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avrg: Illumina Body Map 2 (GSE30611)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 4.85
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Transcription factors associated with MAZ_ZNF281_GTF2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg38_v1_chr19_-_6393205_6393218 | 0.43 | 1.5e-02 | Click! |
| MAZ | hg38_v1_chr16_+_29808125_29808149 | 0.11 | 5.6e-01 | Click! |
| ZNF281 | hg38_v1_chr1_-_200409976_200410000 | 0.03 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 105.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 3.3 | 50.0 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.4 | 48.2 | GO:0007269 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.6 | 44.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 1.9 | 44.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 2.5 | 42.8 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 1.5 | 39.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.9 | 39.7 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.6 | 39.5 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 1.1 | 36.5 | GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 197.5 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.7 | 147.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.6 | 90.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 88.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 84.1 | GO:0045202 | synapse(GO:0045202) |
| 0.3 | 75.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.6 | 72.1 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 2.2 | 65.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 1.2 | 61.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.5 | 60.9 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 88.3 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.9 | 53.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 50.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.8 | 44.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 1.2 | 39.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 1.7 | 37.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.0 | 36.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 1.0 | 36.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 2.0 | 34.8 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 1.7 | 34.8 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 65.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 36.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.6 | 34.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.4 | 33.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 30.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 1.0 | 25.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 22.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 21.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.4 | 21.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 19.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 82.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.0 | 61.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.9 | 53.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 1.8 | 46.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.5 | 42.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.5 | 40.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.3 | 39.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.8 | 39.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.7 | 38.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 36.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |