83 ENST00000446923.7
zinc finger E-box binding homeobox 1
chr8_+_2045037 4.77 ENST00000262113.9
myomesin 2
chr2_-_160200251 4.73 ENST00000428609.6
ENST00000409967.6
ENST00000283249.7
integrin subunit beta 6
chr6_+_151239951 4.72 ENST00000402676.7
A-kinase anchoring protein 12
chr17_-_29622732 4.22 ENST00000683819.1
ENST00000492276.7
coronin 6
chr19_+_45467988 4.21 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FosB proto-oncogene, AP-1 transcription factor subunit
chr6_+_151240368 4.19 ENST00000253332.5
A-kinase anchoring protein 12
chr2_+_100562941 4.17 ENST00000264254.11
phosducin like 3
chr10_+_69318831 3.97 ENST00000359426.7
hexokinase 1
chr5_-_33891941 3.84 ENST00000352040.7
ENST00000504830.6
ADAM metallopeptidase with thrombospondin type 1 motif 12
chr17_-_42979993 3.80 ENST00000409103.5
ENST00000360221.8
ENST00000454303.1
ENST00000591916.7
ENST00000451885.3
PTGES3L-AARSD1 readthrough
prostaglandin E synthase 3 like
chr19_+_13024626 3.67 ENST00000586873.1
nuclear factor I X
chr2_+_26692686 3.65 ENST00000620977.1
ENST00000302909.4
potassium two pore domain channel subfamily K member 3
chr14_-_89417148 3.62 ENST00000557258.6
forkhead box N3
chr6_+_43171260 3.58 ENST00000265354.6
serum response factor
chr3_-_123620571 3.57 ENST00000583087.5
myosin light chain kinase
chr19_+_53869384 3.55 ENST00000391769.2
myeloid associated differentiation marker
chr19_+_16067016 3.54 ENST00000589897.1
tropomyosin 4
chr17_-_10657302 3.42 ENST00000583535.6
myosin heavy chain 3
chr5_-_177496802 3.39 ENST00000506161.5
PDZ and LIM domain 7
chr5_+_66958870 3.32 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr3_-_123620496 3.31 ENST00000578202.1
myosin light chain kinase
chr19_+_53869439 3.28 ENST00000391768.2
myeloid associated differentiation marker
chrX_-_11265975 3.20 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr5_-_33892013 3.18 ENST00000515401.1
ADAM metallopeptidase with thrombospondin type 1 motif 12
chr7_-_94655993 3.18 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
sarcoglycan epsilon
chr16_+_30065753 3.14 ENST00000642816.3
ENST00000643777.4
ENST00000569798.5
aldolase, fructose-bisphosphate A
chr11_-_65900413 3.12 ENST00000448083.6
ENST00000531493.5
ENST00000532401.1
FOS like 1, AP-1 transcription factor subunit
chr2_-_160200310 3.05 ENST00000620391.4
integrin subunit beta 6
chr16_+_30065777 3.04 ENST00000395240.7
ENST00000566846.5
aldolase, fructose-bisphosphate A
chr11_-_47352693 3.03 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
myosin binding protein C3
chr19_+_1026566 2.95 ENST00000562015.5
ENST00000263097.9
ENST00000348419.7
ENST00000565096.6
ENST00000562958.6
ENST00000568865.3
ENST00000606983.5
ENST00000562075.6
ENST00000607102.1
calponin 2
chr7_-_94656160 2.92 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
sarcoglycan epsilon
chr7_-_94656197 2.92 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
sarcoglycan epsilon
chr5_-_177496845 2.90 ENST00000506537.1
PDZ and LIM domain 7
chr1_-_89126066 2.89 ENST00000370466.4
guanylate binding protein 2
chr1_-_11848345 2.88 ENST00000376476.1
natriuretic peptide A
chr5_+_96742183 2.84 ENST00000509259.5
ENST00000503828.5
calpastatin
chr19_+_57389839 2.73 ENST00000366197.9
ENST00000336128.12
ENST00000596282.5
ENST00000597400.5
ENST00000598895.5
ENST00000596617.5
zinc finger protein 548
novel transcript
chr3_+_188212641 2.72 ENST00000420410.5
LIM domain containing preferred translocation partner in lipoma
chr16_-_11281322 2.67 ENST00000312511.4
protamine 1
chr11_-_2141238 2.66 ENST00000434045.6
insulin like growth factor 2
chr9_-_76906041 2.57 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
prune homolog 2 with BCH domain
chr4_+_87007175 2.54 ENST00000511722.5
AF4/FMR2 family member 1
chr11_-_2140967 2.52 ENST00000381389.5
insulin like growth factor 2
chr17_-_42980393 2.32 ENST00000409446.8
ENST00000409399.6
ENST00000421990.7
prostaglandin E synthase 3 like
PTGES3L-AARSD1 readthrough
chr7_+_114414809 2.24 ENST00000350908.9
forkhead box P2
chr8_+_96584920 2.17 ENST00000521590.5
syndecan 2
chr10_-_16817362 2.16 ENST00000377921.7
ENST00000345264.10
Ras suppressor protein 1
chr17_-_48593748 2.09 ENST00000239151.6
homeobox B5
chr12_-_50222694 2.05 ENST00000552783.5
LIM domain and actin binding 1
chr2_-_96145431 1.97 ENST00000288943.5
dual specificity phosphatase 2
chr19_+_16067526 1.92 ENST00000646974.2
tropomyosin 4
chr13_+_27251545 1.90 ENST00000311549.11
ribosomal protein L21
chr20_+_4721901 1.86 ENST00000305817.3
prion like protein doppel
chr9_-_76906090 1.84 ENST00000376718.8
prune homolog 2 with BCH domain
chr11_-_65900375 1.75 ENST00000312562.7
FOS like 1, AP-1 transcription factor subunit
chr22_-_35961623 1.71 ENST00000408983.2
RNA binding fox-1 homolog 2
chr12_-_50222348 1.70 ENST00000552823.5
ENST00000552909.5
LIM domain and actin binding 1
chr2_-_231125032 1.69 ENST00000258400.4
5-hydroxytryptamine receptor 2B
chr5_-_58999885 1.67 ENST00000317118.12
phosphodiesterase 4D
chr10_-_16817443 1.63 ENST00000602389.1
Ras suppressor protein 1
chr12_-_11310420 1.61 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
proline rich protein BstNI subfamily 4
chr10_+_6144883 1.60 ENST00000379789.8
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_+_219496128 1.49 ENST00000651166.2
SPEG neighbor
chr19_+_53869623 1.44 ENST00000414489.1
myeloid associated differentiation marker
chr13_+_27251569 1.43 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
ribosomal protein L21
chr1_+_167630093 1.43 ENST00000537350.5
ENST00000361496.3
ENST00000367854.8
RCSD domain containing 1
chr15_+_45114324 1.43 ENST00000323030.6
dual oxidase maturation factor 2
chr6_-_3751703 1.40 ENST00000380283.5
PX domain containing 1
chr14_+_104800573 1.37 ENST00000555360.1
zinc finger and BTB domain containing 42
chr7_+_112480853 1.25 ENST00000439068.6
ENST00000312849.4
leucine rich single-pass membrane protein 1
chr7_+_107891135 1.16 ENST00000639772.1
ENST00000440410.5
ENST00000437604.6
ENST00000205402.10
dihydrolipoamide dehydrogenase
chr9_+_36136416 1.16 ENST00000396613.7
GLI pathogenesis related 2
chr7_+_143381286 1.10 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
zyxin
chr5_+_138439020 1.06 ENST00000378339.7
ENST00000254901.9
ENST00000506158.5
receptor accessory protein 2
chr22_+_37608716 1.05 ENST00000381756.9
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr3_-_157503574 0.99 ENST00000494677.5
ENST00000468233.5
ventricular zone expressed PH domain containing 1
chr10_+_110497898 0.95 ENST00000369583.4
dual specificity phosphatase 5
chr3_-_9792691 0.93 ENST00000343450.2
transcriptional adaptor 3
chr2_-_160200289 0.88 ENST00000409872.1
integrin subunit beta 6
chr2_-_207167220 0.84 ENST00000421199.5
ENST00000457962.5
Kruppel like factor 7
chr14_+_75278820 0.79 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr9_+_36136703 0.76 ENST00000377960.9
ENST00000377959.5
GLI pathogenesis related 2
chr1_+_223701607 0.73 ENST00000434648.5
calpain 2
chr1_+_11934651 0.70 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chr18_-_56651122 0.66 ENST00000590954.5
thioredoxin like 1
chr9_+_36136752 0.66 ENST00000619700.1
GLI pathogenesis related 2
chr22_+_45318791 0.62 ENST00000424557.1
family with sequence similarity 118 member A
chr7_+_143381561 0.59 ENST00000354434.8
zyxin
chr1_+_223701582 0.58 ENST00000433674.6
calpain 2
chr19_-_17245889 0.56 ENST00000291442.4
nuclear receptor subfamily 2 group F member 6
chr11_-_72112750 0.52 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
anaphase promoting complex subunit 15
chr14_+_104801082 0.51 ENST00000342537.8
zinc finger and BTB domain containing 42
chr10_-_62816309 0.50 ENST00000411732.3
early growth response 2
chr22_+_45318420 0.50 ENST00000427777.1
family with sequence similarity 118 member A
chr1_-_23014024 0.48 ENST00000440767.2
ENST00000622840.1
testis expressed 46
chr3_-_9792779 0.48 ENST00000439043.1
transcriptional adaptor 3
chr22_+_37608826 0.46 ENST00000405147.7
ENST00000343632.9
ENST00000429218.5
ENST00000325180.12
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr7_-_520216 0.38 ENST00000405692.2
platelet derived growth factor subunit A
chr7_+_149719345 0.35 ENST00000497895.5
KRAB-A domain containing 1
chr10_+_19489054 0.32 ENST00000377265.3
MAM and LDL receptor class A domain containing 1
chr17_-_4967790 0.30 ENST00000575142.5
ENST00000206020.8
sperm associated antigen 7
chr19_+_57670242 0.28 ENST00000612521.1
zinc finger and SCAN domain containing 4
chr5_-_124744513 0.26 ENST00000504926.5
zinc finger protein 608
chr1_-_248755754 0.25 ENST00000590317.4
LY6/PLAUR domain containing 8
chr8_-_22693469 0.18 ENST00000317216.3
early growth response 3
chrX_-_104254921 0.09 ENST00000372588.4
ESX homeobox 1
chr11_-_65900539 0.08 ENST00000534222.1
FOS like 1, AP-1 transcription factor subunit
chr15_+_83107572 0.06 ENST00000379390.10
ENST00000322019.14
ENST00000565774.5
ENST00000565982.1
transmembrane 6 superfamily member 1
chr2_+_190927649 0.04 ENST00000409428.5
ENST00000409215.5
glutaminase
chr14_+_74239447 0.03 ENST00000261980.3
visual system homeobox 2
chr1_-_89065357 0.02 ENST00000681280.1
guanylate binding protein 1
chr1_+_76074698 0.02 ENST00000328299.4
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr2_+_206159884 0.01 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.4 122.4 GO:0090131 mesenchyme migration(GO:0090131)
10.4 52.1 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
9.6 28.8 GO:0072209 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
5.4 10.8 GO:0003350 pulmonary myocardium development(GO:0003350)
4.4 35.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
3.9 15.4 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
3.4 57.0 GO:0006600 creatine metabolic process(GO:0006600)
3.2 25.6 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
2.5 7.4 GO:0021758 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
2.0 22.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.9 7.5 GO:0009956 radial pattern formation(GO:0009956)
1.8 3.6 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
1.7 7.0 GO:0060435 bronchiole development(GO:0060435)
1.4 8.2 GO:1902304 positive regulation of potassium ion export(GO:1902304)
1.3 6.7 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
1.2 6.2 GO:1903413 cellular response to bile acid(GO:1903413)
1.2 29.6 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
1.2 8.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.2 7.0 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
1.1 6.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.1 10.3 GO:0003228 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
1.0 3.0 GO:0032971 regulation of muscle filament sliding(GO:0032971)
1.0 6.0 GO:0015853 adenine transport(GO:0015853)
0.9 6.0 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.8 4.2 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.8 8.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.7 8.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.7 16.6 GO:0030497 fatty acid elongation(GO:0030497)
0.7 8.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.7 68.4 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.6 4.9 GO:0007296 vitellogenesis(GO:0007296)
0.6 25.0 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.6 21.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.5 5.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.5 4.8 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.5 5.9 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 7.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.4 7.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 2.2 GO:0008218 bioluminescence(GO:0008218)
0.4 4.0 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.3 1.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 6.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 20.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3 6.9 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.3 40.5 GO:0045445 myoblast differentiation(GO:0045445)
0.3 17.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 1.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 1.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.2 0.4 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.2 16.5 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 1.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 5.0 GO:0051412 response to corticosterone(GO:0051412)
0.1 3.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 2.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.7 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 3.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.4 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.1 15.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 6.2 GO:0045214 sarcomere organization(GO:0045214)
0.1 0.3 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.1 1.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 8.3 GO:0001706 endoderm formation(GO:0001706)
0.1 1.9 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 3.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.1 1.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 1.3 GO:0016540 protein autoprocessing(GO:0016540)
0.1 2.7 GO:0030261 chromosome condensation(GO:0030261)
0.1 6.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 3.7 GO:0031529 ruffle organization(GO:0031529)
0.0 31.6 GO:0003012 muscle system process(GO:0003012)
0.0 0.3 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 3.0 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.5 GO:1901998 toxin transport(GO:1901998)
0.0 6.9 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.6 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 12.0 GO:0006260 DNA replication(GO:0006260)
0.0 3.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 2.1 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 1.7 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 2.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 44.2 GO:0042643 actomyosin, actin portion(GO:0042643)
6.7 26.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
3.7 52.1 GO:0030314 junctional membrane complex(GO:0030314) sarcoplasmic reticulum lumen(GO:0033018)
3.4 40.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
3.2 32.1 GO:0032982 myosin filament(GO:0032982)
2.6 15.4 GO:1990584 cardiac Troponin complex(GO:1990584)
2.5 115.7 GO:0005859 muscle myosin complex(GO:0005859)
2.2 8.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
1.8 5.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
1.3 8.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
1.0 9.0 GO:0016012 sarcoglycan complex(GO:0016012)
1.0 28.8 GO:0046930 pore complex(GO:0046930)
1.0 42.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.9 17.9 GO:0036449 microtubule minus-end(GO:0036449)
0.6 31.8 GO:0031430 M band(GO:0031430)
0.5 16.9 GO:0031143 pseudopodium(GO:0031143)
0.4 7.1 GO:0016013 syntrophin complex(GO:0016013)
0.4 13.1 GO:0031672 A band(GO:0031672)
0.4 1.2 GO:0043159 acrosomal matrix(GO:0043159)
0.3 6.9 GO:0005916 fascia adherens(GO:0005916)
0.2 22.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 8.2 GO:0042629 mast cell granule(GO:0042629)
0.2 14.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.8 GO:0035976 AP1 complex(GO:0035976)
0.1 11.8 GO:0005811 lipid particle(GO:0005811)
0.1 8.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.0 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.2 GO:0030914 STAGA complex(GO:0030914)
0.1 16.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 45.1 GO:0005925 focal adhesion(GO:0005925)
0.0 5.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 5.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.6 GO:0005884 actin filament(GO:0005884)
0.0 4.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 8.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 57.0 GO:0004111 creatine kinase activity(GO:0004111)
5.5 16.6 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
3.5 83.2 GO:0032036 myosin heavy chain binding(GO:0032036)
2.6 28.8 GO:0043199 sulfate binding(GO:0043199)
1.7 13.7 GO:0017018 myosin phosphatase activity(GO:0017018)
1.5 15.4 GO:0031013 troponin I binding(GO:0031013)
1.5 6.0 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
1.3 50.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.9 3.6 GO:0010736 serum response element binding(GO:0010736)
0.8 16.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.8 82.5 GO:0017022 myosin binding(GO:0017022)
0.8 25.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.7 6.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 2.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.6 4.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.5 6.7 GO:0016015 morphogen activity(GO:0016015)
0.5 6.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 10.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 4.0 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 8.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 6.9 GO:0002162 dystroglycan binding(GO:0002162)
0.3 6.0 GO:0008430 selenium binding(GO:0008430)
0.3 33.0 GO:0050681 androgen receptor binding(GO:0050681)
0.3 7.8 GO:0031005 filamin binding(GO:0031005)
0.2 21.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 2.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 14.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 8.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 1.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 7.5 GO:0001972 retinoic acid binding(GO:0001972)
0.2 15.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 50.6 GO:0044325 ion channel binding(GO:0044325)
0.1 6.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.7 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.7 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 3.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.2 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 5.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 38.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 3.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 18.4 GO:0051015 actin filament binding(GO:0051015)
0.1 8.8 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 18.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 8.7 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 28.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.8 GO:0070888 E-box binding(GO:0070888)
0.0 8.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 7.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 4.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.9 GO:0005507 copper ion binding(GO:0005507)
0.0 3.3 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 94.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.5 25.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 29.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 36.6 PID RHOA PATHWAY RhoA signaling pathway
0.4 57.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 8.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 17.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 10.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 5.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 18.7 PID CMYB PATHWAY C-MYB transcription factor network
0.1 17.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 8.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 7.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 11.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 6.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 5.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 10.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 10.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 6.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 128.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.9 16.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.8 48.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 11.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 28.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 5.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 8.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 7.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 51.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 3.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 40.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 8.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 6.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 7.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 5.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 6.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 14.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 22.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 3.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling