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avrg: Illumina Body Map 2 (GSE30611)
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Results for NR1I2
Z-value: 2.31
Motif logo
Transcription factors associated with NR1I2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NR1I2
|
ENSG00000144852.20 | NR1I2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1I2 | hg38_v1_chr3_+_119782094_119782114 | -0.08 | 6.8e-01 | Click! |
Activity profile of NR1I2 motif
Sorted Z-values of NR1I2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 12.5 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 1.8 | 7.2 | GO:0009956 | radial pattern formation(GO:0009956) |
| 1.2 | 3.7 | GO:0051695 | actin filament uncapping(GO:0051695) |
| 0.9 | 10.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.8 | 3.4 | GO:0060366 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 0.8 | 15.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 4.8 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.7 | 2.1 | GO:0060957 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 0.7 | 2.7 | GO:0097252 | oligodendrocyte apoptotic process(GO:0097252) |
| 0.6 | 2.5 | GO:0003290 | atrial septum secundum morphogenesis(GO:0003290) embryonic heart tube anterior/posterior pattern specification(GO:0035054) |
| 0.6 | 1.7 | GO:1903280 | negative regulation of calcium:sodium antiporter activity(GO:1903280) |
| 0.6 | 4.5 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 0.5 | 2.7 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.5 | 4.2 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.5 | 1.6 | GO:0014876 | response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.5 | 4.5 | GO:0036022 | limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) |
| 0.5 | 2.8 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.5 | 3.2 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.4 | 1.8 | GO:0033686 | positive regulation of luteinizing hormone secretion(GO:0033686) |
| 0.4 | 1.3 | GO:0071962 | mitotic sister chromatid cohesion, centromeric(GO:0071962) |
| 0.4 | 0.8 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.4 | 1.2 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 0.4 | 2.6 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.4 | 2.9 | GO:0035990 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.4 | 6.8 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.4 | 2.8 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.3 | 1.0 | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway(GO:0036323) |
| 0.3 | 8.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 1.4 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 0.3 | 2.0 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.3 | 2.6 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.3 | 1.3 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.3 | 1.6 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.3 | 2.2 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.3 | 0.9 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.3 | 3.3 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.3 | 3.5 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.3 | 0.8 | GO:0060664 | epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664) |
| 0.3 | 1.6 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.3 | 1.1 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.3 | 0.8 | GO:0014034 | neural crest cell fate commitment(GO:0014034) |
| 0.3 | 0.5 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.3 | 0.5 | GO:2001027 | negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 0.3 | 7.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 2.0 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
| 0.2 | 0.7 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.2 | 0.6 | GO:0060003 | copper ion export(GO:0060003) |
| 0.2 | 2.3 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
| 0.2 | 0.9 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.2 | 0.8 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 0.2 | 5.6 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.2 | 0.6 | GO:0015847 | putrescine transport(GO:0015847) |
| 0.2 | 0.6 | GO:0046041 | ITP metabolic process(GO:0046041) |
| 0.2 | 0.6 | GO:0007225 | patched ligand maturation(GO:0007225) signal maturation(GO:0035638) |
| 0.2 | 9.2 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.2 | 1.3 | GO:0060356 | leucine import(GO:0060356) |
| 0.2 | 1.1 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.2 | 8.9 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.2 | 0.9 | GO:0042851 | L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853) |
| 0.2 | 2.0 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
| 0.2 | 1.0 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.2 | 3.2 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.2 | 0.8 | GO:0030821 | negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) |
| 0.2 | 1.6 | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) |
| 0.2 | 0.6 | GO:0039003 | pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) thyroid-stimulating hormone secretion(GO:0070460) kidney field specification(GO:0072004) metanephric nephron tubule formation(GO:0072289) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594) positive regulation of thyroid hormone generation(GO:2000611) regulation of thyroid-stimulating hormone secretion(GO:2000612) |
| 0.1 | 1.6 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 0.7 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 1.8 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.1 | 1.4 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.1 | 0.8 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.1 | 1.4 | GO:0071799 | response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799) |
| 0.1 | 0.6 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.1 | 3.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.9 | GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340) response to interleukin-9(GO:0071104) |
| 0.1 | 2.5 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.1 | 12.1 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.1 | 1.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 2.9 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.1 | 0.8 | GO:1904862 | inhibitory synapse assembly(GO:1904862) |
| 0.1 | 4.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 9.5 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.1 | 2.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.1 | 0.8 | GO:0060161 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) positive regulation of dopamine receptor signaling pathway(GO:0060161) |
| 0.1 | 0.4 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 0.6 | GO:1904674 | positive regulation of somatic stem cell population maintenance(GO:1904674) |
| 0.1 | 1.6 | GO:0016264 | gap junction assembly(GO:0016264) |
| 0.1 | 0.3 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.1 | 0.4 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.1 | 0.3 | GO:0003218 | cardiac left ventricle formation(GO:0003218) |
| 0.1 | 0.6 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.1 | 0.5 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.5 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.1 | 2.8 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 2.8 | GO:1901881 | positive regulation of protein depolymerization(GO:1901881) |
| 0.1 | 1.0 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.2 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 0.1 | 0.7 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 0.3 | GO:1903367 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.1 | 0.4 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.1 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 4.5 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 1.1 | GO:0010623 | programmed cell death involved in cell development(GO:0010623) |
| 0.1 | 0.8 | GO:0021678 | third ventricle development(GO:0021678) |
| 0.1 | 0.2 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.1 | 1.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 0.3 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.1 | 1.0 | GO:0036309 | protein localization to M-band(GO:0036309) |
| 0.1 | 0.6 | GO:0001878 | response to yeast(GO:0001878) |
| 0.1 | 1.3 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 1.1 | GO:0003085 | negative regulation of systemic arterial blood pressure(GO:0003085) |
| 0.1 | 1.3 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.1 | 1.0 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 1.3 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 2.4 | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915) |
| 0.1 | 0.5 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.1 | 1.2 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.1 | 0.6 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.1 | 0.4 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 0.1 | 0.3 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.1 | 1.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.5 | GO:0061589 | calcium activated phosphatidylserine scrambling(GO:0061589) |
| 0.1 | 0.7 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.1 | 1.1 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.1 | 2.1 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.1 | 0.8 | GO:0002138 | retinoic acid biosynthetic process(GO:0002138) |
| 0.1 | 0.8 | GO:0003360 | brainstem development(GO:0003360) |
| 0.1 | 0.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 2.1 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.1 | 1.0 | GO:0001976 | neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976) |
| 0.1 | 0.5 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.1 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.1 | 0.8 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 0.3 | GO:0015783 | GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079) |
| 0.1 | 2.2 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 1.0 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 0.3 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.1 | 0.2 | GO:0035498 | carnosine metabolic process(GO:0035498) |
| 0.0 | 0.8 | GO:0000730 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.0 | 0.8 | GO:1904354 | negative regulation of telomere capping(GO:1904354) |
| 0.0 | 0.6 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 3.5 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.0 | 3.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.3 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.0 | 0.8 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 0.4 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 0.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.0 | 0.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.8 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.2 | GO:2000691 | regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.0 | 0.1 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.0 | 0.8 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.0 | 2.9 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 1.4 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.4 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.0 | 0.1 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.0 | 0.3 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.0 | 0.7 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.6 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.0 | 1.5 | GO:0034122 | negative regulation of toll-like receptor signaling pathway(GO:0034122) |
| 0.0 | 0.7 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 2.2 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 1.5 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.8 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 0.7 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.8 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.0 | 0.4 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.8 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.5 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 0.6 | GO:0000466 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466) |
| 0.0 | 0.1 | GO:0070346 | positive regulation of fat cell proliferation(GO:0070346) |
| 0.0 | 0.4 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.0 | 0.4 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.1 | GO:0072752 | cellular response to rapamycin(GO:0072752) |
| 0.0 | 2.3 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 10.3 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.6 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.4 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.0 | 0.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 2.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 2.3 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 0.1 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 0.0 | 0.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.5 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 1.5 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 0.4 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.0 | 0.1 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.0 | 0.1 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA(GO:0090625) |
| 0.0 | 2.9 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 0.1 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 0.1 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 0.0 | 0.5 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.0 | 1.0 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.0 | 0.5 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 2.5 | GO:0031638 | zymogen activation(GO:0031638) |
| 0.0 | 0.2 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 0.0 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.0 | 0.4 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 0.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.1 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.0 | 0.1 | GO:0010536 | positive regulation of activation of Janus kinase activity(GO:0010536) |
| 0.0 | 0.2 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.2 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.0 | 0.4 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) |
| 0.0 | 1.3 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.1 | GO:0070900 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.0 | 1.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 11.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.7 | 3.3 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.6 | 2.3 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
| 0.5 | 8.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 4.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.4 | 2.1 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.3 | 10.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 1.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.3 | 3.1 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.3 | 13.4 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 0.7 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.2 | 3.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 0.9 | GO:0032798 | Swi5-Sfr1 complex(GO:0032798) |
| 0.2 | 0.8 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.2 | 1.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 3.5 | GO:0045180 | basal cortex(GO:0045180) |
| 0.2 | 2.0 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.2 | 8.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 8.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.2 | 4.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 1.3 | GO:0031415 | NatA complex(GO:0031415) |
| 0.2 | 2.0 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 7.1 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 2.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.5 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.1 | 5.3 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 16.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 3.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 2.8 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 15.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 0.2 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 0.7 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 0.9 | GO:1990630 | IRE1-RACK1-PP2A complex(GO:1990630) |
| 0.1 | 5.2 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 1.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 1.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 3.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 0.4 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.1 | 0.4 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 3.4 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 0.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 13.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 10.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.3 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.0 | 1.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 1.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 9.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.3 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.2 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
| 0.0 | 2.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 1.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.2 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 1.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.6 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 1.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.9 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.0 | 2.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.4 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 15.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 4.3 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.3 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.6 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.2 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 2.5 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 0.3 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 2.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.8 | GO:0031012 | extracellular matrix(GO:0031012) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.7 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.5 | 3.1 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 0.5 | 2.0 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
| 0.5 | 2.8 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.5 | 1.4 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
| 0.4 | 1.3 | GO:0052858 | peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) |
| 0.4 | 2.5 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.4 | 2.2 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.4 | 3.2 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.3 | 1.0 | GO:0036332 | VEGF-A-activated receptor activity(GO:0036326) VEGF-B-activated receptor activity(GO:0036327) placental growth factor-activated receptor activity(GO:0036332) |
| 0.3 | 4.2 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.3 | 0.9 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 0.3 | 2.0 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.3 | 1.1 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.3 | 1.6 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.3 | 8.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 4.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.2 | 2.1 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.2 | 7.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.2 | 0.6 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.2 | 3.3 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.2 | 0.6 | GO:0015203 | polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) |
| 0.2 | 1.6 | GO:0035473 | lipase binding(GO:0035473) |
| 0.2 | 2.5 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 0.9 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 1.6 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.2 | 2.0 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.2 | 0.9 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 30.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 0.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.2 | 0.8 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.2 | 0.5 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.2 | 12.2 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.2 | 1.0 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.2 | 6.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.2 | 2.8 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.2 | 1.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 3.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.6 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.1 | 5.3 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 0.4 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 0.9 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 2.8 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.6 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 0.7 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.5 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 0.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.1 | 1.4 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 0.8 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.1 | 0.4 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.1 | 1.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 11.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 5.6 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 3.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.7 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.1 | 0.9 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.7 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.1 | 0.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.8 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 6.0 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.1 | 1.0 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 0.4 | GO:0008267 | poly-glutamine tract binding(GO:0008267) |
| 0.1 | 0.8 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 0.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.6 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.1 | 1.0 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 1.3 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 0.5 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 3.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 3.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 1.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 1.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.9 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.1 | 0.3 | GO:0005457 | GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080) |
| 0.1 | 0.4 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 1.1 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 0.5 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 1.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 3.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.4 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.1 | 1.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 4.8 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 2.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 2.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.5 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 1.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.0 | 0.3 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.0 | 0.4 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.5 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 21.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 1.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.1 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.8 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 11.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.3 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 0.5 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.0 | 0.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 1.3 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 0.4 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.3 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.0 | 0.1 | GO:0008413 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539) |
| 0.0 | 0.5 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.0 | 0.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.0 | 0.4 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.2 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.0 | 0.6 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 0.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.6 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 1.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.3 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.7 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.5 | GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627) |
| 0.0 | 0.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 1.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 1.0 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 0.0 | 0.6 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 4.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.2 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 1.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 25.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 7.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 12.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.5 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 8.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 11.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 4.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.1 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 2.1 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 0.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.6 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 2.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 3.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.6 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 5.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.7 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 0.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.3 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 10.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 8.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 2.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 10.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 22.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 12.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 3.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.1 | 4.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.0 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 2.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 1.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 0.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 2.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.8 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 3.1 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 2.6 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 3.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 2.3 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 1.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.3 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 2.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 3.0 | REACTOME REGULATION OF APOPTOSIS | Genes involved in Regulation of Apoptosis |
| 0.0 | 1.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 1.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 2.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.7 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.6 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 0.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 2.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.5 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.3 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.6 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |