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avrg: Illumina Body Map 2 (GSE30611)
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Results for BARHL1
Z-value: 2.81
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Transcription factors associated with BARHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL1 | hg38_v1_chr9_+_132582631_132582659 | -0.10 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_68050615 Show fit | 3.76 |
ENST00000646789.1
|
DIRAS family GTPase 3 |
|
| chr11_-_13496018 Show fit | 3.73 |
ENST00000529816.1
|
parathyroid hormone |
|
| chr18_+_31591869 Show fit | 3.69 |
ENST00000237014.8
|
transthyretin |
|
| chr11_+_27055215 Show fit | 3.63 |
ENST00000525090.1
|
gamma-butyrobetaine hydroxylase 1 |
|
| chr6_-_136466858 Show fit | 3.48 |
ENST00000544465.5
|
microtubule associated protein 7 |
|
| chr6_+_30888730 Show fit | 3.48 |
ENST00000376575.7
ENST00000513240.5 |
discoidin domain receptor tyrosine kinase 1 |
|
| chr6_-_110179995 Show fit | 3.45 |
ENST00000392586.5
ENST00000419252.1 ENST00000359451.6 ENST00000392588.5 |
WASP family member 1 |
|
| chr11_+_27040725 Show fit | 3.41 |
ENST00000529202.5
ENST00000263182.8 |
gamma-butyrobetaine hydroxylase 1 |
|
| chr6_-_49744434 Show fit | 3.19 |
ENST00000433368.6
ENST00000354620.4 |
cysteine rich secretory protein 3 |
|
| chr8_+_78591222 Show fit | 3.18 |
ENST00000518467.1
|
cAMP-dependent protein kinase inhibitor alpha |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 14.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 13.2 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.0 | 12.4 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.6 | 12.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 10.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 8.9 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.9 | 7.7 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.6 | 7.7 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 7.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 26.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 22.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 18.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.3 | 10.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 10.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.5 | 8.9 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.7 | 8.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 8.5 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.3 | 8.1 | GO:0036038 | MKS complex(GO:0036038) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.0 | 12.1 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.3 | 12.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 11.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 10.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.5 | 9.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 8.8 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 8.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 7.5 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.3 | 7.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 6.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 6.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 5.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 4.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 13.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 12.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 9.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 8.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 7.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 7.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 6.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 5.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |