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avrg: Illumina Body Map 2 (GSE30611)
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Results for HNF1A_HNF1B
Z-value: 12.24
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1A | hg38_v1_chr12_+_120978686_120978749 | 0.94 | 1.3e-15 | Click! |
| HNF1B | hg38_v1_chr17_-_37745018_37745069 | 0.65 | 5.4e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 26.0 | 311.8 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 16.1 | 225.9 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 19.8 | 217.9 | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process(GO:0036112) |
| 16.5 | 197.7 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 14.2 | 170.1 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 18.1 | 163.1 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 34.4 | 137.4 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 4.0 | 135.5 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 22.5 | 135.2 | GO:0008218 | bioluminescence(GO:0008218) |
| 18.0 | 108.0 | GO:0038185 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 463.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 404.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 329.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 22.2 | 288.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 261.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 185.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 160.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 6.1 | 134.4 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 124.3 | GO:0005576 | extracellular region(GO:0005576) |
| 2.3 | 108.0 | GO:0005719 | nuclear euchromatin(GO:0005719) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.2 | 363.0 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 6.9 | 325.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 1.9 | 303.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.2 | 219.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 34.1 | 136.6 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.7 | 112.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 18.4 | 110.7 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 18.0 | 108.0 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 25.5 | 101.9 | GO:0008431 | vitamin E binding(GO:0008431) |
| 4.8 | 96.6 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 348.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.1 | 283.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 3.4 | 220.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.2 | 112.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.5 | 105.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.4 | 103.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.2 | 97.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 1.0 | 89.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.6 | 60.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 53.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 312.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 14.3 | 271.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 7.8 | 203.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 3.0 | 170.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 6.8 | 162.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 3.0 | 136.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 4.5 | 125.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.1 | 113.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.7 | 111.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 4.9 | 87.8 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |