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avrg: Illumina Body Map 2 (GSE30611)

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Results for HOXD4

Z-value: 1.76

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Transcription factors associated with HOXD4

Gene Symbol Gene ID Gene Info
HOXD4
ENSG00000170166.6 HOXD4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD4hg38_v1_chr2_+_176151543_1761515590.019.5e-01Click!

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_10549612 7.69 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
MYH2
myosin heavy chain 2
chr17_-_10549652 7.09 ENST00000245503.10
MYH2
myosin heavy chain 2
chr17_-_10549694 4.80 ENST00000622564.4
MYH2
myosin heavy chain 2
chr10_+_68109433 3.09 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
MYPN
myopalladin
chr10_-_49762335 2.77 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr5_-_151347552 2.36 ENST00000335244.9
ENST00000521967.1
SLC36A2
solute carrier family 36 member 2
chr10_-_49762276 2.24 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr2_+_167187364 1.99 ENST00000672671.1
XIRP2
xin actin binding repeat containing 2
chr3_+_142623386 1.96 ENST00000337777.7
ENST00000497199.5
PLS1
plastin 1
chr8_+_78591222 1.95 ENST00000518467.1
PKIA
cAMP-dependent protein kinase inhibitor alpha
chr4_-_99657820 1.92 ENST00000511828.2
C4orf54
chromosome 4 open reading frame 54
chr4_+_154563003 1.92 ENST00000302068.9
ENST00000509493.1
FGB
fibrinogen beta chain
chr6_-_87095059 1.80 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr5_+_90899183 1.73 ENST00000640815.1
ADGRV1
adhesion G protein-coupled receptor V1
chr12_-_39340963 1.52 ENST00000552961.5
KIF21A
kinesin family member 21A
chr7_-_137343752 1.46 ENST00000393083.2
PTN
pleiotrophin
chr2_+_190180930 1.42 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr2_-_224569782 1.38 ENST00000409096.5
CUL3
cullin 3
chr11_-_72781858 1.35 ENST00000537947.5
STARD10
StAR related lipid transfer domain containing 10
chr2_+_190180835 1.31 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr6_-_136526472 1.25 ENST00000454590.5
ENST00000432797.6
MAP7
microtubule associated protein 7
chr3_+_159069252 1.24 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr2_+_233681877 1.22 ENST00000373426.4
UGT1A7
UDP glucuronosyltransferase family 1 member A7
chr10_-_29736956 1.21 ENST00000674475.1
SVIL
supervillin
chr7_+_55365317 1.07 ENST00000254770.3
LANCL2
LanC like 2
chrX_-_23884017 1.06 ENST00000633372.1
APOO
apolipoprotein O
chr2_-_182242031 1.05 ENST00000358139.6
PDE1A
phosphodiesterase 1A
chr7_-_29146436 1.04 ENST00000396276.7
CPVL
carboxypeptidase vitellogenic like
chr7_-_29146527 1.01 ENST00000265394.10
CPVL
carboxypeptidase vitellogenic like
chr11_-_72781833 1.01 ENST00000535054.1
ENST00000545082.5
STARD10
StAR related lipid transfer domain containing 10
chr5_-_35047935 0.99 ENST00000510428.1
ENST00000231420.11
AGXT2
alanine--glyoxylate aminotransferase 2
chrX_-_143636094 0.98 ENST00000356928.2
SLITRK4
SLIT and NTRK like family member 4
chr8_-_42541042 0.95 ENST00000518717.1
SLC20A2
solute carrier family 20 member 2
chr7_-_137343688 0.93 ENST00000348225.7
PTN
pleiotrophin
chr11_+_66011994 0.92 ENST00000312134.3
CST6
cystatin E/M
chr5_-_59430600 0.89 ENST00000636120.1
PDE4D
phosphodiesterase 4D
chr12_+_28452493 0.89 ENST00000542801.5
CCDC91
coiled-coil domain containing 91
chr10_+_94089067 0.88 ENST00000371375.1
ENST00000675218.1
PLCE1
phospholipase C epsilon 1
chr7_+_77798750 0.86 ENST00000416283.6
ENST00000422959.6
ENST00000307305.12
ENST00000424760.5
PHTF2
putative homeodomain transcription factor 2
chr2_+_27663441 0.85 ENST00000326019.10
ENST00000613058.4
SLC4A1AP
solute carrier family 4 member 1 adaptor protein
chr22_+_41092869 0.85 ENST00000674155.1
EP300
E1A binding protein p300
chr15_-_55917129 0.85 ENST00000338963.6
ENST00000508342.5
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr5_+_69415065 0.85 ENST00000647531.1
ENST00000645446.1
ENST00000325631.10
ENST00000454295.6
MARVELD2
MARVEL domain containing 2
chr12_-_86256299 0.85 ENST00000552808.6
ENST00000547225.5
MGAT4C
MGAT4 family member C
chr2_-_70553638 0.83 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
TGFA
transforming growth factor alpha
chr1_-_17045219 0.82 ENST00000491274.5
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr15_-_55917080 0.81 ENST00000506154.1
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr6_-_136526177 0.79 ENST00000617204.4
MAP7
microtubule associated protein 7
chr3_+_109136707 0.78 ENST00000622536.6
C3orf85
chromosome 3 open reading frame 85
chr3_+_51861604 0.78 ENST00000333127.4
IQCF2
IQ motif containing F2
chr7_+_123848070 0.76 ENST00000476325.5
HYAL4
hyaluronidase 4
chrX_+_37990773 0.75 ENST00000341016.5
H2AP
H2A.P histone
chr7_-_122699108 0.75 ENST00000340112.3
RNF133
ring finger protein 133
chr8_-_71361860 0.75 ENST00000303824.11
ENST00000645451.1
EYA1
EYA transcriptional coactivator and phosphatase 1
chr10_+_70052582 0.75 ENST00000676699.1
MACROH2A2
macroH2A.2 histone
chr19_-_47886308 0.73 ENST00000222002.4
SULT2A1
sulfotransferase family 2A member 1
chr7_+_77798832 0.71 ENST00000415251.6
ENST00000275575.11
PHTF2
putative homeodomain transcription factor 2
chr15_+_21651844 0.68 ENST00000623441.1
OR4N4C
olfactory receptor family 4 subfamily N member 4C
chrX_+_38006551 0.67 ENST00000297875.7
SYTL5
synaptotagmin like 5
chr15_-_72228676 0.67 ENST00000561609.5
PKM
pyruvate kinase M1/2
chr2_+_170178136 0.66 ENST00000409044.7
ENST00000408978.9
MYO3B
myosin IIIB
chr2_-_158380960 0.65 ENST00000409187.5
CCDC148
coiled-coil domain containing 148
chr22_-_28711931 0.64 ENST00000434810.5
ENST00000456369.5
CHEK2
checkpoint kinase 2
chr8_-_69834970 0.61 ENST00000260126.9
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr12_-_86256267 0.61 ENST00000620241.4
MGAT4C
MGAT4 family member C
chr1_+_182450132 0.61 ENST00000294854.13
RGSL1
regulator of G protein signaling like 1
chr2_+_233917371 0.61 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr2_-_169573856 0.61 ENST00000453153.7
ENST00000445210.1
FASTKD1
FAST kinase domains 1
chr17_-_66229380 0.60 ENST00000205948.11
APOH
apolipoprotein H
chr1_-_151006471 0.59 ENST00000493834.2
MINDY1
MINDY lysine 48 deubiquitinase 1
chrX_-_93673558 0.58 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr14_-_99480831 0.56 ENST00000331768.10
ENST00000630307.2
SETD3
SET domain containing 3, actin histidine methyltransferase
chrX_+_56563569 0.56 ENST00000338222.7
UBQLN2
ubiquilin 2
chr4_+_158210479 0.56 ENST00000504569.5
ENST00000509278.5
ENST00000514558.5
ENST00000503200.5
ENST00000296529.11
TMEM144
transmembrane protein 144
chr6_+_26158115 0.55 ENST00000377777.5
ENST00000289316.2
H2BC5
H2B clustered histone 5
chr7_+_92057602 0.54 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr1_-_247679739 0.53 ENST00000642119.1
OR13G1
olfactory receptor family 13 subfamily G member 1
chr6_+_142147162 0.52 ENST00000452973.6
ENST00000620996.4
ENST00000367621.1
ENST00000367630.9
VTA1
vesicle trafficking 1
chr3_-_18438678 0.52 ENST00000414509.5
SATB1
SATB homeobox 1
chr13_+_77741212 0.52 ENST00000441784.5
SLAIN1
SLAIN motif family member 1
chr3_-_18438767 0.52 ENST00000454909.6
SATB1
SATB homeobox 1
chr15_+_36594868 0.52 ENST00000566807.5
ENST00000643612.1
ENST00000567389.5
ENST00000562877.5
CDIN1
CDAN1 interacting nuclease 1
chr20_-_31390580 0.51 ENST00000339144.3
ENST00000376321.4
DEFB119
defensin beta 119
chr3_-_157503574 0.51 ENST00000494677.5
ENST00000468233.5
VEPH1
ventricular zone expressed PH domain containing 1
chr20_-_31390483 0.49 ENST00000376315.2
DEFB119
defensin beta 119
chr5_+_69415190 0.49 ENST00000515844.1
MARVELD2
MARVEL domain containing 2
chr11_-_11353241 0.48 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr5_-_55692620 0.47 ENST00000503817.5
ENST00000512595.5
SLC38A9
solute carrier family 38 member 9
chr9_-_21368057 0.47 ENST00000449498.2
IFNA13
interferon alpha 13
chr7_+_101817601 0.46 ENST00000292535.12
ENST00000546411.7
ENST00000549414.6
ENST00000550008.6
ENST00000556210.1
CUX1
cut like homeobox 1
chr12_+_112906777 0.46 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr16_-_29899532 0.46 ENST00000308713.9
ENST00000617533.5
SEZ6L2
seizure related 6 homolog like 2
chr19_-_44401575 0.45 ENST00000591679.5
ENST00000544719.6
ENST00000614994.5
ENST00000585868.1
ENST00000588212.1
ZNF285
ENSG00000267173.1
zinc finger protein 285
novel protein
chr11_-_78079819 0.45 ENST00000534029.5
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000281031.5
ENST00000528251.1
ENST00000530054.1
NDUFC2
NDUFC2-KCTD14
NADH:ubiquinone oxidoreductase subunit C2
NDUFC2-KCTD14 readthrough
chr12_+_15956585 0.45 ENST00000526530.1
DERA
deoxyribose-phosphate aldolase
chr4_-_183320267 0.44 ENST00000323319.7
CLDN22
claudin 22
chr2_+_186590022 0.44 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr12_-_118190510 0.42 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr7_-_77798359 0.42 ENST00000257663.4
TMEM60
transmembrane protein 60
chr7_+_138460238 0.42 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr1_+_28438104 0.42 ENST00000633167.1
ENST00000373836.4
PHACTR4
phosphatase and actin regulator 4
chr10_+_96304392 0.41 ENST00000630152.1
DNTT
DNA nucleotidylexotransferase
chr9_-_24545866 0.41 ENST00000543880.7
ENST00000418122.1
IZUMO3
IZUMO family member 3
chr13_-_23433676 0.41 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chr10_-_17129786 0.40 ENST00000377833.10
CUBN
cubilin
chr3_+_4680617 0.40 ENST00000648212.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr13_+_77741160 0.40 ENST00000314070.9
ENST00000351546.7
SLAIN1
SLAIN motif family member 1
chr18_-_36798482 0.40 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr8_+_23288081 0.39 ENST00000265806.12
ENST00000519952.6
ENST00000518840.6
R3HCC1
R3H domain and coiled-coil containing 1
chr15_+_45634721 0.39 ENST00000561735.5
SQOR
sulfide quinone oxidoreductase
chr11_-_129192291 0.39 ENST00000682385.1
ARHGAP32
Rho GTPase activating protein 32
chr17_-_37542361 0.39 ENST00000614196.1
SYNRG
synergin gamma
chr2_+_182718046 0.39 ENST00000537515.5
DNAJC10
DnaJ heat shock protein family (Hsp40) member C10
chr5_+_116032315 0.38 ENST00000601302.3
ARL14EPL
ADP ribosylation factor like GTPase 14 effector protein like
chr8_-_42843201 0.38 ENST00000529779.1
ENST00000345117.2
ENST00000254250.7
THAP1
THAP domain containing 1
chr13_-_61415508 0.37 ENST00000409204.4
PCDH20
protocadherin 20
chr18_+_24460655 0.37 ENST00000426880.2
HRH4
histamine receptor H4
chr14_+_22598224 0.37 ENST00000428304.6
ENST00000542041.1
ENST00000216327.10
ABHD4
abhydrolase domain containing 4, N-acyl phospholipase B
chr1_-_100894649 0.37 ENST00000450240.2
EXTL2
exostosin like glycosyltransferase 2
chr4_-_69639642 0.36 ENST00000604629.6
ENST00000604021.1
UGT2A2
UDP glucuronosyltransferase family 2 member A2
chr14_+_19935608 0.36 ENST00000285600.4
OR4K1
olfactory receptor family 4 subfamily K member 1
chr8_-_71362054 0.36 ENST00000340726.8
EYA1
EYA transcriptional coactivator and phosphatase 1
chr15_-_64093746 0.36 ENST00000557835.5
ENST00000380290.7
ENST00000300030.8
ENST00000559950.1
CIAO2A
cytosolic iron-sulfur assembly component 2A
chr1_+_197268222 0.35 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
CRB1
crumbs cell polarity complex component 1
chr13_-_23433735 0.35 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
SACS
sacsin molecular chaperone
chr11_-_129192198 0.35 ENST00000310343.13
ARHGAP32
Rho GTPase activating protein 32
chr18_-_21703688 0.34 ENST00000584464.1
ENST00000578270.5
ABHD3
abhydrolase domain containing 3, phospholipase
chr3_+_97821984 0.34 ENST00000389622.7
CRYBG3
crystallin beta-gamma domain containing 3
chr11_+_18396823 0.34 ENST00000625635.1
LDHA
lactate dehydrogenase A
chr19_-_13953302 0.34 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr8_+_49909783 0.33 ENST00000518864.5
SNTG1
syntrophin gamma 1
chr11_+_92969651 0.33 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr5_+_141966820 0.32 ENST00000513019.5
ENST00000394519.5
ENST00000356143.5
RNF14
ring finger protein 14
chr17_-_42980393 0.32 ENST00000409446.8
ENST00000409399.6
ENST00000421990.7
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 like
PTGES3L-AARSD1 readthrough
chr4_+_73481737 0.32 ENST00000226355.5
AFM
afamin
chr2_+_223957431 0.32 ENST00000258383.4
MRPL44
mitochondrial ribosomal protein L44
chrX_+_150699208 0.32 ENST00000436701.5
ENST00000438018.5
MTMR1
myotubularin related protein 1
chr7_-_105269007 0.31 ENST00000357311.7
SRPK2
SRSF protein kinase 2
chr15_+_80072559 0.31 ENST00000560228.5
ENST00000559835.5
ENST00000559775.5
ENST00000558688.5
ENST00000560392.5
ENST00000560976.5
ENST00000558272.5
ENST00000558390.5
ZFAND6
zinc finger AN1-type containing 6
chr9_-_104536856 0.30 ENST00000641090.1
OR13C3
olfactory receptor family 13 subfamily C member 3
chr20_-_10420737 0.30 ENST00000649912.1
ENSG00000285723.1
novel protein
chr1_+_210328244 0.30 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr2_-_165204042 0.29 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr8_-_71362119 0.29 ENST00000388741.7
EYA1
EYA transcriptional coactivator and phosphatase 1
chr4_+_68447453 0.29 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr10_+_84425148 0.29 ENST00000493409.5
CCSER2
coiled-coil serine rich protein 2
chr13_+_51339683 0.29 ENST00000419898.2
ENST00000681248.1
SERPINE3
serpin family E member 3
chr1_-_246193727 0.29 ENST00000391836.3
SMYD3
SET and MYND domain containing 3
chr1_-_100894775 0.28 ENST00000416479.1
ENST00000370113.7
EXTL2
exostosin like glycosyltransferase 2
chr6_-_50049923 0.28 ENST00000651554.2
DEFB112
defensin beta 112
chr10_+_12129637 0.27 ENST00000379051.5
ENST00000379033.7
ENST00000441368.5
ENST00000298428.14
ENST00000304267.12
ENST00000379020.8
ENST00000379017.7
SEC61A2
SEC61 translocon subunit alpha 2
chr11_+_55723776 0.27 ENST00000641440.1
OR5D3P
olfactory receptor family 5 subfamily D member 3 pseudogene
chr1_+_197268204 0.27 ENST00000535699.5
ENST00000538660.5
CRB1
crumbs cell polarity complex component 1
chr4_-_36243939 0.26 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_141262614 0.26 ENST00000504264.5
PXYLP1
2-phosphoxylose phosphatase 1
chr20_+_33562365 0.26 ENST00000346541.7
ENST00000397800.5
ENST00000492345.5
CBFA2T2
CBFA2/RUNX1 partner transcriptional co-repressor 2
chr12_+_18242955 0.26 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr7_+_112423137 0.26 ENST00000005558.8
ENST00000621379.4
IFRD1
interferon related developmental regulator 1
chr5_+_140841183 0.25 ENST00000378123.4
ENST00000531613.2
PCDHA8
protocadherin alpha 8
chr4_+_74308492 0.25 ENST00000502358.5
ENST00000503098.5
ENST00000505212.5
ENST00000509145.5
ENST00000514968.5
EPGN
epithelial mitogen
chr3_+_69763726 0.25 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr20_-_47351877 0.25 ENST00000446894.5
ZMYND8
zinc finger MYND-type containing 8
chrX_+_49879475 0.25 ENST00000621775.2
USP27X
ubiquitin specific peptidase 27 X-linked
chr9_-_94640130 0.25 ENST00000414122.1
FBP1
fructose-bisphosphatase 1
chr2_+_108621260 0.25 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr15_+_64094060 0.24 ENST00000560829.5
SNX1
sorting nexin 1
chr4_-_39977836 0.23 ENST00000303538.13
ENST00000503396.5
PDS5A
PDS5 cohesin associated factor A
chr12_+_14365661 0.23 ENST00000261168.9
ENST00000538511.5
ENST00000545723.1
ENST00000543189.5
ATF7IP
activating transcription factor 7 interacting protein
chr9_-_125484490 0.23 ENST00000444226.1
MAPKAP1
MAPK associated protein 1
chr6_+_122996227 0.23 ENST00000275162.10
CLVS2
clavesin 2
chr11_+_124256376 0.22 ENST00000641992.2
OR8G5
olfactory receptor family 8 subfamily G member 5
chr9_+_470291 0.22 ENST00000382303.5
KANK1
KN motif and ankyrin repeat domains 1
chr2_+_32277883 0.22 ENST00000238831.9
YIPF4
Yip1 domain family member 4
chr14_+_60982358 0.22 ENST00000526105.5
SLC38A6
solute carrier family 38 member 6
chr21_-_29061351 0.22 ENST00000432178.5
CCT8
chaperonin containing TCP1 subunit 8
chr17_-_40782544 0.22 ENST00000301656.4
KRT27
keratin 27
chr13_+_23570370 0.22 ENST00000403372.6
ENST00000248484.9
TNFRSF19
TNF receptor superfamily member 19
chr11_-_16397521 0.21 ENST00000533411.5
SOX6
SRY-box transcription factor 6
chr2_+_71453538 0.21 ENST00000258104.8
DYSF
dysferlin
chr6_-_49744378 0.21 ENST00000371159.8
ENST00000263045.9
CRISP3
cysteine rich secretory protein 3
chr1_-_100894818 0.21 ENST00000370114.8
EXTL2
exostosin like glycosyltransferase 2
chr5_-_139198358 0.21 ENST00000394817.7
SIL1
SIL1 nucleotide exchange factor
chr3_-_180989678 0.21 ENST00000491873.5
ENST00000382564.8
ENST00000486355.1
DNAJC19
DnaJ heat shock protein family (Hsp40) member C19
chr16_-_2329687 0.20 ENST00000567910.1
ABCA3
ATP binding cassette subfamily A member 3
chr1_-_28058087 0.20 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr4_-_84966637 0.20 ENST00000295888.9
WDFY3
WD repeat and FYVE domain containing 3
chr4_+_129093682 0.20 ENST00000502887.5
C4orf33
chromosome 4 open reading frame 33
chr6_+_46793379 0.19 ENST00000230588.9
ENST00000611727.2
MEP1A
meprin A subunit alpha
chr5_-_55692731 0.19 ENST00000502247.1
SLC38A9
solute carrier family 38 member 9
chr15_+_92900189 0.19 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr2_+_165239388 0.17 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
SCN2A
sodium voltage-gated channel alpha subunit 2
chr6_-_26108125 0.17 ENST00000338379.6
H1-6
H1.6 linker histone, cluster member
chr6_-_49744434 0.16 ENST00000433368.6
ENST00000354620.4
CRISP3
cysteine rich secretory protein 3
chr2_-_213151590 0.15 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKZF2
IKAROS family zinc finger 2
chr12_-_48852153 0.15 ENST00000308025.8
DDX23
DEAD-box helicase 23
chr5_-_177780633 0.15 ENST00000513554.5
ENST00000440605.7
FAM153A
family with sequence similarity 153 member A
chr2_-_162838728 0.15 ENST00000328032.8
ENST00000332142.10
KCNH7
potassium voltage-gated channel subfamily H member 7
chr22_-_28712136 0.14 ENST00000464581.6
CHEK2
checkpoint kinase 2
chr18_+_63702958 0.14 ENST00000544088.6
SERPINB11
serpin family B member 11
chr5_-_56116946 0.14 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 19.8 GO:0001778 plasma membrane repair(GO:0001778)
0.8 2.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.6 1.7 GO:0051821 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821)
0.4 2.0 GO:1902896 terminal web assembly(GO:1902896)
0.3 1.4 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.3 1.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.3 0.8 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.2 1.0 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.2 2.4 GO:0015808 L-alanine transport(GO:0015808)
0.2 0.6 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.2 1.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.2 0.9 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.4 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.7 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 1.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 2.4 GO:0032782 bile acid secretion(GO:0032782)
0.1 1.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 5.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 0.4 GO:0061386 closure of optic fissure(GO:0061386)
0.1 2.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.4 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 2.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.3 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.9 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.6 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 1.1 GO:0042407 cristae formation(GO:0042407)
0.1 0.4 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.9 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.1 1.7 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 1.0 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 1.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.2 GO:1903756 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.5 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.1 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.2 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.8 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 1.8 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0035724 CD24 biosynthetic process(GO:0035724) activation of meiosis involved in egg activation(GO:0060466) negative regulation of monocyte extravasation(GO:2000438) regulation of CD24 biosynthetic process(GO:2000559) positive regulation of CD24 biosynthetic process(GO:2000560)
0.0 0.8 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.1 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
0.0 0.1 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0098942 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.1 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.3 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 2.2 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.2 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.1 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.3 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.4 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.2 GO:0003281 ventricular septum development(GO:0003281)
0.0 0.0 GO:0003350 pulmonary myocardium development(GO:0003350)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 19.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.5 5.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.3 2.0 GO:1990357 terminal web(GO:1990357)
0.2 0.7 GO:1902912 pyruvate kinase complex(GO:1902912)
0.2 0.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 2.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.1 GO:0061617 MICOS complex(GO:0061617)
0.1 1.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 1.4 GO:0005827 polar microtubule(GO:0005827)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 1.3 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.7 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.8 GO:0070852 cell body fiber(GO:0070852)
0.1 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 1.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089) chylomicron(GO:0042627)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.0 2.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.6 2.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 19.6 GO:0000146 microfilament motor activity(GO:0000146)
0.3 1.4 GO:0031208 POZ domain binding(GO:0031208)
0.2 0.9 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.2 2.4 GO:0022858 hydrogen:amino acid symporter activity(GO:0005280) L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.2 1.7 GO:0050816 phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)
0.2 0.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 1.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.0 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 0.3 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.7 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0070004 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.1 0.4 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.1 0.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 3.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.3 GO:0008431 vitamin E binding(GO:0008431)
0.1 2.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 2.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 2.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 2.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0052854 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.4 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.0 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 19.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 2.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta