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avrg: Illumina Body Map 2 (GSE30611)

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Results for IRX6_IRX4

Z-value: 0.90

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.8 IRX6
IRX4
ENSG00000113430.10 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg38_v1_chr5_-_1882902_1882932-0.212.5e-01Click!
IRX6hg38_v1_chr16_+_55324191_55324208-0.115.6e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_46142834 3.11 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr1_-_150808251 2.55 ENST00000271651.8
ENST00000676970.1
ENST00000679260.1
ENST00000676751.1
ENST00000677887.1
CTSK
cathepsin K
chr14_-_106154113 2.44 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr15_+_88635626 2.05 ENST00000379224.10
ISG20
interferon stimulated exonuclease gene 20
chr5_+_55024250 2.01 ENST00000231009.3
GZMK
granzyme K
chr8_-_100712761 1.91 ENST00000517403.5
PABPC1
poly(A) binding protein cytoplasmic 1
chr1_+_26317950 1.49 ENST00000374213.3
CD52
CD52 molecule
chr12_-_76068933 1.48 ENST00000552056.5
NAP1L1
nucleosome assembly protein 1 like 1
chr6_+_144330797 1.46 ENST00000628146.2
UTRN
utrophin
chr14_+_21918161 1.43 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr15_-_51338575 1.34 ENST00000557858.5
ENST00000558328.5
ENST00000396402.6
ENST00000396404.8
ENST00000561075.5
ENST00000405011.6
ENST00000559980.5
ENST00000453807.6
CYP19A1
cytochrome P450 family 19 subfamily A member 1
chr3_-_27456743 1.28 ENST00000295736.9
ENST00000428386.5
ENST00000428179.1
SLC4A7
solute carrier family 4 member 7
chr1_-_3650063 1.23 ENST00000419924.2
ENST00000270708.12
WRAP73
WD repeat containing, antisense to TP73
chr6_+_43130583 1.20 ENST00000481946.5
PTK7
protein tyrosine kinase 7 (inactive)
chr12_+_32502114 0.95 ENST00000682739.1
ENST00000427716.7
ENST00000583694.2
FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_-_23154369 0.89 ENST00000453702.5
SLC7A8
solute carrier family 7 member 8
chr17_-_49646581 0.86 ENST00000510476.5
ENST00000503676.5
SPOP
speckle type BTB/POZ protein
chr6_-_107824294 0.85 ENST00000369020.8
ENST00000369022.6
SCML4
Scm polycomb group protein like 4
chr22_-_23754376 0.85 ENST00000398465.3
ENST00000248948.4
VPREB3
V-set pre-B cell surrogate light chain 3
chr14_-_21269392 0.84 ENST00000554891.5
ENST00000555883.5
ENST00000553753.5
ENST00000555914.5
ENST00000557336.1
ENST00000555215.5
ENST00000556628.5
ENST00000555137.5
ENST00000556226.5
ENST00000555309.5
ENST00000556142.5
ENST00000554969.5
ENST00000554455.5
ENST00000556513.5
ENST00000557201.5
ENST00000420743.6
ENST00000557768.1
ENST00000553300.6
ENST00000554383.5
ENST00000554539.5
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chrX_-_136880754 0.82 ENST00000565438.1
RBMX
RNA binding motif protein X-linked
chr17_-_31314040 0.73 ENST00000330927.5
EVI2B
ecotropic viral integration site 2B
chr14_-_23155302 0.72 ENST00000529705.6
SLC7A8
solute carrier family 7 member 8
chr17_-_31314066 0.72 ENST00000577894.1
EVI2B
ecotropic viral integration site 2B
chr12_-_10130143 0.66 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr14_-_23154422 0.66 ENST00000422941.6
SLC7A8
solute carrier family 7 member 8
chr7_-_55516045 0.65 ENST00000453256.5
VOPP1
VOPP1 WW domain binding protein
chr4_+_40193642 0.59 ENST00000617441.4
ENST00000503941.5
RHOH
ras homolog family member H
chr12_-_10130241 0.58 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chrX_+_15749848 0.57 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B
chr2_-_55917699 0.57 ENST00000634374.1
EFEMP1
EGF containing fibulin extracellular matrix protein 1
chr12_-_31792290 0.56 ENST00000340398.5
H3-5
H3.5 histone
chr7_-_16804987 0.56 ENST00000401412.5
ENST00000419304.7
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr1_-_38881587 0.54 ENST00000357771.5
ENST00000621281.1
GJA9
ENSG00000274944.4
gap junction protein alpha 9
novel protein
chr2_-_39121000 0.54 ENST00000402219.8
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
chr7_-_80512041 0.53 ENST00000398291.4
GNAT3
G protein subunit alpha transducin 3
chr12_+_53454764 0.53 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr3_-_169147734 0.52 ENST00000464456.5
MECOM
MDS1 and EVI1 complex locus
chr5_+_93583212 0.50 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr2_+_159733958 0.43 ENST00000409591.5
MARCHF7
membrane associated ring-CH-type finger 7
chr15_-_63156774 0.42 ENST00000462430.5
RPS27L
ribosomal protein S27 like
chr12_+_5432101 0.38 ENST00000423158.4
NTF3
neurotrophin 3
chr3_-_132684685 0.38 ENST00000512094.5
ENST00000632629.1
NPHP3
NPHP3-ACAD11
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr14_+_55661242 0.38 ENST00000553624.5
KTN1
kinectin 1
chr22_+_24270776 0.37 ENST00000437398.5
ENST00000421374.5
ENST00000314328.14
ENST00000651059.1
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1 like
chr4_-_142560669 0.36 ENST00000510812.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chrX_-_19970298 0.36 ENST00000379687.7
ENST00000379682.8
BCLAF3
BCLAF1 and THRAP3 family member 3
chr10_+_84425148 0.35 ENST00000493409.5
CCSER2
coiled-coil serine rich protein 2
chr14_+_55661272 0.34 ENST00000555573.5
KTN1
kinectin 1
chr20_+_45361936 0.31 ENST00000372727.5
ENST00000414310.5
SYS1
SYS1 golgi trafficking protein
chr13_+_111186773 0.29 ENST00000426073.6
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr16_+_727739 0.28 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase like
chr4_+_40192989 0.26 ENST00000508513.5
RHOH
ras homolog family member H
chr3_-_9952337 0.26 ENST00000411976.2
ENST00000412055.6
PRRT3
proline rich transmembrane protein 3
chr12_-_10130082 0.26 ENST00000533022.5
CLEC7A
C-type lectin domain containing 7A
chr1_-_8703219 0.26 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide repeats
chr11_+_60280577 0.26 ENST00000679988.1
MS4A4A
membrane spanning 4-domains A4A
chrX_+_100644183 0.25 ENST00000640889.1
ENST00000373004.5
SRPX2
sushi repeat containing protein X-linked 2
chr11_+_62123991 0.23 ENST00000533896.5
ENST00000278849.4
ENST00000394818.8
INCENP
inner centromere protein
chr6_+_116369837 0.22 ENST00000645988.1
DSE
dermatan sulfate epimerase
chr6_+_36871841 0.21 ENST00000359359.6
C6orf89
chromosome 6 open reading frame 89
chr15_+_80933358 0.21 ENST00000560027.1
CEMIP
cell migration inducing hyaluronidase 1
chr10_+_84424919 0.21 ENST00000543283.2
ENST00000494586.5
CCSER2
coiled-coil serine rich protein 2
chr11_+_60280531 0.21 ENST00000532114.6
MS4A4A
membrane spanning 4-domains A4A
chr3_+_111911604 0.20 ENST00000495180.1
PHLDB2
pleckstrin homology like domain family B member 2
chr9_-_92404690 0.18 ENST00000447356.1
OGN
osteoglycin
chr10_-_114144599 0.18 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr9_-_41189310 0.17 ENST00000456520.5
ENST00000377391.8
ENST00000613716.4
ENST00000617933.1
CBWD6
COBW domain containing 6
chr2_+_37342816 0.16 ENST00000650442.1
QPCT
glutaminyl-peptide cyclotransferase
chr17_-_3398410 0.15 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr1_+_212301806 0.14 ENST00000537030.3
PPP2R5A
protein phosphatase 2 regulatory subunit B'alpha
chr20_+_56358938 0.14 ENST00000371384.4
ENST00000437418.1
FAM210B
family with sequence similarity 210 member B
chr2_-_206718396 0.13 ENST00000452335.2
DYTN
dystrotelin
chr1_+_220094086 0.13 ENST00000366922.3
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr12_-_123633604 0.13 ENST00000534960.5
ENST00000424014.7
EIF2B1
eukaryotic translation initiation factor 2B subunit alpha
chr8_+_67064316 0.13 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
CSPP1
centrosome and spindle pole associated protein 1
chr10_+_116591010 0.11 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chrX_+_22136552 0.11 ENST00000682888.1
ENST00000684356.1
PHEX
phosphate regulating endopeptidase homolog X-linked
chr21_-_32813679 0.10 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr16_+_726936 0.09 ENST00000549114.5
ENST00000341413.8
ENST00000562187.1
ENST00000564537.5
ENST00000389703.8
HAGHL
hydroxyacylglutathione hydrolase like
chr18_-_59318544 0.08 ENST00000587244.5
CPLX4
complexin 4
chr15_+_66293217 0.08 ENST00000319194.9
ENST00000525134.6
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chr4_+_70592253 0.08 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr10_+_116590956 0.07 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr4_-_176269213 0.07 ENST00000296525.7
ASB5
ankyrin repeat and SOCS box containing 5
chr19_+_54497879 0.06 ENST00000412608.5
ENST00000610651.1
LAIR2
leukocyte associated immunoglobulin like receptor 2
chr4_+_112637456 0.06 ENST00000505034.5
ENST00000324052.10
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr6_+_149566356 0.05 ENST00000367419.10
GINM1
glycoprotein integral membrane 1
chr6_-_39322968 0.05 ENST00000507712.5
KCNK16
potassium two pore domain channel subfamily K member 16
chr6_-_49866527 0.04 ENST00000335847.9
CRISP1
cysteine rich secretory protein 1
chr2_+_225399684 0.04 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr4_+_157220795 0.03 ENST00000506284.5
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr16_+_727246 0.03 ENST00000561546.5
ENST00000564545.1
ENST00000567414.5
ENST00000568141.5
HAGHL
hydroxyacylglutathione hydrolase like
chr1_+_170935526 0.03 ENST00000367758.7
ENST00000367759.9
MROH9
maestro heat like repeat family member 9
chr4_+_70592295 0.03 ENST00000449493.2
AMBN
ameloblastin
chr7_+_831922 0.03 ENST00000421580.5
SUN1
Sad1 and UNC84 domain containing 1
chrX_+_48007796 0.03 ENST00000376940.3
SPACA5
sperm acrosome associated 5
chr6_-_49866453 0.02 ENST00000507853.5
CRISP1
cysteine rich secretory protein 1
chr9_+_68241854 0.02 ENST00000616550.4
ENST00000618217.4
ENST00000377342.9
ENST00000478048.5
ENST00000360171.11
CBWD3
COBW domain containing 3
chr2_-_182242031 0.02 ENST00000358139.6
PDE1A
phosphodiesterase 1A
chr15_+_66293541 0.02 ENST00000319212.9
ENST00000525109.1
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chr9_-_27573653 0.02 ENST00000379995.1
ENST00000647196.1
ENST00000619707.5
ENST00000379997.7
C9orf72
C9orf72-SMCR8 complex subunit
chr18_-_36798482 0.01 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr10_+_116590407 0.01 ENST00000531984.5
PNLIPRP1
pancreatic lipase related protein 1
chr4_+_129096144 0.00 ENST00000425929.6
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 1.3 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 2.6 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.9 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 3.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.6 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.9 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.5 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 1.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 1.5 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 1.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 1.5 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 2.3 GO:0015695 organic cation transport(GO:0015695)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.3 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.8 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 1.5 GO:0045730 respiratory burst(GO:0045730)
0.0 0.2 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 2.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.3 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.4 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.5 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 3.1 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.5 GO:0070938 contractile ring(GO:0070938)
0.0 1.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 2.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0000322 storage vacuole(GO:0000322)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 2.3 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.6 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway(GO:0071936) coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 2.3 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.3 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 1.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.5 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.5 GO:0017166 vinculin binding(GO:0017166)
0.0 2.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 2.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing