Project
Illumina Body Map 2 (GSE30611)
Navigation
Downloads
Results for ZIC1
Z-value: 1.12
Motif logo
Transcription factors associated with ZIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC1 | hg38_v1_chr3_+_147393718_147393895 | 0.01 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_54588636 Show fit | 5.73 |
ENST00000257905.13
|
protein phosphatase 1 regulatory inhibitor subunit 1A |
|
| chr11_+_116830529 Show fit | 5.10 |
ENST00000630701.1
|
apolipoprotein C3 |
|
| chr1_+_65147514 Show fit | 3.75 |
ENST00000545314.5
|
adenylate kinase 4 |
|
| chr5_+_151026966 Show fit | 3.60 |
ENST00000520059.1
|
glutathione peroxidase 3 |
|
| chr1_+_65147657 Show fit | 3.30 |
ENST00000546702.5
|
adenylate kinase 4 |
|
| chr19_+_44905785 Show fit | 3.30 |
ENST00000446996.5
ENST00000252486.9 ENST00000434152.5 |
apolipoprotein E |
|
| chr14_-_64942720 Show fit | 2.99 |
ENST00000557049.1
ENST00000389614.6 |
glutathione peroxidase 2 |
|
| chr14_-_64942783 Show fit | 2.75 |
ENST00000612794.1
|
glutathione peroxidase 2 |
|
| chr3_-_12158901 Show fit | 2.65 |
ENST00000287814.5
|
TIMP metallopeptidase inhibitor 4 |
|
| chr3_+_50155024 Show fit | 2.56 |
ENST00000414301.5
ENST00000450338.5 ENST00000413852.5 |
semaphorin 3F |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.1 | 9.0 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 1.4 | 8.4 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.5 | 7.1 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 5.9 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 1.5 | 5.8 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 1.3 | 5.1 | GO:1904835 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.3 | 5.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.4 | 4.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.5 | 3.6 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 8.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 8.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 6.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 6.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.5 | 5.1 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 4.8 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 3.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 2.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 2.3 | GO:0044301 | climbing fiber(GO:0044301) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.5 | 8.0 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 1.2 | 7.1 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.5 | 5.9 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 5.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.4 | 5.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 1.0 | 5.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 3.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.7 | 3.3 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 3.0 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 5.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 5.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.1 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 2.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 7.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 2.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 2.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 2.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |