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avrg: Illumina Body Map 2 (GSE30611)
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Results for KLF16_SP2
Z-value: 3.39
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF16 | hg38_v1_chr19_-_1863497_1863587 | 0.18 | 3.2e-01 | Click! |
| SP2 | hg38_v1_chr17_+_47896150_47896262 | -0.10 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_1491140 Show fit | 11.81 |
ENST00000233596.8
ENST00000395479.10 |
receptor accessory protein 6 |
|
| chr14_+_94174284 Show fit | 8.73 |
ENST00000304338.8
|
protein phosphatase 4 regulatory subunit 4 |
|
| chr19_+_49930219 Show fit | 7.55 |
ENST00000596658.1
|
activating transcription factor 5 |
|
| chr13_-_113364085 Show fit | 7.05 |
ENST00000375431.9
|
growth hormone regulated TBC protein 1 |
|
| chr1_-_204152010 Show fit | 6.48 |
ENST00000367202.9
|
ethanolamine kinase 2 |
|
| chr7_-_100642721 Show fit | 6.02 |
ENST00000462107.1
|
transferrin receptor 2 |
|
| chr18_+_57435366 Show fit | 6.01 |
ENST00000491143.3
|
one cut homeobox 2 |
|
| chr7_-_100641507 Show fit | 5.90 |
ENST00000431692.5
ENST00000223051.8 |
transferrin receptor 2 |
|
| chr14_+_104085691 Show fit | 5.76 |
ENST00000546892.6
ENST00000551177.6 |
asparaginase |
|
| chr12_+_130337872 Show fit | 5.74 |
ENST00000245255.7
|
piwi like RNA-mediated gene silencing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.9 | GO:0007286 | spermatid development(GO:0007286) |
| 0.8 | 22.7 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 19.2 | GO:0006415 | translational termination(GO:0006415) |
| 0.2 | 17.3 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.5 | 16.5 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.4 | 16.3 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.6 | 16.2 | GO:0021924 | cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.6 | 16.0 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.2 | 15.2 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 14.0 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 75.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.4 | 29.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 25.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 24.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.2 | 22.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 19.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 17.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.8 | 14.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 14.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.3 | 13.4 | GO:0034451 | centriolar satellite(GO:0034451) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.3 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 40.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 33.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 21.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 2.0 | 16.3 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 16.0 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 1.6 | 14.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.4 | 14.3 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 1.9 | 13.6 | GO:0004122 | cystathionine beta-synthase activity(GO:0004122) |
| 1.3 | 11.6 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 12.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 11.9 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 11.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 10.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 7.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 7.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 7.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 6.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 24.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.2 | 23.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.5 | 23.0 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.5 | 20.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.5 | 17.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 15.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 15.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 13.9 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 13.9 | REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism |