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Illumina Body Map 2 (GSE30611)
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Results for TLX1_NFIC
Z-value: 2.16
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Transcription factors associated with TLX1_NFIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg38_v1_chr19_+_3314403_3314472 | 0.40 | 2.4e-02 | Click! |
| TLX1 | hg38_v1_chr10_+_101131284_101131321 | -0.27 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 23.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 2.8 | 22.3 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.5 | 16.1 | GO:0031639 | plasminogen activation(GO:0031639) |
| 3.9 | 15.4 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.9 | 14.6 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.1 | 11.9 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.5 | 10.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 3.4 | 10.1 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) |
| 3.3 | 9.8 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 1.9 | 9.6 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 1.4 | 24.5 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.8 | 15.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.8 | 14.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 14.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.9 | 12.5 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 11.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 10.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 9.8 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 9.1 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 21.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 16.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 4.1 | 16.4 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 0.1 | 16.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 3.9 | 15.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 1.8 | 14.6 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.4 | 13.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 12.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 10.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 10.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 16.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 15.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 14.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 12.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 9.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 9.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 8.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 7.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 7.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 21.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 13.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.4 | 12.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 10.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 10.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 9.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 8.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 7.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 6.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |