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avrg: Illumina Body Map 2 (GSE30611)
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Results for NR2E3
Z-value: 2.89
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Transcription factors associated with NR2E3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2E3 | hg38_v1_chr15_+_71810539_71810592 | 0.26 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.5 | 17.8 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 16.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.8 | 16.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.6 | 16.4 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.8 | 13.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.8 | 11.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.7 | 11.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.7 | 10.9 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.4 | 10.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 39.2 | GO:0043005 | neuron projection(GO:0043005) |
| 0.2 | 26.1 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 21.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 19.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 19.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.9 | 16.8 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.8 | 15.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.4 | 13.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.4 | 13.3 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.8 | 11.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 2.2 | 22.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.6 | 18.2 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.6 | 17.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 15.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 15.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.5 | 15.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 14.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 13.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.1 | 11.0 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 14.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 12.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 10.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 7.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 7.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 7.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 5.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 13.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 13.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 11.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 10.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 9.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 9.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 8.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 7.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 5.6 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |