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Illumina Body Map 2 (GSE30611)
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Results for ZBTB3
Z-value: 0.71
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Transcription factors associated with ZBTB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB3 | hg38_v1_chr11_-_62754141_62754184 | 0.06 | 7.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0030168 | platelet activation(GO:0030168) |
| 0.9 | 3.6 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
| 0.1 | 2.9 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.3 | 2.7 | GO:0021633 | optic nerve structural organization(GO:0021633) |
| 0.1 | 2.7 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.4 | 2.6 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.1 | 2.3 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.1 | 2.2 | GO:2001015 | negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 0.1 | 2.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 1.9 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.1 | 3.6 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 2.7 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 2.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 1.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 1.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.3 | GO:1990909 | Wnt signalosome(GO:1990909) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.6 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 0.0 | 2.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 2.7 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 2.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 2.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 2.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 2.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 2.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.4 | 1.9 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.0 | 1.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 2.3 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 2.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 1.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.8 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.7 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |