ISMARA results: TP53

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Illumina Body Map 2 (GSE30611)

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Results for TP53

Z-value: 1.56

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Transcription factors associated with TP53

Gene Symbol	Gene ID	Gene Info
TP53 Ensembl NCBI GeneCards UniProt	ENSG00000141510.18	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TP53	hg38_v1_chr17_-_7687427_7687538	0.42	1.7e-02	Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106235582 Show fit	5.53	ENST00000390607.2	IGHV3-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-21
chr8_+_23102913 Show fit	5.20	ENST00000356864.4	TNFRSF10C Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10c
chr11_-_47378527 Show fit	5.15	ENST00000378538.8	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr11_-_47378391 Show fit	4.84	ENST00000227163.8	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr11_-_47378494 Show fit	4.84	ENST00000533030.1	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr11_-_47378479 Show fit	4.65	ENST00000533968.1	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr11_+_65879791 Show fit	4.12	ENST00000528419.6 ENST00000307886.8 ENST00000526034.2 ENST00000679584.1 ENST00000680443.1 ENST00000680670.1	CTSW Ensembl NCBI GeneCards UniProt Show fit	cathepsin W
chr18_+_59899988 Show fit	3.96	ENST00000316660.7 ENST00000269518.9	PMAIP1 Ensembl NCBI GeneCards UniProt Show fit	phorbol-12-myristate-13-acetate-induced protein 1
chr8_-_23225061 Show fit	3.94	ENST00000613472.1 ENST00000221132.8	TNFRSF10A Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10a
chr19_+_3136026 Show fit	3.36	ENST00000262958.4	GNA15 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha 15
chr8_-_23164020 Show fit	3.26	ENST00000312584.4	TNFRSF10D Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10d
chr2_-_234497035 Show fit	3.23	ENST00000390645.2 ENST00000339728.6	ARL4C Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor like GTPase 4C
chr8_-_10730498 Show fit	3.21	ENST00000304501.2	SOX7 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 7
chr20_-_1393045 Show fit	3.07	ENST00000400137.9 ENST00000381715.4	FKBP1A Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 1A
chr7_+_99374722 Show fit	3.01	ENST00000418347.6 ENST00000429246.6 ENST00000417330.6 ENST00000431816.6 ENST00000458033.6 ENST00000451682.5 ENST00000427217.6 ENST00000646101.2	ARPC1B Ensembl NCBI GeneCards UniProt Show fit	actin related protein 2/3 complex subunit 1B
chr1_-_150765735 Show fit	3.00	ENST00000679898.1 ENST00000448301.7 ENST00000680664.1 ENST00000679512.1 ENST00000368985.8 ENST00000679582.1	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr19_+_827823 Show fit	2.97	ENST00000233997.4	AZU1 Ensembl NCBI GeneCards UniProt Show fit	azurocidin 1
chr1_-_37947010 Show fit	2.90	ENST00000458109.6 ENST00000373024.8 ENST00000373023.6	INPP5B Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase B
chr9_+_36136416 Show fit	2.79	ENST00000396613.7	GLIPR2 Ensembl NCBI GeneCards UniProt Show fit	GLI pathogenesis related 2
chr20_-_1393074 Show fit	2.78	ENST00000614856.2 ENST00000678408.1 ENST00000618612.5 ENST00000439640.5 ENST00000381719.8 ENST00000677533.1	FKBP1A Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 1A
chr5_-_132490750 Show fit	2.57	ENST00000437654.6 ENST00000245414.9 ENST00000680139.1 ENST00000680352.1 ENST00000679440.1 ENST00000680903.1	IRF1 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 1
chr6_+_36130484 Show fit	2.46	ENST00000373766.9 ENST00000211287.9	MAPK13 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 13
chr1_+_161524539 Show fit	2.44	ENST00000309758.6	HSPA6 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 6
chr11_-_65859282 Show fit	2.43	ENST00000526975.1 ENST00000531413.5 ENST00000525451.6	CFL1 Ensembl NCBI GeneCards UniProt Show fit	cofilin 1
chr7_+_99374675 Show fit	2.42	ENST00000645391.1 ENST00000455009.6	ARPC1B Ensembl NCBI GeneCards UniProt Show fit	actin related protein 2/3 complex subunit 1B
chr19_+_48954850 Show fit	2.40	ENST00000345358.12 ENST00000539787.2 ENST00000415969.6 ENST00000354470.7 ENST00000506183.5 ENST00000391871.4 ENST00000293288.12	BAX Ensembl NCBI GeneCards UniProt Show fit	BCL2 associated X, apoptosis regulator
chr1_+_27879638 Show fit	2.38	ENST00000456990.1	THEMIS2 Ensembl NCBI GeneCards UniProt Show fit	thymocyte selection associated family member 2
chr11_-_44950839 Show fit	2.38	ENST00000395648.7 ENST00000531928.6	TP53I11 Ensembl NCBI GeneCards UniProt Show fit	tumor protein p53 inducible protein 11
chr10_+_88990736 Show fit	2.35	ENST00000357339.6 ENST00000652046.1 ENST00000355279.2	FAS Ensembl NCBI GeneCards UniProt Show fit	Fas cell surface death receptor
chr19_-_6481769 Show fit	2.33	ENST00000381480.7 ENST00000543576.5 ENST00000590173.5	DENND1C Ensembl NCBI GeneCards UniProt Show fit	DENN domain containing 1C
chr1_-_160862700 Show fit	2.32	ENST00000322302.7 ENST00000368033.7	CD244 Ensembl NCBI GeneCards UniProt Show fit	CD244 molecule
chr17_+_14301069 Show fit	2.31	ENST00000360954.3	HS3ST3B1 Ensembl NCBI GeneCards UniProt Show fit	heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr1_-_150765785 Show fit	2.30	ENST00000680311.1 ENST00000681728.1 ENST00000680288.1	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr8_-_23069012 Show fit	2.28	ENST00000347739.3 ENST00000276431.9	TNFRSF10B Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10b
chr10_-_103452356 Show fit	2.24	ENST00000260743.10	CALHM2 Ensembl NCBI GeneCards UniProt Show fit	calcium homeostasis modulator family member 2
chr1_-_160862880 Show fit	2.24	ENST00000368034.9	CD244 Ensembl NCBI GeneCards UniProt Show fit	CD244 molecule
chr1_-_54018167 Show fit	2.23	ENST00000371362.7 ENST00000371360.2 ENST00000545928.5 ENST00000420619.5	LDLRAD1 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor class A domain containing 1
chr16_+_527698 Show fit	2.23	ENST00000219611.7 ENST00000562370.5 ENST00000568988.5	CAPN15 Ensembl NCBI GeneCards UniProt Show fit	calpain 15
chr19_-_42217667 Show fit	2.19	ENST00000336034.8 ENST00000596251.6 ENST00000598200.1 ENST00000598727.5	DEDD2 Ensembl NCBI GeneCards UniProt Show fit	death effector domain containing 2
chr11_+_67403887 Show fit	2.18	ENST00000526387.5	TBC1D10C Ensembl NCBI GeneCards UniProt Show fit	TBC1 domain family member 10C
chr6_-_30744537 Show fit	2.16	ENST00000259874.6 ENST00000376377.2	IER3 Ensembl NCBI GeneCards UniProt Show fit	immediate early response 3
chr11_-_73982830 Show fit	2.14	ENST00000536983.5 ENST00000663595.2 ENST00000310473.9	UCP2 Ensembl NCBI GeneCards UniProt Show fit	uncoupling protein 2
chr19_+_41860236 Show fit	2.14	ENST00000601492.5 ENST00000600467.6 ENST00000598742.6 ENST00000221975.6 ENST00000598261.2	RPS19 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S19
chr11_+_5691004 Show fit	2.12	ENST00000414641.5	TRIM22 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 22
chr1_+_17308194 Show fit	2.11	ENST00000375453.5 ENST00000375448.4	PADI4 Ensembl NCBI GeneCards UniProt Show fit	peptidyl arginine deiminase 4
chrX_-_154354889 Show fit	2.09	ENST00000438732.2	FLNA Ensembl NCBI GeneCards UniProt Show fit	filamin A
chr19_-_47232649 Show fit	2.06	ENST00000449228.5 ENST00000300880.11 ENST00000341983.8	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr6_-_132714045 Show fit	2.05	ENST00000367928.5	VNN1 Ensembl NCBI GeneCards UniProt Show fit	vanin 1
chr1_+_9997220 Show fit	2.02	ENST00000294435.8	RBP7 Ensembl NCBI GeneCards UniProt Show fit	retinol binding protein 7
chr7_+_48088596 Show fit	1.97	ENST00000416681.5 ENST00000331803.8 ENST00000432131.5	UPP1 Ensembl NCBI GeneCards UniProt Show fit	uridine phosphorylase 1
chrX_+_100644183 Show fit	1.97	ENST00000640889.1 ENST00000373004.5	SRPX2 Ensembl NCBI GeneCards UniProt Show fit	sushi repeat containing protein X-linked 2
chr19_+_56141317 Show fit	1.86	ENST00000592949.5	ZNF444 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 444
chr19_-_51646800 Show fit	1.83	ENST00000599649.5 ENST00000429354.3 ENST00000360844.6	SIGLEC5 Ensembl NCBI GeneCards UniProt Show fit SIGLEC14 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig like lectin 5 sialic acid binding Ig like lectin 14
chr10_-_103452384 Show fit	1.77	ENST00000369788.7	CALHM2 Ensembl NCBI GeneCards UniProt Show fit	calcium homeostasis modulator family member 2
chr20_+_35172046 Show fit	1.76	ENST00000216968.5	PROCR Ensembl NCBI GeneCards UniProt Show fit	protein C receptor
chr3_-_39281663 Show fit	1.70	ENST00000358309.3	CX3CR1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine receptor 1
chr17_-_63446168 Show fit	1.69	ENST00000584031.5 ENST00000392976.5	CYB561 Ensembl NCBI GeneCards UniProt Show fit	cytochrome b561
chr3_-_52445085 Show fit	1.69	ENST00000475739.1 ENST00000231721.7	SEMA3G Ensembl NCBI GeneCards UniProt Show fit	semaphorin 3G
chr17_-_63446260 Show fit	1.68	ENST00000448884.6 ENST00000582297.5 ENST00000360793.8 ENST00000582034.5 ENST00000578072.1	CYB561 Ensembl NCBI GeneCards UniProt Show fit	cytochrome b561
chr12_-_14567714 Show fit	1.68	ENST00000240617.10	PLBD1 Ensembl NCBI GeneCards UniProt Show fit	phospholipase B domain containing 1
chr19_+_56141277 Show fit	1.67	ENST00000337080.8 ENST00000586123.5	ZNF444 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 444
chr1_+_26826682 Show fit	1.66	ENST00000374142.9	ZDHHC18 Ensembl NCBI GeneCards UniProt Show fit	zinc finger DHHC-type palmitoyltransferase 18
chr4_+_25648011 Show fit	1.65	ENST00000645788.1	SLC34A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 34 member 2
chr1_+_11736120 Show fit	1.63	ENST00000400895.6 ENST00000314340.10 ENST00000376629.8 ENST00000376627.6 ENST00000452018.6 ENST00000510878.1	AGTRAP Ensembl NCBI GeneCards UniProt Show fit	angiotensin II receptor associated protein
chr15_-_64162965 Show fit	1.62	ENST00000300026.4 ENST00000681397.1 ENST00000681658.1	PPIB Ensembl NCBI GeneCards UniProt Show fit	peptidylprolyl isomerase B
chr3_+_52495330 Show fit	1.62	ENST00000321725.10	STAB1 Ensembl NCBI GeneCards UniProt Show fit	stabilin 1
chr3_-_12759224 Show fit	1.59	ENST00000314124.12 ENST00000435218.6 ENST00000435575.5	TMEM40 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 40
chr9_-_133121148 Show fit	1.59	ENST00000372047.7	RALGDS Ensembl NCBI GeneCards UniProt Show fit	ral guanine nucleotide dissociation stimulator
chr1_-_209652329 Show fit	1.58	ENST00000367030.7 ENST00000356082.9	LAMB3 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit beta 3
chr19_-_6591103 Show fit	1.57	ENST00000423145.7 ENST00000245903.4	CD70 Ensembl NCBI GeneCards UniProt Show fit	CD70 molecule
chr7_-_38349972 Show fit	1.55	ENST00000390344.2	TRGV5 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor gamma variable 5
chr22_-_39319595 Show fit	1.54	ENST00000427905.5 ENST00000216146.9 ENST00000402527.5	RPL3 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L3
chr1_-_156020789 Show fit	1.51	ENST00000531917.5 ENST00000480567.5 ENST00000526212.2 ENST00000529008.5 ENST00000496742.5 ENST00000295702.9	SSR2 Ensembl NCBI GeneCards UniProt Show fit	signal sequence receptor subunit 2
chr16_-_14694308 Show fit	1.49	ENST00000438167.8	PLA2G10 Ensembl NCBI GeneCards UniProt Show fit	phospholipase A2 group X
chr1_+_11736068 Show fit	1.48	ENST00000376637.7	AGTRAP Ensembl NCBI GeneCards UniProt Show fit	angiotensin II receptor associated protein
chr9_-_127755030 Show fit	1.48	ENST00000414380.1	SH2D3C Ensembl NCBI GeneCards UniProt Show fit	SH2 domain containing 3C
chr4_-_10116724 Show fit	1.45	ENST00000502702.5	WDR1 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 1
chr14_+_92513766 Show fit	1.44	ENST00000216487.12 ENST00000620541.4 ENST00000557762.1	RIN3 Ensembl NCBI GeneCards UniProt Show fit	Ras and Rab interactor 3
chr19_-_54364983 Show fit	1.43	ENST00000434277.6	LAIR1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte associated immunoglobulin like receptor 1
chr11_-_68844252 Show fit	1.43	ENST00000561996.1	CPT1A Ensembl NCBI GeneCards UniProt Show fit	carnitine palmitoyltransferase 1A
chr7_+_101127095 Show fit	1.42	ENST00000223095.5	SERPINE1 Ensembl NCBI GeneCards UniProt Show fit	serpin family E member 1
chr20_+_62952674 Show fit	1.42	ENST00000370349.7 ENST00000370351.9	SLC17A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17 member 9
chr10_+_46375721 Show fit	1.41	ENST00000616785.1 ENST00000611655.1 ENST00000619162.5	ENSG00000285402.1 Ensembl NCBI GeneCards UniProt Show fit ANXA8L1 Ensembl NCBI GeneCards UniProt Show fit	novel transcript annexin A8 like 1
chr17_+_27294076 Show fit	1.41	ENST00000581440.5 ENST00000583742.1 ENST00000579733.5 ENST00000583193.5 ENST00000581185.5 ENST00000427287.6 ENST00000262394.7 ENST00000348811.6	WSB1 Ensembl NCBI GeneCards UniProt Show fit	WD repeat and SOCS box containing 1
chr17_+_76376581 Show fit	1.40	ENST00000591651.5 ENST00000545180.5	SPHK1 Ensembl NCBI GeneCards UniProt Show fit	sphingosine kinase 1
chr10_-_47484081 Show fit	1.39	ENST00000583448.2 ENST00000583874.5 ENST00000585281.6	ANXA8 Ensembl NCBI GeneCards UniProt Show fit	annexin A8
chr1_-_3611470 Show fit	1.38	ENST00000356575.9	MEGF6 Ensembl NCBI GeneCards UniProt Show fit	multiple EGF like domains 6
chr1_-_154968874 Show fit	1.36	ENST00000444179.5 ENST00000414115.5	SHC1 Ensembl NCBI GeneCards UniProt Show fit	SHC adaptor protein 1
chr10_+_46375619 Show fit	1.33	ENST00000584982.7 ENST00000613703.4	ANXA8L1 Ensembl NCBI GeneCards UniProt Show fit	annexin A8 like 1
chr19_+_19385815 Show fit	1.29	ENST00000494516.6 ENST00000360315.7	GATAD2A Ensembl NCBI GeneCards UniProt Show fit	GATA zinc finger domain containing 2A
chr19_+_3585473 Show fit	1.28	ENST00000644452.3 ENST00000644946.1	GIPC3 Ensembl NCBI GeneCards UniProt Show fit	GIPC PDZ domain containing family member 3
chr10_-_47484133 Show fit	1.27	ENST00000583911.5 ENST00000611843.4	ANXA8 Ensembl NCBI GeneCards UniProt Show fit	annexin A8
chr10_-_71851313 Show fit	1.27	ENST00000394934.4 ENST00000610929.3	PSAP Ensembl NCBI GeneCards UniProt Show fit	prosaposin
chr2_+_112645930 Show fit	1.25	ENST00000272542.8	SLC20A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 20 member 1
chr20_+_44966478 Show fit	1.25	ENST00000499879.6 ENST00000372806.8 ENST00000372801.5	STK4 Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 4
chr9_-_133121228 Show fit	1.24	ENST00000372050.8	RALGDS Ensembl NCBI GeneCards UniProt Show fit	ral guanine nucleotide dissociation stimulator
chr12_-_6342066 Show fit	1.23	ENST00000162749.7 ENST00000440083.6	TNFRSF1A Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 1A
chr19_+_926001 Show fit	1.23	ENST00000263620.8	ARID3A Ensembl NCBI GeneCards UniProt Show fit	AT-rich interaction domain 3A
chr12_-_6342020 Show fit	1.22	ENST00000540022.5 ENST00000536194.1	TNFRSF1A Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 1A
chr10_-_125158704 Show fit	1.19	ENST00000531469.5	CTBP2 Ensembl NCBI GeneCards UniProt Show fit	C-terminal binding protein 2
chr11_-_75306688 Show fit	1.19	ENST00000532525.1	ARRB1 Ensembl NCBI GeneCards UniProt Show fit	arrestin beta 1
chr7_+_43583091 Show fit	1.19	ENST00000319357.6	STK17A Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 17a
chr16_+_8797716 Show fit	1.18	ENST00000682008.1	PMM2 Ensembl NCBI GeneCards UniProt Show fit	phosphomannomutase 2
chr16_+_57372525 Show fit	1.18	ENST00000564948.1	CX3CL1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine ligand 1
chr17_+_27456393 Show fit	1.18	ENST00000644974.1	KSR1 Ensembl NCBI GeneCards UniProt Show fit	kinase suppressor of ras 1
chr12_-_6341848 Show fit	1.17	ENST00000366159.8 ENST00000539372.5	TNFRSF1A Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 1A
chr2_+_95025700 Show fit	1.14	ENST00000309988.9 ENST00000353004.7 ENST00000354078.7 ENST00000349807.3	MAL Ensembl NCBI GeneCards UniProt Show fit	mal, T cell differentiation protein
chr6_+_36130586 Show fit	1.13	ENST00000373759.1	MAPK13 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 13
chr19_+_507487 Show fit	1.12	ENST00000359315.6	TPGS1 Ensembl NCBI GeneCards UniProt Show fit	tubulin polyglutamylase complex subunit 1
chr1_+_25272527 Show fit	1.12	ENST00000342055.9 ENST00000357542.8 ENST00000417538.6 ENST00000423810.6 ENST00000568195.5	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr2_-_288759 Show fit	1.11	ENST00000452023.1	ALKAL2 Ensembl NCBI GeneCards UniProt Show fit	ALK and LTK ligand 2
chr7_-_38354517 Show fit	1.10	ENST00000390345.2	TRGV4 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor gamma variable 4
chr19_-_54364908 Show fit	1.09	ENST00000391742.7	LAIR1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte associated immunoglobulin like receptor 1
chr16_-_31094890 Show fit	1.09	ENST00000532364.1 ENST00000529564.1 ENST00000319788.11 ENST00000354895.4	ENSG00000255439.6 Ensembl NCBI GeneCards UniProt Show fit VKORC1 Ensembl NCBI GeneCards UniProt Show fit	novel protein, VKORC1 and PRSS53 readthrough vitamin K epoxide reductase complex subunit 1
chr1_+_224356852 Show fit	1.08	ENST00000366858.7 ENST00000366857.9 ENST00000465271.6 ENST00000366856.3	CNIH4 Ensembl NCBI GeneCards UniProt Show fit	cornichon family AMPA receptor auxiliary protein 4
chr16_+_57372481 Show fit	1.06	ENST00000006053.7	CX3CL1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine ligand 1
chr20_+_32358303 Show fit	1.02	ENST00000651418.1 ENST00000375687.10 ENST00000542461.5 ENST00000613218.4 ENST00000646367.1 ENST00000620121.4	ASXL1 Ensembl NCBI GeneCards UniProt Show fit	ASXL transcriptional regulator 1
chr1_-_12618198 Show fit	1.01	ENST00000616661.5	DHRS3 Ensembl NCBI GeneCards UniProt Show fit	dehydrogenase/reductase 3
chr16_-_31094727 Show fit	1.00	ENST00000300851.10 ENST00000394975.3	VKORC1 Ensembl NCBI GeneCards UniProt Show fit	vitamin K epoxide reductase complex subunit 1
chr1_-_45340080 Show fit	1.00	ENST00000354383.10 ENST00000355498.6 ENST00000531105.5	MUTYH Ensembl NCBI GeneCards UniProt Show fit	mutY DNA glycosylase
chr1_+_32180044 Show fit	0.99	ENST00000373609.1	TXLNA Ensembl NCBI GeneCards UniProt Show fit	taxilin alpha
chr4_-_10116324 Show fit	0.99	ENST00000508079.1	WDR1 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 1
chr16_+_57372465 Show fit	0.99	ENST00000563383.1	CX3CL1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine ligand 1
chr19_+_19385919 Show fit	0.99	ENST00000417582.6	GATAD2A Ensembl NCBI GeneCards UniProt Show fit	GATA zinc finger domain containing 2A
chr9_-_113275560 Show fit	0.98	ENST00000374206.4	CDC26 Ensembl NCBI GeneCards UniProt Show fit	cell division cycle 26
chr1_+_113905290 Show fit	0.97	ENST00000650450.2	DCLRE1B Ensembl NCBI GeneCards UniProt Show fit	DNA cross-link repair 1B
chr15_+_88621290 Show fit	0.96	ENST00000332810.4 ENST00000559528.1	AEN Ensembl NCBI GeneCards UniProt Show fit	apoptosis enhancing nuclease
chr10_+_46375645 Show fit	0.96	ENST00000622769.4	ANXA8L1 Ensembl NCBI GeneCards UniProt Show fit	annexin A8 like 1
chr22_+_37051731 Show fit	0.95	ENST00000610767.4 ENST00000402077.7 ENST00000403888.7	KCTD17 Ensembl NCBI GeneCards UniProt Show fit	potassium channel tetramerization domain containing 17
chr1_+_113905156 Show fit	0.95	ENST00000650596.1	DCLRE1B Ensembl NCBI GeneCards UniProt Show fit	DNA cross-link repair 1B
chr17_-_80220325 Show fit	0.93	ENST00000326317.11 ENST00000570427.1 ENST00000570923.1	SGSH Ensembl NCBI GeneCards UniProt Show fit	N-sulfoglucosamine sulfohydrolase
chr11_-_44950731 Show fit	0.91	ENST00000528473.5	TP53I11 Ensembl NCBI GeneCards UniProt Show fit	tumor protein p53 inducible protein 11
chr14_-_74612021 Show fit	0.90	ENST00000556690.5	LTBP2 Ensembl NCBI GeneCards UniProt Show fit	latent transforming growth factor beta binding protein 2
chr19_-_40425982 Show fit	0.88	ENST00000357949.5	SERTAD1 Ensembl NCBI GeneCards UniProt Show fit	SERTA domain containing 1
chr2_+_197500398 Show fit	0.88	ENST00000604458.1	HSPE1-MOB4 Ensembl NCBI GeneCards UniProt Show fit	HSPE1-MOB4 readthrough
chr1_-_45340381 Show fit	0.86	ENST00000412971.5 ENST00000372110.7 ENST00000372098.7 ENST00000672818.3 ENST00000529984.5 ENST00000372115.7	MUTYH Ensembl NCBI GeneCards UniProt Show fit	mutY DNA glycosylase
chr1_-_93180261 Show fit	0.86	ENST00000370280.1 ENST00000479918.5	TMED5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane p24 trafficking protein 5
chr14_-_36521149 Show fit	0.86	ENST00000518149.5	NKX2-1 Ensembl NCBI GeneCards UniProt Show fit	NK2 homeobox 1
chr2_-_288056 Show fit	0.86	ENST00000403610.9	ALKAL2 Ensembl NCBI GeneCards UniProt Show fit	ALK and LTK ligand 2
chr17_-_41525326 Show fit	0.86	ENST00000593096.1	KRT19 Ensembl NCBI GeneCards UniProt Show fit	keratin 19
chr20_-_23637933 Show fit	0.85	ENST00000398411.5	CST3 Ensembl NCBI GeneCards UniProt Show fit	cystatin C
chr2_+_32357009 Show fit	0.84	ENST00000421745.6	BIRC6 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 6
chr15_-_34343112 Show fit	0.84	ENST00000557912.1 ENST00000328848.6	NOP10 Ensembl NCBI GeneCards UniProt Show fit	NOP10 ribonucleoprotein
chr20_+_63658286 Show fit	0.83	ENST00000360203.11 ENST00000508582.7 ENST00000318100.9 ENST00000356810.5	RTEL1 Ensembl NCBI GeneCards UniProt Show fit	regulator of telomere elongation helicase 1
chr1_-_113905020 Show fit	0.83	ENST00000432415.5 ENST00000369571.2 ENST00000256658.8 ENST00000369564.5	AP4B1 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 4 subunit beta 1
chr7_+_75395629 Show fit	0.83	ENST00000323819.7 ENST00000430211.5	TRIM73 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 73
chr17_+_79074822 Show fit	0.83	ENST00000311595.14 ENST00000579016.6	ENGASE Ensembl NCBI GeneCards UniProt Show fit	endo-beta-N-acetylglucosaminidase
chr1_-_54053394 Show fit	0.81	ENST00000452421.5 ENST00000420738.5 ENST00000440019.5	TMEM59 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 59
chr19_-_51027662 Show fit	0.80	ENST00000594768.5	KLK11 Ensembl NCBI GeneCards UniProt Show fit	kallikrein related peptidase 11
chr4_-_128288163 Show fit	0.79	ENST00000512483.5	PGRMC2 Ensembl NCBI GeneCards UniProt Show fit	progesterone receptor membrane component 2
chr1_-_45339995 Show fit	0.78	ENST00000488731.6 ENST00000435155.1	MUTYH Ensembl NCBI GeneCards UniProt Show fit	mutY DNA glycosylase
chr22_-_17774412 Show fit	0.78	ENST00000342111.9 ENST00000622694.5	BID Ensembl NCBI GeneCards UniProt Show fit	BH3 interacting domain death agonist
chr20_-_23637947 Show fit	0.77	ENST00000376925.8	CST3 Ensembl NCBI GeneCards UniProt Show fit	cystatin C
chr3_-_58210961 Show fit	0.77	ENST00000486455.5 ENST00000394549.7	DNASE1L3 Ensembl NCBI GeneCards UniProt Show fit	deoxyribonuclease 1 like 3
chr14_+_24232921 Show fit	0.76	ENST00000557854.5 ENST00000399440.7 ENST00000559104.5 ENST00000456667.7	GMPR2 Ensembl NCBI GeneCards UniProt Show fit	guanosine monophosphate reductase 2
chr7_+_116526277 Show fit	0.76	ENST00000393468.1 ENST00000393467.1	CAV1 Ensembl NCBI GeneCards UniProt Show fit	caveolin 1
chrX_+_40580894 Show fit	0.75	ENST00000636409.1 ENST00000637327.1 ENST00000637526.1 ENST00000638153.1 ENST00000378438.9 ENST00000636970.1 ENST00000636196.1 ENST00000636251.1 ENST00000637482.1 ENST00000636580.2 ENST00000423649.2 ENST00000636287.1	ATP6AP2 Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting accessory protein 2
chr2_-_74529670 Show fit	0.75	ENST00000377526.4	AUP1 Ensembl NCBI GeneCards UniProt Show fit	AUP1 lipid droplet regulating VLDL assembly factor
chr16_-_31094549 Show fit	0.75	ENST00000394971.7	VKORC1 Ensembl NCBI GeneCards UniProt Show fit	vitamin K epoxide reductase complex subunit 1
chr4_+_26857678 Show fit	0.73	ENST00000494628.6	STIM2 Ensembl NCBI GeneCards UniProt Show fit	stromal interaction molecule 2
chrX_+_40581035 Show fit	0.73	ENST00000447485.6	ATP6AP2 Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting accessory protein 2
chr19_-_43754901 Show fit	0.72	ENST00000270066.11 ENST00000601170.5	SMG9 Ensembl NCBI GeneCards UniProt Show fit	SMG9 nonsense mediated mRNA decay factor
chr12_-_113335030 Show fit	0.72	ENST00000552014.5 ENST00000680972.1 ENST00000548186.5 ENST00000202831.7 ENST00000549181.5	SLC8B1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 8 member B1
chr12_+_121132869 Show fit	0.72	ENST00000328963.10	P2RX7 Ensembl NCBI GeneCards UniProt Show fit	purinergic receptor P2X 7
chr14_-_74612226 Show fit	0.72	ENST00000261978.9	LTBP2 Ensembl NCBI GeneCards UniProt Show fit	latent transforming growth factor beta binding protein 2
chr16_+_88382950 Show fit	0.70	ENST00000565624.3	ZNF469 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 469
chrX_+_71254781 Show fit	0.70	ENST00000677446.1	NONO Ensembl NCBI GeneCards UniProt Show fit	non-POU domain containing octamer binding
chr1_-_153608136 Show fit	0.70	ENST00000368703.6	S100A16 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A16
chr20_+_36605820 Show fit	0.68	ENST00000342422.3	RAB5IF Ensembl NCBI GeneCards UniProt Show fit	RAB5 interacting factor
chr22_-_17774482 Show fit	0.67	ENST00000399765.5 ENST00000614949.4 ENST00000399767.6	BID Ensembl NCBI GeneCards UniProt Show fit	BH3 interacting domain death agonist
chr22_+_37051787 Show fit	0.67	ENST00000456470.1	KCTD17 Ensembl NCBI GeneCards UniProt Show fit	potassium channel tetramerization domain containing 17
chr1_-_54053192 Show fit	0.66	ENST00000371337.3 ENST00000234831.10	TMEM59 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 59
chr14_-_36320582 Show fit	0.65	ENST00000604336.5 ENST00000359527.11 ENST00000621657.4 ENST00000603139.1 ENST00000318473.11 ENST00000416007.9	MBIP Ensembl NCBI GeneCards UniProt Show fit	MAP3K12 binding inhibitory protein 1
chr12_+_6828377 Show fit	0.65	ENST00000290510.10	P3H3 Ensembl NCBI GeneCards UniProt Show fit	prolyl 3-hydroxylase 3
chr2_+_109129199 Show fit	0.64	ENST00000309415.8	SH3RF3 Ensembl NCBI GeneCards UniProt Show fit	SH3 domain containing ring finger 3
chr11_+_64359142 Show fit	0.63	ENST00000528057.5 ENST00000334205.9	RPS6KA4 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A4
chr15_-_22980334 Show fit	0.63	ENST00000610365.4 ENST00000617928.5 ENST00000611832.4	CYFIP1 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic FMR1 interacting protein 1
chr11_+_45805108 Show fit	0.62	ENST00000530471.1 ENST00000314134.4	SLC35C1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 35 member C1
chr13_+_51584435 Show fit	0.59	ENST00000612477.1 ENST00000298125.7	WDFY2 Ensembl NCBI GeneCards UniProt Show fit	WD repeat and FYVE domain containing 2
chr17_+_78214186 Show fit	0.59	ENST00000301633.8 ENST00000350051.8 ENST00000374948.6 ENST00000590449.1	BIRC5 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 5
chr5_+_122312164 Show fit	0.59	ENST00000514497.6 ENST00000261367.11	SNCAIP Ensembl NCBI GeneCards UniProt Show fit	synuclein alpha interacting protein
chr14_-_50532518 Show fit	0.58	ENST00000682126.1	MAP4K5 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 5
chr4_-_48906720 Show fit	0.58	ENST00000381464.6 ENST00000508632.6	OCIAD2 Ensembl NCBI GeneCards UniProt Show fit	OCIA domain containing 2
chr14_-_64504570 Show fit	0.58	ENST00000394715.1	ZBTB25 Ensembl NCBI GeneCards UniProt Show fit	zinc finger and BTB domain containing 25
chr1_-_54406385 Show fit	0.57	ENST00000610401.5	SSBP3 Ensembl NCBI GeneCards UniProt Show fit	single stranded DNA binding protein 3
chr5_+_122311740 Show fit	0.57	ENST00000506272.5 ENST00000508681.5 ENST00000509154.6	SNCAIP Ensembl NCBI GeneCards UniProt Show fit	synuclein alpha interacting protein
chr11_+_64359199 Show fit	0.56	ENST00000530504.1	RPS6KA4 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A4
chr1_-_93180377 Show fit	0.56	ENST00000370282.8	TMED5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane p24 trafficking protein 5
chr8_+_119416427 Show fit	0.55	ENST00000259526.4	CCN3 Ensembl NCBI GeneCards UniProt Show fit	cellular communication network factor 3
chr17_+_28371656 Show fit	0.55	ENST00000585482.6	SARM1 Ensembl NCBI GeneCards UniProt Show fit	sterile alpha and TIR motif containing 1
chr14_-_50532590 Show fit	0.55	ENST00000013125.9	MAP4K5 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 5
chr22_+_40370578 Show fit	0.55	ENST00000457767.5 ENST00000248929.14	SGSM3 Ensembl NCBI GeneCards UniProt Show fit	small G protein signaling modulator 3
chr4_+_2536630 Show fit	0.54	ENST00000637812.2	FAM193A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 193 member A
chr1_-_53945661 Show fit	0.54	ENST00000194214.10	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr22_+_37906275 Show fit	0.54	ENST00000215957.10 ENST00000445494.6 ENST00000680578.1 ENST00000424008.2	MICALL1 Ensembl NCBI GeneCards UniProt Show fit	MICAL like 1
chr20_+_36605734 Show fit	0.53	ENST00000344795.8 ENST00000373852.9	RAB5IF Ensembl NCBI GeneCards UniProt Show fit	RAB5 interacting factor
chr13_+_38349822 Show fit	0.53	ENST00000379649.5 ENST00000239878.9	UFM1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin fold modifier 1
chr1_-_54053461 Show fit	0.52	ENST00000371341.5	TMEM59 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 59
chr16_+_51553436 Show fit	0.52	ENST00000565308.2	HNRNPA1P48 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein A1 pseudogene 48
chr11_-_65540610 Show fit	0.51	ENST00000532661.5	LTBP3 Ensembl NCBI GeneCards UniProt Show fit	latent transforming growth factor beta binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.8	19.8	GO:0044027	hypermethylation of CpG island(GO:0044027)
1.8	5.3	GO:0034769	basement membrane disassembly(GO:0034769)
1.5	4.6	GO:0071663	granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.1	3.2	GO:0051041	positive regulation of calcium-independent cell-cell adhesion(GO:0051041)
1.0	3.0	GO:0050720	interleukin-1 beta biosynthetic process(GO:0050720)
0.8	2.4	GO:0002339	B cell selection(GO:0002339) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.7	2.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.7	2.7	GO:1900138	negative regulation of phospholipase A2 activity(GO:1900138)
0.7	2.0	GO:0046108	uridine metabolic process(GO:0046108)
0.6	2.6	GO:0035740	CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.6	2.4	GO:0016333	morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.5	1.6	GO:0060309	elastin catabolic process(GO:0060309)
0.5	3.6	GO:0071550	death-inducing signaling complex assembly(GO:0071550)
0.5	2.0	GO:0090285	negative regulation of protein glycosylation in Golgi(GO:0090285)
0.5	1.4	GO:0001300	chronological cell aging(GO:0001300)
0.5	1.4	GO:0046521	sphingoid catabolic process(GO:0046521)
0.4	1.7	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.4	2.1	GO:0036414	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4	2.1	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.4	0.8	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.4	1.6	GO:1901873	regulation of post-translational protein modification(GO:1901873)
0.3	2.4	GO:0010286	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.3	2.4	GO:2000782	regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.3	3.4	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3	2.6	GO:0045007	depurination(GO:0045007)
0.3	5.9	GO:0022417	protein maturation by protein folding(GO:0022417)
0.3	2.3	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3	2.0	GO:0070378	positive regulation of ERK5 cascade(GO:0070378)
0.3	8.6	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3	1.5	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.3	1.9	GO:0031627	telomeric loop formation(GO:0031627)
0.3	1.0	GO:0007231	osmosensory signaling pathway(GO:0007231)
0.2	0.7	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2	1.2	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.2	4.0	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.2	0.7	GO:0071962	mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.2	0.8	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2	0.6	GO:1903422	negative regulation of synaptic vesicle recycling(GO:1903422)
0.2	1.2	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2	1.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2	2.8	GO:0042373	vitamin K metabolic process(GO:0042373)
0.2	0.8	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.2	1.2	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.2	2.2	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2	0.6	GO:2000742	anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.2	1.1	GO:2000466	negative regulation of glycogen (starch) synthase activity(GO:2000466) regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.2	0.8	GO:1903609	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.2	2.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2	3.0	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.2	2.6	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.2	2.9	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.2	0.9	GO:0030200	heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2	0.6	GO:0032915	positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1	1.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423) negative regulation of defense response to virus by host(GO:0050689)
0.1	1.5	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1	1.2	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1	0.4	GO:0006679	glucosylceramide biosynthetic process(GO:0006679)
0.1	0.4	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1	0.6	GO:2000176	regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1	2.0	GO:0033089	pantothenate metabolic process(GO:0015939) positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1	1.2	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.1	0.6	GO:0015783	GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1	0.5	GO:1902460	regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1	0.9	GO:0021759	globus pallidus development(GO:0021759)
0.1	5.4	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	1.9	GO:0090161	Golgi ribbon formation(GO:0090161)
0.1	1.4	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1	2.2	GO:0016075	rRNA catabolic process(GO:0016075)
0.1	2.1	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1	1.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.1	0.5	GO:0046208	spermine catabolic process(GO:0046208)
0.1	2.0	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1	0.5	GO:0042494	detection of bacterial lipoprotein(GO:0042494)
0.1	0.7	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1	0.7	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	1.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.5	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.3	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.1	0.5	GO:1990592	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1	5.5	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	2.1	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1	2.9	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.1	1.2	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.1	0.3	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	0.5	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1	9.3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1	1.6	GO:0097435	fibril organization(GO:0097435)
0.1	0.2	GO:0043335	protein unfolding(GO:0043335)
0.1	0.6	GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0	0.4	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	4.8	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.9	GO:0010623	programmed cell death involved in cell development(GO:0010623)
0.0	1.6	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.2	GO:1903575	cornified envelope assembly(GO:1903575)
0.0	1.6	GO:0045724	positive regulation of cilium assembly(GO:0045724)
0.0	1.8	GO:0015695	organic cation transport(GO:0015695)
0.0	2.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.3	GO:1905123	regulation of glucosylceramidase activity(GO:1905123)
0.0	0.3	GO:0030311	poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	1.1	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.0	0.2	GO:0071348	response to interleukin-11(GO:0071105) cellular response to interleukin-11(GO:0071348)
0.0	0.5	GO:0060056	mammary gland involution(GO:0060056)
0.0	1.7	GO:0018345	protein palmitoylation(GO:0018345)
0.0	1.5	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.0	0.1	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.4	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	3.6	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.0	0.2	GO:1904398	positive regulation of neuromuscular junction development(GO:1904398)
0.0	1.7	GO:0030517	negative regulation of axon extension(GO:0030517)
0.0	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.2	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0	1.3	GO:1903206	negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0	0.9	GO:0060706	cell differentiation involved in embryonic placenta development(GO:0060706)
0.0	1.9	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.5	GO:0070986	left/right axis specification(GO:0070986)
0.0	0.4	GO:0019532	oxalate transport(GO:0019532)
0.0	0.4	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	2.1	GO:0070206	protein trimerization(GO:0070206)
0.0	0.8	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.3	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	1.8	GO:0050819	negative regulation of coagulation(GO:0050819)
0.0	0.2	GO:0002943	tRNA dihydrouridine synthesis(GO:0002943)
0.0	0.2	GO:0010536	positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	1.1	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	0.7	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.8	GO:0006517	protein deglycosylation(GO:0006517)
0.0	1.5	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	1.0	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.2	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0	0.4	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.0	0.2	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.2	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	1.4	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.0	2.7	GO:0002576	platelet degranulation(GO:0002576)
0.0	1.6	GO:0016525	negative regulation of angiogenesis(GO:0016525)
0.0	0.3	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.3	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0	0.5	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	1.3	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.8	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.5	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	1.5	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	1.2	GO:0019933	cAMP-mediated signaling(GO:0019933)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.8	5.4	GO:0036284	tubulobulbar complex(GO:0036284)
1.2	5.9	GO:1990425	ryanodine receptor complex(GO:1990425)
0.8	5.3	GO:0036021	endolysosome lumen(GO:0036021)
0.5	2.4	GO:0042643	actomyosin, actin portion(GO:0042643)
0.3	2.1	GO:0031523	Myb complex(GO:0031523)
0.3	1.0	GO:0035517	PR-DUB complex(GO:0035517)
0.2	2.0	GO:0005797	Golgi medial cisterna(GO:0005797)
0.2	4.1	GO:0031089	platelet dense granule lumen(GO:0031089)
0.2	2.4	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.2	1.4	GO:0070435	Shc-EGFR complex(GO:0070435)
0.2	1.6	GO:0005610	laminin-5 complex(GO:0005610)
0.1	0.7	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1	0.9	GO:1990357	terminal web(GO:1990357)
0.1	0.8	GO:1902560	GMP reductase complex(GO:1902560)
0.1	0.8	GO:0072589	box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1	0.4	GO:0071001	U4/U6 snRNP(GO:0071001)
0.1	0.3	GO:1905103	integral component of lysosomal membrane(GO:1905103)
0.1	2.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	5.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	0.8	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	0.7	GO:0031415	NatA complex(GO:0031415)
0.1	1.6	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	1.1	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.1	0.8	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1	1.2	GO:0097470	ribbon synapse(GO:0097470)
0.1	0.7	GO:0042382	paraspeckles(GO:0042382)
0.1	0.7	GO:0030061	mitochondrial crista(GO:0030061)
0.1	0.6	GO:0044294	dendritic growth cone(GO:0044294)
0.1	6.1	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	4.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.1	5.5	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	2.3	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	0.2	GO:0070195	growth hormone receptor complex(GO:0070195)
0.0	0.3	GO:1990393	3M complex(GO:1990393)
0.0	1.4	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	2.8	GO:0008180	COP9 signalosome(GO:0008180)
0.0	1.4	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.8	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	1.0	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	22.0	GO:0000790	nuclear chromatin(GO:0000790)
0.0	0.7	GO:0032059	bleb(GO:0032059)
0.0	1.8	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	1.7	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	2.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	2.5	GO:0070821	tertiary granule membrane(GO:0070821)
0.0	1.6	GO:0005771	multivesicular body(GO:0005771)
0.0	2.9	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	2.3	GO:0015030	Cajal body(GO:0015030)
0.0	1.4	GO:0032592	integral component of mitochondrial membrane(GO:0032592)
0.0	1.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.2	GO:0097443	sorting endosome(GO:0097443)
0.0	0.8	GO:0030057	desmosome(GO:0030057)
0.0	4.0	GO:0031902	late endosome membrane(GO:0031902)
0.0	4.5	GO:0005903	brush border(GO:0005903)
0.0	2.9	GO:0030175	filopodium(GO:0030175)
0.0	0.6	GO:0031904	endosome lumen(GO:0031904)
0.0	3.9	GO:0031225	anchored component of membrane(GO:0031225)
0.0	0.4	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	18.7	GO:0009986	cell surface(GO:0009986)
0.0	0.5	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.6	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	1.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.5	GO:0005921	gap junction(GO:0005921)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.2	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	1.2	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.0	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.3	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.7	GO:0031201	SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.7	14.7	GO:0045569	TRAIL binding(GO:0045569)
1.4	19.5	GO:0051525	NFAT protein binding(GO:0051525)
1.1	3.2	GO:0031737	CX3C chemokine receptor binding(GO:0031737)
0.8	3.4	GO:0022865	transmembrane electron transfer carrier(GO:0022865)
0.7	6.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.7	2.6	GO:0032408	MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.7	2.0	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.5	2.1	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.5	2.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.5	1.4	GO:1990698	palmitoleoyltransferase activity(GO:1990698)
0.4	3.0	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.4	1.7	GO:0016495	C-X3-C chemokine receptor activity(GO:0016495)
0.4	2.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.4	2.8	GO:0016900	oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.4	1.2	GO:0031896	V2 vasopressin receptor binding(GO:0031896)
0.4	1.2	GO:0004615	phosphomannomutase activity(GO:0004615)
0.3	1.0	GO:0030366	molybdopterin synthase activity(GO:0030366)
0.3	2.3	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3	1.2	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.3	5.9	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.3	2.0	GO:0030298	receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2	4.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2	2.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.2	0.7	GO:0052858	peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858)
0.2	0.8	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2	2.9	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2	1.4	GO:0017050	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2	2.4	GO:0051434	BH3 domain binding(GO:0051434)
0.2	8.4	GO:0043394	proteoglycan binding(GO:0043394)
0.2	0.8	GO:0098808	mRNA cap binding(GO:0098808)
0.2	1.9	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	1.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.1	1.2	GO:0030267	hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1	0.4	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.1	0.6	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1	0.8	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1	1.4	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	4.6	GO:0042288	MHC class I protein binding(GO:0042288)
0.1	0.5	GO:0052901	polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1	0.3	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.1	3.6	GO:0004707	MAP kinase activity(GO:0004707)
0.1	1.1	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.1	0.8	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.1	0.6	GO:0005457	GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1	1.3	GO:0004565	beta-galactosidase activity(GO:0004565)
0.1	2.0	GO:0019841	retinol binding(GO:0019841)
0.1	1.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.1	5.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	0.7	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.1	3.6	GO:0004623	phospholipase A2 activity(GO:0004623)
0.1	1.1	GO:0008097	5S rRNA binding(GO:0008097)
0.1	0.3	GO:0047223	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1	1.0	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.1	1.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	3.4	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1	0.7	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	0.5	GO:0043426	MRF binding(GO:0043426)
0.1	3.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.1	0.6	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.1	0.3	GO:1903135	cupric ion binding(GO:1903135)
0.1	2.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	0.7	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	6.2	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.1	4.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	1.6	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	1.4	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	1.4	GO:0005123	death receptor binding(GO:0005123)
0.0	1.4	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.2	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0	0.4	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	1.0	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	1.7	GO:0038191	neuropilin binding(GO:0038191)
0.0	1.8	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	0.9	GO:0044213	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0	2.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	1.7	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	4.1	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.7	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	1.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.6	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	2.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	1.1	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.9	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.4	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.2	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	5.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	4.1	GO:0019838	growth factor binding(GO:0019838)
0.0	0.3	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	1.6	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.5	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.8	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.2	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.6	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	2.1	GO:0051117	ATPase binding(GO:0051117)
0.0	0.5	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.7	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	2.4	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	1.8	GO:0002020	protease binding(GO:0002020)
0.0	0.3	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	3.7	GO:0030674	protein binding, bridging(GO:0030674)
0.0	0.7	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.6	PID ALK2 PATHWAY	ALK2 signaling events
0.2	4.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	14.7	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	20.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	3.9	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	3.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	3.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	3.6	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	1.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	7.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	11.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	1.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	2.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.6	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	3.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.1	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	1.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	1.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	12.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	7.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	1.2	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	2.3	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	0.7	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	1.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	3.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	7.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	8.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	3.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	6.4	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.2	5.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	3.6	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.1	2.8	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	2.0	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	2.0	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1	1.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	0.9	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	2.7	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	4.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	1.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	1.6	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.1	1.4	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.1	2.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	2.0	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	1.6	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	2.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.1	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	1.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	1.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	1.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.4	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.8	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.5	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	3.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	3.0	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	0.4	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.6	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Results for TP53

Z-value: 1.56

Motif logo

Transcription factors associated with TP53

Activity-expression correlation:

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: