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avrg: Illumina Body Map 2 (GSE30611)
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Results for BACH1_NFE2_NFE2L2
Z-value: 3.10
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Transcription factors associated with BACH1_NFE2_NFE2L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg38_v1_chr2_-_177263418_177263470 | -0.48 | 5.2e-03 | Click! |
| NFE2 | hg38_v1_chr12_-_54295748_54295798 | -0.09 | 6.2e-01 | Click! |
| BACH1 | hg38_v1_chr21_+_29300770_29300814 | 0.07 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_30065777 Show fit | 12.32 |
ENST00000395240.7
ENST00000566846.5 |
aldolase, fructose-bisphosphate A |
|
| chr16_+_30065753 Show fit | 11.86 |
ENST00000642816.3
ENST00000643777.4 ENST00000569798.5 |
aldolase, fructose-bisphosphate A |
|
| chr5_+_179820876 Show fit | 9.55 |
ENST00000626660.1
|
sequestosome 1 |
|
| chr10_-_75109172 Show fit | 7.95 |
ENST00000372700.7
ENST00000473072.2 ENST00000491677.6 ENST00000372702.7 |
dual specificity phosphatase 13 |
|
| chr9_-_114078293 Show fit | 7.56 |
ENST00000265132.8
|
alpha-1-microglobulin/bikunin precursor |
|
| chr2_-_210315160 Show fit | 7.04 |
ENST00000352451.4
|
myosin light chain 1 |
|
| chr3_-_48016400 Show fit | 6.72 |
ENST00000434267.5
ENST00000683076.1 ENST00000633710.1 |
microtubule associated protein 4 |
|
| chr2_+_54115437 Show fit | 6.67 |
ENST00000303536.8
ENST00000394666.7 |
acylphosphatase 2 |
|
| chr1_-_51878799 Show fit | 6.28 |
ENST00000354831.11
ENST00000544028.5 |
nardilysin convertase |
|
| chr12_+_55681711 Show fit | 6.12 |
ENST00000394252.4
|
methyltransferase like 7B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 1.2 | 24.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 19.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.6 | 16.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.7 | 16.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.8 | 15.2 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 13.0 | GO:0032259 | methylation(GO:0032259) |
| 0.7 | 10.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.5 | 9.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.3 | 9.2 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.1 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 16.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 2.5 | 15.2 | GO:0044753 | amphisome(GO:0044753) |
| 1.0 | 14.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 11.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 10.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.8 | 10.0 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 10.0 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.3 | 8.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.5 | 7.0 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 24.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 19.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.4 | 17.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.5 | 15.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.6 | 15.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 14.5 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 13.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.1 | 12.1 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 1.8 | 10.6 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 10.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 18.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 8.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 5.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.3 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 5.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.6 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 4.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 38.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 32.7 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.9 | 15.2 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 9.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 8.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.4 | 8.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 7.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 7.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 6.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 5.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |