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avrg: Illumina Body Map 2 (GSE30611)
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Results for CUX2
Z-value: 2.47
Motif logo
Transcription factors associated with CUX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CUX2
|
ENSG00000111249.14 | CUX2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX2 | hg38_v1_chr12_+_111034136_111034173 | 0.12 | 5.0e-01 | Click! |
Activity profile of CUX2 motif
Sorted Z-values of CUX2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 8.0 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 1.1 | 19.0 | GO:0034197 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 1.0 | 3.0 | GO:0019836 | hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.7 | 3.0 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.7 | 2.2 | GO:1904237 | regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237) |
| 0.6 | 1.9 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.6 | 8.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.6 | 2.4 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 0.6 | 1.8 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.5 | 1.6 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.5 | 4.7 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.5 | 0.5 | GO:0007199 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) |
| 0.5 | 1.4 | GO:1902994 | lipid transport involved in lipid storage(GO:0010877) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646) |
| 0.5 | 1.8 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.5 | 1.8 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.4 | 1.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.4 | 1.3 | GO:0038158 | granulocyte colony-stimulating factor signaling pathway(GO:0038158) |
| 0.4 | 6.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 1.2 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 0.4 | 2.4 | GO:0038112 | interleukin-8-mediated signaling pathway(GO:0038112) |
| 0.4 | 0.8 | GO:1901074 | regulation of engulfment of apoptotic cell(GO:1901074) |
| 0.4 | 1.2 | GO:1902523 | positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.4 | 1.5 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 0.4 | 2.9 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.3 | 1.4 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.3 | 1.3 | GO:0019520 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
| 0.3 | 5.9 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.3 | 1.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.3 | 7.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.3 | 1.3 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.3 | 1.5 | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) |
| 0.3 | 1.0 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.3 | 1.8 | GO:1903978 | regulation of microglial cell activation(GO:1903978) |
| 0.2 | 1.5 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.2 | 2.2 | GO:0046618 | drug export(GO:0046618) |
| 0.2 | 0.7 | GO:0060730 | regulation of intestinal epithelial structure maintenance(GO:0060730) |
| 0.2 | 1.0 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.2 | 2.0 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 0.7 | GO:0036245 | cellular response to menadione(GO:0036245) |
| 0.2 | 1.3 | GO:0030581 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.2 | 1.5 | GO:0002353 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.2 | 2.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.2 | 0.6 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.2 | 1.7 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.2 | 0.6 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.2 | 1.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 3.5 | GO:0008228 | opsonization(GO:0008228) |
| 0.2 | 1.1 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 0.2 | 0.5 | GO:0035378 | carbon dioxide transmembrane transport(GO:0035378) |
| 0.2 | 0.5 | GO:0032701 | negative regulation of interleukin-18 production(GO:0032701) |
| 0.2 | 2.8 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.2 | 2.0 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.2 | 1.5 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.1 | 0.6 | GO:0034553 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 0.1 | 1.2 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 0.9 | GO:0006565 | L-serine catabolic process(GO:0006565) |
| 0.1 | 1.4 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.9 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.1 | 1.0 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.1 | 1.0 | GO:0072011 | glomerular endothelium development(GO:0072011) |
| 0.1 | 0.7 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.1 | 0.6 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 0.4 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 1.7 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.1 | 1.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 8.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 0.4 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.1 | 1.7 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.7 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.1 | 0.6 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.1 | 16.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 2.9 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 0.2 | GO:0032304 | negative regulation of icosanoid secretion(GO:0032304) |
| 0.1 | 1.4 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 1.3 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 0.6 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 1.6 | GO:0002857 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.1 | 0.9 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 3.0 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.1 | 1.6 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 0.4 | GO:0010585 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 0.1 | 0.6 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.1 | 0.3 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.1 | 0.5 | GO:0019605 | butyrate metabolic process(GO:0019605) |
| 0.1 | 1.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.7 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.1 | 1.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 0.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.1 | 0.8 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 1.0 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.1 | 2.4 | GO:0071800 | podosome assembly(GO:0071800) |
| 0.1 | 2.4 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 1.2 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 0.9 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 1.7 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.1 | 0.5 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.1 | 3.4 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.1 | 0.4 | GO:1904124 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 1.1 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.1 | 0.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 0.2 | GO:0097010 | eukaryotic translation initiation factor 4F complex assembly(GO:0097010) |
| 0.1 | 1.2 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 0.3 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.1 | 0.7 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.1 | 1.1 | GO:0043383 | negative T cell selection(GO:0043383) |
| 0.1 | 1.1 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.1 | 1.1 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 0.2 | GO:0001546 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
| 0.1 | 0.7 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.1 | 0.5 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343) |
| 0.1 | 0.3 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.1 | 0.8 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.1 | 0.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 0.2 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.1 | 1.1 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 3.6 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 0.4 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 1.2 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.7 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.2 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.0 | 0.2 | GO:0032764 | negative regulation of mast cell cytokine production(GO:0032764) |
| 0.0 | 0.3 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.3 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
| 0.0 | 0.3 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 0.0 | 0.8 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.1 | GO:1903762 | positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033) |
| 0.0 | 0.2 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.0 | 1.4 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.0 | 0.3 | GO:0060356 | leucine import(GO:0060356) |
| 0.0 | 3.3 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.0 | 0.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.7 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.5 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.0 | 0.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.8 | GO:0007614 | short-term memory(GO:0007614) |
| 0.0 | 0.3 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.0 | 0.2 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.0 | 1.4 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 1.0 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 0.8 | GO:0000469 | cleavage involved in rRNA processing(GO:0000469) |
| 0.0 | 0.9 | GO:0043304 | regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304) |
| 0.0 | 0.5 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.5 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.0 | 1.4 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.0 | 0.5 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 1.1 | GO:0002820 | negative regulation of adaptive immune response(GO:0002820) |
| 0.0 | 0.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 5.9 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.3 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.3 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.0 | 0.1 | GO:0002339 | B cell selection(GO:0002339) response to mycotoxin(GO:0010046) |
| 0.0 | 0.2 | GO:0051945 | negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 2.9 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 0.4 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.3 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.0 | 0.6 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 1.9 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.0 | 2.2 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.2 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.0 | 2.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 2.4 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.0 | 0.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.3 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.0 | 0.3 | GO:0015747 | urate transport(GO:0015747) |
| 0.0 | 1.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.4 | GO:0033189 | response to vitamin A(GO:0033189) |
| 0.0 | 0.4 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 0.6 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.0 | 0.2 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.6 | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 0.3 | GO:0060158 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.0 | 0.6 | GO:0031640 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 0.1 | GO:0072733 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.0 | 0.4 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.0 | 0.6 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 0.4 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 0.9 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
| 0.0 | 0.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.1 | GO:0009597 | detection of virus(GO:0009597) |
| 0.0 | 0.3 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 0.1 | GO:0061084 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.0 | 1.4 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.0 | 0.2 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.4 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 2.4 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.0 | 0.6 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.1 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.8 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.1 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.0 | 0.1 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 0.3 | GO:0050427 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.0 | 0.1 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.0 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.0 | 0.2 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.0 | 0.1 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.2 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.0 | 0.2 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.3 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 1.6 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.0 | 0.4 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.4 | 3.5 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.4 | 1.1 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.3 | 1.3 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.3 | 13.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 5.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 8.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 0.6 | GO:0097679 | other organism cytoplasm(GO:0097679) |
| 0.2 | 2.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 4.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 32.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 1.9 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 0.7 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.8 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 0.8 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 0.5 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
| 0.1 | 6.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 0.6 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 1.8 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 0.6 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 0.4 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.0 | 1.1 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.2 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
| 0.0 | 2.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 21.0 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.8 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 4.6 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.0 | 0.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.0 | 0.2 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.0 | 0.6 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 1.4 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.1 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 2.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.0 | 0.3 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 3.8 | GO:0044853 | plasma membrane raft(GO:0044853) |
| 0.0 | 0.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.3 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 0.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 2.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 4.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.4 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.2 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.4 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 0.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.7 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.2 | GO:0032426 | stereocilium tip(GO:0032426) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.4 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 1.4 | 4.2 | GO:0017129 | triglyceride binding(GO:0017129) |
| 1.0 | 11.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.0 | 3.8 | GO:0033265 | choline binding(GO:0033265) |
| 0.9 | 9.0 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.9 | 5.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.7 | 3.0 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.7 | 2.8 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.7 | 2.0 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.5 | 1.5 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.5 | 2.9 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.4 | 1.8 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.4 | 1.2 | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 0.4 | 2.4 | GO:0004918 | interleukin-8 receptor activity(GO:0004918) |
| 0.4 | 2.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.4 | 1.2 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.4 | 1.1 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.3 | 1.7 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.3 | 1.4 | GO:0047946 | glutamine N-acyltransferase activity(GO:0047946) |
| 0.3 | 1.4 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.3 | 1.9 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.3 | 1.4 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.3 | 1.5 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.2 | 2.4 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 1.7 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) |
| 0.2 | 1.2 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.2 | 1.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 0.8 | GO:0047977 | hepoxilin-epoxide hydrolase activity(GO:0047977) |
| 0.2 | 7.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 0.5 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.2 | 1.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 0.9 | GO:0098809 | oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.2 | 1.3 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.2 | 1.5 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.2 | 0.8 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.2 | 0.5 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.2 | 2.0 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 2.1 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.0 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.1 | 0.6 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 4.2 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 0.7 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 1.1 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 0.4 | GO:0008988 | rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) |
| 0.1 | 0.6 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 3.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 1.9 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 3.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 1.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 3.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.9 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 2.8 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 0.6 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.1 | 3.4 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 0.8 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.1 | 6.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 1.9 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.1 | 0.3 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
| 0.1 | 0.3 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.1 | 0.7 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.1 | 0.6 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 2.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.5 | GO:0004945 | angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945) |
| 0.1 | 0.2 | GO:0052870 | alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.1 | 0.9 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 0.5 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 0.1 | 0.7 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.1 | 2.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 0.7 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 0.5 | GO:0051022 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.1 | 0.2 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 0.1 | 0.9 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 1.1 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 0.5 | GO:0004144 | diacylglycerol O-acyltransferase activity(GO:0004144) |
| 0.1 | 0.2 | GO:0034057 | RNA strand-exchange activity(GO:0034057) |
| 0.1 | 1.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.2 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.7 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.1 | 0.4 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.1 | 0.7 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.1 | 1.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 10.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 0.7 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 8.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.3 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 1.9 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 0.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.2 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.0 | 0.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 4.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 2.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.3 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.0 | 0.4 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.0 | 0.6 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.4 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 1.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 2.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.5 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.3 | GO:0050733 | DNA topoisomerase binding(GO:0044547) RS domain binding(GO:0050733) |
| 0.0 | 0.3 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.1 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.0 | 0.4 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 1.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.0 | 0.9 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.2 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 0.0 | 0.2 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.2 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 0.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.3 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 0.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.2 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.0 | 0.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.3 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.2 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.5 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.3 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.0 | 0.3 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.4 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.0 | 0.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 0.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.2 | GO:0008381 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 6.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.7 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 1.1 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.1 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.5 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 0.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 1.1 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 2.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.1 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.0 | 0.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 1.6 | GO:0008144 | drug binding(GO:0008144) |
| 0.0 | 0.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 8.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 4.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 5.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 10.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 5.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.7 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 6.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 0.4 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 0.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.4 | 11.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 8.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 3.5 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 9.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 5.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 2.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 3.2 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 0.7 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.1 | 2.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 12.1 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 3.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 0.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 0.5 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 1.0 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 3.0 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 1.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 0.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 0.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 3.1 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 2.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.7 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 1.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.0 | 2.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.9 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 1.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.0 | 0.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.2 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 1.5 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 2.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 1.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.8 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 0.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 2.2 | REACTOME SIGNALING BY ERBB2 | Genes involved in Signaling by ERBB2 |
| 0.0 | 0.4 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 1.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 2.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.3 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |