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avrg: Illumina Body Map 2 (GSE30611)
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Results for FOXF2_FOXJ1
Z-value: 1.56
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Transcription factors associated with FOXF2_FOXJ1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXF2 | hg38_v1_chr6_+_1389553_1389605 | -0.22 | 2.4e-01 | Click! |
| FOXJ1 | hg38_v1_chr17_-_76141240_76141267 | -0.17 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXF2_FOXJ1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 2.2 | 8.8 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.4 | 7.1 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 5.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.8 | 5.3 | GO:0006711 | estrogen catabolic process(GO:0006711) |
| 0.1 | 5.2 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 4.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 1.5 | 4.4 | GO:0015993 | molecular hydrogen transport(GO:0015993) |
| 0.1 | 4.4 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.2 | 4.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 10.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 10.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 8.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 8.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.9 | 7.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 7.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.5 | 4.6 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 4.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.4 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 1.8 | 8.8 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 6.0 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 5.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 5.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 5.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 4.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.3 | 4.4 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 3.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 3.8 | GO:0097110 | scaffold protein binding(GO:0097110) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 5.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 4.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 2.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 6.3 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.2 | 5.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 5.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 4.1 | REACTOME BILE ACID AND BILE SALT METABOLISM | Genes involved in Bile acid and bile salt metabolism |
| 0.2 | 3.9 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.2 | 3.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 3.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |