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avrg: Illumina Body Map 2 (GSE30611)
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Results for NFATC4
Z-value: 2.30
Motif logo
Transcription factors associated with NFATC4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NFATC4
|
ENSG00000100968.14 | NFATC4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC4 | hg38_v1_chr14_+_24368020_24368341 | 0.72 | 4.1e-06 | Click! |
Activity profile of NFATC4 motif
Sorted Z-values of NFATC4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.0 | GO:0061552 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 1.5 | 7.7 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 1.5 | 6.1 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 1.2 | 3.7 | GO:0031104 | dendrite regeneration(GO:0031104) |
| 1.2 | 3.5 | GO:2000485 | negative regulation of glucagon secretion(GO:0070093) activation of protein kinase C activity(GO:1990051) regulation of glutamine transport(GO:2000485) |
| 1.1 | 3.4 | GO:1903280 | negative regulation of calcium:sodium antiporter activity(GO:1903280) |
| 1.1 | 8.9 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 1.0 | 2.9 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 1.0 | 2.9 | GO:0003193 | pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905) |
| 0.9 | 4.4 | GO:0044856 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.8 | 5.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.8 | 10.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.8 | 3.0 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.7 | 3.7 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.7 | 4.1 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.6 | 2.6 | GO:1903892 | negative regulation of ATF6-mediated unfolded protein response(GO:1903892) |
| 0.6 | 2.3 | GO:1902463 | protein localization to cell leading edge(GO:1902463) |
| 0.5 | 1.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.5 | 2.2 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.5 | 2.0 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.5 | 3.5 | GO:0018032 | protein amidation(GO:0018032) |
| 0.5 | 2.0 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.5 | 3.4 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.5 | 1.4 | GO:2001035 | tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037) |
| 0.5 | 3.2 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.4 | 4.3 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.4 | 3.0 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.4 | 1.3 | GO:0048058 | compound eye corneal lens development(GO:0048058) |
| 0.4 | 1.2 | GO:1903033 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.4 | 3.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.4 | 4.2 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.4 | 10.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 7.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 2.1 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.3 | 9.1 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.3 | 2.4 | GO:0097491 | sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) |
| 0.3 | 2.4 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.3 | 3.7 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.3 | 1.8 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
| 0.3 | 3.6 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.3 | 2.0 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.2 | 3.2 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.2 | 1.2 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 1.4 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.2 | 4.7 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.2 | 3.6 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway(GO:0035791) |
| 0.2 | 6.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.2 | 7.8 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 0.6 | GO:1990641 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641) |
| 0.2 | 0.9 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.2 | 1.7 | GO:0070944 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944) |
| 0.2 | 0.7 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.2 | 1.1 | GO:0003228 | atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009) |
| 0.2 | 2.1 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.2 | 1.9 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.2 | 1.8 | GO:0060426 | lung vasculature development(GO:0060426) |
| 0.2 | 4.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.4 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 0.1 | 3.4 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 1.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 0.8 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 2.4 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 7.2 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 1.7 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 0.1 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
| 0.1 | 3.8 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 1.4 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 0.1 | 0.5 | GO:0045918 | positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918) |
| 0.1 | 0.7 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.1 | 12.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 0.9 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.1 | 1.0 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.1 | 1.4 | GO:1903944 | negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 0.3 | GO:0070446 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.1 | 1.9 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.6 | GO:1903677 | regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690) |
| 0.1 | 1.2 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 1.0 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 0.6 | GO:0001757 | somite specification(GO:0001757) |
| 0.1 | 1.5 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.1 | 1.2 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.1 | 1.4 | GO:0035404 | histone-serine phosphorylation(GO:0035404) |
| 0.1 | 1.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 0.5 | GO:1990785 | response to water-immersion restraint stress(GO:1990785) |
| 0.1 | 3.2 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 0.6 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.1 | 3.8 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 1.4 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.1 | 0.6 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.1 | 1.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 1.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 2.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.9 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 0.7 | GO:0046959 | habituation(GO:0046959) |
| 0.1 | 2.0 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.5 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.1 | 0.5 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 10.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 0.2 | GO:0010983 | positive regulation of high-density lipoprotein particle clearance(GO:0010983) |
| 0.1 | 0.6 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.2 | GO:0044417 | translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836) |
| 0.1 | 4.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.2 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.1 | 6.2 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.1 | 1.1 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.1 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.1 | 0.2 | GO:1904908 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.1 | 0.4 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.0 | 0.2 | GO:0086053 | AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) |
| 0.0 | 1.6 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 0.9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.8 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 9.3 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.4 | GO:0001547 | antral ovarian follicle growth(GO:0001547) |
| 0.0 | 0.4 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.0 | 0.2 | GO:1904588 | thyroid-stimulating hormone signaling pathway(GO:0038194) cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229) |
| 0.0 | 0.3 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.0 | 2.9 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.0 | 0.3 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.0 | 1.9 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.4 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.0 | 4.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.8 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.3 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.0 | 4.2 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 8.0 | GO:0031638 | zymogen activation(GO:0031638) |
| 0.0 | 1.2 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.5 | GO:0042148 | strand invasion(GO:0042148) |
| 0.0 | 0.3 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.0 | 1.7 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 0.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 2.0 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.0 | 3.0 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 1.1 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.0 | 0.3 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.0 | 1.5 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 2.8 | GO:0003151 | outflow tract morphogenesis(GO:0003151) |
| 0.0 | 0.3 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 0.5 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.0 | 2.8 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 0.4 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 1.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 1.3 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.4 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) negative regulation of cellular response to hypoxia(GO:1900038) |
| 0.0 | 0.2 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.0 | 1.0 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.0 | 1.3 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 2.3 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.0 | 2.9 | GO:0048738 | cardiac muscle tissue development(GO:0048738) |
| 0.0 | 1.5 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.3 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.0 | 1.0 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.1 | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.0 | 1.1 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.0 | 0.1 | GO:0070378 | positive regulation of ERK5 cascade(GO:0070378) |
| 0.0 | 0.1 | GO:1903251 | multi-ciliated epithelial cell differentiation(GO:1903251) |
| 0.0 | 0.4 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.0 | 0.1 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.0 | 0.8 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.1 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.0 | 1.6 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.0 | 0.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.9 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 0.3 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.2 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.0 | 0.5 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.1 | GO:0048341 | paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.5 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.5 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.0 | 0.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 2.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.6 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.0 | 0.5 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.0 | 0.6 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.1 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.2 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.6 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.6 | GO:1901998 | toxin transport(GO:1901998) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 16.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 1.0 | 3.0 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.8 | 4.0 | GO:0071149 | TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149) |
| 0.7 | 7.0 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.7 | 2.0 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.6 | 8.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 2.0 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.4 | 3.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 11.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 2.9 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.3 | 0.9 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.3 | 4.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.3 | 1.0 | GO:0071757 | hexameric IgM immunoglobulin complex(GO:0071757) |
| 0.2 | 2.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.2 | 3.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 7.6 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.2 | 2.3 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 1.7 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 4.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 3.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.2 | 7.0 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 0.9 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 1.0 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 1.0 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.1 | 3.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.5 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.1 | 3.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 0.6 | GO:0045293 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.1 | 3.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.6 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.5 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 2.4 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 1.6 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 11.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.6 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.1 | 11.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 3.1 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 2.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 8.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 1.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 3.0 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 1.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 6.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 0.7 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.3 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.1 | 1.8 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 0.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.2 | GO:1990879 | CST complex(GO:1990879) |
| 0.0 | 1.9 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 3.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0036457 | keratohyalin granule(GO:0036457) |
| 0.0 | 2.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 4.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.1 | GO:0043159 | cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159) |
| 0.0 | 3.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.9 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.2 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.3 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 3.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 3.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 3.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 7.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.8 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.5 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.4 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 10.8 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 1.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.2 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 0.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 3.2 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.1 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 2.9 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 2.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 5.5 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.1 | GO:0042587 | glycogen granule(GO:0042587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 1.2 | 7.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 1.1 | 6.8 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 1.1 | 3.4 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.8 | 3.4 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 0.8 | 6.1 | GO:0043120 | interleukin-8 binding(GO:0019959) tumor necrosis factor binding(GO:0043120) |
| 0.7 | 4.1 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.7 | 3.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.6 | 3.7 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.6 | 2.9 | GO:0086020 | gap junction hemi-channel activity(GO:0055077) gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.6 | 5.0 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 3.5 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.5 | 1.4 | GO:1990175 | EH domain binding(GO:1990175) |
| 0.5 | 1.4 | GO:0050405 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 0.4 | 1.2 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.4 | 5.5 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.4 | 6.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 0.9 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.3 | 8.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.3 | 1.7 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.3 | 3.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 3.1 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.3 | 1.8 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.3 | 3.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 4.4 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 2.4 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.2 | 2.1 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 8.0 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.2 | 0.6 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 0.2 | 0.2 | GO:0086077 | gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077) |
| 0.2 | 1.3 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.2 | 3.6 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 0.8 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.2 | 5.4 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.2 | 3.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.2 | 0.9 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.1 | 0.7 | GO:0052829 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) |
| 0.1 | 1.1 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.1 | 1.0 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.1 | 5.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 3.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 1.0 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 1.5 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.3 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.1 | 0.6 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 2.6 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 0.6 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 0.8 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 0.9 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) |
| 0.1 | 0.3 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.1 | 3.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 0.3 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 0.1 | 1.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.7 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 2.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 2.4 | GO:0070402 | NADPH binding(GO:0070402) |
| 0.1 | 1.7 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 3.8 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 1.7 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 1.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.6 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.1 | 0.5 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.1 | 3.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 2.3 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 0.4 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.1 | 12.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 8.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 6.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.4 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.1 | 0.3 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 0.3 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 1.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.2 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 0.8 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.0 | 0.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.0 | 0.7 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 2.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.4 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 1.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 2.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 6.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 3.1 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.1 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.0 | 0.2 | GO:0005502 | 11-cis retinal binding(GO:0005502) |
| 0.0 | 0.2 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.0 | 1.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 11.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 5.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.1 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 1.1 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 1.0 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 2.1 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 1.7 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 2.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.1 | GO:0043273 | CTPase activity(GO:0043273) |
| 0.0 | 0.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.2 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.0 | 2.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.2 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.0 | 0.1 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.4 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 2.6 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.2 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 0.3 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.0 | 0.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.1 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.0 | 0.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.3 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.5 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.2 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.1 | GO:0030298 | receptor signaling protein tyrosine kinase activator activity(GO:0030298) |
| 0.0 | 0.1 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.8 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.6 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 1.6 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 1.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.1 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.0 | 0.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 2.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 8.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 12.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.2 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.5 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 3.7 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.2 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 1.0 | GO:0035064 | methylated histone binding(GO:0035064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 19.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 38.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 1.4 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.1 | 1.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 5.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 3.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 5.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.7 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.5 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.4 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 3.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 5.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 2.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.3 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.3 | 6.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 3.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 6.4 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 13.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 4.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 2.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 3.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.1 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 1.0 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 1.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 3.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 1.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 3.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 4.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 2.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.3 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.8 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 2.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.3 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |
| 0.0 | 0.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 1.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |