ISMARA results: ZIC2

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Illumina Body Map 2 (GSE30611)

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Results for ZIC2_GLI1

Z-value: 1.69

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Transcription factors associated with ZIC2_GLI1

Gene Symbol	Gene ID	Gene Info
ZIC2 Ensembl NCBI GeneCards UniProt	ENSG00000043355.12	Zic family member 2
GLI1 Ensembl NCBI GeneCards UniProt	ENSG00000111087.10	GLI family zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLI1	hg38_v1_chr12_+_57460127_57460151	0.16	3.9e-01	Click!
ZIC2	hg38_v1_chr13_+_99981775_99981791	0.08	6.5e-01	Click!

Activity profile of ZIC2_GLI1 motif

Sorted Z-values of ZIC2_GLI1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_111913195 Show fit	14.32	ENST00000531198.5 ENST00000616970.5 ENST00000527899.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_111913134 Show fit	12.92	ENST00000533971.2 ENST00000526180.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr19_+_44809089 Show fit	12.00	ENST00000270233.12 ENST00000591520.6	BCAM Ensembl NCBI GeneCards UniProt Show fit	basal cell adhesion molecule (Lutheran blood group)
chr19_+_44809053 Show fit	11.81	ENST00000611077.5	BCAM Ensembl NCBI GeneCards UniProt Show fit	basal cell adhesion molecule (Lutheran blood group)
chr1_+_46798998 Show fit	10.30	ENST00000640628.1 ENST00000271153.8 ENST00000371923.9 ENST00000371919.8 ENST00000614163.4	CYP4B1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 4 subfamily B member 1
chr5_-_168883333 Show fit	10.26	ENST00000404867.7	SLIT3 Ensembl NCBI GeneCards UniProt Show fit	slit guidance ligand 3
chr4_+_165378998 Show fit	9.90	ENST00000402744.9	CPE Ensembl NCBI GeneCards UniProt Show fit	carboxypeptidase E
chr11_+_111912725 Show fit	9.35	ENST00000304298.4	HSPB2 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 2
chr11_-_111912871 Show fit	8.46	ENST00000528628.5	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr5_-_169300782 Show fit	8.15	ENST00000332966.8	SLIT3 Ensembl NCBI GeneCards UniProt Show fit	slit guidance ligand 3
chr3_-_73624840 Show fit	7.36	ENST00000308537.4 ENST00000263666.9	PDZRN3 Ensembl NCBI GeneCards UniProt Show fit	PDZ domain containing ring finger 3
chr21_-_26843063 Show fit	7.23	ENST00000678221.1	ADAMTS1 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif 1
chr19_+_676385 Show fit	7.13	ENST00000166139.9	FSTL3 Ensembl NCBI GeneCards UniProt Show fit	follistatin like 3
chr21_-_26843012 Show fit	7.01	ENST00000517777.6	ADAMTS1 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif 1
chr4_-_5019437 Show fit	6.09	ENST00000506508.1 ENST00000509419.1 ENST00000307746.9	CYTL1 Ensembl NCBI GeneCards UniProt Show fit	cytokine like 1
chr8_+_19939246 Show fit	5.71	ENST00000650287.1	LPL Ensembl NCBI GeneCards UniProt Show fit	lipoprotein lipase
chr20_+_37521206 Show fit	5.65	ENST00000346199.3 ENST00000647955.1 ENST00000649451.1 ENST00000649697.1 ENST00000649309.1	NNAT Ensembl NCBI GeneCards UniProt Show fit	neuronatin
chr16_+_31472130 Show fit	5.65	ENST00000394863.8 ENST00000565360.5 ENST00000361773.7	TGFB1I1 Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta 1 induced transcript 1
chr1_-_39639626 Show fit	5.63	ENST00000372852.4	HEYL Ensembl NCBI GeneCards UniProt Show fit	hes related family bHLH transcription factor with YRPW motif like
chr8_-_17697654 Show fit	5.20	ENST00000297488.10	MTUS1 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated scaffold protein 1
chr21_-_26573211 Show fit	5.08	ENST00000299340.9 ENST00000652641.2	CYYR1 Ensembl NCBI GeneCards UniProt Show fit	cysteine and tyrosine rich 1
chr5_+_72107453 Show fit	4.79	ENST00000296755.12 ENST00000511641.2	MAP1B Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 1B
chr2_+_26692686 Show fit	4.57	ENST00000620977.1 ENST00000302909.4	KCNK3 Ensembl NCBI GeneCards UniProt Show fit	potassium two pore domain channel subfamily K member 3
chr3_+_154121366 Show fit	4.23	ENST00000465093.6 ENST00000496710.5 ENST00000465817.1	ARHGEF26 Ensembl NCBI GeneCards UniProt Show fit	Rho guanine nucleotide exchange factor 26
chr3_+_50269140 Show fit	4.21	ENST00000616701.5 ENST00000433753.4 ENST00000611067.4	SEMA3B Ensembl NCBI GeneCards UniProt Show fit	semaphorin 3B
chr11_+_118607598 Show fit	4.17	ENST00000600882.6 ENST00000356063.9	PHLDB1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology like domain family B member 1
chr20_+_44714835 Show fit	4.02	ENST00000372868.6	CCN5 Ensembl NCBI GeneCards UniProt Show fit	cellular communication network factor 5
chr11_-_12008584 Show fit	3.90	ENST00000534511.5 ENST00000683431.1	DKK3 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 3
chr17_+_7023042 Show fit	3.89	ENST00000293805.10	BCL6B Ensembl NCBI GeneCards UniProt Show fit	BCL6B transcription repressor
chr5_-_122077152 Show fit	3.71	ENST00000513319.5 ENST00000503759.5	LOX Ensembl NCBI GeneCards UniProt Show fit	lysyl oxidase
chr1_-_171652675 Show fit	3.65	ENST00000037502.11	MYOC Ensembl NCBI GeneCards UniProt Show fit	myocilin
chr3_+_170418856 Show fit	3.53	ENST00000064724.8 ENST00000486975.1	CLDN11 Ensembl NCBI GeneCards UniProt Show fit ENSG00000285218.1 Ensembl NCBI GeneCards UniProt Show fit	claudin 11 novel protein
chr8_+_30387064 Show fit	3.52	ENST00000523115.5 ENST00000519647.5	RBPMS Ensembl NCBI GeneCards UniProt Show fit	RNA binding protein, mRNA processing factor
chr11_-_11621991 Show fit	3.52	ENST00000227756.5	GALNT18 Ensembl NCBI GeneCards UniProt Show fit	polypeptide N-acetylgalactosaminyltransferase 18
chr11_-_111911759 Show fit	3.47	ENST00000650687.2	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr20_+_44714853 Show fit	3.45	ENST00000372865.4	CCN5 Ensembl NCBI GeneCards UniProt Show fit	cellular communication network factor 5
chr22_-_42720861 Show fit	3.40	ENST00000642412.2	A4GALT Ensembl NCBI GeneCards UniProt Show fit	alpha 1,4-galactosyltransferase (P blood group)
chr21_-_26845402 Show fit	3.39	ENST00000284984.8 ENST00000676955.1	ADAMTS1 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif 1
chr10_-_88952763 Show fit	3.31	ENST00000224784.10	ACTA2 Ensembl NCBI GeneCards UniProt Show fit	actin alpha 2, smooth muscle
chr22_-_42720813 Show fit	3.28	ENST00000381278.4	A4GALT Ensembl NCBI GeneCards UniProt Show fit	alpha 1,4-galactosyltransferase (P blood group)
chrX_+_91434829 Show fit	3.27	ENST00000312600.4	PABPC5 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 5
chr7_+_130492066 Show fit	3.26	ENST00000223215.10 ENST00000437945.6	MEST Ensembl NCBI GeneCards UniProt Show fit	mesoderm specific transcript
chr20_+_63696643 Show fit	3.23	ENST00000369996.3	TNFRSF6B Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 6b
chr17_-_35795592 Show fit	3.13	ENST00000615136.4 ENST00000605424.6 ENST00000612672.1	MMP28 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 28
chr17_-_76537699 Show fit	3.02	ENST00000293230.10	CYGB Ensembl NCBI GeneCards UniProt Show fit	cytoglobin
chr17_+_62627628 Show fit	3.02	ENST00000303375.10	MRC2 Ensembl NCBI GeneCards UniProt Show fit	mannose receptor C type 2
chr11_-_8593940 Show fit	2.99	ENST00000315204.5 ENST00000396672.5 ENST00000431279.6 ENST00000418597.5	STK33 Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 33
chr17_+_42682470 Show fit	2.84	ENST00000264638.9	CNTNAP1 Ensembl NCBI GeneCards UniProt Show fit	contactin associated protein 1
chr2_+_158968608 Show fit	2.80	ENST00000263635.8	TANC1 Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr19_-_40413364 Show fit	2.76	ENST00000291825.11 ENST00000324001.8	PRX Ensembl NCBI GeneCards UniProt Show fit	periaxin
chr14_+_64540734 Show fit	2.72	ENST00000247207.7	HSPA2 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 2
chr5_-_142325001 Show fit	2.71	ENST00000344120.4 ENST00000434127.3	SPRY4 Ensembl NCBI GeneCards UniProt Show fit	sprouty RTK signaling antagonist 4
chr5_-_44389407 Show fit	2.71	ENST00000264664.5	FGF10 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor 10
chr10_+_80413817 Show fit	2.70	ENST00000372187.9	PRXL2A Ensembl NCBI GeneCards UniProt Show fit	peroxiredoxin like 2A
chr2_+_216633411 Show fit	2.68	ENST00000233809.9	IGFBP2 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor binding protein 2
chr22_-_19524400 Show fit	2.59	ENST00000618236.2	CLDN5 Ensembl NCBI GeneCards UniProt Show fit	claudin 5
chrX_-_17861236 Show fit	2.52	ENST00000331511.5 ENST00000415486.7 ENST00000451717.6 ENST00000545871.1	RAI2 Ensembl NCBI GeneCards UniProt Show fit	retinoic acid induced 2
chr1_-_205813177 Show fit	2.40	ENST00000367137.4	SLC41A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 41 member 1
chr19_-_42253888 Show fit	2.39	ENST00000593944.5	ERF Ensembl NCBI GeneCards UniProt Show fit	ETS2 repressor factor
chr11_-_75668566 Show fit	2.37	ENST00000526740.3	MAP6 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 6
chr19_-_35135011 Show fit	2.34	ENST00000310123.8	LGI4 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat LGI family member 4
chr16_-_21440719 Show fit	2.30	ENST00000521589.5	NPIPB3 Ensembl NCBI GeneCards UniProt Show fit	nuclear pore complex interacting protein family member B3
chr21_-_26573145 Show fit	2.23	ENST00000400043.3	CYYR1 Ensembl NCBI GeneCards UniProt Show fit	cysteine and tyrosine rich 1
chr8_+_74824526 Show fit	2.21	ENST00000649643.1 ENST00000260113.7	PI15 Ensembl NCBI GeneCards UniProt Show fit	peptidase inhibitor 15
chr2_-_85663393 Show fit	2.19	ENST00000494165.1	SFTPB Ensembl NCBI GeneCards UniProt Show fit	surfactant protein B
chr1_-_182604379 Show fit	2.19	ENST00000367558.6	RGS16 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 16
chr17_-_76537630 Show fit	2.15	ENST00000589342.1	CYGB Ensembl NCBI GeneCards UniProt Show fit	cytoglobin
chr19_-_35134861 Show fit	2.10	ENST00000591633.2	LGI4 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat LGI family member 4
chr16_+_28863946 Show fit	2.09	ENST00000395532.8	SH2B1 Ensembl NCBI GeneCards UniProt Show fit	SH2B adaptor protein 1
chr9_+_106863121 Show fit	2.04	ENST00000472574.1 ENST00000277225.10	ZNF462 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 462
chr4_-_186596770 Show fit	1.99	ENST00000512772.5	FAT1 Ensembl NCBI GeneCards UniProt Show fit	FAT atypical cadherin 1
chr9_-_122227525 Show fit	1.96	ENST00000373755.6 ENST00000373754.6	LHX6 Ensembl NCBI GeneCards UniProt Show fit	LIM homeobox 6
chr22_+_31093358 Show fit	1.95	ENST00000404574.5	SMTN Ensembl NCBI GeneCards UniProt Show fit	smoothelin
chr5_+_53480619 Show fit	1.95	ENST00000396947.7 ENST00000256759.8	FST Ensembl NCBI GeneCards UniProt Show fit	follistatin
chr1_-_44843240 Show fit	1.89	ENST00000372192.4	PTCH2 Ensembl NCBI GeneCards UniProt Show fit	patched 2
chr9_+_128411715 Show fit	1.89	ENST00000420034.5 ENST00000372842.5	CERCAM Ensembl NCBI GeneCards UniProt Show fit	cerebral endothelial cell adhesion molecule
chr10_-_93601228 Show fit	1.85	ENST00000371464.8	RBP4 Ensembl NCBI GeneCards UniProt Show fit	retinol binding protein 4
chr11_-_64759967 Show fit	1.80	ENST00000377432.7 ENST00000164139.4	PYGM Ensembl NCBI GeneCards UniProt Show fit	glycogen phosphorylase, muscle associated
chr7_+_116672187 Show fit	1.75	ENST00000318493.11 ENST00000397752.8	MET Ensembl NCBI GeneCards UniProt Show fit	MET proto-oncogene, receptor tyrosine kinase
chr7_-_82443715 Show fit	1.71	ENST00000356253.9 ENST00000423588.1	CACNA2D1 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr6_-_29633171 Show fit	1.69	ENST00000377034.9	GABBR1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type B receptor subunit 1
chrX_-_17860707 Show fit	1.69	ENST00000360011.5	RAI2 Ensembl NCBI GeneCards UniProt Show fit	retinoic acid induced 2
chr1_+_183186238 Show fit	1.68	ENST00000493293.5 ENST00000264144.5	LAMC2 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit gamma 2
chr1_-_183418364 Show fit	1.67	ENST00000287713.7	NMNAT2 Ensembl NCBI GeneCards UniProt Show fit	nicotinamide nucleotide adenylyltransferase 2
chr11_+_76782250 Show fit	1.65	ENST00000533752.1 ENST00000612930.1	TSKU Ensembl NCBI GeneCards UniProt Show fit	tsukushi, small leucine rich proteoglycan
chr6_-_29633056 Show fit	1.64	ENST00000377016.8	GABBR1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type B receptor subunit 1
chr6_+_36948257 Show fit	1.61	ENST00000647861.1 ENST00000611814.4	PI16 Ensembl NCBI GeneCards UniProt Show fit	peptidase inhibitor 16
chr17_-_7234262 Show fit	1.61	ENST00000575756.5 ENST00000575458.5	DVL2 Ensembl NCBI GeneCards UniProt Show fit	dishevelled segment polarity protein 2
chr10_-_95290992 Show fit	1.61	ENST00000329399.7	PDLIM1 Ensembl NCBI GeneCards UniProt Show fit	PDZ and LIM domain 1
chr7_+_90403386 Show fit	1.61	ENST00000287916.8 ENST00000394604.5 ENST00000496677.6 ENST00000394605.2 ENST00000480135.1	CLDN12 Ensembl NCBI GeneCards UniProt Show fit ENSG00000273299.1 Ensembl NCBI GeneCards UniProt Show fit	claudin 12 novel transcript
chr11_-_75668434 Show fit	1.58	ENST00000434603.2	MAP6 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 6
chr6_+_43771960 Show fit	1.55	ENST00000230480.10	VEGFA Ensembl NCBI GeneCards UniProt Show fit	vascular endothelial growth factor A
chr9_-_34397800 Show fit	1.52	ENST00000297623.7	C9orf24 Ensembl NCBI GeneCards UniProt Show fit	chromosome 9 open reading frame 24
chr11_+_118607579 Show fit	1.52	ENST00000530708.4	PHLDB1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology like domain family B member 1
chr9_+_113349514 Show fit	1.49	ENST00000374183.5	BSPRY Ensembl NCBI GeneCards UniProt Show fit	B-box and SPRY domain containing
chr12_-_6688859 Show fit	1.48	ENST00000542351.5 ENST00000538829.5	ZNF384 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 384
chr1_-_85465147 Show fit	1.47	ENST00000284031.13	DDAH1 Ensembl NCBI GeneCards UniProt Show fit	dimethylarginine dimethylaminohydrolase 1
chr10_-_75401746 Show fit	1.46	ENST00000372524.5	ZNF503 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 503
chr3_-_9878765 Show fit	1.46	ENST00000430427.6 ENST00000383817.5 ENST00000679265.1	CIDEC Ensembl NCBI GeneCards UniProt Show fit	cell death inducing DFFA like effector c
chr3_+_137998735 Show fit	1.45	ENST00000343735.8	CLDN18 Ensembl NCBI GeneCards UniProt Show fit	claudin 18
chr9_-_127877665 Show fit	1.42	ENST00000644144.2	AK1 Ensembl NCBI GeneCards UniProt Show fit	adenylate kinase 1
chr11_-_12009082 Show fit	1.40	ENST00000396505.7	DKK3 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 3
chr10_+_134465 Show fit	1.40	ENST00000439456.5 ENST00000397962.8 ENST00000309776.8 ENST00000397959.7	ZMYND11 Ensembl NCBI GeneCards UniProt Show fit	zinc finger MYND-type containing 11
chr11_-_12009134 Show fit	1.38	ENST00000529338.1	DKK3 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 3
chr3_+_159764002 Show fit	1.37	ENST00000460298.3	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	IQCJ-SCHIP1 readthrough
chr4_-_185775271 Show fit	1.35	ENST00000430503.5 ENST00000319454.10 ENST00000450341.5	SORBS2 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 2
chr10_-_34815257 Show fit	1.34	ENST00000374789.8 ENST00000374788.8 ENST00000346874.9 ENST00000374794.8 ENST00000350537.9 ENST00000374790.8 ENST00000374776.6 ENST00000374773.6 ENST00000545260.5 ENST00000545693.5 ENST00000340077.9	PARD3 Ensembl NCBI GeneCards UniProt Show fit	par-3 family cell polarity regulator
chr5_+_80960694 Show fit	1.34	ENST00000638442.1	RASGRF2 Ensembl NCBI GeneCards UniProt Show fit	Ras protein specific guanine nucleotide releasing factor 2
chr7_-_108456378 Show fit	1.33	ENST00000613830.4 ENST00000413765.6 ENST00000379028.8	NRCAM Ensembl NCBI GeneCards UniProt Show fit	neuronal cell adhesion molecule
chr3_+_113897470 Show fit	1.33	ENST00000440446.2 ENST00000488680.1	GRAMD1C Ensembl NCBI GeneCards UniProt Show fit	GRAM domain containing 1C
chr7_-_108456321 Show fit	1.33	ENST00000379024.8 ENST00000351718.8	NRCAM Ensembl NCBI GeneCards UniProt Show fit	neuronal cell adhesion molecule
chr15_+_39581068 Show fit	1.29	ENST00000397591.2 ENST00000260356.6	THBS1 Ensembl NCBI GeneCards UniProt Show fit	thrombospondin 1
chr22_+_37805218 Show fit	1.27	ENST00000340857.4	H1-0 Ensembl NCBI GeneCards UniProt Show fit	H1.0 linker histone
chrX_+_51893533 Show fit	1.26	ENST00000375722.5 ENST00000326587.12 ENST00000375695.2	MAGED1 Ensembl NCBI GeneCards UniProt Show fit	MAGE family member D1
chr17_-_7234462 Show fit	1.25	ENST00000005340.10	DVL2 Ensembl NCBI GeneCards UniProt Show fit	dishevelled segment polarity protein 2
chr2_+_24793394 Show fit	1.23	ENST00000380834.7 ENST00000260662.2	CENPO Ensembl NCBI GeneCards UniProt Show fit	centromere protein O
chr17_+_7023062 Show fit	1.21	ENST00000576705.1	BCL6B Ensembl NCBI GeneCards UniProt Show fit	BCL6B transcription repressor
chr6_-_29628038 Show fit	1.20	ENST00000355973.7 ENST00000377012.8	GABBR1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type B receptor subunit 1
chr4_-_185775890 Show fit	1.15	ENST00000437304.6	SORBS2 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 2
chr7_-_151410024 Show fit	1.15	ENST00000628331.1 ENST00000334493.11	WDR86 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 86
chr8_+_42152946 Show fit	1.14	ENST00000518421.5 ENST00000174653.3 ENST00000396926.8 ENST00000521280.5 ENST00000522288.5	AP3M2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 3 subunit mu 2
chr6_+_162727941 Show fit	1.13	ENST00000366888.6	PACRG Ensembl NCBI GeneCards UniProt Show fit	parkin coregulated
chr22_-_30387078 Show fit	1.12	ENST00000215798.10	RNF215 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 215
chr2_+_136765508 Show fit	1.11	ENST00000409968.6	THSD7B Ensembl NCBI GeneCards UniProt Show fit	thrombospondin type 1 domain containing 7B
chr12_-_6689244 Show fit	1.08	ENST00000361959.7 ENST00000436774.6 ENST00000544482.1	ZNF384 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 384
chr5_+_72107234 Show fit	1.08	ENST00000512974.5	MAP1B Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 1B
chr4_+_76949743 Show fit	1.07	ENST00000502584.5 ENST00000264893.11 ENST00000510641.5	SEPTIN11 Ensembl NCBI GeneCards UniProt Show fit	septin 11
chr9_+_34990250 Show fit	1.06	ENST00000454002.6 ENST00000545841.5	DNAJB5 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member B5
chr12_-_106084023 Show fit	1.06	ENST00000553094.1 ENST00000549704.1	NUAK1 Ensembl NCBI GeneCards UniProt Show fit	NUAK family kinase 1
chr3_-_24495532 Show fit	1.02	ENST00000643772.1 ENST00000642307.1 ENST00000645139.1	THRB Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor beta
chr15_-_93073706 Show fit	1.02	ENST00000425933.6	RGMA Ensembl NCBI GeneCards UniProt Show fit	repulsive guidance molecule BMP co-receptor a
chr18_+_23949847 Show fit	1.01	ENST00000588004.1	LAMA3 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit alpha 3
chr4_+_76949807 Show fit	1.00	ENST00000505788.5 ENST00000510515.5 ENST00000504637.5	SEPTIN11 Ensembl NCBI GeneCards UniProt Show fit	septin 11
chr3_+_138010143 Show fit	0.99	ENST00000183605.10	CLDN18 Ensembl NCBI GeneCards UniProt Show fit	claudin 18
chr11_+_57761787 Show fit	0.98	ENST00000358694.10 ENST00000361332.8 ENST00000361391.10 ENST00000361796.9 ENST00000415361.6 ENST00000426142.6 ENST00000428599.6 ENST00000525902.5 ENST00000526357.5 ENST00000526772.5 ENST00000527467.5 ENST00000528232.5 ENST00000528621.5 ENST00000529526.5 ENST00000529873.5 ENST00000529986.5 ENST00000530094.5 ENST00000530748.5 ENST00000531014.5 ENST00000532245.5 ENST00000532463.5 ENST00000532649.5 ENST00000532787.5 ENST00000532844.5 ENST00000533667.5 ENST00000534579.5 ENST00000399050.10 ENST00000526938.5 ENST00000674015.1 ENST00000531007.2 ENST00000673826.1	CTNND1 Ensembl NCBI GeneCards UniProt Show fit	catenin delta 1
chr17_+_7705193 Show fit	0.97	ENST00000226091.3	EFNB3 Ensembl NCBI GeneCards UniProt Show fit	ephrin B3
chr22_-_45977154 Show fit	0.97	ENST00000339464.9	WNT7B Ensembl NCBI GeneCards UniProt Show fit	Wnt family member 7B
chrX_+_71144818 Show fit	0.96	ENST00000536169.5 ENST00000358741.4 ENST00000395855.6 ENST00000374051.7	NLGN3 Ensembl NCBI GeneCards UniProt Show fit	neuroligin 3
chr1_-_43367956 Show fit	0.95	ENST00000372458.8	ELOVL1 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 1
chr2_+_24793098 Show fit	0.95	ENST00000473706.5	CENPO Ensembl NCBI GeneCards UniProt Show fit	centromere protein O
chr5_-_90409720 Show fit	0.94	ENST00000522864.5 ENST00000283122.8 ENST00000522083.5 ENST00000522565.5 ENST00000522842.1	CETN3 Ensembl NCBI GeneCards UniProt Show fit	centrin 3
chr10_-_79444216 Show fit	0.91	ENST00000372333.3	ZCCHC24 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCHC-type containing 24
chr9_+_34989641 Show fit	0.91	ENST00000453597.8 ENST00000312316.9 ENST00000458263.6 ENST00000537321.5 ENST00000682809.1 ENST00000684748.1	DNAJB5 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member B5
chr10_+_24466487 Show fit	0.90	ENST00000396446.5 ENST00000396445.5 ENST00000376451.4	KIAA1217 Ensembl NCBI GeneCards UniProt Show fit	KIAA1217
chr6_-_110179623 Show fit	0.90	ENST00000265601.7 ENST00000447287.5 ENST00000392589.6 ENST00000444391.5	WASF1 Ensembl NCBI GeneCards UniProt Show fit	WASP family member 1
chr6_+_125219804 Show fit	0.88	ENST00000524679.1	TPD52L1 Ensembl NCBI GeneCards UniProt Show fit	TPD52 like 1
chr3_+_4493471 Show fit	0.88	ENST00000544951.6 ENST00000650294.1	ITPR1 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-trisphosphate receptor type 1
chr4_-_89837106 Show fit	0.88	ENST00000394986.5 ENST00000394991.8 ENST00000506244.5 ENST00000394989.6 ENST00000673902.1 ENST00000674129.1	SNCA Ensembl NCBI GeneCards UniProt Show fit	synuclein alpha
chr17_-_31858952 Show fit	0.87	ENST00000378634.6	COPRS Ensembl NCBI GeneCards UniProt Show fit	coordinator of PRMT5 and differentiation stimulator
chr17_+_76001338 Show fit	0.86	ENST00000425876.6	CDK3 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 3
chr17_+_7886178 Show fit	0.86	ENST00000672274.1	CHD3 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 3
chr16_-_85112390 Show fit	0.85	ENST00000629253.1 ENST00000539556.6	CIBAR2 Ensembl NCBI GeneCards UniProt Show fit	CBY1 interacting BAR domain containing 2
chr12_-_6689450 Show fit	0.84	ENST00000355772.8 ENST00000417772.7 ENST00000319770.7 ENST00000396801.7	ZNF384 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 384
chr17_+_48054675 Show fit	0.84	ENST00000582155.5 ENST00000583378.5 ENST00000536222.5	NFE2L1 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor, erythroid 2 like 1
chrX_+_54809060 Show fit	0.84	ENST00000396224.1	MAGED2 Ensembl NCBI GeneCards UniProt Show fit	MAGE family member D2
chr22_-_27801712 Show fit	0.84	ENST00000302326.5	MN1 Ensembl NCBI GeneCards UniProt Show fit	MN1 proto-oncogene, transcriptional regulator
chr9_-_113340248 Show fit	0.83	ENST00000341761.8 ENST00000374195.7 ENST00000374193.9	WDR31 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 31
chr9_-_122228845 Show fit	0.83	ENST00000394319.8 ENST00000340587.7	LHX6 Ensembl NCBI GeneCards UniProt Show fit	LIM homeobox 6
chr5_-_149379286 Show fit	0.81	ENST00000261796.4	IL17B Ensembl NCBI GeneCards UniProt Show fit	interleukin 17B
chr17_+_7884783 Show fit	0.81	ENST00000380358.9	CHD3 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 3
chr19_+_3314403 Show fit	0.80	ENST00000641145.1	NFIC Ensembl NCBI GeneCards UniProt Show fit	nuclear factor I C
chrX_-_139204275 Show fit	0.79	ENST00000441825.8	FGF13 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor 13
chr9_-_33264559 Show fit	0.79	ENST00000473781.1 ENST00000379704.7 ENST00000488499.1	BAG1 Ensembl NCBI GeneCards UniProt Show fit	BAG cochaperone 1
chr4_+_71187269 Show fit	0.78	ENST00000425175.5 ENST00000351898.10	SLC4A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 4 member 4
chr16_+_86578543 Show fit	0.77	ENST00000320241.5	FOXL1 Ensembl NCBI GeneCards UniProt Show fit	forkhead box L1
chr3_-_185824966 Show fit	0.74	ENST00000457616.6 ENST00000346192.7	IGF2BP2 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor 2 mRNA binding protein 2
chr9_+_40223317 Show fit	0.73	ENST00000611747.1 ENST00000377601.3 ENST00000654136.1 ENST00000659103.1	ANKRD20A2P Ensembl NCBI GeneCards UniProt Show fit ENSG00000240240.9 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 20 family member A2, pseudogene novel transcript
chr16_+_55324191 Show fit	0.72	ENST00000290552.8	IRX6 Ensembl NCBI GeneCards UniProt Show fit	iroquois homeobox 6
chr11_+_45146631 Show fit	0.69	ENST00000534751.3 ENST00000683152.1	PRDM11 Ensembl NCBI GeneCards UniProt Show fit	PR/SET domain 11
chr12_-_6689359 Show fit	0.69	ENST00000683879.1	ZNF384 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 384
chr11_-_19201976 Show fit	0.68	ENST00000647990.1 ENST00000649235.1 ENST00000265968.9 ENST00000649842.1	CSRP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine and glycine rich protein 3
chr11_-_120120880 Show fit	0.67	ENST00000526881.1	TRIM29 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 29
chrX_-_139205006 Show fit	0.66	ENST00000436198.5 ENST00000626909.2	FGF13 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor 13
chr6_-_110179702 Show fit	0.64	ENST00000392587.6	WASF1 Ensembl NCBI GeneCards UniProt Show fit	WASP family member 1
chr3_-_185825029 Show fit	0.64	ENST00000382199.7	IGF2BP2 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor 2 mRNA binding protein 2
chrX_-_52069172 Show fit	0.62	ENST00000486010.1 ENST00000497164.5 ENST00000360134.10 ENST00000485287.5 ENST00000335504.9	MAGED4B Ensembl NCBI GeneCards UniProt Show fit	MAGE family member D4B
chr16_-_981259 Show fit	0.60	ENST00000563837.1 ENST00000563863.5 ENST00000565069.5 ENST00000570014.5	CEROX1 Ensembl NCBI GeneCards UniProt Show fit LMF1 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic endogenous regulator of oxidative phosphorylation 1 lipase maturation factor 1
chr1_-_43368039 Show fit	0.60	ENST00000413844.3	ELOVL1 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 1
chr3_-_16512895 Show fit	0.58	ENST00000449415.5 ENST00000441460.5	RFTN1 Ensembl NCBI GeneCards UniProt Show fit	raftlin, lipid raft linker 1
chr10_+_134703 Show fit	0.57	ENST00000509513.6	ZMYND11 Ensembl NCBI GeneCards UniProt Show fit	zinc finger MYND-type containing 11
chr4_-_185775432 Show fit	0.57	ENST00000457247.5 ENST00000435480.5 ENST00000425679.5 ENST00000457934.5	SORBS2 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 2
chr17_+_48055945 Show fit	0.56	ENST00000580037.1	NFE2L1 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor, erythroid 2 like 1
chr1_-_43367689 Show fit	0.56	ENST00000621943.4	ELOVL1 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 1
chr2_+_68467544 Show fit	0.55	ENST00000303795.9	APLF Ensembl NCBI GeneCards UniProt Show fit	aprataxin and PNKP like factor
chr2_-_132670194 Show fit	0.54	ENST00000397463.3	LYPD1 Ensembl NCBI GeneCards UniProt Show fit	LY6/PLAUR domain containing 1
chr9_+_132410183 Show fit	0.53	ENST00000393216.3 ENST00000343036.6	CFAP77 Ensembl NCBI GeneCards UniProt Show fit	cilia and flagella associated protein 77
chr12_+_4269771 Show fit	0.52	ENST00000676411.1	CCND2 Ensembl NCBI GeneCards UniProt Show fit	cyclin D2
chr14_-_106211453 Show fit	0.52	ENST00000390606.3	IGHV3-20 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-20
chr3_+_111071773 Show fit	0.52	ENST00000485303.6	NECTIN3 Ensembl NCBI GeneCards UniProt Show fit	nectin cell adhesion molecule 3
chr9_+_33265013 Show fit	0.52	ENST00000223500.9	CHMP5 Ensembl NCBI GeneCards UniProt Show fit	charged multivesicular body protein 5
chr9_+_33264848 Show fit	0.51	ENST00000419016.6	CHMP5 Ensembl NCBI GeneCards UniProt Show fit	charged multivesicular body protein 5
chr7_+_90403506 Show fit	0.51	ENST00000427904.1	CLDN12 Ensembl NCBI GeneCards UniProt Show fit	claudin 12
chr19_-_12957198 Show fit	0.50	ENST00000316939.3	GADD45GIP1 Ensembl NCBI GeneCards UniProt Show fit	GADD45G interacting protein 1
chr13_-_30306837 Show fit	0.49	ENST00000414289.5	KATNAL1 Ensembl NCBI GeneCards UniProt Show fit	katanin catalytic subunit A1 like 1
chr9_-_113056670 Show fit	0.49	ENST00000553380.1 ENST00000374227.8	ZFP37 Ensembl NCBI GeneCards UniProt Show fit	ZFP37 zinc finger protein
chr1_+_6613722 Show fit	0.48	ENST00000377648.5	PHF13 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 13
chr8_-_41665261 Show fit	0.48	ENST00000522231.5 ENST00000314214.12 ENST00000348036.8 ENST00000522543.5	ANK1 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 1
chr1_+_32209074 Show fit	0.47	ENST00000409358.2	DCDC2B Ensembl NCBI GeneCards UniProt Show fit	doublecortin domain containing 2B
chr4_+_61202142 Show fit	0.47	ENST00000514591.5	ADGRL3 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor L3
chr17_+_75093287 Show fit	0.46	ENST00000538213.6 ENST00000584118.1	SLC16A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 16 member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	18.4	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
2.6	10.3	GO:0018879	biphenyl metabolic process(GO:0018879)
2.0	9.9	GO:0030070	insulin processing(GO:0030070)
1.7	39.2	GO:0007021	tubulin complex assembly(GO:0007021)
1.3	6.7	GO:0001575	globoside metabolic process(GO:0001575)
0.9	3.7	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.9	2.7	GO:0060876	semicircular canal formation(GO:0060876) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.8	6.7	GO:1902612	regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.8	17.6	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.7	2.9	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.7	5.7	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.6	5.2	GO:2000490	negative regulation of hepatic stellate cell activation(GO:2000490)
0.6	5.7	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.6	5.6	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.6	3.3	GO:0090131	glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
0.5	3.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.5	1.6	GO:1903570	coronary vein morphogenesis(GO:0003169) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.5	1.0	GO:0072061	inner medullary collecting duct development(GO:0072061)
0.5	5.7	GO:0009249	protein lipoylation(GO:0009249)
0.4	5.8	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.4	1.3	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4	1.7	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.4	9.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.4	1.9	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.3	1.6	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.3	2.4	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.3	3.7	GO:0048251	elastic fiber assembly(GO:0048251)
0.3	5.4	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3	10.7	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3	6.8	GO:0070831	basement membrane assembly(GO:0070831)
0.2	1.7	GO:0086048	membrane depolarization during bundle of His cell action potential(GO:0086048)
0.2	1.0	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.2	6.2	GO:0061162	establishment of monopolar cell polarity(GO:0061162)
0.2	1.5	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.2	2.8	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2	1.7	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.2	2.1	GO:0034626	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	4.6	GO:0071294	cellular response to zinc ion(GO:0071294)
0.1	0.4	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.1	1.5	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	1.5	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1	6.0	GO:0022011	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1	0.8	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.1	0.7	GO:0051945	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1	2.7	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	1.2	GO:0071816	tail-anchored membrane protein insertion into ER membrane(GO:0071816) protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1	0.3	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.1	1.0	GO:0008050	female courtship behavior(GO:0008050)
0.1	6.1	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1	0.7	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1	1.0	GO:0016198	axon choice point recognition(GO:0016198)
0.1	0.6	GO:0060481	lobar bronchus epithelium development(GO:0060481)
0.1	2.0	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1	0.5	GO:1903862	positive regulation of oxidative phosphorylation(GO:1903862)
0.1	0.8	GO:0035995	detection of muscle stretch(GO:0035995)
0.1	2.8	GO:0097062	dendritic spine maintenance(GO:0097062)
0.1	0.2	GO:0043932	ossification involved in bone remodeling(GO:0043932)
0.1	1.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1	0.3	GO:0002086	diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1	0.6	GO:0051106	positive regulation of DNA ligation(GO:0051106)
0.1	4.5	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.1	0.8	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	0.4	GO:0006311	meiotic gene conversion(GO:0006311)
0.1	4.0	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1	1.3	GO:0045023	G0 to G1 transition(GO:0045023)
0.1	0.8	GO:0070294	renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1	1.5	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.1	0.9	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.1	0.8	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	1.0	GO:1904903	ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1	0.6	GO:0002457	T cell antigen processing and presentation(GO:0002457)
0.1	0.8	GO:0051013	microtubule severing(GO:0051013)
0.1	0.9	GO:1902414	protein localization to cell junction(GO:1902414)
0.1	1.7	GO:0034389	lipid particle organization(GO:0034389)
0.1	1.3	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1	6.3	GO:0007528	neuromuscular junction development(GO:0007528)
0.1	0.3	GO:0000459	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) CUT catabolic process(GO:0071034) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) CUT metabolic process(GO:0071043)
0.1	2.7	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104)
0.0	0.6	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	2.2	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	1.3	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.0	2.9	GO:0042092	type 2 immune response(GO:0042092)
0.0	1.8	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.8	GO:1900017	positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0	0.4	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.5	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	1.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.5	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.0	0.3	GO:0010814	substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0	16.8	GO:0007160	cell-matrix adhesion(GO:0007160)
0.0	1.6	GO:0034243	regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0	1.1	GO:0099517	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	1.4	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.2	GO:0060667	fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.0	1.0	GO:0035635	entry of bacterium into host cell(GO:0035635)
0.0	0.6	GO:0045199	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0	0.5	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	8.3	GO:0006986	response to unfolded protein(GO:0006986)
0.0	0.5	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	2.1	GO:0045840	positive regulation of mitotic nuclear division(GO:0045840)
0.0	0.3	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	2.0	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	2.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	1.6	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	2.2	GO:0007585	respiratory gaseous exchange(GO:0007585)
0.0	1.4	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	2.2	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.5	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.0	0.5	GO:1905145	acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0	3.0	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.0	0.1	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0015684	ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0	2.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	1.3	GO:0032508	DNA duplex unwinding(GO:0032508)
0.0	1.5	GO:0042633	molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	1.4	GO:0032418	lysosome localization(GO:0032418)
0.0	4.3	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.0	1.5	GO:0007498	mesoderm development(GO:0007498)
0.0	0.4	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	39.2	GO:0097512	cardiac myofibril(GO:0097512)
0.9	4.5	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5	3.3	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.3	5.1	GO:0045180	basal cortex(GO:0045180)
0.2	2.7	GO:0072687	meiotic spindle(GO:0072687)
0.2	5.7	GO:0042627	chylomicron(GO:0042627)
0.2	2.5	GO:0043194	axon initial segment(GO:0043194)
0.2	2.7	GO:0043256	laminin complex(GO:0043256)
0.2	0.3	GO:1990584	cardiac Troponin complex(GO:1990584)
0.2	2.8	GO:0033010	paranodal junction(GO:0033010)
0.2	2.2	GO:0097486	alveolar lamellar body(GO:0097208) multivesicular body lumen(GO:0097486)
0.1	1.7	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.3	GO:0033269	internode region of axon(GO:0033269)
0.1	3.5	GO:0005685	U1 snRNP(GO:0005685)
0.1	1.2	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	1.3	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.5	GO:0031209	SCAR complex(GO:0031209)
0.1	3.7	GO:0033268	node of Ranvier(GO:0033268)
0.1	16.0	GO:0005604	basement membrane(GO:0005604)
0.1	6.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	6.0	GO:0031594	neuromuscular junction(GO:0031594)
0.1	5.1	GO:0045178	basal part of cell(GO:0045178)
0.1	0.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	2.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.7	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	1.0	GO:0005915	zonula adherens(GO:0005915)
0.0	1.1	GO:0097225	sperm midpiece(GO:0097225)
0.0	5.6	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	3.9	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.3	GO:0031302	intrinsic component of endosome membrane(GO:0031302)
0.0	17.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	1.7	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	9.4	GO:0030658	transport vesicle membrane(GO:0030658)
0.0	6.7	GO:0044306	neuron projection terminus(GO:0044306)
0.0	0.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.8	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.4	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	3.6	GO:0005581	collagen trimer(GO:0005581)
0.0	50.3	GO:0005615	extracellular space(GO:0005615)
0.0	2.8	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	1.7	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	2.2	GO:0030175	filopodium(GO:0030175)
0.0	0.3	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	1.0	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	4.1	GO:0030018	Z disc(GO:0030018)
0.0	3.2	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.4	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.6	GO:0035861	site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.9	23.8	GO:0005055	laminin receptor activity(GO:0005055)
2.4	24.1	GO:0048495	Roundabout binding(GO:0048495)
1.9	5.7	GO:0017129	triglyceride binding(GO:0017129)
1.4	5.6	GO:0035939	microsatellite binding(GO:0035939)
1.3	5.2	GO:0047888	fatty acid peroxidase activity(GO:0047888)
1.2	37.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.8	18.2	GO:0015643	toxic substance binding(GO:0015643)
0.8	4.5	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.6	3.5	GO:0035614	snRNA stem-loop binding(GO:0035614)
0.6	1.7	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.5	2.7	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.5	1.8	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.4	1.7	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.4	3.7	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.4	9.1	GO:0048185	activin binding(GO:0048185)
0.4	9.9	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.3	1.6	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.3	3.7	GO:0032027	myosin light chain binding(GO:0032027)
0.3	1.3	GO:0070051	fibrinogen binding(GO:0070051) collagen V binding(GO:0070052)
0.2	1.7	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2	2.7	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.2	1.5	GO:0016403	dimethylargininase activity(GO:0016403)
0.2	2.1	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1	3.9	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.1	0.5	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.1	3.5	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1	0.7	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	20.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	2.4	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.1	0.6	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.1	4.2	GO:0038191	neuropilin binding(GO:0038191)
0.1	4.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.8	GO:0035500	MH2 domain binding(GO:0035500)
0.1	1.9	GO:0019841	retinol binding(GO:0019841)
0.1	2.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1	3.2	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1	3.8	GO:0005109	frizzled binding(GO:0005109)
0.1	1.0	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	1.1	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	1.3	GO:1990459	transferrin receptor binding(GO:1990459)
0.1	1.4	GO:0004017	adenylate kinase activity(GO:0004017)
0.1	2.3	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	0.8	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.1	0.4	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1	0.7	GO:0051434	BH3 domain binding(GO:0051434)
0.0	1.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.8	GO:0031433	telethonin binding(GO:0031433)
0.0	2.6	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	1.0	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.3	GO:0031013	troponin I binding(GO:0031013)
0.0	1.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.8	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.6	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	1.6	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.2	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	2.5	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.3	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	1.3	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.8	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.2	GO:0036122	BMP binding(GO:0036122)
0.0	0.3	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	3.3	GO:0051082	unfolded protein binding(GO:0051082)
0.0	3.0	GO:0005518	collagen binding(GO:0005518)
0.0	1.4	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	1.9	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.3	GO:0009881	photoreceptor activity(GO:0009881)
0.0	3.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	1.5	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	2.9	GO:0035591	signaling adaptor activity(GO:0035591)
0.0	6.0	GO:0008017	microtubule binding(GO:0008017)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	4.8	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	0.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	1.7	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.4	GO:0019789	SUMO transferase activity(GO:0019789)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	10.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	5.9	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	1.6	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	2.9	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	23.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	18.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.7	ST GAQ PATHWAY	G alpha q Pathway
0.0	3.3	PID BMP PATHWAY	BMP receptor signaling
0.0	4.8	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	1.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.7	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.7	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	6.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	1.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.2	12.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	5.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	17.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.2	3.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.2	3.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	10.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	2.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	2.2	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1	2.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	1.5	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.1	1.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	3.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	2.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	3.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	3.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	5.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	1.3	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	1.4	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.6	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	1.0	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	3.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.2	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.7	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.3	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.7	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.9	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	1.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK

Results for ZIC2_GLI1

Z-value: 1.69

Motif logo

Transcription factors associated with ZIC2_GLI1

Activity-expression correlation:

Activity profile of ZIC2_GLI1 motif

Sorted Z-values of ZIC2_GLI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: