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avrg: Illumina Body Map 2 (GSE30611)
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Results for FOSL1
Z-value: 2.73
Motif logo
Transcription factors associated with FOSL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FOSL1
|
ENSG00000175592.9 | FOSL1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg38_v1_chr11_-_65900375_65900397 | 0.73 | 2.6e-06 | Click! |
Activity profile of FOSL1 motif
Sorted Z-values of FOSL1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 11.9 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 2.1 | 12.4 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 2.0 | 5.9 | GO:0060981 | cell migration involved in coronary angiogenesis(GO:0060981) |
| 1.3 | 3.8 | GO:0035378 | carbon dioxide transmembrane transport(GO:0035378) |
| 1.2 | 3.7 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 1.1 | 4.4 | GO:1990637 | response to prolactin(GO:1990637) |
| 1.1 | 4.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.0 | 19.5 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.9 | 2.7 | GO:0043465 | fermentation(GO:0006113) regulation of fermentation(GO:0043465) |
| 0.9 | 7.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.9 | 8.0 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.9 | 3.5 | GO:0035853 | chromosome passenger complex localization to spindle midzone(GO:0035853) |
| 0.8 | 4.2 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.8 | 2.5 | GO:1901389 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 0.8 | 5.0 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.8 | 2.5 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 0.8 | 3.1 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
| 0.8 | 3.8 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.7 | 2.9 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.7 | 13.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.7 | 9.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 3.3 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.7 | 4.6 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 0.6 | 2.6 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.6 | 3.9 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.6 | 4.8 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.5 | 2.7 | GO:0032796 | uropod organization(GO:0032796) |
| 0.5 | 8.6 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.5 | 2.1 | GO:0060367 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 0.5 | 2.6 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.5 | 2.5 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.5 | 10.8 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.5 | 9.4 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.5 | 4.1 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.4 | 1.3 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.4 | 1.3 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.4 | 16.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 7.7 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.4 | 9.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 1.2 | GO:0035425 | autocrine signaling(GO:0035425) |
| 0.4 | 8.8 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.4 | 2.3 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.4 | 5.7 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.4 | 10.7 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.4 | 7.1 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.3 | 6.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 11.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 1.4 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 0.3 | 4.0 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.3 | 1.3 | GO:0044115 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.3 | 1.0 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.3 | 5.7 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.3 | 5.0 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.3 | 5.0 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.3 | 2.5 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.3 | 4.0 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.3 | 2.1 | GO:0018032 | protein amidation(GO:0018032) |
| 0.3 | 4.4 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.3 | 3.0 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
| 0.3 | 4.1 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.3 | 5.0 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.3 | 1.8 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 2.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.2 | 0.7 | GO:0042946 | glucoside transport(GO:0042946) |
| 0.2 | 1.2 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.2 | 1.7 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 0.7 | GO:0060723 | spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723) |
| 0.2 | 1.2 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.2 | 0.7 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.2 | 0.9 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.2 | 2.8 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.2 | 3.2 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.2 | 5.7 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 9.1 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 1.6 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.2 | 2.0 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 3.2 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.2 | 1.9 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.2 | 1.0 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.2 | 1.8 | GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054) |
| 0.2 | 1.3 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 1.3 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.2 | 0.6 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.2 | 0.7 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.2 | 0.9 | GO:0032848 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.2 | 3.1 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.2 | 1.0 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.2 | 8.2 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.2 | 0.8 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.2 | 3.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.2 | 4.9 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.2 | 1.4 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 1.7 | GO:0030807 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.2 | 1.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 1.7 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.1 | 0.4 | GO:0051821 | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) development involved in symbiotic interaction(GO:0044111) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821) |
| 0.1 | 1.1 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.1 | 0.7 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 2.1 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.8 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.1 | 0.5 | GO:1902463 | protein localization to cell leading edge(GO:1902463) |
| 0.1 | 0.4 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) |
| 0.1 | 4.8 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.1 | 2.0 | GO:0030728 | ovulation(GO:0030728) |
| 0.1 | 0.5 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 0.3 | GO:0046108 | uridine metabolic process(GO:0046108) |
| 0.1 | 2.2 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.1 | 0.7 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.1 | 1.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 2.1 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.1 | 2.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.1 | 9.0 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.1 | 0.3 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.1 | 0.3 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 0.4 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.1 | 0.8 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 1.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.2 | GO:1903238 | positive regulation of leukocyte tethering or rolling(GO:1903238) |
| 0.1 | 2.5 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 0.6 | GO:0014004 | microglia differentiation(GO:0014004) microglia development(GO:0014005) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 0.1 | 0.3 | GO:1903347 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.1 | 0.5 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.1 | 1.2 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.1 | 2.5 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.1 | 5.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.5 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 3.4 | GO:0019430 | removal of superoxide radicals(GO:0019430) |
| 0.1 | 1.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 1.5 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.1 | 0.8 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.1 | 2.9 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 1.4 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.1 | 2.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 1.4 | GO:0090154 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 0.4 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) |
| 0.1 | 0.5 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 2.3 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.1 | 0.4 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.1 | 1.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 2.3 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 2.0 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 0.2 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 1.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 1.1 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 0.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 4.3 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.1 | 1.0 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.1 | 1.0 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 1.9 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 2.3 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.1 | 0.1 | GO:2001280 | positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.1 | 3.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 1.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.3 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.1 | 2.1 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 1.6 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.1 | 0.4 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.1 | 0.7 | GO:0014010 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) Schwann cell proliferation(GO:0014010) |
| 0.1 | 0.3 | GO:1903296 | glutamate secretion, neurotransmission(GO:0061535) regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 0.1 | 1.0 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.1 | 0.2 | GO:0015734 | taurine transport(GO:0015734) |
| 0.1 | 1.6 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.1 | 0.7 | GO:2000389 | regulation of neutrophil extravasation(GO:2000389) |
| 0.0 | 0.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 1.0 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.0 | 0.9 | GO:0060742 | epithelial cell differentiation involved in prostate gland development(GO:0060742) |
| 0.0 | 0.5 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.0 | 0.6 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.0 | 0.9 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 1.1 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.0 | 1.5 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.0 | 0.2 | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
| 0.0 | 0.2 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.0 | 3.3 | GO:0030239 | myofibril assembly(GO:0030239) |
| 0.0 | 1.0 | GO:0044849 | estrous cycle(GO:0044849) |
| 0.0 | 2.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 1.6 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 1.5 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) |
| 0.0 | 3.1 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 1.5 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.0 | 5.0 | GO:0042476 | odontogenesis(GO:0042476) |
| 0.0 | 0.6 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.0 | 0.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.6 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.3 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 1.7 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 1.4 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.5 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.0 | 0.2 | GO:0050849 | negative regulation of calcium-mediated signaling(GO:0050849) |
| 0.0 | 3.1 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 1.7 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 3.5 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.0 | 0.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 0.0 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.0 | 0.2 | GO:0071486 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.0 | 4.4 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.4 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.6 | GO:0048745 | smooth muscle tissue development(GO:0048745) |
| 0.0 | 1.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.3 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.4 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.6 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.0 | 0.6 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.0 | 0.8 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.2 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.0 | 1.1 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.0 | 1.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 1.3 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 1.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.0 | 3.2 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.0 | 2.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.5 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.9 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 0.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.1 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.0 | 1.5 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181) |
| 0.0 | 0.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 1.1 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.0 | 0.3 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 3.1 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 0.9 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 4.5 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.1 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.0 | 1.6 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.0 | 0.4 | GO:0033599 | regulation of mammary gland epithelial cell proliferation(GO:0033599) |
| 0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.4 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
| 0.0 | 0.0 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0097444 | spine apparatus(GO:0097444) |
| 1.3 | 3.8 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 1.1 | 12.4 | GO:0005638 | lamin filament(GO:0005638) |
| 1.0 | 12.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.9 | 13.1 | GO:0043256 | laminin complex(GO:0043256) |
| 0.8 | 2.5 | GO:1990917 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 0.8 | 9.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.7 | 4.4 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.7 | 2.8 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.7 | 4.9 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.6 | 1.9 | GO:1990617 | CHOP-ATF4 complex(GO:1990617) |
| 0.6 | 3.1 | GO:0071149 | TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149) |
| 0.6 | 9.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.5 | 1.6 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.5 | 2.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.4 | 1.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.4 | 13.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.3 | 3.5 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.3 | 1.4 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.3 | 2.1 | GO:0044753 | amphisome(GO:0044753) |
| 0.3 | 4.8 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.3 | 1.0 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.3 | 4.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.3 | 13.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 1.3 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.3 | 17.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 3.3 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 1.9 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.2 | 9.8 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.2 | 3.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.2 | 0.8 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.2 | 1.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 1.7 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 3.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 2.8 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.2 | 8.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.2 | 31.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 7.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.9 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.1 | 0.7 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 2.5 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.1 | 1.0 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 0.5 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 6.5 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 2.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 9.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.1 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.9 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 3.5 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 12.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 0.9 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.1 | 2.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 9.0 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 2.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 1.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 0.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 1.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 8.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 3.9 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.3 | GO:0097059 | CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059) |
| 0.1 | 2.2 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 2.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 0.2 | GO:0035517 | PR-DUB complex(GO:0035517) |
| 0.1 | 1.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.6 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 7.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 4.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 2.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 7.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 9.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 1.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 4.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 3.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 3.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 6.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 8.7 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 2.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.9 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 1.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 7.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 3.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 2.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.2 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 1.0 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 1.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.8 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.2 | GO:0097433 | dense body(GO:0097433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 24.4 | GO:1990254 | keratin filament binding(GO:1990254) |
| 1.5 | 4.5 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) |
| 1.5 | 5.9 | GO:0005019 | platelet-derived growth factor beta-receptor activity(GO:0005019) |
| 1.4 | 4.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.3 | 3.8 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 1.1 | 4.6 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 1.1 | 10.0 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.8 | 2.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.6 | 1.9 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.6 | 2.5 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.5 | 1.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.5 | 4.7 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.4 | 4.9 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.4 | 2.6 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.4 | 4.4 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.4 | 2.8 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.4 | 2.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.4 | 1.9 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.4 | 2.6 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
| 0.4 | 9.1 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.3 | 4.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.3 | 4.8 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 4.0 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.3 | 0.9 | GO:0015322 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.3 | 2.1 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.3 | 2.3 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.3 | 1.4 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.3 | 11.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 5.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 11.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 8.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 0.7 | GO:0042947 | glucoside transmembrane transporter activity(GO:0042947) |
| 0.2 | 0.7 | GO:0086039 | lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039) |
| 0.2 | 1.4 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.2 | 1.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.2 | 4.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.2 | 9.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 3.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 1.3 | GO:0004471 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.2 | 1.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.2 | 0.9 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.2 | 5.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 4.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.2 | 2.6 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.2 | 1.3 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 2.0 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.2 | 4.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 19.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 1.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 1.1 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.1 | 1.6 | GO:0036122 | BMP binding(GO:0036122) |
| 0.1 | 2.0 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.1 | 3.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.5 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.1 | 2.1 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 0.8 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.8 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 4.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 3.3 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.1 | 1.0 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.4 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.1 | 4.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.3 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.1 | 1.5 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 1.0 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.1 | 1.6 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.1 | 2.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 7.7 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 18.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.9 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 2.8 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.1 | 0.2 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.1 | 0.5 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 0.4 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 0.1 | 4.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 1.7 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 3.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.8 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 15.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 0.4 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 1.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 1.9 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 0.7 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.1 | 2.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.8 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 2.1 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 6.3 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 0.4 | GO:0004347 | glucose-6-phosphate isomerase activity(GO:0004347) |
| 0.1 | 0.3 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 1.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 2.7 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 0.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.3 | GO:0055103 | ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 1.6 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 0.9 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.4 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.1 | 0.4 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.1 | 0.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.3 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 3.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 0.5 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 14.2 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 0.3 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.1 | 2.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.2 | GO:0005368 | taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369) |
| 0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 1.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 1.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.9 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 41.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 0.8 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 21.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 3.4 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 2.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.7 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.0 | 0.4 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 0.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 1.1 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.4 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.3 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.6 | GO:0070402 | NADPH binding(GO:0070402) |
| 0.0 | 0.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 13.5 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.5 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 2.9 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.9 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.1 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 2.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.0 | 0.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 1.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 4.6 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.1 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.0 | 2.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 2.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 1.6 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.4 | 31.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 19.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 8.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 18.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 6.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 7.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 13.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.5 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 2.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 5.1 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 12.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 4.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 7.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 1.4 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 6.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 2.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 8.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 20.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 1.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 1.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 4.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 3.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.9 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 2.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 6.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.4 | 12.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 17.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 6.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 11.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 3.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 4.4 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 10.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 10.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 7.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 12.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 3.1 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.2 | 5.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 7.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 3.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 13.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 5.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 5.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 3.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 3.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 0.7 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 7.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 0.9 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 4.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 5.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.1 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 1.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.1 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.0 | 3.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 4.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 5.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.9 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.5 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.0 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 3.0 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 4.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 1.0 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.1 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.1 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 1.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.3 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.4 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 0.8 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 3.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.1 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |