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Illumina Body Map 2 (GSE30611)
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Results for TBX3
Z-value: 0.98
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Transcription factors associated with TBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX3 | hg38_v1_chr12_-_114684151_114684221 | -0.18 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.5 | 4.5 | GO:2000296 | negative regulation of hydrogen peroxide catabolic process(GO:2000296) |
| 0.0 | 4.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 3.6 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.0 | 3.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 3.4 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.7 | 2.9 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.1 | 2.9 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.1 | 2.8 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.8 | 2.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.1 | 4.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 4.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 3.9 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 3.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.3 | 1.9 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 1.9 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 1.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 8.4 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 7.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 7.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 7.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.8 | 2.5 | GO:0051990 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990) |
| 0.8 | 2.4 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.1 | 2.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 2.2 | GO:0019863 | IgE binding(GO:0019863) |
| 0.1 | 2.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 1.2 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 2.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 2.4 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 2.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.9 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 1.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |