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Illumina Body Map 2 (GSE30611)

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Results for ZKSCAN3

Z-value: 0.48

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.14 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg38_v1_chr6_+_28349907_28349983-0.105.8e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_77017042 2.69 ENST00000359645.7
ENST00000397875.7
ENST00000397869.7
ENST00000578193.5
ENST00000578873.5
ENST00000397866.8
ENST00000528160.1
ENST00000527041.1
ENST00000526111.5
ENST00000397865.9
ENST00000382582.7
MBP
myelin basic protein
chr1_+_65792889 1.43 ENST00000341517.9
PDE4B
phosphodiesterase 4B
chr6_+_42929430 1.13 ENST00000372836.5
CNPY3
canopy FGF signaling regulator 3
chr14_-_106130061 1.12 ENST00000390602.3
IGHV3-13
immunoglobulin heavy variable 3-13
chr14_-_106675544 1.11 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr1_+_156153568 0.91 ENST00000368284.5
ENST00000368286.6
ENST00000368285.8
ENST00000438830.5
SEMA4A
semaphorin 4A
chr14_-_106593319 0.82 ENST00000390627.3
IGHV3-53
immunoglobulin heavy variable 3-53
chr11_-_111449981 0.82 ENST00000531398.1
POU2AF1
POU class 2 homeobox associating factor 1
chr7_-_151210488 0.78 ENST00000644661.2
H2BE1
H2B.E variant histone 1
chr5_-_65722094 0.77 ENST00000381007.9
SGTB
small glutamine rich tetratricopeptide repeat containing beta
chr16_-_695946 0.67 ENST00000562563.1
FBXL16
F-box and leucine rich repeat protein 16
chr1_-_19484635 0.67 ENST00000433834.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr1_+_226062704 0.58 ENST00000366814.3
ENST00000366815.10
ENST00000655399.1
ENST00000667897.1
H3-3A
H3.3 histone A
chr5_+_176810498 0.58 ENST00000509580.2
UNC5A
unc-5 netrin receptor A
chr2_+_190880809 0.56 ENST00000320717.8
GLS
glutaminase
chr15_-_72231583 0.54 ENST00000566809.1
ENST00000567087.5
ENST00000569050.1
ENST00000568883.5
PKM
pyruvate kinase M1/2
chr1_+_113930371 0.47 ENST00000514621.5
HIPK1
homeodomain interacting protein kinase 1
chr5_+_65722190 0.45 ENST00000380985.10
ENST00000502464.5
NLN
neurolysin
chr14_-_106389858 0.45 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr15_-_72231113 0.44 ENST00000565154.6
ENST00000565184.6
ENST00000335181.10
PKM
pyruvate kinase M1/2
chr14_+_64113084 0.41 ENST00000673797.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr6_+_116529013 0.41 ENST00000628083.1
ENST00000368597.6
ENST00000452373.5
ENST00000405399.5
CALHM4
calcium homeostasis modulator family member 4
chr6_+_32968557 0.40 ENST00000374825.9
BRD2
bromodomain containing 2
chr5_+_176810552 0.39 ENST00000329542.9
UNC5A
unc-5 netrin receptor A
chr17_+_38752731 0.38 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chrX_-_154547546 0.37 ENST00000440967.5
ENST00000369620.6
ENST00000393564.6
G6PD
glucose-6-phosphate dehydrogenase
chr3_-_122793772 0.37 ENST00000306103.3
HSPBAP1
HSPB1 associated protein 1
chr19_+_39296399 0.37 ENST00000333625.3
IFNL1
interferon lambda 1
chr19_+_48755512 0.37 ENST00000593756.6
FGF21
fibroblast growth factor 21
chr2_-_61017414 0.37 ENST00000421319.5
PUS10
pseudouridine synthase 10
chr14_+_64113054 0.36 ENST00000673869.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr1_-_19485468 0.35 ENST00000375142.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr12_-_3873382 0.34 ENST00000228820.9
ENST00000450737.2
ENST00000447133.7
PARP11
poly(ADP-ribose) polymerase family member 11
chr21_+_38296556 0.34 ENST00000398927.1
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr2_+_190880834 0.34 ENST00000338435.8
GLS
glutaminase
chr1_-_19485502 0.33 ENST00000264203.7
ENST00000375144.6
ENST00000674432.1
ENST00000264202.8
CAPZB
capping actin protein of muscle Z-line subunit beta
chr16_+_2429427 0.33 ENST00000397066.9
CCNF
cyclin F
chr12_-_3873346 0.32 ENST00000427057.6
PARP11
poly(ADP-ribose) polymerase family member 11
chr16_-_28495519 0.31 ENST00000569430.7
CLN3
CLN3 lysosomal/endosomal transmembrane protein, battenin
chr5_+_140700437 0.30 ENST00000274712.8
ZMAT2
zinc finger matrin-type 2
chr5_-_180808742 0.29 ENST00000502678.1
MGAT1
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr1_+_113930728 0.27 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr17_-_30292042 0.27 ENST00000580709.1
BLMH
bleomycin hydrolase
chr6_+_12749419 0.25 ENST00000406205.7
PHACTR1
phosphatase and actin regulator 1
chrX_+_154547606 0.23 ENST00000594239.6
ENST00000615874.4
ENST00000619941.4
ENST00000617207.4
ENST00000611176.4
IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
chr12_+_71754834 0.23 ENST00000261263.5
RAB21
RAB21, member RAS oncogene family
chr1_-_28088564 0.19 ENST00000373863.3
ENST00000373871.8
ENST00000540618.5
ENST00000436342.6
EYA3
EYA transcriptional coactivator and phosphatase 3
chr16_-_782054 0.19 ENST00000543963.5
MSLNL
mesothelin like
chrX_+_154547654 0.15 ENST00000615186.4
IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
chr19_-_4182527 0.14 ENST00000601571.1
ENST00000601488.5
ENST00000305232.10
ENST00000337491.7
SIRT6
sirtuin 6
chr19_-_2328573 0.13 ENST00000587502.2
ENST00000252622.15
ENST00000585409.2
LSM7
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr21_+_38296909 0.13 ENST00000419868.1
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr20_-_59042748 0.11 ENST00000355937.9
ENST00000371033.9
PRELID3B
PRELI domain containing 3B
chrX_+_86148441 0.10 ENST00000373125.9
ENST00000373131.5
DACH2
dachshund family transcription factor 2
chr12_-_113135710 0.08 ENST00000446861.7
RASAL1
RAS protein activator like 1
chr1_-_99005003 0.07 ENST00000672681.1
ENST00000370188.7
PLPPR5
phospholipid phosphatase related 5
chr22_-_49918404 0.06 ENST00000330817.11
ALG12
ALG12 alpha-1,6-mannosyltransferase
chr5_-_115262851 0.06 ENST00000379615.3
ENST00000419445.6
PGGT1B
protein geranylgeranyltransferase type I subunit beta
chr19_-_4182500 0.04 ENST00000597896.5
SIRT6
sirtuin 6
chr1_+_3682306 0.04 ENST00000603362.5
ENST00000604479.5
TP73
tumor protein p73
chr1_+_233327760 0.03 ENST00000366623.7
MAP3K21
mitogen-activated protein kinase kinase kinase 21
chr16_-_1378989 0.02 ENST00000513783.1
UNKL
unk like zinc finger

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.7 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2 1.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.1 0.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.5 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 1.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 1.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.0 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.4 GO:0009051 NADPH regeneration(GO:0006740) pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.4 GO:1904640 response to methionine(GO:1904640)
0.1 0.2 GO:1990619 histone H3-K9 deacetylation(GO:1990619)
0.0 0.7 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.0 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.3 GO:0043418 homocysteine catabolic process(GO:0043418)
0.0 0.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 3.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.2 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1902912 pyruvate kinase complex(GO:1902912)
0.2 2.7 GO:0033269 internode region of axon(GO:0033269)
0.1 0.4 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.1 1.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.8 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 2.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.9 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.4 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.2 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events