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Illumina Body Map 2 (GSE30611)

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Results for TBX20

Z-value: 0.82

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.11 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX20hg38_v1_chr7_-_35254074_35254106-0.232.1e-01Click!

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_57628507 17.01 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
ADGRG1
adhesion G protein-coupled receptor G1
chr16_+_57628684 11.98 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
ADGRG1
adhesion G protein-coupled receptor G1
chr8_+_27325516 2.78 ENST00000346049.10
ENST00000420218.3
PTK2B
protein tyrosine kinase 2 beta
chr15_-_22160868 2.68 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chrX_+_78945332 2.32 ENST00000544091.1
ENST00000171757.3
P2RY10
P2Y receptor family member 10
chr15_-_21718245 2.12 ENST00000630556.1
ENSG00000281179.1
novel gene identicle to IGHV1OR15-1
chr14_-_105987068 2.00 ENST00000390594.3
IGHV1-2
immunoglobulin heavy variable 1-2
chr12_+_15322480 1.66 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chr14_-_106235582 1.49 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr6_-_2841853 1.35 ENST00000380739.6
SERPINB1
serpin family B member 1
chr5_+_134525649 1.28 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
JADE2
jade family PHD finger 2
chrX_+_68693629 1.15 ENST00000374597.3
STARD8
StAR related lipid transfer domain containing 8
chr7_+_30145789 1.14 ENST00000324489.5
MTURN
maturin, neural progenitor differentiation regulator homolog
chr12_+_15322257 1.07 ENST00000674316.1
PTPRO
protein tyrosine phosphatase receptor type O
chr12_-_121038967 1.00 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr17_-_3696133 0.99 ENST00000225328.10
P2RX5
purinergic receptor P2X 5
chr7_+_142424942 0.98 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr19_-_39320839 0.95 ENST00000248668.5
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr3_-_183555696 0.93 ENST00000341319.8
KLHL6
kelch like family member 6
chr12_+_15322529 0.93 ENST00000348962.7
PTPRO
protein tyrosine phosphatase receptor type O
chr16_+_31033781 0.92 ENST00000613541.1
STX4
syntaxin 4
chr4_+_159104148 0.84 ENST00000505478.5
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr10_-_54801262 0.78 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
PCDH15
protocadherin related 15
chr2_+_60881553 0.77 ENST00000394479.4
REL
REL proto-oncogene, NF-kB subunit
chr12_-_121039236 0.71 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_121039204 0.70 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr16_+_31033513 0.67 ENST00000313843.8
STX4
syntaxin 4
chr5_+_162067500 0.67 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr2_+_60881515 0.66 ENST00000295025.12
REL
REL proto-oncogene, NF-kB subunit
chr12_-_121039156 0.65 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr5_+_136059151 0.62 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr5_+_162067458 0.62 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr10_-_102114935 0.62 ENST00000361198.9
LDB1
LIM domain binding 1
chr18_-_55587335 0.62 ENST00000638154.3
TCF4
transcription factor 4
chrX_-_101617921 0.51 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr12_-_16609869 0.45 ENST00000534946.5
LMO3
LIM domain only 3
chr1_+_87331668 0.44 ENST00000370542.1
LMO4
LIM domain only 4
chr19_+_7680822 0.43 ENST00000596148.3
ENST00000317378.5
ENST00000426877.2
TRAPPC5
trafficking protein particle complex 5
chr12_-_16610037 0.41 ENST00000540590.1
LMO3
LIM domain only 3
chr3_+_187197486 0.36 ENST00000312295.5
RTP1
receptor transporter protein 1
chr13_+_113001270 0.30 ENST00000409954.6
MCF2L
MCF.2 cell line derived transforming sequence like
chr3_-_50359480 0.28 ENST00000266025.4
TMEM115
transmembrane protein 115
chr19_+_45668191 0.25 ENST00000652180.1
ENST00000590918.6
ENST00000263281.7
ENST00000304207.12
GIPR
gastric inhibitory polypeptide receptor
chr8_-_141496759 0.23 ENST00000521161.5
MROH5
maestro heat like repeat family member 5 (gene/pseudogene)
chr8_-_108443409 0.20 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr17_-_78828893 0.17 ENST00000586066.3
USP36
ubiquitin specific peptidase 36
chr1_-_158330957 0.17 ENST00000451207.5
CD1B
CD1b molecule
chr15_-_84716384 0.15 ENST00000559729.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr20_+_45881218 0.14 ENST00000372523.1
ZSWIM1
zinc finger SWIM-type containing 1
chr12_-_84912783 0.14 ENST00000680892.1
ENST00000266682.10
ENST00000680714.1
ENST00000552192.5
SLC6A15
solute carrier family 6 member 15
chr3_+_161496808 0.11 ENST00000327928.4
OTOL1
otolin 1
chr15_-_84716153 0.09 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr2_+_153871909 0.07 ENST00000392825.8
ENST00000434213.1
GALNT13
polypeptide N-acetylgalactosaminyltransferase 13
chr19_-_40714641 0.05 ENST00000678467.1
COQ8B
coenzyme Q8B
chr4_-_26490453 0.04 ENST00000295589.4
CCKAR
cholecystokinin A receptor
chr13_-_113974062 0.04 ENST00000636427.3
C13orf46
chromosome 13 open reading frame 46
chr15_-_84716099 0.03 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr11_+_6259806 0.02 ENST00000532715.5
ENST00000334619.7
ENST00000525014.1
ENST00000531712.5
ENST00000525462.1
CCKBR
cholecystokinin B receptor
chr12_+_64780465 0.02 ENST00000542120.6
TBC1D30
TBC1 domain family member 30
chr21_-_30598902 0.02 ENST00000334897.4
KRTAP6-2
keratin associated protein 6-2
chr22_+_37823382 0.00 ENST00000249041.3
GALR3
galanin receptor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 29.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.9 3.7 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.5 2.8 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.6 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.2 0.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.8 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 2.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.8 GO:0050957 equilibrioception(GO:0050957)
0.1 1.0 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 1.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 4.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.9 GO:0002467 germinal center formation(GO:0002467)
0.0 3.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.4 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.2 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 1.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0015820 leucine transport(GO:0015820)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 29.0 GO:0097451 glial limiting end-foot(GO:0097451)
0.1 2.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0000322 storage vacuole(GO:0000322)
0.1 4.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 3.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2 29.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 3.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 2.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 3.7 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) Wnt-protein binding(GO:0017147) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.0 GO:0016502 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.1 1.3 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 4.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 3.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 3.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin