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Illumina Body Map 2 (GSE30611)

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Results for ZIC1

Z-value: 1.12

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Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ZIC1
ENSG00000152977.10 Zic family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg38_v1_chr3_+_147393718_1473938950.019.7e-01Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_54588636 5.73 ENST00000257905.13
PPP1R1A
protein phosphatase 1 regulatory inhibitor subunit 1A
chr11_+_116830529 5.10 ENST00000630701.1
APOC3
apolipoprotein C3
chr1_+_65147514 3.75 ENST00000545314.5
AK4
adenylate kinase 4
chr5_+_151026966 3.60 ENST00000520059.1
GPX3
glutathione peroxidase 3
chr1_+_65147657 3.30 ENST00000546702.5
AK4
adenylate kinase 4
chr19_+_44905785 3.30 ENST00000446996.5
ENST00000252486.9
ENST00000434152.5
APOE
apolipoprotein E
chr14_-_64942720 2.99 ENST00000557049.1
ENST00000389614.6
GPX2
glutathione peroxidase 2
chr14_-_64942783 2.75 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr3_-_12158901 2.65 ENST00000287814.5
TIMP4
TIMP metallopeptidase inhibitor 4
chr3_+_50155024 2.56 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
SEMA3F
semaphorin 3F
chr13_-_28495079 2.53 ENST00000615840.4
ENST00000282397.9
ENST00000541932.5
ENST00000539099.1
ENST00000639477.1
FLT1
fms related receptor tyrosine kinase 1
chr2_+_119431846 2.44 ENST00000306406.5
TMEM37
transmembrane protein 37
chr12_-_54588516 2.27 ENST00000547431.5
PPP1R1A
protein phosphatase 1 regulatory inhibitor subunit 1A
chr15_+_73684373 2.24 ENST00000558689.5
ENST00000560786.6
ENST00000318443.10
ENST00000561213.5
CD276
CD276 molecule
chr16_+_30985181 2.20 ENST00000262520.10
ENST00000297679.10
ENST00000562932.5
ENST00000574447.1
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr2_+_79120474 2.07 ENST00000233735.2
REG1A
regenerating family member 1 alpha
chr22_-_24226112 2.05 ENST00000425408.5
GGT5
gamma-glutamyltransferase 5
chr4_+_110476133 2.04 ENST00000265162.10
ENPEP
glutamyl aminopeptidase
chr2_+_233760265 2.02 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr22_+_43923755 2.02 ENST00000423180.2
ENST00000216180.8
PNPLA3
patatin like phospholipase domain containing 3
chr11_-_2161158 1.99 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
INS
INS-IGF2
insulin
INS-IGF2 readthrough
chr10_-_33334625 1.95 ENST00000374875.5
ENST00000374822.8
ENST00000374867.7
NRP1
neuropilin 1
chr2_-_1744442 1.93 ENST00000433670.5
ENST00000425171.1
ENST00000252804.9
PXDN
peroxidasin
chr15_+_73684204 1.88 ENST00000537340.6
ENST00000318424.9
CD276
CD276 molecule
chr10_-_33334898 1.88 ENST00000395995.5
NRP1
neuropilin 1
chr4_-_185812209 1.73 ENST00000393523.6
ENST00000393528.7
ENST00000449407.6
SORBS2
sorbin and SH3 domain containing 2
chr19_-_42427379 1.70 ENST00000244289.9
LIPE
lipase E, hormone sensitive type
chr4_+_24795560 1.67 ENST00000382120.4
SOD3
superoxide dismutase 3
chr8_-_119673368 1.66 ENST00000427067.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_41003946 1.62 ENST00000593831.1
CYP2B6
cytochrome P450 family 2 subfamily B member 6
chr1_+_22636577 1.59 ENST00000374642.8
ENST00000438241.1
C1QA
complement C1q A chain
chr6_-_35688907 1.59 ENST00000539068.5
ENST00000357266.9
FKBP5
FKBP prolyl isomerase 5
chr17_-_55732074 1.58 ENST00000575734.5
TMEM100
transmembrane protein 100
chrX_-_130165699 1.54 ENST00000676328.1
ENST00000675857.1
ENST00000675427.1
ENST00000675092.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr11_+_67056805 1.53 ENST00000308831.7
RHOD
ras homolog family member D
chrX_-_130165825 1.50 ENST00000675240.1
ENST00000319908.8
ENST00000674546.1
ENST00000287295.8
AIFM1
apoptosis inducing factor mitochondria associated 1
chr16_+_55479188 1.50 ENST00000219070.9
MMP2
matrix metallopeptidase 2
chrX_-_130165664 1.42 ENST00000535724.6
ENST00000346424.6
ENST00000676436.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr9_-_109498251 1.41 ENST00000374541.4
ENST00000262539.7
PTPN3
protein tyrosine phosphatase non-receptor type 3
chr17_-_44968263 1.40 ENST00000253407.4
C1QL1
complement C1q like 1
chr1_-_59926724 1.37 ENST00000371204.4
CYP2J2
cytochrome P450 family 2 subfamily J member 2
chr1_+_16043736 1.35 ENST00000619181.4
CLCNKB
chloride voltage-gated channel Kb
chrX_-_130165873 1.34 ENST00000676229.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr8_-_63038788 1.33 ENST00000518113.2
ENST00000260118.7
ENST00000677482.1
GGH
gamma-glutamyl hydrolase
chr12_+_109154661 1.24 ENST00000544726.2
ACACB
acetyl-CoA carboxylase beta
chr10_-_33335074 1.24 ENST00000432372.6
NRP1
neuropilin 1
chr1_+_16043776 1.23 ENST00000375679.9
CLCNKB
chloride voltage-gated channel Kb
chr6_-_35688935 1.22 ENST00000542713.1
FKBP5
FKBP prolyl isomerase 5
chr1_+_16021871 1.20 ENST00000375692.5
CLCNKA
chloride voltage-gated channel Ka
chr1_+_16022030 1.14 ENST00000331433.5
CLCNKA
chloride voltage-gated channel Ka
chr9_-_35103178 1.12 ENST00000452248.6
ENST00000619795.4
STOML2
stomatin like 2
chr17_+_41265339 1.11 ENST00000391355.1
KRTAP9-6
keratin associated protein 9-6
chr4_+_6269831 1.11 ENST00000503569.5
ENST00000673991.1
ENST00000682275.1
ENST00000226760.5
WFS1
wolframin ER transmembrane glycoprotein
chr11_+_67056875 1.09 ENST00000532559.1
RHOD
ras homolog family member D
chr4_-_128286875 1.09 ENST00000503872.1
PGRMC2
progesterone receptor membrane component 2
chr21_-_38498415 1.05 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr19_+_44809089 1.05 ENST00000270233.12
ENST00000591520.6
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr9_-_35103108 1.04 ENST00000356493.10
STOML2
stomatin like 2
chr1_+_16022004 1.01 ENST00000439316.6
CLCNKA
chloride voltage-gated channel Ka
chr4_-_128286787 1.00 ENST00000503588.1
PGRMC2
progesterone receptor membrane component 2
chr17_-_69060906 0.97 ENST00000495634.5
ENST00000453985.6
ENST00000340001.9
ENST00000585714.1
ABCA9
ATP binding cassette subfamily A member 9
chr3_+_149129610 0.96 ENST00000460120.5
ENST00000296051.7
HPS3
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
chr19_+_46303599 0.96 ENST00000300862.7
HIF3A
hypoxia inducible factor 3 subunit alpha
chr3_-_73433904 0.95 ENST00000479530.5
PDZRN3
PDZ domain containing ring finger 3
chr1_+_61404076 0.92 ENST00000357977.5
NFIA
nuclear factor I A
chr3_-_58577367 0.91 ENST00000464064.5
ENST00000360997.7
FAM107A
family with sequence similarity 107 member A
chr9_+_121567057 0.91 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2IP
DAB2 interacting protein
chr12_-_106084023 0.89 ENST00000553094.1
ENST00000549704.1
NUAK1
NUAK family kinase 1
chr3_+_51977833 0.87 ENST00000637978.1
ABHD14A-ACY1
ABHD14A-ACY1 readthrough
chr2_+_6978624 0.87 ENST00000433456.1
RNF144A
ring finger protein 144A
chr2_-_75518697 0.86 ENST00000452003.1
EVA1A
eva-1 homolog A, regulator of programmed cell death
chrX_+_46912412 0.86 ENST00000614628.5
JADE3
jade family PHD finger 3
chr7_-_150800533 0.86 ENST00000434545.5
TMEM176B
transmembrane protein 176B
chr1_-_153616289 0.83 ENST00000368701.5
ENST00000344616.4
S100A14
S100 calcium binding protein A14
chr6_-_116765709 0.82 ENST00000368557.6
FAM162B
family with sequence similarity 162 member B
chr13_-_44474296 0.81 ENST00000611198.4
TSC22D1
TSC22 domain family member 1
chr19_+_44809053 0.81 ENST00000611077.5
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr5_-_150137403 0.81 ENST00000517957.1
PDGFRB
platelet derived growth factor receptor beta
chr10_-_69416323 0.80 ENST00000619173.4
TACR2
tachykinin receptor 2
chr14_+_38207893 0.80 ENST00000267377.3
SSTR1
somatostatin receptor 1
chr13_-_44474250 0.80 ENST00000472477.1
TSC22D1
TSC22 domain family member 1
chr19_-_55117336 0.77 ENST00000592993.1
PPP1R12C
protein phosphatase 1 regulatory subunit 12C
chr19_-_3028356 0.72 ENST00000586422.5
TLE2
TLE family member 2, transcriptional corepressor
chr1_-_43367956 0.71 ENST00000372458.8
ELOVL1
ELOVL fatty acid elongase 1
chrX_+_46912276 0.71 ENST00000424392.5
ENST00000611250.4
JADE3
jade family PHD finger 3
chr15_+_84980440 0.70 ENST00000310298.8
ENST00000557957.5
PDE8A
phosphodiesterase 8A
chr1_+_61952036 0.67 ENST00000646453.1
ENST00000635137.1
PATJ
PATJ crumbs cell polarity complex component
chr3_+_42850966 0.66 ENST00000494619.1
ACKR2
atypical chemokine receptor 2
chr14_-_68979436 0.66 ENST00000193403.10
ACTN1
actinin alpha 1
chr3_-_86991135 0.66 ENST00000398399.7
VGLL3
vestigial like family member 3
chr12_+_77324608 0.65 ENST00000550042.2
NAV3
neuron navigator 3
chr19_-_16660104 0.63 ENST00000593459.5
ENST00000627144.2
ENST00000358726.6
ENST00000487416.7
ENST00000597711.5
ENSG00000268790.5
SMIM7
novel protein
small integral membrane protein 7
chr19_-_14475307 0.61 ENST00000292513.4
PTGER1
prostaglandin E receptor 1
chr1_-_43368039 0.61 ENST00000413844.3
ELOVL1
ELOVL fatty acid elongase 1
chr8_+_84184875 0.61 ENST00000517638.5
ENST00000522647.1
RALYL
RALY RNA binding protein like
chr17_-_58531941 0.60 ENST00000581607.1
ENST00000317256.10
ENST00000426861.5
ENST00000580809.5
ENST00000577729.5
ENST00000583291.1
SEPTIN4
septin 4
chr3_-_50292404 0.59 ENST00000417626.8
IFRD2
interferon related developmental regulator 2
chr12_-_102478539 0.59 ENST00000424202.6
IGF1
insulin like growth factor 1
chr14_-_68979274 0.58 ENST00000394419.9
ACTN1
actinin alpha 1
chr1_+_99850485 0.58 ENST00000370165.7
ENST00000370163.7
ENST00000294724.8
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr17_-_979726 0.57 ENST00000336868.8
NXN
nucleoredoxin
chr14_-_68979314 0.57 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
ACTN1
actinin alpha 1
chrX_+_46912629 0.57 ENST00000455411.1
JADE3
jade family PHD finger 3
chr2_-_68319398 0.56 ENST00000409559.7
CNRIP1
cannabinoid receptor interacting protein 1
chr1_-_43367689 0.55 ENST00000621943.4
ELOVL1
ELOVL fatty acid elongase 1
chr4_-_185811965 0.55 ENST00000419063.5
SORBS2
sorbin and SH3 domain containing 2
chr11_-_123754518 0.54 ENST00000327930.3
OR6X1
olfactory receptor family 6 subfamily X member 1
chr7_-_108240049 0.54 ENST00000379022.8
NRCAM
neuronal cell adhesion molecule
chr15_+_73683938 0.54 ENST00000567189.5
CD276
CD276 molecule
chr22_-_30387078 0.53 ENST00000215798.10
RNF215
ring finger protein 215
chr16_-_31088963 0.53 ENST00000280606.6
PRSS53
serine protease 53
chr3_-_86991109 0.53 ENST00000383698.3
VGLL3
vestigial like family member 3
chr1_+_23793649 0.52 ENST00000374501.1
LYPLA2
lysophospholipase 2
chr14_+_22871732 0.51 ENST00000359591.9
LRP10
LDL receptor related protein 10
chr1_+_46203321 0.51 ENST00000371980.4
LURAP1
leucine rich adaptor protein 1
chr4_+_6269869 0.51 ENST00000506362.2
WFS1
wolframin ER transmembrane glycoprotein
chrX_+_69616067 0.51 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
EDA
ectodysplasin A
chr5_-_127073467 0.49 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
C5orf63
chromosome 5 open reading frame 63
chr7_-_73842508 0.49 ENST00000297873.9
METTL27
methyltransferase like 27
chr14_-_21634940 0.48 ENST00000542433.1
OR10G2
olfactory receptor family 10 subfamily G member 2
chr19_-_35501878 0.48 ENST00000593342.5
ENST00000601650.1
ENST00000408915.6
DMKN
dermokine
chr20_+_56629296 0.47 ENST00000201031.3
TFAP2C
transcription factor AP-2 gamma
chr22_-_30557586 0.47 ENST00000338911.6
ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr15_+_59372685 0.46 ENST00000558348.5
FAM81A
family with sequence similarity 81 member A
chr6_-_168075831 0.46 ENST00000440994.6
FRMD1
FERM domain containing 1
chr2_+_241813947 0.45 ENST00000428592.1
NEU4
neuraminidase 4
chr1_+_18631513 0.45 ENST00000400661.3
PAX7
paired box 7
chr1_+_99850348 0.44 ENST00000361915.8
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr17_-_58544315 0.43 ENST00000671766.1
ENST00000672673.2
ENST00000321691.3
SEPTIN4
septin 4
chr6_+_31762996 0.42 ENST00000415669.3
ENST00000425424.4
SAPCD1
suppressor APC domain containing 1
chr16_+_28846637 0.41 ENST00000567536.5
SH2B1
SH2B adaptor protein 1
chr14_-_68979251 0.41 ENST00000438964.6
ENST00000679147.1
ACTN1
actinin alpha 1
chr12_+_56996151 0.40 ENST00000556850.1
GPR182
G protein-coupled receptor 182
chr1_+_18631006 0.40 ENST00000375375.7
PAX7
paired box 7
chr1_-_111449209 0.40 ENST00000235090.10
WDR77
WD repeat domain 77
chr14_-_68979076 0.40 ENST00000538545.6
ENST00000684639.1
ACTN1
actinin alpha 1
chr15_+_73684435 0.39 ENST00000563584.5
ENST00000561416.5
CD276
CD276 molecule
chr12_-_58920465 0.39 ENST00000320743.8
LRIG3
leucine rich repeats and immunoglobulin like domains 3
chr9_-_122629573 0.39 ENST00000623530.1
OR1B1
olfactory receptor family 1 subfamily B member 1
chr1_+_111449442 0.39 ENST00000369722.8
ENST00000483994.1
ATP5PB
ATP synthase peripheral stalk-membrane subunit b
chr11_-_59845496 0.39 ENST00000257248.3
CBLIF
cobalamin binding intrinsic factor
chr17_-_41168219 0.38 ENST00000391356.4
KRTAP4-3
keratin associated protein 4-3
chrX_+_3006546 0.38 ENST00000381130.3
ARSH
arylsulfatase family member H
chr1_-_89175997 0.38 ENST00000294671.3
ENST00000650452.1
GBP7
guanylate binding protein 7
chrX_-_47574738 0.38 ENST00000640721.1
SYN1
synapsin I
chr16_+_28846596 0.37 ENST00000563591.5
SH2B1
SH2B adaptor protein 1
chr1_-_94121105 0.36 ENST00000649773.1
ENST00000370225.4
ABCA4
ATP binding cassette subfamily A member 4
chr6_-_168319762 0.36 ENST00000366795.4
DACT2
dishevelled binding antagonist of beta catenin 2
chr3_+_4303602 0.36 ENST00000358950.4
SETMAR
SET domain and mariner transposase fusion gene
chr11_+_89710650 0.35 ENST00000534392.4
TRIM77
tripartite motif containing 77
chr11_+_75815180 0.35 ENST00000356136.8
UVRAG
UV radiation resistance associated
chr1_+_161118083 0.35 ENST00000368009.7
ENST00000368007.8
ENST00000392190.9
ENST00000368008.5
NIT1
nitrilase 1
chr21_+_30396030 0.34 ENST00000355459.4
KRTAP13-1
keratin associated protein 13-1
chr11_+_58179431 0.33 ENST00000612174.1
OR9Q1
olfactory receptor family 9 subfamily Q member 1
chr19_-_58098203 0.33 ENST00000600845.1
ENST00000240727.10
ENST00000600897.5
ENST00000421612.6
ENST00000601063.1
ENST00000601144.6
ZSCAN18
zinc finger and SCAN domain containing 18
chr2_-_96868575 0.33 ENST00000442264.5
SEMA4C
semaphorin 4C
chr1_+_61952283 0.33 ENST00000307297.8
PATJ
PATJ crumbs cell polarity complex component
chr17_-_41027198 0.32 ENST00000361883.6
KRTAP1-5
keratin associated protein 1-5
chr6_-_168319691 0.31 ENST00000610183.1
ENST00000607983.1
DACT2
dishevelled binding antagonist of beta catenin 2
chr6_+_132570322 0.31 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr8_-_81841958 0.31 ENST00000519817.5
ENST00000521773.5
ENST00000523757.5
ENST00000345957.9
SNX16
sorting nexin 16
chr12_+_5432101 0.31 ENST00000423158.4
NTF3
neurotrophin 3
chr14_-_23548437 0.30 ENST00000555334.1
ZFHX2
zinc finger homeobox 2
chr3_-_45796518 0.30 ENST00000413781.1
ENST00000358525.9
SLC6A20
solute carrier family 6 member 20
chr10_+_49610297 0.29 ENST00000374115.5
SLC18A3
solute carrier family 18 member A3
chr13_+_101452569 0.29 ENST00000618057.4
ITGBL1
integrin subunit beta like 1
chr14_+_57268940 0.28 ENST00000556995.1
AP5M1
adaptor related protein complex 5 subunit mu 1
chr11_-_2171805 0.28 ENST00000381178.5
ENST00000381175.5
ENST00000333684.9
ENST00000352909.8
TH
tyrosine hydroxylase
chr9_-_16870702 0.28 ENST00000380667.6
ENST00000545497.5
ENST00000486514.5
BNC2
basonuclin 2
chr1_+_171600621 0.27 ENST00000636697.1
MYOCOS
myocilin opposite strand
chr3_-_45796467 0.27 ENST00000353278.8
ENST00000456124.6
SLC6A20
solute carrier family 6 member 20
chr4_-_4226929 0.25 ENST00000296358.5
OTOP1
otopetrin 1
chr6_+_89562620 0.25 ENST00000522779.5
ANKRD6
ankyrin repeat domain 6
chr1_-_211133945 0.24 ENST00000640044.1
ENST00000640566.1
KCNH1
potassium voltage-gated channel subfamily H member 1
chr19_-_6433754 0.23 ENST00000321510.7
SLC25A41
solute carrier family 25 member 41
chr22_-_30591850 0.23 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
PES1
pescadillo ribosomal biogenesis factor 1
chr11_+_89710299 0.23 ENST00000398290.7
TRIM77
tripartite motif containing 77
chr8_-_81842192 0.22 ENST00000353788.8
ENST00000520618.5
ENST00000518183.5
ENST00000396330.6
ENST00000519119.5
SNX16
sorting nexin 16
chr21_+_44697427 0.21 ENST00000618832.1
KRTAP10-12
keratin associated protein 10-12
chr17_+_38428456 0.21 ENST00000622683.5
ENST00000620417.4
ARHGAP23
Rho GTPase activating protein 23
chr11_+_15073562 0.21 ENST00000533448.1
ENST00000324229.11
CALCB
calcitonin related polypeptide beta
chr17_-_41065879 0.20 ENST00000394015.3
KRTAP2-4
keratin associated protein 2-4
chr4_-_40515967 0.19 ENST00000381795.10
RBM47
RNA binding motif protein 47
chr4_+_26576670 0.19 ENST00000512840.5
TBC1D19
TBC1 domain family member 19
chr17_-_5468951 0.19 ENST00000225296.8
DHX33
DEAH-box helicase 33
chr20_+_33031648 0.19 ENST00000349552.1
BPIFB6
BPI fold containing family B member 6
chr21_+_30440275 0.18 ENST00000334067.4
KRTAP15-1
keratin associated protein 15-1
chr6_-_168319744 0.17 ENST00000366796.7
DACT2
dishevelled binding antagonist of beta catenin 2
chr6_+_89562766 0.17 ENST00000485637.5
ENST00000522705.5
ANKRD6
ankyrin repeat domain 6
chr21_-_44540195 0.17 ENST00000400375.1
KRTAP10-1
keratin associated protein 10-1
chr14_+_57269007 0.16 ENST00000431972.6
AP5M1
adaptor related protein complex 5 subunit mu 1
chr17_+_45999250 0.16 ENST00000537309.1
STH
saitohin
chr4_+_94995919 0.16 ENST00000509540.6
BMPR1B
bone morphogenetic protein receptor type 1B
chr7_-_103149056 0.16 ENST00000465647.6
ENST00000418294.1
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D
chr22_+_29306582 0.15 ENST00000616432.4
ENST00000416823.1
ENST00000428622.1
GAS2L1
growth arrest specific 2 like 1
chr3_-_79767987 0.15 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr11_-_559377 0.15 ENST00000486629.1
LMNTD2
lamin tail domain containing 2
chr18_+_63752935 0.15 ENST00000425392.5
ENST00000336429.6
SERPINB7
serpin family B member 7
chr1_-_244730962 0.14 ENST00000640271.2
ENSG00000284188.2
novel protein
chr14_+_57268963 0.14 ENST00000261558.8
AP5M1
adaptor related protein complex 5 subunit mu 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:1904045 cellular response to aldosterone(GO:1904045)
1.4 8.4 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
1.3 5.1 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.8 2.5 GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway(GO:0036323)
0.7 2.0 GO:0060266 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.5 7.1 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.5 3.6 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 2.0 GO:0018879 biphenyl metabolic process(GO:0018879)
0.4 2.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.4 1.6 GO:1903892 negative regulation of ATF6-mediated unfolded protein response(GO:1903892)
0.4 4.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.4 2.6 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.3 2.0 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.3 1.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.3 0.8 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.3 5.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 0.3 GO:0018963 phthalate metabolic process(GO:0018963)
0.3 0.8 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.3 1.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 1.4 GO:0099558 maintenance of synapse structure(GO:0099558)
0.2 2.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 1.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 1.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 0.8 GO:1900108 inner medullary collecting duct development(GO:0072061) negative regulation of nodal signaling pathway(GO:1900108)
0.2 0.8 GO:0035106 operant conditioning(GO:0035106)
0.2 0.8 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 1.5 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.9 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 2.0 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 2.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 3.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.6 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.9 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 2.0 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.4 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 1.6 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 2.6 GO:0051639 actin filament network formation(GO:0051639)
0.1 5.9 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 0.9 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 9.0 GO:0005977 glycogen metabolic process(GO:0005977)
0.1 0.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 0.4 GO:0097676 histone H3-K36 dimethylation(GO:0097676) positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 9.9 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 0.5 GO:0002084 protein depalmitoylation(GO:0002084)
0.1 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 2.9 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.8 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.2 GO:0035900 response to isolation stress(GO:0035900)
0.0 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 2.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.6 GO:0015824 proline transport(GO:0015824)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.3 GO:0015870 acetylcholine transport(GO:0015870)
0.0 0.1 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.5 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.9 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0021825 substrate-dependent cerebral cortex tangential migration(GO:0021825)
0.0 1.6 GO:0010039 response to iron ion(GO:0010039)
0.0 0.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.7 GO:1903206 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.0 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 3.2 GO:0031424 keratinization(GO:0031424)
0.0 0.0 GO:1902995 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0006622 protein targeting to lysosome(GO:0006622)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 8.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.5 5.1 GO:0097443 sorting endosome(GO:0097443)
0.4 1.6 GO:0005602 complement component C1 complex(GO:0005602)
0.3 2.3 GO:0044301 climbing fiber(GO:0044301)
0.2 1.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 2.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.6 GO:0005916 fascia adherens(GO:0005916)
0.1 8.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 6.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 2.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 2.6 GO:0045095 keratin filament(GO:0045095)
0.0 3.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0034709 methylosome(GO:0034709)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 2.1 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.6 GO:0000502 proteasome complex(GO:0000502)
0.0 1.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 4.8 GO:0030017 sarcomere(GO:0030017)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
1.0 5.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.8 2.5 GO:0036326 VEGF-A-activated receptor activity(GO:0036326) VEGF-B-activated receptor activity(GO:0036327) placental growth factor-activated receptor activity(GO:0036332)
0.7 3.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.6 1.9 GO:0005055 laminin receptor activity(GO:0005055)
0.6 1.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.5 5.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 8.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 5.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 1.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 1.7 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.3 0.8 GO:0016497 substance K receptor activity(GO:0016497)
0.3 9.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 2.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 2.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) long-chain fatty acyl-CoA binding(GO:0036042)
0.2 5.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 1.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 3.0 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 1.9 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.4 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 3.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.9 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 2.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.3 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.1 2.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 2.6 GO:0017166 vinculin binding(GO:0017166)
0.1 0.4 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 2.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 2.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 2.0 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.5 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.0 0.3 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 1.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 2.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 2.1 GO:0020037 heme binding(GO:0020037)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.8 GO:0042379 chemokine receptor binding(GO:0042379)
0.0 2.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 5.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 5.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 2.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 4.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 8.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.0 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins