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Illumina Body Map 2 (GSE30611)
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Results for TBX21_TBR1
Z-value: 1.04
Motif logo
Transcription factors associated with TBX21_TBR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBX21
|
ENSG00000073861.3 | T-box transcription factor 21 |
|
TBR1
|
ENSG00000136535.15 | T-box brain transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX21 | hg38_v1_chr17_+_47733228_47733242 | 0.66 | 4.2e-05 | Click! |
| TBR1 | hg38_v1_chr2_+_161416273_161416325 | 0.03 | 8.9e-01 | Click! |
Activity profile of TBX21_TBR1 motif
Sorted Z-values of TBX21_TBR1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX21_TBR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0010932 | macrophage tolerance induction(GO:0010931) regulation of macrophage tolerance induction(GO:0010932) positive regulation of macrophage tolerance induction(GO:0010933) |
| 0.9 | 2.8 | GO:0060559 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.9 | 5.6 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.9 | 2.7 | GO:2000547 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 0.8 | 3.3 | GO:0070839 | divalent metal ion export(GO:0070839) |
| 0.6 | 1.8 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.6 | 2.9 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.5 | 2.7 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.5 | 1.6 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.5 | 4.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.5 | 3.2 | GO:0038112 | interleukin-8-mediated signaling pathway(GO:0038112) |
| 0.4 | 1.3 | GO:0045082 | interleukin-13 biosynthetic process(GO:0042231) positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.4 | 0.9 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) |
| 0.4 | 3.8 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.4 | 2.4 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.4 | 1.2 | GO:0061011 | hepatic duct development(GO:0061011) hepatoblast differentiation(GO:0061017) |
| 0.4 | 1.1 | GO:0051714 | negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
| 0.4 | 2.3 | GO:0051622 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.4 | 1.8 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 0.3 | 1.4 | GO:1902524 | negative regulation of interferon-alpha biosynthetic process(GO:0045355) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.3 | 1.0 | GO:1902523 | positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.3 | 1.3 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.3 | 8.7 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.3 | 2.4 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.3 | 1.0 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.3 | 2.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.2 | 0.7 | GO:0086092 | regulation of the force of heart contraction by cardiac conduction(GO:0086092) |
| 0.2 | 1.1 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.2 | 0.7 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.2 | 2.4 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.2 | 1.1 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.2 | 1.5 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.2 | 1.9 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.2 | 2.5 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.2 | 1.0 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 2.7 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 1.3 | GO:2000670 | positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.2 | 1.1 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.2 | 1.2 | GO:0046103 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.2 | 2.9 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.2 | 0.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.2 | 0.8 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.2 | 2.9 | GO:0035630 | bone mineralization involved in bone maturation(GO:0035630) |
| 0.2 | 1.1 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.2 | 2.0 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.2 | 0.5 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.1 | 0.7 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 1.3 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 1.8 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.1 | 0.8 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.4 | GO:0060309 | elastin catabolic process(GO:0060309) |
| 0.1 | 0.4 | GO:0002769 | natural killer cell inhibitory signaling pathway(GO:0002769) |
| 0.1 | 0.4 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.1 | 2.0 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.1 | 0.4 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 0.1 | 0.8 | GO:0031179 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.1 | 1.0 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.1 | 1.5 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 1.7 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.1 | 1.0 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.4 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 0.8 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 1.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 2.3 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 1.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.6 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.1 | 0.4 | GO:0099542 | trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542) |
| 0.1 | 0.3 | GO:0035962 | response to interleukin-13(GO:0035962) |
| 0.1 | 1.7 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.1 | 0.6 | GO:0097368 | membrane to membrane docking(GO:0022614) establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 1.5 | GO:0015884 | folic acid transport(GO:0015884) |
| 0.1 | 1.0 | GO:0070543 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 2.8 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.1 | 0.4 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.1 | 0.5 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 0.4 | GO:2001184 | positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.1 | 7.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.1 | 0.4 | GO:0036493 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) |
| 0.1 | 0.6 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.3 | GO:0032764 | negative regulation of mast cell cytokine production(GO:0032764) |
| 0.1 | 0.4 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 1.5 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.1 | 0.2 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.1 | 1.1 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.1 | 0.5 | GO:1903593 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of histamine secretion by mast cell(GO:1903593) |
| 0.1 | 0.7 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.1 | 0.3 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.1 | 0.8 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 2.8 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 1.7 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.1 | 1.2 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.1 | 4.6 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 0.2 | GO:0001207 | histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039) |
| 0.1 | 0.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 0.4 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.1 | 0.8 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 1.0 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 0.2 | GO:0071626 | mastication(GO:0071626) learned vocalization behavior(GO:0098583) |
| 0.1 | 0.6 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 0.3 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.1 | 0.1 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 0.2 | GO:0071288 | cellular response to mercury ion(GO:0071288) |
| 0.1 | 0.7 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 1.5 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 1.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.1 | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.1 | 0.7 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.1 | 0.2 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 0.6 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.1 | 0.6 | GO:0097647 | positive regulation of protein kinase A signaling(GO:0010739) dimeric G-protein coupled receptor signaling pathway(GO:0038042) calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 1.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.5 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 0.8 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 0.6 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 0.4 | GO:0002353 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.0 | 0.3 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.0 | 0.2 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.0 | 0.4 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.0 | 0.9 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.0 | 0.5 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 0.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.0 | 2.1 | GO:0002820 | negative regulation of adaptive immune response(GO:0002820) |
| 0.0 | 0.5 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.0 | 0.2 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.0 | 0.4 | GO:1905066 | blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.2 | GO:0072695 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.0 | 0.2 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.0 | 0.2 | GO:0061015 | snRNA import into nucleus(GO:0061015) |
| 0.0 | 1.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.1 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.0 | 0.2 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 0.0 | 0.1 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.0 | 0.3 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.0 | 1.7 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 0.2 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.0 | 0.4 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.0 | 0.2 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.0 | 1.3 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.3 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
| 0.0 | 0.3 | GO:0055118 | negative regulation of cardiac muscle contraction(GO:0055118) |
| 0.0 | 0.3 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.0 | 5.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.0 | 1.1 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 3.1 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.1 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.0 | 0.7 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 0.1 | GO:0034729 | histone H3-K79 methylation(GO:0034729) regulation of genetic imprinting(GO:2000653) |
| 0.0 | 1.1 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.0 | 0.4 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.0 | 0.6 | GO:0008228 | opsonization(GO:0008228) |
| 0.0 | 0.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.7 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.3 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 0.6 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.0 | 0.6 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 1.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.4 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 0.4 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
| 0.0 | 0.4 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.1 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
| 0.0 | 0.4 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.5 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.0 | 0.3 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 0.1 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.0 | 0.1 | GO:0002001 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001) |
| 0.0 | 0.7 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.2 | GO:0031022 | nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear migration along microfilament(GO:0031022) |
| 0.0 | 0.3 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 0.0 | 0.1 | GO:0006407 | rRNA export from nucleus(GO:0006407) |
| 0.0 | 1.5 | GO:0030101 | natural killer cell activation(GO:0030101) |
| 0.0 | 1.9 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.0 | 2.5 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway(GO:0048010) |
| 0.0 | 0.3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 1.0 | GO:0002279 | mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303) |
| 0.0 | 0.3 | GO:0031163 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.1 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
| 0.0 | 1.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.2 | GO:0040023 | establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.2 | GO:0051963 | regulation of synapse assembly(GO:0051963) |
| 0.0 | 0.6 | GO:0001569 | patterning of blood vessels(GO:0001569) |
| 0.0 | 0.4 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.4 | GO:0006677 | glycosylceramide metabolic process(GO:0006677) |
| 0.0 | 0.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.1 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.0 | 1.1 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 0.1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.0 | 1.5 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.3 | GO:0030261 | chromosome condensation(GO:0030261) |
| 0.0 | 0.1 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.0 | 0.4 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.3 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.0 | 0.2 | GO:0021860 | pyramidal neuron development(GO:0021860) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.3 | 2.7 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.3 | 1.8 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.2 | 1.4 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.2 | 0.7 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.2 | 0.8 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.2 | 8.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 2.4 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.2 | 1.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 0.5 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.2 | 2.8 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 0.6 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 0.4 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.1 | 3.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.5 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 0.6 | GO:0072557 | IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169) |
| 0.1 | 1.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 2.3 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.2 | GO:0044308 | axonal spine(GO:0044308) |
| 0.1 | 1.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 0.4 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.1 | 1.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 0.4 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.1 | 0.6 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 3.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.2 | GO:0035101 | FACT complex(GO:0035101) |
| 0.1 | 1.3 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 1.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 9.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 0.2 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.1 | 1.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.6 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.8 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.2 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 2.1 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 3.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 2.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.5 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.4 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.0 | 1.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.3 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 11.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 0.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.2 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.0 | 0.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.0 | 2.9 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.3 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 0.0 | 0.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.2 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.0 | 1.5 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 0.5 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 0.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 4.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.2 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 4.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 2.0 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.9 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.4 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 1.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.1 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 0.1 | GO:0030891 | VCB complex(GO:0030891) |
| 0.0 | 2.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.9 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 0.3 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.2 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.7 | 2.0 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.6 | 1.8 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.5 | 3.2 | GO:0004918 | interleukin-8 receptor activity(GO:0004918) |
| 0.5 | 4.0 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.5 | 2.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.4 | 2.3 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 3.3 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.3 | 1.1 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.3 | 1.7 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.3 | 2.4 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.2 | 0.6 | GO:0032428 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.2 | 1.2 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 1.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 1.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.2 | 0.9 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.2 | 1.5 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.2 | 2.9 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.2 | 7.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 2.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.2 | 2.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.0 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.1 | 5.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.7 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.1 | 0.8 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.1 | 2.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 0.8 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.1 | 1.2 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 1.5 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.5 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.1 | 1.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.2 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.1 | 0.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 1.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 3.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 1.3 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 1.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 1.6 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 3.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 2.7 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 0.3 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 1.8 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.5 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.1 | 1.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 11.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 4.0 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 0.6 | GO:0070728 | leucine binding(GO:0070728) |
| 0.1 | 0.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 0.7 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 0.6 | GO:0030882 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.1 | 1.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.5 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 1.1 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.1 | 0.2 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.1 | 0.2 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.1 | 0.6 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.1 | 0.3 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 2.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 2.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 1.0 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.0 | 1.2 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.3 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.0 | 0.4 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.2 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.0 | 0.8 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 1.2 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.2 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.0 | 0.4 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.7 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.0 | 3.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 3.7 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.4 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.0 | 5.6 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.6 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.5 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 1.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.6 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 0.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 1.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.4 | GO:0051525 | mitogen-activated protein kinase p38 binding(GO:0048273) NFAT protein binding(GO:0051525) |
| 0.0 | 9.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0030547 | receptor inhibitor activity(GO:0030547) |
| 0.0 | 0.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 1.3 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.5 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 1.0 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.5 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 2.2 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.3 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 1.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.7 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.3 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.6 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 3.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.1 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.0 | 0.5 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 3.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.1 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.3 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 0.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.0 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.1 | GO:0030274 | LIM domain binding(GO:0030274) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 3.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 6.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 8.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 1.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 2.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 1.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 3.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 5.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 5.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 4.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 6.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.7 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 1.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.9 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.0 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.4 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 0.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 4.9 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 4.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 9.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 4.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 1.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 5.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 6.1 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 2.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 3.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 2.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.1 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 2.8 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 2.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 2.2 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.6 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.0 | 1.5 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.3 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.6 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.0 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 1.0 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 1.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.9 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 0.0 | 0.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 2.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.1 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.3 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.3 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.4 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.4 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.0 | 2.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.4 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |