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Illumina Body Map 2 (GSE30611)

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Results for VDR

Z-value: 0.91

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Transcription factors associated with VDR

Gene Symbol Gene ID Gene Info
ENSG00000111424.12 vitamin D receptor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VDRhg38_v1_chr12_-_47882895_47882935-0.318.2e-02Click!

Activity profile of VDR motif

Sorted Z-values of VDR motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_94581407 7.80 ENST00000553511.1
ENST00000329597.12
ENST00000554633.5
ENST00000555681.1
ENST00000554276.1
serpin family A member 5
chr6_+_31948956 3.54 ENST00000483004.1
complement factor B
chr14_+_94581880 3.29 ENST00000557598.1
ENST00000556064.1
serpin family A member 5
chr14_+_94581388 3.06 ENST00000554866.5
ENST00000556775.5
serpin family A member 5
chr7_-_95396349 3.02 ENST00000427422.5
ENST00000451904.5
ENST00000265627.10
paraoxonase 3
chr17_-_66229380 2.64 ENST00000205948.11
apolipoprotein H
chr17_-_6713359 2.57 ENST00000381074.8
ENST00000433363.7
ENST00000293800.10
ENST00000572352.5
ENST00000573648.5
solute carrier family 13 member 5
chr3_+_48223325 2.39 ENST00000296435.2
cathelicidin antimicrobial peptide
chr21_-_46155567 2.35 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
formimidoyltransferase cyclodeaminase
chr7_+_155297776 2.16 ENST00000344756.8
ENST00000425172.1
ENST00000340368.9
ENST00000342407.5
insulin induced gene 1
chr10_-_52772763 1.99 ENST00000675947.1
ENST00000674931.1
mannose binding lectin 2
chr11_-_116792386 1.98 ENST00000433069.2
ENST00000542499.5
apolipoprotein A5
chr1_+_46671821 1.95 ENST00000334122.5
ENST00000415500.1
testis expressed 38
chr9_+_136945234 1.92 ENST00000371634.7
complement C8 gamma chain
chr8_+_24440930 1.87 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM metallopeptidase domain 7
chr7_+_155298561 1.84 ENST00000476756.1
insulin induced gene 1
chr14_+_94619313 1.77 ENST00000621603.1
serpin family A member 3
chr5_-_147831663 1.71 ENST00000296695.10
serine peptidase inhibitor Kazal type 1
chr2_+_108288869 1.65 ENST00000251481.11
ENST00000438339.5
ENST00000409880.5
ENST00000437390.6
sulfotransferase family 1C member 2
chrX_+_71215156 1.65 ENST00000374029.2
ENST00000675209.1
ENST00000647424.1
ENST00000675368.1
ENST00000675609.1
ENST00000646835.1
ENST00000447581.2
gap junction protein beta 1
chr1_+_46671871 1.63 ENST00000564373.1
testis expressed 38
chr9_-_34895722 1.59 ENST00000603640.6
ENST00000603592.1
ENST00000340783.11
family with sequence similarity 205 member C
chr12_+_52233235 1.59 ENST00000331817.6
keratin 7
chr20_+_31440626 1.54 ENST00000376309.4
defensin beta 123
chr11_+_57597563 1.45 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
serpin family G member 1
chr4_-_74099187 1.43 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr19_-_3478478 1.42 ENST00000591708.1
small integral membrane protein 24
chr1_-_74733253 1.42 ENST00000417775.5
crystallin zeta
chr12_-_7088848 1.35 ENST00000649804.1
complement C1r
chr17_-_7179544 1.34 ENST00000619926.4
asialoglycoprotein receptor 1
chr14_+_21030201 1.31 ENST00000321760.11
ENST00000460647.6
ENST00000530140.6
ENST00000472458.5
tubulin polymerization promoting protein family member 2
chr14_+_94174284 1.24 ENST00000304338.8
protein phosphatase 4 regulatory subunit 4
chr20_-_23568474 1.22 ENST00000376979.4
cystatin 9 like
chr3_+_190388120 1.18 ENST00000456423.2
ENST00000264734.3
claudin 16
chr5_-_147831627 1.17 ENST00000510027.2
serine peptidase inhibitor Kazal type 1
chr1_-_201023694 1.15 ENST00000332129.6
ENST00000422435.2
ENST00000461742.7
kinesin family member 21B
chr1_+_91949343 1.14 ENST00000448194.6
ENST00000470955.6
ENST00000362005.7
ENST00000370389.6
ENST00000394530.7
ENST00000423434.5
ENST00000440509.5
ENST00000426141.6
bromodomain testis associated
chr12_-_95996302 1.09 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
histidine ammonia-lyase
chr9_-_133738331 1.07 ENST00000439388.6
ENST00000427237.6
sarcosine dehydrogenase
chr1_-_205357033 1.06 ENST00000367156.7
ENST00000606887.5
ENST00000539253.5
ENST00000607173.5
kelch domain containing 8A
chr1_-_156082412 1.06 ENST00000532414.3
mex-3 RNA binding family member A
chr12_+_48482492 1.04 ENST00000548364.7
chromosome 12 open reading frame 54
chr12_-_25195074 1.01 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
cilia and flagella associated protein 94
chr17_-_8744787 1.00 ENST00000539522.2
ENST00000293845.8
coiled-coil domain containing 42
chr20_+_43565115 0.99 ENST00000423407.7
serum/glucocorticoid regulated kinase 2
chr11_-_28108109 0.98 ENST00000263181.7
kinesin family member 18A
chr2_+_11612253 0.97 ENST00000396123.2
growth regulating estrogen receptor binding 1
chr10_-_18651576 0.89 ENST00000377304.7
NOP2/Sun RNA methyltransferase 6
chr16_-_31094727 0.88 ENST00000300851.10
ENST00000394975.3
vitamin K epoxide reductase complex subunit 1
chr3_-_27722316 0.87 ENST00000449599.4
eomesodermin
chr2_-_201619144 0.87 ENST00000439802.5
ENST00000286195.7
ENST00000439140.6
ENST00000450242.1
C2 calcium dependent domain containing 6
chr6_+_142301926 0.87 ENST00000296932.13
ENST00000367609.8
adhesion G protein-coupled receptor G6
chr19_-_15934853 0.86 ENST00000620614.4
ENST00000248041.12
cytochrome P450 family 4 subfamily F member 11
chr16_-_31094890 0.86 ENST00000532364.1
ENST00000529564.1
ENST00000319788.11
ENST00000354895.4
novel protein, VKORC1 and PRSS53 readthrough
vitamin K epoxide reductase complex subunit 1
chr9_+_108862255 0.86 ENST00000333999.5
actin like 7A
chr18_-_50825373 0.85 ENST00000588444.5
ENST00000256425.6
ENST00000428869.6
maestro
chrX_+_151563662 0.84 ENST00000370357.5
PAS domain containing repressor 1
chr8_+_10525529 0.83 ENST00000328655.8
ENST00000522210.1
serine protease 55
chr2_+_38666059 0.83 ENST00000272252.10
ENST00000410063.5
galactose mutarotase
chr6_+_46693835 0.82 ENST00000450697.1
tudor domain containing 6
chr4_+_145680146 0.81 ENST00000438731.7
chromosome 4 open reading frame 51
chr22_+_19131271 0.81 ENST00000399635.4
testis specific serine kinase 2
chr18_+_36187483 0.80 ENST00000261326.6
molybdenum cofactor sulfurase
chr1_-_205356894 0.80 ENST00000367155.8
kelch domain containing 8A
chr1_+_91949395 0.79 ENST00000449584.5
ENST00000427104.5
ENST00000355011.7
ENST00000399546.7
ENST00000450792.5
ENST00000548992.5
ENST00000552654.1
ENST00000457265.1
bromodomain testis associated
chr3_+_51977833 0.77 ENST00000637978.1
ABHD14A-ACY1 readthrough
chr16_-_31094549 0.77 ENST00000394971.7
vitamin K epoxide reductase complex subunit 1
chr3_-_59049947 0.75 ENST00000491845.5
ENST00000472469.5
ENST00000482387.6
ENST00000295966.11
CFAP20 domain containing
chr7_-_16804987 0.75 ENST00000401412.5
ENST00000419304.7
anterior gradient 2, protein disulphide isomerase family member
chr11_-_111512339 0.74 ENST00000525791.5
ENST00000456861.2
ENST00000356018.6
BTG anti-proliferation factor 4
chr2_+_229922482 0.74 ENST00000283946.8
ENST00000409992.1
F-box protein 36
chr22_+_22711689 0.74 ENST00000390308.2
immunoglobulin lambda variable 3-21
chr13_-_52011337 0.73 ENST00000400366.6
ENST00000400370.8
ENST00000634844.1
ENST00000673772.1
ENST00000418097.7
ENST00000242839.10
ENST00000344297.9
ENST00000448424.7
ATPase copper transporting beta
chr15_+_41559189 0.72 ENST00000263798.8
TYRO3 protein tyrosine kinase
chr4_-_102345469 0.71 ENST00000356736.5
ENST00000682932.1
solute carrier family 39 member 8
chr20_+_57329801 0.71 ENST00000371263.8
ENST00000345868.8
ENST00000371260.8
ENST00000418127.5
SPO11 initiator of meiotic double stranded breaks
chr2_+_219498857 0.71 ENST00000684669.1
ENST00000373917.7
ENST00000435316.6
ENST00000313597.10
ENST00000358215.8
ENST00000373908.5
ENST00000622191.2
ENST00000683752.1
ENST00000341142.8
GDP-mannose pyrophosphorylase A
chr5_-_177783398 0.71 ENST00000510276.5
family with sequence similarity 153 member A
chr18_-_6414885 0.69 ENST00000317931.12
ENST00000400104.7
L3MBTL histone methyl-lysine binding protein 4
chr9_-_127854636 0.68 ENST00000344849.4
ENST00000373203.9
endoglin
chr12_+_53461015 0.68 ENST00000553064.6
ENST00000547859.2
poly(rC) binding protein 2
chr11_+_94973640 0.66 ENST00000335080.6
ENST00000536741.1
lysine demethylase 4D
chr1_-_205356864 0.66 ENST00000491471.5
kelch domain containing 8A
chr15_+_68930488 0.65 ENST00000310673.4
ENST00000448182.7
ENST00000260364.9
sperm equatorial segment protein 1
NADPH oxidase 5
chr17_+_32927910 0.64 ENST00000394642.7
transmembrane protein 98
chr16_-_67150951 0.64 ENST00000449549.4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr1_-_205356568 0.62 ENST00000460687.5
kelch domain containing 8A
chr16_-_2210833 0.62 ENST00000562360.5
ENST00000328540.8
ENST00000566018.1
BRICHOS domain containing 5
chr3_-_146460440 0.62 ENST00000610787.5
phospholipid scramblase 2
chr7_+_98211431 0.61 ENST00000609256.2
basic helix-loop-helix family member a15
chr20_+_44401397 0.60 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
hepatocyte nuclear factor 4 alpha
chr7_-_100428657 0.60 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
zinc finger CW-type and PWWP domain containing 1
chr19_+_589873 0.59 ENST00000251287.3
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
chr13_+_24270681 0.58 ENST00000343003.10
ENST00000399949.6
spermatogenesis associated 13
chr3_-_27722699 0.58 ENST00000461503.2
eomesodermin
chr12_+_53501578 0.58 ENST00000552817.5
ENST00000394357.6
TARBP2 subunit of RISC loading complex
chr16_-_67183948 0.58 ENST00000561621.5
ENST00000563902.2
ENST00000290881.11
KIAA0895 like
chr1_+_154502207 0.58 ENST00000368482.8
tudor domain containing 10
chr1_+_40988513 0.57 ENST00000649215.1
CTP synthase 1
chr10_+_117542416 0.56 ENST00000442245.5
empty spiracles homeobox 2
chr1_-_89270751 0.54 ENST00000370459.7
guanylate binding protein 5
chr18_-_48409292 0.53 ENST00000589194.5
ENST00000591279.5
ENST00000590855.5
ENST00000587107.5
ENST00000588970.5
ENST00000586525.5
ENST00000592387.5
ENST00000590800.6
zinc finger and BTB domain containing 7C
chr17_-_37989048 0.51 ENST00000617678.2
ENST00000612727.5
TBC1 domain family member 3L
chr11_+_61102465 0.50 ENST00000347785.8
ENST00000544014.1
CD5 molecule
chr11_-_60183191 0.50 ENST00000412309.6
membrane spanning 4-domains A6A
chr16_-_68371005 0.49 ENST00000574662.1
sphingomyelin phosphodiesterase 3
chr12_-_25648544 0.49 ENST00000540106.5
ENST00000445693.5
ENST00000545543.1
lamin tail domain containing 1
chrX_-_135816265 0.49 ENST00000605791.7
cancer/testis antigen family 45 member A2
chr1_+_26021768 0.48 ENST00000374280.4
exostosin like glycosyltransferase 1
chr6_+_38715288 0.47 ENST00000327475.11
dynein axonemal heavy chain 8
chr7_+_1232865 0.47 ENST00000316333.9
UNC homeobox
chr4_-_36244438 0.47 ENST00000303965.9
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_7261092 0.46 ENST00000574070.5
claudin 7
chr12_+_54284258 0.46 ENST00000677666.1
heterogeneous nuclear ribonucleoprotein A1
chr17_-_36264514 0.46 ENST00000618620.4
ENST00000621034.1
TBC1 domain family member 3I
chr3_+_101849505 0.45 ENST00000326151.9
ENST00000326172.9
NFKB inhibitor zeta
chr8_+_97887903 0.44 ENST00000520016.5
matrilin 2
chr21_+_6561954 0.44 ENST00000624932.1
crystallin alpha A2
chr1_-_204190324 0.44 ENST00000638118.1
renin
chr17_+_36323884 0.44 ENST00000569055.2
TBC1 domain family member 3G
chr1_-_99005003 0.43 ENST00000672681.1
ENST00000370188.7
phospholipid phosphatase related 5
chr7_+_69967464 0.43 ENST00000664521.1
activator of transcription and developmental regulator AUTS2
chr22_+_50185894 0.43 ENST00000380909.9
ENST00000303434.8
TraB domain containing
chr14_+_100065400 0.42 ENST00000555706.5
ENST00000392920.8
ENST00000555048.5
Enah/Vasp-like
chr4_-_7042931 0.42 ENST00000310085.6
coiled-coil domain containing 96
chr1_+_198638968 0.42 ENST00000348564.11
ENST00000530727.5
ENST00000442510.8
ENST00000645247.1
ENST00000367367.8
ENST00000367364.5
ENST00000413409.6
protein tyrosine phosphatase receptor type C
chr19_+_1407517 0.42 ENST00000336761.10
ENST00000233078.9
ENST00000592522.5
DAZ associated protein 1
chr19_+_48619291 0.42 ENST00000340932.7
ENST00000601712.5
ENST00000600537.5
sphingosine kinase 2
chr17_+_37924415 0.41 ENST00000620247.1
TBC1 domain family member 3K
chr15_-_28848675 0.41 ENST00000567390.6
golgin A6 family like 7
chr1_+_23743462 0.40 ENST00000609199.1
elongin A
chr6_+_131199979 0.40 ENST00000537868.5
A-kinase anchoring protein 7
chr19_+_54966343 0.40 ENST00000537859.5
ENST00000585500.5
ENST00000427260.6
ENST00000448584.7
ENST00000263437.10
NLR family pyrin domain containing 2
chr1_-_99004812 0.40 ENST00000263177.5
phospholipid phosphatase related 5
chr9_+_128276222 0.40 ENST00000608796.6
ENST00000419867.7
ENST00000418976.2
SWI5 homologous recombination repair protein
chr19_+_40799155 0.40 ENST00000303961.9
egl-9 family hypoxia inducible factor 2
chr19_+_48619489 0.38 ENST00000245222.9
sphingosine kinase 2
chr2_+_108288639 0.37 ENST00000326853.9
sulfotransferase family 1C member 2
chr5_-_7868995 0.37 ENST00000264669.10
ENST00000507572.1
ENST00000504695.1
FAST kinase domains 3
chr11_-_61815106 0.37 ENST00000539419.5
ENST00000545245.5
ENST00000545405.5
ENST00000542506.5
fatty acid desaturase 1
chr6_+_112347322 0.37 ENST00000441065.3
ret finger protein like 4B
chr17_-_38068634 0.37 ENST00000622206.2
TBC1 domain family member 3C
chr1_-_54053461 0.37 ENST00000371341.5
transmembrane protein 59
chr6_+_33620329 0.37 ENST00000374316.9
inositol 1,4,5-trisphosphate receptor type 3
chr15_-_80989792 0.37 ENST00000261758.6
ENST00000561312.5
mesoderm development LRP chaperone
chr17_-_36439566 0.37 ENST00000620210.1
TBC1 domain family member 3F
chr1_+_43991588 0.36 ENST00000372318.8
coiled-coil domain containing 24
chrX_-_48919015 0.36 ENST00000376509.4
Pim-2 proto-oncogene, serine/threonine kinase
chr7_-_105389365 0.36 ENST00000482897.5
SRSF protein kinase 2
chr11_-_63917129 0.36 ENST00000301459.5
REST corepressor 2
chr12_-_109309278 0.35 ENST00000299162.10
forkhead box N4
chr19_+_38335775 0.35 ENST00000410018.5
ENST00000409235.8
ENST00000409410.6
cation channel sperm associated auxiliary subunit gamma
chr10_+_130136379 0.35 ENST00000331244.10
ENST00000368644.5
glutaredoxin 3
chr17_-_38192555 0.35 ENST00000620215.3
TBC1 domain family member 3
chr3_-_122564253 0.35 ENST00000492382.5
ENST00000682323.1
ENST00000462315.5
poly(ADP-ribose) polymerase family member 9
chr9_+_128882502 0.35 ENST00000259324.5
leucine rich repeat containing 8 VRAC subunit A
chr12_-_95995920 0.34 ENST00000552509.5
histidine ammonia-lyase
chr6_+_170554333 0.34 ENST00000540980.5
ENST00000616883.4
ENST00000392092.7
ENST00000230354.10
TATA-box binding protein
chrX_-_135868069 0.34 ENST00000604569.1
cancer/testis antigen family 45 member A9
chrX_-_135850791 0.34 ENST00000611438.1
cancer/testis antigen family 45 member A8
chr21_-_14546297 0.33 ENST00000400566.6
ENST00000400564.5
SAM domain, SH3 domain and nuclear localization signals 1
chr3_-_94062906 0.33 ENST00000314636.3
ENST00000394221.3
dihydrofolate reductase 2
chr18_+_23134561 0.33 ENST00000400473.6
Cdk5 and Abl enzyme substrate 1
chr5_-_177782837 0.33 ENST00000505531.5
ENST00000503567.5
family with sequence similarity 153 member A
chr7_+_66087761 0.33 ENST00000450043.2
novel protein
chr19_-_12484773 0.33 ENST00000397732.8
zinc finger protein 709
chr5_-_39270623 0.33 ENST00000512138.1
ENST00000646045.2
FYN binding protein 1
chr3_-_122564232 0.33 ENST00000471785.5
ENST00000466126.1
poly(ADP-ribose) polymerase family member 9
chr19_+_48619528 0.32 ENST00000598088.5
sphingosine kinase 2
chr16_+_28822982 0.32 ENST00000336783.9
ENST00000340394.12
ENST00000325215.10
ENST00000382686.8
ENST00000395547.6
ENST00000564304.5
ataxin 2 like
chr17_-_36388423 0.32 ENST00000610350.3
TBC1 domain family member 3H
chr14_+_58331253 0.31 ENST00000417477.2
AT-rich interaction domain 4A
chr1_-_115338231 0.31 ENST00000369512.3
ENST00000680116.1
ENST00000681124.1
ENST00000675637.2
ENST00000676038.2
nerve growth factor
chr15_+_75724034 0.31 ENST00000332145.3
outer dense fiber of sperm tails 3 like 1
chr3_+_2098846 0.31 ENST00000418658.6
contactin 4
chr17_+_38003976 0.30 ENST00000616101.4
TBC1 domain family member 3D
chrX_+_48130626 0.30 ENST00000304270.6
sperm acrosome associated 5B
chr16_+_2026834 0.30 ENST00000424542.7
ENST00000432365.6
SLC9A3 regulator 2
chr3_+_156674579 0.29 ENST00000295924.12
TCDD inducible poly(ADP-ribose) polymerase
chr11_-_111449981 0.29 ENST00000531398.1
POU class 2 homeobox associating factor 1
chr1_-_54053192 0.29 ENST00000371337.3
ENST00000234831.10
transmembrane protein 59
chr20_+_43565217 0.29 ENST00000412111.6
serum/glucocorticoid regulated kinase 2
chr1_-_54053394 0.28 ENST00000452421.5
ENST00000420738.5
ENST00000440019.5
transmembrane protein 59
chr17_-_81239085 0.28 ENST00000300714.7
TEPSIN adaptor related protein complex 4 accessory protein
chr11_-_74170975 0.27 ENST00000539061.6
ENST00000680645.1
ENST00000334126.12
ENST00000680718.1
C2 domain containing 3 centriole elongation regulator
chr6_-_27312258 0.27 ENST00000444565.2
POM121 transmembrane nucleoporin like 2
chr15_+_75206014 0.27 ENST00000567617.1
chromosome 15 open reading frame 39
chrX_+_154542194 0.27 ENST00000618670.4
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
chr6_+_85449584 0.27 ENST00000369651.7
5'-nucleotidase ecto
chr1_+_43991769 0.26 ENST00000466180.1
coiled-coil domain containing 24
chr1_+_2555639 0.26 ENST00000426449.5
ENST00000434817.5
ENST00000435221.6
TNF receptor superfamily member 14
chr14_+_37772383 0.26 ENST00000476979.5
tetratricopeptide repeat domain 6
chr10_+_35195843 0.25 ENST00000488741.5
ENST00000474931.5
ENST00000468236.5
ENST00000344351.5
ENST00000490511.1
cAMP responsive element modulator
chr1_+_92168915 0.25 ENST00000637221.2
BTB domain containing 8
chr10_-_43396831 0.25 ENST00000443950.6
heterogeneous nuclear ribonucleoprotein F
chrX_+_150568595 0.25 ENST00000370396.7
ENST00000424519.1
myotubularin 1
chr22_+_22369601 0.25 ENST00000390295.3
immunoglobulin lambda variable 7-46
chr10_-_43397220 0.25 ENST00000477108.5
ENST00000544000.5
heterogeneous nuclear ribonucleoprotein F
chr14_-_102305125 0.25 ENST00000522874.5
ENST00000361847.7
MOK protein kinase
chr2_-_88861563 0.24 ENST00000624935.3
ENST00000390241.3
novel transcript
immunoglobulin kappa joining 2

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 14.1 GO:0061107 seminal vesicle development(GO:0061107)
1.3 4.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
1.0 3.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.9 2.6 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.6 1.9 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.5 3.8 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.5 2.0 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.5 1.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 2.9 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.4 1.5 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 1.1 GO:1901052 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.3 0.7 GO:0001300 chronological cell aging(GO:0001300)
0.3 0.8 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 5.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 4.4 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.2 0.7 GO:0060003 copper ion export(GO:0060003)
0.2 3.4 GO:0042373 vitamin K metabolic process(GO:0042373)
0.2 2.6 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.2 0.9 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.2 1.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.2 0.7 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.2 0.7 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.2 0.3 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.1 0.7 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.4 GO:0031104 dendrite regeneration(GO:0031104)
0.1 0.7 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.6 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.8 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 1.4 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.6 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.4 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.6 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423) negative regulation of defense response to virus by host(GO:0050689)
0.1 0.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.7 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.1 0.5 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.1 0.7 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.0 GO:0070305 response to cGMP(GO:0070305)
0.1 1.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.2 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 2.0 GO:0051923 sulfation(GO:0051923)
0.1 0.4 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.5 GO:0032621 interleukin-18 production(GO:0032621)
0.1 1.1 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 1.2 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 0.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 1.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.7 GO:0060068 vagina development(GO:0060068)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.5 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.3 GO:0046086 AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086)
0.0 0.8 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.3 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0015677 copper ion import(GO:0015677)
0.0 0.5 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.0 0.2 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0 1.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.4 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.4 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0 2.1 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.5 GO:0021889 olfactory bulb interneuron differentiation(GO:0021889)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 1.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.4 GO:0036109 alpha-linolenic acid metabolic process(GO:0036109)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.1 GO:0036026 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.8 4.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 2.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 0.7 GO:0072563 endothelial microparticle(GO:0072563)
0.2 1.9 GO:0005579 membrane attack complex(GO:0005579)
0.2 4.6 GO:0042627 chylomicron(GO:0042627)
0.1 0.6 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.9 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.4 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.7 GO:0001940 male pronucleus(GO:0001940)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0070449 elongin complex(GO:0070449)
0.0 0.9 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.8 GO:0033391 chromatoid body(GO:0033391)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.6 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 9.5 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.8 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.2 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 14.1 GO:0032190 acrosin binding(GO:0032190)
0.8 4.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.8 3.0 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.6 2.6 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.5 3.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.4 2.5 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.4 1.1 GO:0008480 sarcosine dehydrogenase activity(GO:0008480)
0.3 1.4 GO:0070404 NADH binding(GO:0070404)
0.3 1.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.2 0.7 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.2 0.7 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.2 1.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.7 GO:0001034 RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 1.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.5 GO:0004146 dihydrofolate reductase activity(GO:0004146)
0.1 0.5 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.4 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.5 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.1 1.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.4 GO:0032090 Pyrin domain binding(GO:0032090)
0.1 0.8 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.9 GO:0019841 retinol binding(GO:0019841)
0.1 2.0 GO:0005537 mannose binding(GO:0005537)
0.1 0.7 GO:0005534 galactose binding(GO:0005534)
0.1 0.6 GO:0003883 CTP synthase activity(GO:0003883)
0.1 1.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.7 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.3 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.1 0.7 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 0.4 GO:0045485 omega-6 fatty acid desaturase activity(GO:0045485)
0.1 0.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.7 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 1.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 1.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.1 GO:0043236 laminin binding(GO:0043236)
0.0 0.7 GO:0001848 complement binding(GO:0001848)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.5 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.5 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 20.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.7 PID ALK1 PATHWAY ALK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 2.5 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.6 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 3.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha