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Illumina Body Map 2 (GSE30611)

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Results for TP53

Z-value: 1.56

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Transcription factors associated with TP53

Gene Symbol Gene ID Gene Info
ENSG00000141510.18 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP53hg38_v1_chr17_-_7687427_76875380.421.7e-02Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_106235582 5.53 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr8_+_23102913 5.20 ENST00000356864.4
TNF receptor superfamily member 10c
chr11_-_47378527 5.15 ENST00000378538.8
Spi-1 proto-oncogene
chr11_-_47378391 4.84 ENST00000227163.8
Spi-1 proto-oncogene
chr11_-_47378494 4.84 ENST00000533030.1
Spi-1 proto-oncogene
chr11_-_47378479 4.65 ENST00000533968.1
Spi-1 proto-oncogene
chr11_+_65879791 4.12 ENST00000528419.6
ENST00000307886.8
ENST00000526034.2
ENST00000679584.1
ENST00000680443.1
ENST00000680670.1
cathepsin W
chr18_+_59899988 3.96 ENST00000316660.7
ENST00000269518.9
phorbol-12-myristate-13-acetate-induced protein 1
chr8_-_23225061 3.94 ENST00000613472.1
ENST00000221132.8
TNF receptor superfamily member 10a
chr19_+_3136026 3.36 ENST00000262958.4
G protein subunit alpha 15
chr8_-_23164020 3.26 ENST00000312584.4
TNF receptor superfamily member 10d
chr2_-_234497035 3.23 ENST00000390645.2
ENST00000339728.6
ADP ribosylation factor like GTPase 4C
chr8_-_10730498 3.21 ENST00000304501.2
SRY-box transcription factor 7
chr20_-_1393045 3.07 ENST00000400137.9
ENST00000381715.4
FKBP prolyl isomerase 1A
chr7_+_99374722 3.01 ENST00000418347.6
ENST00000429246.6
ENST00000417330.6
ENST00000431816.6
ENST00000458033.6
ENST00000451682.5
ENST00000427217.6
ENST00000646101.2
actin related protein 2/3 complex subunit 1B
chr1_-_150765735 3.00 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
cathepsin S
chr19_+_827823 2.97 ENST00000233997.4
azurocidin 1
chr1_-_37947010 2.90 ENST00000458109.6
ENST00000373024.8
ENST00000373023.6
inositol polyphosphate-5-phosphatase B
chr9_+_36136416 2.79 ENST00000396613.7
GLI pathogenesis related 2
chr20_-_1393074 2.78 ENST00000614856.2
ENST00000678408.1
ENST00000618612.5
ENST00000439640.5
ENST00000381719.8
ENST00000677533.1
FKBP prolyl isomerase 1A
chr5_-_132490750 2.57 ENST00000437654.6
ENST00000245414.9
ENST00000680139.1
ENST00000680352.1
ENST00000679440.1
ENST00000680903.1
interferon regulatory factor 1
chr6_+_36130484 2.46 ENST00000373766.9
ENST00000211287.9
mitogen-activated protein kinase 13
chr1_+_161524539 2.44 ENST00000309758.6
heat shock protein family A (Hsp70) member 6
chr11_-_65859282 2.43 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
cofilin 1
chr7_+_99374675 2.42 ENST00000645391.1
ENST00000455009.6
actin related protein 2/3 complex subunit 1B
chr19_+_48954850 2.40 ENST00000345358.12
ENST00000539787.2
ENST00000415969.6
ENST00000354470.7
ENST00000506183.5
ENST00000391871.4
ENST00000293288.12
BCL2 associated X, apoptosis regulator
chr1_+_27879638 2.38 ENST00000456990.1
thymocyte selection associated family member 2
chr11_-_44950839 2.38 ENST00000395648.7
ENST00000531928.6
tumor protein p53 inducible protein 11
chr10_+_88990736 2.35 ENST00000357339.6
ENST00000652046.1
ENST00000355279.2
Fas cell surface death receptor
chr19_-_6481769 2.33 ENST00000381480.7
ENST00000543576.5
ENST00000590173.5
DENN domain containing 1C
chr1_-_160862700 2.32 ENST00000322302.7
ENST00000368033.7
CD244 molecule
chr17_+_14301069 2.31 ENST00000360954.3
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr1_-_150765785 2.30 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr8_-_23069012 2.28 ENST00000347739.3
ENST00000276431.9
TNF receptor superfamily member 10b
chr10_-_103452356 2.24 ENST00000260743.10
calcium homeostasis modulator family member 2
chr1_-_160862880 2.24 ENST00000368034.9
CD244 molecule
chr1_-_54018167 2.23 ENST00000371362.7
ENST00000371360.2
ENST00000545928.5
ENST00000420619.5
low density lipoprotein receptor class A domain containing 1
chr16_+_527698 2.23 ENST00000219611.7
ENST00000562370.5
ENST00000568988.5
calpain 15
chr19_-_42217667 2.19 ENST00000336034.8
ENST00000596251.6
ENST00000598200.1
ENST00000598727.5
death effector domain containing 2
chr11_+_67403887 2.18 ENST00000526387.5
TBC1 domain family member 10C
chr6_-_30744537 2.16 ENST00000259874.6
ENST00000376377.2
immediate early response 3
chr11_-_73982830 2.14 ENST00000536983.5
ENST00000663595.2
ENST00000310473.9
uncoupling protein 2
chr19_+_41860236 2.14 ENST00000601492.5
ENST00000600467.6
ENST00000598742.6
ENST00000221975.6
ENST00000598261.2
ribosomal protein S19
chr11_+_5691004 2.12 ENST00000414641.5
tripartite motif containing 22
chr1_+_17308194 2.11 ENST00000375453.5
ENST00000375448.4
peptidyl arginine deiminase 4
chrX_-_154354889 2.09 ENST00000438732.2
filamin A
chr19_-_47232649 2.06 ENST00000449228.5
ENST00000300880.11
ENST00000341983.8
BCL2 binding component 3
chr6_-_132714045 2.05 ENST00000367928.5
vanin 1
chr1_+_9997220 2.02 ENST00000294435.8
retinol binding protein 7
chr7_+_48088596 1.97 ENST00000416681.5
ENST00000331803.8
ENST00000432131.5
uridine phosphorylase 1
chrX_+_100644183 1.97 ENST00000640889.1
ENST00000373004.5
sushi repeat containing protein X-linked 2
chr19_+_56141317 1.86 ENST00000592949.5
zinc finger protein 444
chr19_-_51646800 1.83 ENST00000599649.5
ENST00000429354.3
ENST00000360844.6
sialic acid binding Ig like lectin 5
sialic acid binding Ig like lectin 14
chr10_-_103452384 1.77 ENST00000369788.7
calcium homeostasis modulator family member 2
chr20_+_35172046 1.76 ENST00000216968.5
protein C receptor
chr3_-_39281663 1.70 ENST00000358309.3
C-X3-C motif chemokine receptor 1
chr17_-_63446168 1.69 ENST00000584031.5
ENST00000392976.5
cytochrome b561
chr3_-_52445085 1.69 ENST00000475739.1
ENST00000231721.7
semaphorin 3G
chr17_-_63446260 1.68 ENST00000448884.6
ENST00000582297.5
ENST00000360793.8
ENST00000582034.5
ENST00000578072.1
cytochrome b561
chr12_-_14567714 1.68 ENST00000240617.10
phospholipase B domain containing 1
chr19_+_56141277 1.67 ENST00000337080.8
ENST00000586123.5
zinc finger protein 444
chr1_+_26826682 1.66 ENST00000374142.9
zinc finger DHHC-type palmitoyltransferase 18
chr4_+_25648011 1.65 ENST00000645788.1
solute carrier family 34 member 2
chr1_+_11736120 1.63 ENST00000400895.6
ENST00000314340.10
ENST00000376629.8
ENST00000376627.6
ENST00000452018.6
ENST00000510878.1
angiotensin II receptor associated protein
chr15_-_64162965 1.62 ENST00000300026.4
ENST00000681397.1
ENST00000681658.1
peptidylprolyl isomerase B
chr3_+_52495330 1.62 ENST00000321725.10
stabilin 1
chr3_-_12759224 1.59 ENST00000314124.12
ENST00000435218.6
ENST00000435575.5
transmembrane protein 40
chr9_-_133121148 1.59 ENST00000372047.7
ral guanine nucleotide dissociation stimulator
chr1_-_209652329 1.58 ENST00000367030.7
ENST00000356082.9
laminin subunit beta 3
chr19_-_6591103 1.57 ENST00000423145.7
ENST00000245903.4
CD70 molecule
chr7_-_38349972 1.55 ENST00000390344.2
T cell receptor gamma variable 5
chr22_-_39319595 1.54 ENST00000427905.5
ENST00000216146.9
ENST00000402527.5
ribosomal protein L3
chr1_-_156020789 1.51 ENST00000531917.5
ENST00000480567.5
ENST00000526212.2
ENST00000529008.5
ENST00000496742.5
ENST00000295702.9
signal sequence receptor subunit 2
chr16_-_14694308 1.49 ENST00000438167.8
phospholipase A2 group X
chr1_+_11736068 1.48 ENST00000376637.7
angiotensin II receptor associated protein
chr9_-_127755030 1.48 ENST00000414380.1
SH2 domain containing 3C
chr4_-_10116724 1.45 ENST00000502702.5
WD repeat domain 1
chr14_+_92513766 1.44 ENST00000216487.12
ENST00000620541.4
ENST00000557762.1
Ras and Rab interactor 3
chr19_-_54364983 1.43 ENST00000434277.6
leukocyte associated immunoglobulin like receptor 1
chr11_-_68844252 1.43 ENST00000561996.1
carnitine palmitoyltransferase 1A
chr7_+_101127095 1.42 ENST00000223095.5
serpin family E member 1
chr20_+_62952674 1.42 ENST00000370349.7
ENST00000370351.9
solute carrier family 17 member 9
chr10_+_46375721 1.41 ENST00000616785.1
ENST00000611655.1
ENST00000619162.5
novel transcript
annexin A8 like 1
chr17_+_27294076 1.41 ENST00000581440.5
ENST00000583742.1
ENST00000579733.5
ENST00000583193.5
ENST00000581185.5
ENST00000427287.6
ENST00000262394.7
ENST00000348811.6
WD repeat and SOCS box containing 1
chr17_+_76376581 1.40 ENST00000591651.5
ENST00000545180.5
sphingosine kinase 1
chr10_-_47484081 1.39 ENST00000583448.2
ENST00000583874.5
ENST00000585281.6
annexin A8
chr1_-_3611470 1.38 ENST00000356575.9
multiple EGF like domains 6
chr1_-_154968874 1.36 ENST00000444179.5
ENST00000414115.5
SHC adaptor protein 1
chr10_+_46375619 1.33 ENST00000584982.7
ENST00000613703.4
annexin A8 like 1
chr19_+_19385815 1.29 ENST00000494516.6
ENST00000360315.7
GATA zinc finger domain containing 2A
chr19_+_3585473 1.28 ENST00000644452.3
ENST00000644946.1
GIPC PDZ domain containing family member 3
chr10_-_47484133 1.27 ENST00000583911.5
ENST00000611843.4
annexin A8
chr10_-_71851313 1.27 ENST00000394934.4
ENST00000610929.3
prosaposin
chr2_+_112645930 1.25 ENST00000272542.8
solute carrier family 20 member 1
chr20_+_44966478 1.25 ENST00000499879.6
ENST00000372806.8
ENST00000372801.5
serine/threonine kinase 4
chr9_-_133121228 1.24 ENST00000372050.8
ral guanine nucleotide dissociation stimulator
chr12_-_6342066 1.23 ENST00000162749.7
ENST00000440083.6
TNF receptor superfamily member 1A
chr19_+_926001 1.23 ENST00000263620.8
AT-rich interaction domain 3A
chr12_-_6342020 1.22 ENST00000540022.5
ENST00000536194.1
TNF receptor superfamily member 1A
chr10_-_125158704 1.19 ENST00000531469.5
C-terminal binding protein 2
chr11_-_75306688 1.19 ENST00000532525.1
arrestin beta 1
chr7_+_43583091 1.19 ENST00000319357.6
serine/threonine kinase 17a
chr16_+_8797716 1.18 ENST00000682008.1
phosphomannomutase 2
chr16_+_57372525 1.18 ENST00000564948.1
C-X3-C motif chemokine ligand 1
chr17_+_27456393 1.18 ENST00000644974.1
kinase suppressor of ras 1
chr12_-_6341848 1.17 ENST00000366159.8
ENST00000539372.5
TNF receptor superfamily member 1A
chr2_+_95025700 1.14 ENST00000309988.9
ENST00000353004.7
ENST00000354078.7
ENST00000349807.3
mal, T cell differentiation protein
chr6_+_36130586 1.13 ENST00000373759.1
mitogen-activated protein kinase 13
chr19_+_507487 1.12 ENST00000359315.6
tubulin polyglutamylase complex subunit 1
chr1_+_25272527 1.12 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
Rh blood group D antigen
chr2_-_288759 1.11 ENST00000452023.1
ALK and LTK ligand 2
chr7_-_38354517 1.10 ENST00000390345.2
T cell receptor gamma variable 4
chr19_-_54364908 1.09 ENST00000391742.7
leukocyte associated immunoglobulin like receptor 1
chr16_-_31094890 1.09 ENST00000532364.1
ENST00000529564.1
ENST00000319788.11
ENST00000354895.4
novel protein, VKORC1 and PRSS53 readthrough
vitamin K epoxide reductase complex subunit 1
chr1_+_224356852 1.08 ENST00000366858.7
ENST00000366857.9
ENST00000465271.6
ENST00000366856.3
cornichon family AMPA receptor auxiliary protein 4
chr16_+_57372481 1.06 ENST00000006053.7
C-X3-C motif chemokine ligand 1
chr20_+_32358303 1.02 ENST00000651418.1
ENST00000375687.10
ENST00000542461.5
ENST00000613218.4
ENST00000646367.1
ENST00000620121.4
ASXL transcriptional regulator 1
chr1_-_12618198 1.01 ENST00000616661.5
dehydrogenase/reductase 3
chr16_-_31094727 1.00 ENST00000300851.10
ENST00000394975.3
vitamin K epoxide reductase complex subunit 1
chr1_-_45340080 1.00 ENST00000354383.10
ENST00000355498.6
ENST00000531105.5
mutY DNA glycosylase
chr1_+_32180044 0.99 ENST00000373609.1
taxilin alpha
chr4_-_10116324 0.99 ENST00000508079.1
WD repeat domain 1
chr16_+_57372465 0.99 ENST00000563383.1
C-X3-C motif chemokine ligand 1
chr19_+_19385919 0.99 ENST00000417582.6
GATA zinc finger domain containing 2A
chr9_-_113275560 0.98 ENST00000374206.4
cell division cycle 26
chr1_+_113905290 0.97 ENST00000650450.2
DNA cross-link repair 1B
chr15_+_88621290 0.96 ENST00000332810.4
ENST00000559528.1
apoptosis enhancing nuclease
chr10_+_46375645 0.96 ENST00000622769.4
annexin A8 like 1
chr22_+_37051731 0.95 ENST00000610767.4
ENST00000402077.7
ENST00000403888.7
potassium channel tetramerization domain containing 17
chr1_+_113905156 0.95 ENST00000650596.1
DNA cross-link repair 1B
chr17_-_80220325 0.93 ENST00000326317.11
ENST00000570427.1
ENST00000570923.1
N-sulfoglucosamine sulfohydrolase
chr11_-_44950731 0.91 ENST00000528473.5
tumor protein p53 inducible protein 11
chr14_-_74612021 0.90 ENST00000556690.5
latent transforming growth factor beta binding protein 2
chr19_-_40425982 0.88 ENST00000357949.5
SERTA domain containing 1
chr2_+_197500398 0.88 ENST00000604458.1
HSPE1-MOB4 readthrough
chr1_-_45340381 0.86 ENST00000412971.5
ENST00000372110.7
ENST00000372098.7
ENST00000672818.3
ENST00000529984.5
ENST00000372115.7
mutY DNA glycosylase
chr1_-_93180261 0.86 ENST00000370280.1
ENST00000479918.5
transmembrane p24 trafficking protein 5
chr14_-_36521149 0.86 ENST00000518149.5
NK2 homeobox 1
chr2_-_288056 0.86 ENST00000403610.9
ALK and LTK ligand 2
chr17_-_41525326 0.86 ENST00000593096.1
keratin 19
chr20_-_23637933 0.85 ENST00000398411.5
cystatin C
chr2_+_32357009 0.84 ENST00000421745.6
baculoviral IAP repeat containing 6
chr15_-_34343112 0.84 ENST00000557912.1
ENST00000328848.6
NOP10 ribonucleoprotein
chr20_+_63658286 0.83 ENST00000360203.11
ENST00000508582.7
ENST00000318100.9
ENST00000356810.5
regulator of telomere elongation helicase 1
chr1_-_113905020 0.83 ENST00000432415.5
ENST00000369571.2
ENST00000256658.8
ENST00000369564.5
adaptor related protein complex 4 subunit beta 1
chr7_+_75395629 0.83 ENST00000323819.7
ENST00000430211.5
tripartite motif containing 73
chr17_+_79074822 0.83 ENST00000311595.14
ENST00000579016.6
endo-beta-N-acetylglucosaminidase
chr1_-_54053394 0.81 ENST00000452421.5
ENST00000420738.5
ENST00000440019.5
transmembrane protein 59
chr19_-_51027662 0.80 ENST00000594768.5
kallikrein related peptidase 11
chr4_-_128288163 0.79 ENST00000512483.5
progesterone receptor membrane component 2
chr1_-_45339995 0.78 ENST00000488731.6
ENST00000435155.1
mutY DNA glycosylase
chr22_-_17774412 0.78 ENST00000342111.9
ENST00000622694.5
BH3 interacting domain death agonist
chr20_-_23637947 0.77 ENST00000376925.8
cystatin C
chr3_-_58210961 0.77 ENST00000486455.5
ENST00000394549.7
deoxyribonuclease 1 like 3
chr14_+_24232921 0.76 ENST00000557854.5
ENST00000399440.7
ENST00000559104.5
ENST00000456667.7
guanosine monophosphate reductase 2
chr7_+_116526277 0.76 ENST00000393468.1
ENST00000393467.1
caveolin 1
chrX_+_40580894 0.75 ENST00000636409.1
ENST00000637327.1
ENST00000637526.1
ENST00000638153.1
ENST00000378438.9
ENST00000636970.1
ENST00000636196.1
ENST00000636251.1
ENST00000637482.1
ENST00000636580.2
ENST00000423649.2
ENST00000636287.1
ATPase H+ transporting accessory protein 2
chr2_-_74529670 0.75 ENST00000377526.4
AUP1 lipid droplet regulating VLDL assembly factor
chr16_-_31094549 0.75 ENST00000394971.7
vitamin K epoxide reductase complex subunit 1
chr4_+_26857678 0.73 ENST00000494628.6
stromal interaction molecule 2
chrX_+_40581035 0.73 ENST00000447485.6
ATPase H+ transporting accessory protein 2
chr19_-_43754901 0.72 ENST00000270066.11
ENST00000601170.5
SMG9 nonsense mediated mRNA decay factor
chr12_-_113335030 0.72 ENST00000552014.5
ENST00000680972.1
ENST00000548186.5
ENST00000202831.7
ENST00000549181.5
solute carrier family 8 member B1
chr12_+_121132869 0.72 ENST00000328963.10
purinergic receptor P2X 7
chr14_-_74612226 0.72 ENST00000261978.9
latent transforming growth factor beta binding protein 2
chr16_+_88382950 0.70 ENST00000565624.3
zinc finger protein 469
chrX_+_71254781 0.70 ENST00000677446.1
non-POU domain containing octamer binding
chr1_-_153608136 0.70 ENST00000368703.6
S100 calcium binding protein A16
chr20_+_36605820 0.68 ENST00000342422.3
RAB5 interacting factor
chr22_-_17774482 0.67 ENST00000399765.5
ENST00000614949.4
ENST00000399767.6
BH3 interacting domain death agonist
chr22_+_37051787 0.67 ENST00000456470.1
potassium channel tetramerization domain containing 17
chr1_-_54053192 0.66 ENST00000371337.3
ENST00000234831.10
transmembrane protein 59
chr14_-_36320582 0.65 ENST00000604336.5
ENST00000359527.11
ENST00000621657.4
ENST00000603139.1
ENST00000318473.11
ENST00000416007.9
MAP3K12 binding inhibitory protein 1
chr12_+_6828377 0.65 ENST00000290510.10
prolyl 3-hydroxylase 3
chr2_+_109129199 0.64 ENST00000309415.8
SH3 domain containing ring finger 3
chr11_+_64359142 0.63 ENST00000528057.5
ENST00000334205.9
ribosomal protein S6 kinase A4
chr15_-_22980334 0.63 ENST00000610365.4
ENST00000617928.5
ENST00000611832.4
cytoplasmic FMR1 interacting protein 1
chr11_+_45805108 0.62 ENST00000530471.1
ENST00000314134.4
solute carrier family 35 member C1
chr13_+_51584435 0.59 ENST00000612477.1
ENST00000298125.7
WD repeat and FYVE domain containing 2
chr17_+_78214186 0.59 ENST00000301633.8
ENST00000350051.8
ENST00000374948.6
ENST00000590449.1
baculoviral IAP repeat containing 5
chr5_+_122312164 0.59 ENST00000514497.6
ENST00000261367.11
synuclein alpha interacting protein
chr14_-_50532518 0.58 ENST00000682126.1
mitogen-activated protein kinase kinase kinase kinase 5
chr4_-_48906720 0.58 ENST00000381464.6
ENST00000508632.6
OCIA domain containing 2
chr14_-_64504570 0.58 ENST00000394715.1
zinc finger and BTB domain containing 25
chr1_-_54406385 0.57 ENST00000610401.5
single stranded DNA binding protein 3
chr5_+_122311740 0.57 ENST00000506272.5
ENST00000508681.5
ENST00000509154.6
synuclein alpha interacting protein
chr11_+_64359199 0.56 ENST00000530504.1
ribosomal protein S6 kinase A4
chr1_-_93180377 0.56 ENST00000370282.8
transmembrane p24 trafficking protein 5
chr8_+_119416427 0.55 ENST00000259526.4
cellular communication network factor 3
chr17_+_28371656 0.55 ENST00000585482.6
sterile alpha and TIR motif containing 1
chr14_-_50532590 0.55 ENST00000013125.9
mitogen-activated protein kinase kinase kinase kinase 5
chr22_+_40370578 0.55 ENST00000457767.5
ENST00000248929.14
small G protein signaling modulator 3
chr4_+_2536630 0.54 ENST00000637812.2
family with sequence similarity 193 member A
chr1_-_53945661 0.54 ENST00000194214.10
heat shock protein family B (small) member 11
chr22_+_37906275 0.54 ENST00000215957.10
ENST00000445494.6
ENST00000680578.1
ENST00000424008.2
MICAL like 1
chr20_+_36605734 0.53 ENST00000344795.8
ENST00000373852.9
RAB5 interacting factor
chr13_+_38349822 0.53 ENST00000379649.5
ENST00000239878.9
ubiquitin fold modifier 1
chr1_-_54053461 0.52 ENST00000371341.5
transmembrane protein 59
chr16_+_51553436 0.52 ENST00000565308.2
heterogeneous nuclear ribonucleoprotein A1 pseudogene 48
chr11_-_65540610 0.51 ENST00000532661.5
latent transforming growth factor beta binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 19.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.8 5.3 GO:0034769 basement membrane disassembly(GO:0034769)
1.5 4.6 GO:0071663 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.1 3.2 GO:0051041 positive regulation of calcium-independent cell-cell adhesion(GO:0051041)
1.0 3.0 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.8 2.4 GO:0002339 B cell selection(GO:0002339) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.7 2.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.7 2.7 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.7 2.0 GO:0046108 uridine metabolic process(GO:0046108)
0.6 2.6 GO:0035740 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.6 2.4 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.5 1.6 GO:0060309 elastin catabolic process(GO:0060309)
0.5 3.6 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.5 2.0 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.5 1.4 GO:0001300 chronological cell aging(GO:0001300)
0.5 1.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 1.7 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.4 2.1 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 2.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.4 0.8 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.4 1.6 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.3 2.4 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.3 2.4 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.3 3.4 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 2.6 GO:0045007 depurination(GO:0045007)
0.3 5.9 GO:0022417 protein maturation by protein folding(GO:0022417)
0.3 2.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 2.0 GO:0070378 positive regulation of ERK5 cascade(GO:0070378)
0.3 8.6 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3 1.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.3 1.9 GO:0031627 telomeric loop formation(GO:0031627)
0.3 1.0 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.2 0.7 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 1.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.2 4.0 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.2 0.7 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.2 0.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.6 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.2 1.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 1.0 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2 2.8 GO:0042373 vitamin K metabolic process(GO:0042373)
0.2 0.8 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.2 1.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 2.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 0.6 GO:2000742 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.2 1.1 GO:2000466 negative regulation of glycogen (starch) synthase activity(GO:2000466) regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.2 0.8 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.2 2.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 3.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.2 2.6 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 2.9 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 0.9 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 1.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423) negative regulation of defense response to virus by host(GO:0050689)
0.1 1.5 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 1.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.4 GO:0006679 glucosylceramide biosynthetic process(GO:0006679)
0.1 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.6 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1 2.0 GO:0033089 pantothenate metabolic process(GO:0015939) positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 1.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.6 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 0.9 GO:0021759 globus pallidus development(GO:0021759)
0.1 5.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.9 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 1.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 2.2 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 2.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 1.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.5 GO:0046208 spermine catabolic process(GO:0046208)
0.1 2.0 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.5 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.1 0.7 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.7 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 1.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.3 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.1 0.5 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 5.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.1 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 2.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.5 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1 9.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.6 GO:0097435 fibril organization(GO:0097435)
0.1 0.2 GO:0043335 protein unfolding(GO:0043335)
0.1 0.6 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0 0.4 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 4.8 GO:0001706 endoderm formation(GO:0001706)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0 0.9 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 1.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 1.6 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 1.8 GO:0015695 organic cation transport(GO:0015695)
0.0 2.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.3 GO:1905123 regulation of glucosylceramidase activity(GO:1905123)
0.0 0.3 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 1.1 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.2 GO:0071348 response to interleukin-11(GO:0071105) cellular response to interleukin-11(GO:0071348)
0.0 0.5 GO:0060056 mammary gland involution(GO:0060056)
0.0 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 3.6 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.2 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.0 1.7 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.2 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 1.3 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.9 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 1.9 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.5 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 2.1 GO:0070206 protein trimerization(GO:0070206)
0.0 0.8 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.8 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.2 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 1.1 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.8 GO:0006517 protein deglycosylation(GO:0006517)
0.0 1.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 1.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 2.7 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.5 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 1.3 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 1.2 GO:0019933 cAMP-mediated signaling(GO:0019933)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0036284 tubulobulbar complex(GO:0036284)
1.2 5.9 GO:1990425 ryanodine receptor complex(GO:1990425)
0.8 5.3 GO:0036021 endolysosome lumen(GO:0036021)
0.5 2.4 GO:0042643 actomyosin, actin portion(GO:0042643)
0.3 2.1 GO:0031523 Myb complex(GO:0031523)
0.3 1.0 GO:0035517 PR-DUB complex(GO:0035517)
0.2 2.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 4.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 2.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 1.4 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 1.6 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.9 GO:1990357 terminal web(GO:1990357)
0.1 0.8 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.8 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.4 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 0.3 GO:1905103 integral component of lysosomal membrane(GO:1905103)
0.1 2.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 5.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 1.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.2 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.1 0.7 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.6 GO:0044294 dendritic growth cone(GO:0044294)
0.1 6.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 4.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 5.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 22.0 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.7 GO:0032059 bleb(GO:0032059)
0.0 1.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.6 GO:0005771 multivesicular body(GO:0005771)
0.0 2.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 2.3 GO:0015030 Cajal body(GO:0015030)
0.0 1.4 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 4.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 4.5 GO:0005903 brush border(GO:0005903)
0.0 2.9 GO:0030175 filopodium(GO:0030175)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 18.7 GO:0009986 cell surface(GO:0009986)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.6 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.7 GO:0045569 TRAIL binding(GO:0045569)
1.4 19.5 GO:0051525 NFAT protein binding(GO:0051525)
1.1 3.2 GO:0031737 CX3C chemokine receptor binding(GO:0031737)
0.8 3.4 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.7 6.0 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.7 2.6 GO:0032408 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.7 2.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.5 2.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.5 2.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.5 1.4 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.4 3.0 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.4 1.7 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.4 2.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.4 2.8 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.4 1.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 1.2 GO:0004615 phosphomannomutase activity(GO:0004615)
0.3 1.0 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.3 2.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 1.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.3 5.9 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.3 2.0 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2 4.0 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 2.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.7 GO:0052858 peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858)
0.2 0.8 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 2.9 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2 1.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 2.4 GO:0051434 BH3 domain binding(GO:0051434)
0.2 8.4 GO:0043394 proteoglycan binding(GO:0043394)
0.2 0.8 GO:0098808 mRNA cap binding(GO:0098808)
0.2 1.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.4 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.1 0.6 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.8 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 1.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 4.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.5 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.3 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 3.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.6 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 1.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 2.0 GO:0019841 retinol binding(GO:0019841)
0.1 1.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 5.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 3.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.1 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.3 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1 1.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 3.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 3.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.3 GO:1903135 cupric ion binding(GO:1903135)
0.1 2.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 6.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 4.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 1.4 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 1.4 GO:0005123 death receptor binding(GO:0005123)
0.0 1.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.9 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 2.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 1.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 4.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 2.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 5.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.1 GO:0019838 growth factor binding(GO:0019838)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.1 GO:0051117 ATPase binding(GO:0051117)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.8 GO:0002020 protease binding(GO:0002020)
0.0 0.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 3.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 PID ALK2 PATHWAY ALK2 signaling events
0.2 4.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 14.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 20.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 3.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 7.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 11.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 1.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 3.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 12.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 7.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 7.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 8.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 3.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 6.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 5.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.6 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 2.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.0 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 4.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.4 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.1 2.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.0 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules