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avrg: Illumina Body Map 2 (GSE30611)
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Results for CCAGUGU
Z-value: 1.27
Motif logo
miRNA associated with seed CCAGUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-199a-5p
|
MIMAT0000231 |
|
hsa-miR-199b-5p
|
MIMAT0000263 |
Activity profile of CCAGUGU motif
Sorted Z-values of CCAGUGU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CCAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.7 | 2.2 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.7 | 4.2 | GO:0048105 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
| 0.7 | 2.0 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.7 | 2.7 | GO:0072183 | osmosensory signaling pathway(GO:0007231) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) kidney smooth muscle tissue development(GO:0072194) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 0.6 | 2.4 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.6 | 3.5 | GO:2000721 | positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721) |
| 0.5 | 2.7 | GO:0035905 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 0.5 | 2.0 | GO:0061443 | endocardial cushion cell differentiation(GO:0061443) |
| 0.4 | 1.5 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.4 | 2.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.4 | 0.4 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.4 | 1.1 | GO:0031104 | dendrite regeneration(GO:0031104) |
| 0.4 | 1.1 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.4 | 1.4 | GO:0036215 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) |
| 0.3 | 0.6 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.3 | 0.9 | GO:1903570 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.3 | 1.5 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.3 | 0.8 | GO:1904199 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
| 0.2 | 0.7 | GO:1903280 | negative regulation of calcium:sodium antiporter activity(GO:1903280) |
| 0.2 | 1.5 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.2 | 0.9 | GO:0046379 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.2 | 0.6 | GO:1990709 | presynaptic active zone organization(GO:1990709) |
| 0.2 | 2.2 | GO:0001957 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.2 | 2.1 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 1.1 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.2 | 3.1 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.2 | 0.7 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.2 | 1.3 | GO:0090210 | regulation of establishment of blood-brain barrier(GO:0090210) |
| 0.1 | 1.3 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
| 0.1 | 3.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.8 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.1 | 3.1 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 0.4 | GO:0100057 | regulation of phenotypic switching by transcription from RNA polymerase II promoter(GO:0100057) regulation of hydrogen sulfide biosynthetic process(GO:1904826) positive regulation of hydrogen sulfide biosynthetic process(GO:1904828) |
| 0.1 | 3.2 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.1 | 0.3 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.1 | 0.5 | GO:1903891 | regulation of ATF6-mediated unfolded protein response(GO:1903891) |
| 0.1 | 0.5 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.1 | 0.6 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.1 | 0.3 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.1 | 0.5 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 1.1 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.1 | 1.6 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
| 0.1 | 0.4 | GO:0072061 | inner medullary collecting duct development(GO:0072061) |
| 0.1 | 0.6 | GO:0060423 | foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) |
| 0.1 | 0.6 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.3 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.1 | 0.8 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.1 | 1.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.4 | GO:0070101 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) |
| 0.1 | 0.5 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.1 | 0.2 | GO:1990697 | protein depalmitoleylation(GO:1990697) |
| 0.1 | 0.6 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.1 | 0.3 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 0.3 | GO:0043311 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.1 | 0.2 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 1.5 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 1.0 | GO:0051775 | response to redox state(GO:0051775) |
| 0.1 | 1.2 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.0 | 0.8 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.0 | 0.6 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.2 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 0.1 | GO:1904638 | cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) glomerular visceral epithelial cell apoptotic process(GO:1903210) regulation of glomerular visceral epithelial cell apoptotic process(GO:1904633) positive regulation of glomerular visceral epithelial cell apoptotic process(GO:1904635) response to resveratrol(GO:1904638) cellular response to resveratrol(GO:1904639) positive regulation of progesterone biosynthetic process(GO:2000184) |
| 0.0 | 0.1 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 0.0 | 0.3 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.1 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.0 | 1.0 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.0 | 0.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.0 | 0.1 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.0 | 0.7 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.0 | 0.1 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.0 | 0.3 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 0.1 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.0 | 0.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.0 | 0.1 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.0 | 0.7 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 0.0 | 1.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.1 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 0.0 | 0.1 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.0 | 0.3 | GO:2000288 | positive regulation of myoblast proliferation(GO:2000288) |
| 0.0 | 0.1 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
| 0.0 | 0.1 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 0.0 | 0.2 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.0 | 1.5 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 0.6 | GO:0048714 | positive regulation of oligodendrocyte differentiation(GO:0048714) |
| 0.0 | 0.4 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 0.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.9 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.3 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 0.3 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.0 | 1.0 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.0 | 2.2 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
| 0.0 | 2.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.2 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.5 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.0 | 0.6 | GO:2000637 | positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.0 | 0.9 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.7 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.1 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.0 | 0.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.0 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.0 | 0.1 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 0.4 | GO:0033622 | integrin activation(GO:0033622) |
| 0.0 | 0.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 0.4 | 3.5 | GO:0034678 | integrin alpha8-beta1 complex(GO:0034678) |
| 0.2 | 0.7 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 2.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 2.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 1.4 | GO:0098642 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.1 | 0.3 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.1 | 1.1 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 0.5 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 0.6 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 0.2 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.1 | 0.4 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.3 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 2.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.1 | GO:1990844 | subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844) |
| 0.0 | 0.6 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.3 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 1.2 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.0 | 0.1 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 0.8 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.3 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.0 | 1.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 4.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 3.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.3 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 0.6 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 2.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.8 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.0 | 0.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 2.0 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 0.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 2.4 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 1.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.1 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.0 | 0.1 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 0.1 | GO:1990909 | Wnt signalosome(GO:1990909) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 0.6 | 2.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 1.5 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.3 | 1.5 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) |
| 0.2 | 2.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 1.5 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.2 | 1.2 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.2 | 0.9 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.2 | 0.9 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 4.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 0.4 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.1 | 1.5 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.1 | 2.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.1 | GO:0005347 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 1.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 2.1 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 0.6 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 2.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.2 | GO:1990699 | palmitoleyl hydrolase activity(GO:1990699) |
| 0.1 | 0.5 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 0.3 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.9 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 0.7 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 0.5 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 1.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.1 | GO:0070039 | rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039) |
| 0.0 | 4.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.5 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.0 | 0.6 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 1.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 4.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.0 | 0.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.4 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 1.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.1 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 0.2 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.0 | 1.7 | GO:0016860 | intramolecular oxidoreductase activity(GO:0016860) |
| 0.0 | 0.2 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 0.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 2.6 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 0.8 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.3 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 0.1 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.0 | 0.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 1.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.3 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.0 | 0.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 2.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 1.7 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.8 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 0.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 1.6 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 2.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 6.5 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 2.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 2.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 4.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME SIGNALING BY NOTCH3 | Genes involved in Signaling by NOTCH3 |
| 0.1 | 1.8 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 0.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 3.2 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 5.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 6.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.9 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 1.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.6 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 2.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.1 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 1.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.4 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |