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avrg: Illumina Body Map 2 (GSE30611)

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Results for KLF7

Z-value: 0.60

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.15 KLF7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg38_v1_chr2_-_207166159_207166196-0.115.4e-01Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_18902520 1.20 ENST00000538839.5
ENST00000290597.9
ENST00000375341.8
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr17_-_82098223 1.04 ENST00000306749.4
ENST00000635197.1
FASN
fatty acid synthase
chr1_-_18902724 1.00 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr17_-_82098187 0.99 ENST00000634990.1
FASN
fatty acid synthase
chrX_+_103376887 0.57 ENST00000372634.1
BEX3
brain expressed X-linked 3
chrX_+_103376389 0.52 ENST00000372645.3
ENST00000372635.1
BEX3
brain expressed X-linked 3
chrX_+_103376488 0.50 ENST00000361298.9
BEX3
brain expressed X-linked 3
chr12_-_49189053 0.49 ENST00000550767.6
ENST00000546918.1
ENST00000679733.1
ENST00000552924.2
ENST00000301071.12
TUBA1A
tubulin alpha 1a
chrX_-_93673558 0.47 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr21_+_31873010 0.46 ENST00000270112.7
HUNK
hormonally up-regulated Neu-associated kinase
chr7_+_49773632 0.46 ENST00000340652.5
VWC2
von Willebrand factor C domain containing 2
chr6_-_104859828 0.45 ENST00000519645.5
ENST00000262903.9
ENST00000369125.6
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
chr7_+_100483919 0.45 ENST00000300179.7
NYAP1
neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
chr5_+_141968886 0.39 ENST00000347642.7
RNF14
ring finger protein 14
chr7_+_128790749 0.36 ENST00000485998.6
CCDC136
coiled-coil domain containing 136
chr12_-_49188811 0.33 ENST00000295766.9
TUBA1A
tubulin alpha 1a
chr4_+_155758990 0.33 ENST00000505154.5
ENST00000652626.1
ENST00000502959.5
ENST00000264424.13
ENST00000505764.5
ENST00000507146.5
ENST00000503520.5
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr8_+_11284789 0.32 ENST00000221086.8
MTMR9
myotubularin related protein 9
chr4_+_155759365 0.29 ENST00000513437.1
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr18_+_74499329 0.29 ENST00000583216.5
ENST00000581912.1
ENST00000582589.5
CNDP2
carnosine dipeptidase 2
chr19_-_38899710 0.26 ENST00000447739.1
ENST00000407552.5
SIRT2
sirtuin 2
chr19_-_38899800 0.26 ENST00000414941.5
ENST00000358931.9
ENST00000392081.6
SIRT2
sirtuin 2
chr15_+_74130243 0.24 ENST00000561740.5
ENST00000435464.5
ISLR2
immunoglobulin superfamily containing leucine rich repeat 2
chr1_-_157138474 0.23 ENST00000326786.4
ETV3
ETS variant transcription factor 3
chr19_-_38899529 0.23 ENST00000249396.12
ENST00000437828.5
SIRT2
sirtuin 2
chr19_+_7629771 0.23 ENST00000594797.6
ENST00000456958.7
ENST00000601406.5
PET100
PET100 cytochrome c oxidase chaperone
chr3_+_179148099 0.22 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr2_-_97589711 0.22 ENST00000359901.8
ANKRD36B
ankyrin repeat domain 36B
chr2_-_95991793 0.20 ENST00000456556.5
ENST00000619511.1
ANKRD36C
ankyrin repeat domain 36C
chr6_-_109382460 0.20 ENST00000310786.10
CD164
CD164 molecule
chr12_-_6753134 0.19 ENST00000203630.10
MLF2
myeloid leukemia factor 2
chr14_-_100568070 0.19 ENST00000557378.6
ENST00000443071.6
ENST00000637646.1
BEGAIN
brain enriched guanylate kinase associated
chr5_+_141969190 0.18 ENST00000506004.5
ENST00000507291.1
RNF14
ring finger protein 14
chrX_-_25015924 0.18 ENST00000379044.5
ARX
aristaless related homeobox
chrX_+_93674194 0.18 ENST00000332647.5
ENST00000683942.1
FAM133A
family with sequence similarity 133 member A
chr17_+_40219325 0.17 ENST00000585043.5
ENST00000394103.7
WIPF2
WAS/WASL interacting protein family member 2
chr6_-_109382397 0.17 ENST00000512821.5
CD164
CD164 molecule
chr15_+_97960692 0.16 ENST00000268042.7
ARRDC4
arrestin domain containing 4
chr6_-_109382431 0.16 ENST00000324953.9
ENST00000275080.11
ENST00000413644.6
CD164
CD164 molecule
chr2_+_97113600 0.15 ENST00000620383.1
ANKRD36
ankyrin repeat domain 36
chr3_-_33097132 0.15 ENST00000307363.10
ENST00000307377.12
ENST00000440656.1
ENST00000436768.1
ENST00000342462.5
GLB1
TMPPE
galactosidase beta 1
transmembrane protein with metallophosphoesterase domain
chr17_+_43398984 0.15 ENST00000320033.5
ARL4D
ADP ribosylation factor like GTPase 4D
chr3_-_33097100 0.14 ENST00000415454.1
GLB1
galactosidase beta 1
chr2_+_97113496 0.14 ENST00000639293.1
ENST00000461153.7
ANKRD36
ankyrin repeat domain 36
chr8_+_89757789 0.14 ENST00000220751.5
RIPK2
receptor interacting serine/threonine kinase 2
chr7_+_27740095 0.13 ENST00000265393.10
ENST00000433216.6
ENST00000409980.5
ENST00000396319.7
TAX1BP1
Tax1 binding protein 1
chr3_+_173396107 0.13 ENST00000423427.1
NLGN1
neuroligin 1
chr2_-_97589862 0.13 ENST00000258459.11
ENST00000438709.6
ANKRD36B
ankyrin repeat domain 36B
chr19_+_18173148 0.12 ENST00000597802.2
IFI30
IFI30 lysosomal thiol reductase
chr6_-_33271835 0.11 ENST00000482399.5
ENST00000445902.3
VPS52
VPS52 subunit of GARP complex
chr17_-_50200166 0.10 ENST00000507689.1
COL1A1
collagen type I alpha 1 chain
chr7_-_47453184 0.09 ENST00000413551.1
TNS3
tensin 3
chr17_-_48817217 0.09 ENST00000393382.8
TTLL6
tubulin tyrosine ligase like 6
chr3_+_184100179 0.08 ENST00000335304.6
ENST00000431041.5
ENST00000436361.6
ENST00000440596.2
HTR3E
5-hydroxytryptamine receptor 3E
chr1_+_27830761 0.07 ENST00000311772.10
ENST00000236412.11
ENST00000373931.8
PPP1R8
protein phosphatase 1 regulatory subunit 8
chr1_-_157138388 0.05 ENST00000368192.9
ETV3
ETS variant transcription factor 3
chr5_+_173888335 0.05 ENST00000265085.10
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr9_-_125241327 0.04 ENST00000324460.7
ENST00000680272.1
ENST00000680032.1
HSPA5
heat shock protein family A (Hsp70) member 5
chr15_+_92393841 0.04 ENST00000268164.8
ENST00000539113.5
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr17_+_81239310 0.04 ENST00000431388.3
NDUFAF8
NADH:ubiquinone oxidoreductase complex assembly factor 8
chr2_+_69741974 0.03 ENST00000409920.5
ANXA4
annexin A4
chr17_+_40219276 0.02 ENST00000583268.1
ENST00000323571.9
WIPF2
WAS/WASL interacting protein family member 2
chr8_-_17246846 0.01 ENST00000628418.1
ENST00000361272.9
ENST00000523917.5
CNOT7
CCR4-NOT transcription complex subunit 7
chr17_-_42824248 0.01 ENST00000593205.5
ENST00000361523.8
ENST00000590099.6
ENST00000438274.7
BECN1
beclin 1
chr15_+_75282835 0.01 ENST00000434739.3
GOLGA6D
golgin A6 family member D

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 0.8 GO:0061433 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.1 2.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.3 GO:0051413 response to cortisone(GO:0051413)
0.0 0.1 GO:0097115 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.0 0.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.1 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0044691 tooth eruption(GO:0044691)
0.0 0.3 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:0021831 globus pallidus development(GO:0021759) embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0042587 glycogen granule(GO:0042587)
0.1 0.8 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.4 1.6 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.3 0.8 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 2.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation