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avrg: Illumina Body Map 2 (GSE30611)
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Results for ID4_TCF4_SNAI2
Z-value: 5.29
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Transcription factors associated with ID4_TCF4_SNAI2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF4 | hg38_v1_chr18_-_55588184_55588260 | -0.63 | 1.3e-04 | Click! |
| SNAI2 | hg38_v1_chr8_-_48921735_48921757 | -0.57 | 6.8e-04 | Click! |
| ID4 | hg38_v1_chr6_+_19837362_19837381 | -0.29 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ID4_TCF4_SNAI2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 21.4 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 0.8 | 20.9 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 1.4 | 18.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.3 | 17.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.6 | 17.6 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 1.1 | 17.0 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 2.3 | 16.4 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 1.3 | 16.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 16.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.3 | 16.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 106.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 75.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 52.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 37.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 34.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 34.2 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.9 | 33.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.3 | 32.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 31.8 | GO:0044438 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.5 | 30.3 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 39.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.4 | 34.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 32.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.5 | 29.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.5 | 22.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 21.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.9 | 19.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.4 | 18.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 17.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 49.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.5 | 42.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 26.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 14.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 10.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 9.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 9.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 8.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 7.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 6.9 | SIG CHEMOTAXIS | Genes related to chemotaxis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 69.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.1 | 46.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.5 | 31.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.6 | 30.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 30.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.3 | 28.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 24.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 22.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 21.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.1 | 20.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |