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avrg: Illumina Body Map 2 (GSE30611)
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Results for HNF4A
Z-value: 5.59
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Transcription factors associated with HNF4A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg38_v1_chr20_+_44401269_44401301 | 0.93 | 1.2e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 57.4 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 5.7 | 57.2 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 2.5 | 49.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 10.8 | 43.2 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 2.2 | 41.4 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 4.1 | 41.3 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.4 | 40.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 9.7 | 38.7 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 1.0 | 38.5 | GO:0015879 | carnitine transport(GO:0015879) |
| 2.4 | 33.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 203.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 134.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.3 | 75.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 69.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 2.8 | 59.4 | GO:0042627 | chylomicron(GO:0042627) |
| 1.1 | 57.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 6.6 | 52.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.4 | 44.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 39.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.9 | 38.5 | GO:0031528 | microvillus membrane(GO:0031528) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 83.0 | GO:0001848 | complement binding(GO:0001848) |
| 3.3 | 59.1 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 14.3 | 57.2 | GO:0061609 | fructose-1-phosphate aldolase activity(GO:0061609) |
| 11.4 | 56.9 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 7.2 | 43.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 13.8 | 41.3 | GO:0004411 | homogentisate 1,2-dioxygenase activity(GO:0004411) |
| 5.1 | 40.6 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 7.7 | 38.7 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 4.8 | 38.5 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 1.5 | 36.4 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 161.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 61.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 37.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 31.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.8 | 23.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 16.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 3.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 2.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 126.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 3.7 | 91.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.2 | 83.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 77.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.1 | 51.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 44.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 2.7 | 40.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.5 | 38.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.4 | 29.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.1 | 26.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |