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avrg: Illumina Body Map 2 (GSE30611)
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Results for CEBPB
Z-value: 2.62
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg38_v1_chr20_+_50190821_50190839 | 0.30 | 9.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.0 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.8 | 16.5 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.9 | 14.2 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 3.1 | 9.3 | GO:2000296 | negative regulation of hydrogen peroxide catabolic process(GO:2000296) |
| 2.9 | 8.7 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
| 2.8 | 8.5 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.3 | 8.3 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.1 | 8.2 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.7 | 7.9 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.1 | 6.4 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 16.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 1.3 | 16.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.8 | 9.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 2.3 | 9.3 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.4 | 7.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 7.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 6.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 6.1 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 6.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.8 | 16.5 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.2 | 14.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.5 | 10.3 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 1.3 | 9.3 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 2.9 | 8.7 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.9 | 8.5 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 1.3 | 7.9 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 7.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 1.1 | 6.3 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 16.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 14.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 9.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 8.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 4.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.6 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 3.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.6 | 14.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.5 | 10.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 10.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.7 | 9.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.5 | 8.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.2 | 7.1 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.3 | 7.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 6.4 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 6.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |