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avrg: Illumina Body Map 2 (GSE30611)

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Results for HOXB13

Z-value: 0.68

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.8 HOXB13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_487287560.019.5e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_6588708 2.04 ENST00000230568.5
LY86
lymphocyte antigen 86
chr4_+_67558719 1.27 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr1_+_110451132 1.09 ENST00000271331.4
PROK1
prokineticin 1
chr1_+_65992389 1.03 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chr19_+_55643592 0.93 ENST00000270451.6
ENST00000588537.1
ZNF581
zinc finger protein 581
chr1_+_84164962 0.93 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr7_+_129144691 0.89 ENST00000486685.3
TSPAN33
tetraspanin 33
chr4_-_163613505 0.85 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr19_+_35143237 0.82 ENST00000586063.5
ENST00000270310.7
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr16_+_30378312 0.67 ENST00000528032.5
ENST00000622647.3
ZNF48
zinc finger protein 48
chr15_-_55249029 0.65 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr9_+_122371014 0.63 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371036 0.61 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr5_-_140673568 0.58 ENST00000542735.2
DND1
DND microRNA-mediated repression inhibitor 1
chr18_+_3252267 0.53 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr1_+_84164891 0.52 ENST00000413538.5
ENST00000417530.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr21_+_29300111 0.49 ENST00000451655.5
BACH1
BTB domain and CNC homolog 1
chr1_+_44405164 0.46 ENST00000355387.6
RNF220
ring finger protein 220
chr9_+_122370523 0.45 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr1_+_84164370 0.43 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr21_+_29300770 0.42 ENST00000447177.5
BACH1
BTB domain and CNC homolog 1
chr18_-_55322334 0.41 ENST00000630720.3
TCF4
transcription factor 4
chr16_-_24930952 0.40 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr16_-_24931090 0.40 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr9_+_121121760 0.39 ENST00000373847.5
CNTRL
centriolin
chr1_-_155910881 0.38 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr19_+_47994625 0.38 ENST00000339841.7
ELSPBP1
epididymal sperm binding protein 1
chr1_+_78303865 0.38 ENST00000370758.5
PTGFR
prostaglandin F receptor
chr1_+_84164684 0.35 ENST00000370680.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr7_-_75772172 0.35 ENST00000005180.9
CCL26
C-C motif chemokine ligand 26
chr9_-_128067310 0.34 ENST00000373078.5
NAIF1
nuclear apoptosis inducing factor 1
chr12_+_8092881 0.34 ENST00000638334.1
NECAP1
NECAP endocytosis associated 1
chr19_+_47994696 0.33 ENST00000596043.5
ENST00000597519.5
ELSPBP1
epididymal sperm binding protein 1
chr1_+_84164293 0.32 ENST00000370684.5
ENST00000436133.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr17_-_75667088 0.32 ENST00000578201.5
ENST00000423245.6
ENST00000317905.10
RECQL5
RecQ like helicase 5
chr17_-_10657302 0.31 ENST00000583535.6
MYH3
myosin heavy chain 3
chr7_+_18496269 0.30 ENST00000432645.6
HDAC9
histone deacetylase 9
chr14_-_50116553 0.29 ENST00000395860.7
ENST00000395859.2
VCPKMT
valosin containing protein lysine methyltransferase
chr14_-_67533720 0.29 ENST00000554278.6
TMEM229B
transmembrane protein 229B
chr17_-_41489907 0.29 ENST00000328119.11
KRT36
keratin 36
chr1_-_45491150 0.28 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr11_-_13440243 0.28 ENST00000530907.5
BTBD10
BTB domain containing 10
chr9_+_123033660 0.27 ENST00000616002.3
GPR21
G protein-coupled receptor 21
chr3_-_123991352 0.26 ENST00000184183.8
ROPN1
rhophilin associated tail protein 1
chr3_-_115071333 0.26 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_20590823 0.25 ENST00000556526.1
RNASE12
ribonuclease A family member 12 (inactive)
chr8_+_76681208 0.24 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr9_+_20927765 0.23 ENST00000603044.5
ENST00000604254.5
FOCAD
focadhesin
chr18_-_55321986 0.23 ENST00000570287.6
TCF4
transcription factor 4
chr11_+_63838902 0.23 ENST00000377810.8
MARK2
microtubule affinity regulating kinase 2
chr1_+_84164669 0.22 ENST00000450730.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_-_135530561 0.21 ENST00000536680.5
ENST00000401392.5
ZRANB3
zinc finger RANBP2-type containing 3
chr17_-_41382298 0.20 ENST00000394001.3
KRT34
keratin 34
chr1_+_244352627 0.20 ENST00000366537.5
ENST00000308105.5
C1orf100
chromosome 1 open reading frame 100
chr18_-_55322215 0.20 ENST00000457482.7
TCF4
transcription factor 4
chr5_+_136160986 0.18 ENST00000507637.1
SMAD5
SMAD family member 5
chr3_+_68004231 0.18 ENST00000478136.6
TAFA1
TAFA chemokine like family member 1
chr2_-_24328113 0.18 ENST00000622089.4
ITSN2
intersectin 2
chr16_-_77431553 0.17 ENST00000562345.1
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif 18
chr17_-_48728705 0.17 ENST00000290295.8
HOXB13
homeobox B13
chr9_+_73151833 0.16 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr10_+_102245371 0.16 ENST00000676513.1
ENST00000676939.1
ENST00000677947.1
ENST00000677247.1
ENST00000369983.4
ENST00000678351.1
ENST00000679238.1
ENST00000677439.1
ENST00000677240.1
ENST00000677618.1
ENST00000673650.1
ENST00000674034.1
ENST00000676993.1
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr3_-_15798184 0.16 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr11_+_47257604 0.15 ENST00000444396.5
ENST00000457932.5
NR1H3
nuclear receptor subfamily 1 group H member 3
chr22_-_37844308 0.14 ENST00000411961.6
ENST00000434930.1
ENST00000215941.9
ANKRD54
ankyrin repeat domain 54
chr16_+_2155698 0.14 ENST00000565383.5
ENST00000326181.11
ENST00000567653.5
TRAF7
TNF receptor associated factor 7
chr11_-_102843597 0.14 ENST00000299855.10
MMP3
matrix metallopeptidase 3
chr7_+_133253064 0.14 ENST00000393161.6
ENST00000253861.5
EXOC4
exocyst complex component 4
chr18_+_3252208 0.13 ENST00000578562.6
MYL12A
myosin light chain 12A
chr20_-_10420737 0.13 ENST00000649912.1
ENSG00000285723.1
novel protein
chr17_+_18183052 0.12 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr12_+_69825221 0.12 ENST00000552032.7
MYRFL
myelin regulatory factor like
chr14_+_76310708 0.11 ENST00000512784.6
ESRRB
estrogen related receptor beta
chr3_-_15797930 0.11 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr1_+_50105666 0.11 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr13_+_114179247 0.10 ENST00000635901.2
CFAP97D2
CFAP97 domain containing 2
chr17_+_18183803 0.10 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr1_-_36397880 0.09 ENST00000315732.3
LSM10
LSM10, U7 small nuclear RNA associated
chrX_+_116170742 0.09 ENST00000371906.5
ENST00000681852.1
AGTR2
angiotensin II receptor type 2
chr13_+_114179272 0.08 ENST00000646158.1
ENST00000636692.1
CFAP97D2
CFAP97 domain containing 2
chr11_+_118531183 0.08 ENST00000528373.5
ENST00000313236.10
ENST00000354284.8
ENST00000533137.5
ENST00000532762.5
ENST00000526973.5
ENST00000354064.11
ENST00000533102.5
ENST00000527267.1
ENST00000524725.5
ENST00000533689.1
TMEM25
transmembrane protein 25
chr11_+_56274154 0.06 ENST00000641665.1
OR5T1
olfactory receptor family 5 subfamily T member 1
chr18_-_25351615 0.06 ENST00000580488.1
ENST00000577801.5
ZNF521
zinc finger protein 521
chr2_-_216013517 0.05 ENST00000263268.11
MREG
melanoregulin
chr14_-_77423517 0.05 ENST00000555603.1
NOXRED1
NADP dependent oxidoreductase domain containing 1
chr12_-_16277685 0.04 ENST00000344941.3
SLC15A5
solute carrier family 15 member 5
chr17_-_75667165 0.04 ENST00000584999.1
ENST00000420326.6
ENST00000340830.9
RECQL5
RecQ like helicase 5
chr20_+_38066060 0.04 ENST00000614670.1
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr6_-_43053832 0.02 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr11_+_118530990 0.02 ENST00000411589.6
ENST00000359862.8
ENST00000442938.6
TMEM25
transmembrane protein 25
chrX_-_152994108 0.02 ENST00000535214.6
PNMA5
PNMA family member 5
chr12_+_69825273 0.01 ENST00000547771.6
MYRFL
myelin regulatory factor like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.3 2.8 GO:0097338 response to clozapine(GO:0097338)
0.2 2.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 1.0 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.4 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) negative regulation of icosanoid secretion(GO:0032304)
0.0 0.2 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.6 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 1.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 2.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.4 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis