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avrg: Illumina Body Map 2 (GSE30611)
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Results for NR2E3
Z-value: 2.89
Motif logo
Transcription factors associated with NR2E3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NR2E3
|
ENSG00000278570.5 | NR2E3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2E3 | hg38_v1_chr15_+_71810539_71810592 | 0.26 | 1.5e-01 | Click! |
Activity profile of NR2E3 motif
Sorted Z-values of NR2E3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 16.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.6 | 7.7 | GO:1904397 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 2.3 | 9.2 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.9 | 7.5 | GO:0098971 | anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971) |
| 1.6 | 16.4 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 1.4 | 5.7 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 1.4 | 10.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.9 | 4.4 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.9 | 2.6 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.8 | 13.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.8 | 11.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.7 | 11.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.7 | 10.9 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.7 | 6.6 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.6 | 3.9 | GO:0035603 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) |
| 0.6 | 4.4 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.6 | 3.7 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.6 | 1.8 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.6 | 4.1 | GO:0035900 | isocitrate metabolic process(GO:0006102) response to isolation stress(GO:0035900) |
| 0.6 | 2.3 | GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.6 | 9.8 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.6 | 4.0 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.6 | 3.4 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.5 | 7.1 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.5 | 17.8 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.5 | 6.8 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.5 | 3.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) synaptic transmission involved in micturition(GO:0060084) |
| 0.5 | 2.9 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.5 | 3.4 | GO:0050916 | sensory perception of sweet taste(GO:0050916) |
| 0.5 | 5.3 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.5 | 1.4 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.5 | 2.3 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.4 | 1.3 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.4 | 1.8 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.4 | 1.3 | GO:2000742 | anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 0.4 | 5.2 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.4 | 24.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.4 | 5.4 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.4 | 3.2 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.4 | 2.8 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.4 | 8.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 3.4 | GO:2001023 | regulation of response to drug(GO:2001023) |
| 0.4 | 1.9 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.4 | 1.1 | GO:0060151 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.4 | 1.8 | GO:0061364 | apoptotic process involved in luteolysis(GO:0061364) |
| 0.4 | 4.6 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) |
| 0.3 | 1.7 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.3 | 1.8 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 0.3 | 2.6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.3 | 1.5 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.3 | 1.4 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.3 | 4.5 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.3 | 0.8 | GO:1901383 | negative regulation of chorionic trophoblast cell proliferation(GO:1901383) |
| 0.3 | 1.9 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.3 | 6.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 2.4 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.3 | 7.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 2.8 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.3 | 3.0 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 0.3 | 3.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 0.7 | GO:0099403 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.2 | 2.1 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.2 | 3.2 | GO:1903421 | regulation of synaptic vesicle recycling(GO:1903421) |
| 0.2 | 3.2 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.2 | 4.1 | GO:0021984 | adenohypophysis development(GO:0021984) |
| 0.2 | 0.7 | GO:1902997 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.2 | 1.7 | GO:2000670 | positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.2 | 3.6 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.2 | 0.6 | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 0.2 | 1.2 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.2 | 1.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.2 | 2.2 | GO:0002778 | antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) |
| 0.2 | 5.6 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.2 | 1.1 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 0.2 | 1.3 | GO:0015888 | thiamine transport(GO:0015888) |
| 0.2 | 0.6 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.2 | 3.7 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.2 | 2.2 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.2 | 0.9 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) |
| 0.2 | 1.1 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.2 | 1.2 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.2 | 10.0 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.2 | 4.7 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 0.3 | GO:0002860 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.2 | 2.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 1.7 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.2 | 2.0 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.2 | 1.8 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.2 | 6.3 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.2 | 1.8 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.2 | 0.6 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737) |
| 0.2 | 1.5 | GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.1 | 0.6 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.1 | 1.2 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.1 | 1.0 | GO:1903756 | positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 1.4 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.1 | 10.3 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.1 | 3.5 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 1.2 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.1 | 0.7 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.1 | 1.6 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.1 | 0.6 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.1 | 4.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.1 | GO:1902019 | regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 0.1 | 0.4 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 1.0 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.1 | 0.6 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 0.9 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 1.1 | GO:0060025 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) regulation of synaptic activity(GO:0060025) |
| 0.1 | 2.1 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 0.1 | 0.4 | GO:0006175 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) |
| 0.1 | 3.4 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 0.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.6 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 0.8 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 0.1 | 0.3 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 1.0 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 2.5 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 1.0 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.1 | 2.0 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.1 | 0.3 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 0.1 | 1.4 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 2.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 0.3 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.1 | 0.9 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 2.0 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.1 | 16.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 6.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 0.4 | GO:1903974 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.1 | 0.6 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.1 | 1.5 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 2.4 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 0.8 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.1 | 0.2 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.1 | 2.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 0.9 | GO:0021877 | forebrain neuron fate commitment(GO:0021877) commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 2.1 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 0.6 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.1 | 2.1 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.1 | 0.7 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.1 | 5.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 4.1 | GO:0042461 | photoreceptor cell development(GO:0042461) |
| 0.1 | 1.1 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.1 | 0.9 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.1 | 0.6 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.1 | 4.0 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 0.4 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.1 | 0.9 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.1 | 3.9 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.1 | 0.4 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.1 | 0.7 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.3 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.1 | 0.9 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 1.4 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 3.2 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 0.3 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.0 | 0.6 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.0 | 0.7 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.0 | 2.5 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.8 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.0 | 3.2 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.7 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.0 | 1.1 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 2.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 0.9 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 1.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 2.1 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 0.3 | GO:0032916 | positive regulation of transforming growth factor beta3 production(GO:0032916) negative regulation of lung blood pressure(GO:0061767) |
| 0.0 | 1.7 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.0 | 0.3 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 0.0 | 1.2 | GO:0050807 | regulation of synapse organization(GO:0050807) |
| 0.0 | 0.7 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 0.2 | GO:1990418 | response to sodium phosphate(GO:1904383) response to insulin-like growth factor stimulus(GO:1990418) |
| 0.0 | 2.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.4 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.0 | 4.4 | GO:0050770 | regulation of axonogenesis(GO:0050770) |
| 0.0 | 2.1 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 1.5 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.0 | 0.5 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 3.1 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.4 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 1.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.4 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.6 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 2.0 | GO:0003341 | cilium movement(GO:0003341) |
| 0.0 | 0.6 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.0 | 0.3 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 1.8 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 5.2 | GO:0061337 | cardiac conduction(GO:0061337) |
| 0.0 | 0.6 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 0.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.4 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 1.0 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.0 | 0.5 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 1.1 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 0.1 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.0 | 0.3 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.0 | 0.2 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 3.3 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.4 | GO:1904778 | protein localization to cell cortex(GO:0072697) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 0.3 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 2.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.3 | GO:0001832 | blastocyst growth(GO:0001832) |
| 0.0 | 0.7 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.6 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.2 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.0 | 0.9 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.9 | GO:0090102 | cochlea development(GO:0090102) |
| 0.0 | 0.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 1.2 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.4 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.1 | GO:2001295 | negative regulation of fatty acid beta-oxidation(GO:0031999) malonyl-CoA biosynthetic process(GO:2001295) |
| 0.0 | 0.1 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.0 | 1.3 | GO:0008016 | regulation of heart contraction(GO:0008016) |
| 0.0 | 6.0 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.0 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 0.2 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.2 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.5 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.0 | 1.6 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.0 | 0.9 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 1.7 | GO:0016049 | cell growth(GO:0016049) |
| 0.0 | 0.1 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 16.8 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.4 | 5.6 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.9 | 3.7 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.8 | 11.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.8 | 15.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.6 | 1.8 | GO:0001534 | radial spoke(GO:0001534) |
| 0.6 | 1.8 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 0.6 | 4.7 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.5 | 1.1 | GO:0061673 | mitotic spindle astral microtubule(GO:0061673) |
| 0.5 | 3.7 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.5 | 1.5 | GO:0030849 | autosome(GO:0030849) |
| 0.4 | 13.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.4 | 13.3 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.4 | 9.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 1.2 | GO:0038038 | G-protein coupled receptor homodimeric complex(GO:0038038) |
| 0.3 | 1.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 6.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 9.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.2 | 0.9 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 1.8 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 4.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 26.1 | GO:0030315 | T-tubule(GO:0030315) |
| 0.2 | 1.4 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.2 | 2.8 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.2 | 0.3 | GO:0031906 | late endosome lumen(GO:0031906) |
| 0.2 | 2.4 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.2 | 0.8 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.2 | 3.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 0.6 | GO:0039713 | viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517) |
| 0.2 | 5.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 1.5 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.2 | 0.6 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 0.7 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 2.5 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.1 | 2.8 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.6 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 1.0 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 19.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 3.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 2.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 10.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 6.4 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 2.6 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 4.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 3.0 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 8.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 1.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 2.0 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 4.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 3.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 0.8 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 1.5 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.1 | 1.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.8 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 8.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 21.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 1.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 2.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.6 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 2.7 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 9.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 19.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 0.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 2.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.1 | 1.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 0.6 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 3.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.2 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.6 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 6.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 0.4 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 9.6 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 7.1 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 0.3 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 0.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 7.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 39.2 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 2.6 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 8.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.8 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 3.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.6 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 4.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.9 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.0 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.9 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 0.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.7 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 1.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.4 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 22.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.9 | 7.7 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 1.1 | 5.7 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 1.1 | 11.0 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 1.0 | 4.1 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.9 | 2.6 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.8 | 7.5 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.8 | 2.3 | GO:0099530 | G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.7 | 5.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.6 | 18.2 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.6 | 4.5 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.6 | 5.6 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.6 | 17.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.6 | 2.2 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.5 | 15.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.5 | 2.8 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.4 | 15.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.4 | 1.2 | GO:0010348 | lithium:proton antiporter activity(GO:0010348) |
| 0.4 | 3.7 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.4 | 27.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.4 | 2.0 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.4 | 13.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.4 | 1.2 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.4 | 1.4 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.4 | 1.8 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.3 | 1.3 | GO:0033265 | choline binding(GO:0033265) |
| 0.3 | 3.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.3 | 1.9 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.3 | 8.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.3 | 1.2 | GO:0099583 | postsynaptic neurotransmitter receptor activity(GO:0098960) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.3 | 3.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 1.4 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.3 | 0.8 | GO:0038100 | nodal binding(GO:0038100) |
| 0.3 | 4.6 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.3 | 6.5 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.3 | 3.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 2.3 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.2 | 0.7 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 1.5 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.2 | 9.8 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.2 | 7.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 1.1 | GO:0008267 | poly-glutamine tract binding(GO:0008267) |
| 0.2 | 0.9 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.2 | 1.5 | GO:0000995 | transcription factor activity, core RNA polymerase III binding(GO:0000995) |
| 0.2 | 5.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 0.8 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.2 | 10.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 0.8 | GO:0051500 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.2 | 2.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 3.4 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.2 | 1.4 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.2 | 5.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 1.8 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 1.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.2 | 1.7 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.2 | 1.8 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.1 | 4.1 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.1 | 0.4 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.1 | 5.7 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.8 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 0.6 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 1.8 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
| 0.1 | 2.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 0.3 | GO:0097604 | temperature-gated cation channel activity(GO:0097604) |
| 0.1 | 2.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 2.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 3.6 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 3.0 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 0.4 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.1 | 0.9 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 0.6 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 2.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 1.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 2.0 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 0.6 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 0.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 3.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 1.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 3.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 1.0 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.1 | 0.8 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 2.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.3 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.1 | 0.7 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.1 | 6.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 0.9 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.1 | 1.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.1 | 3.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.6 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 2.0 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 15.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 1.0 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 0.6 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 1.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 0.6 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 1.1 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 0.7 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.1 | 4.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 0.9 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.4 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.1 | 0.3 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 0.1 | 0.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 1.8 | GO:0015172 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.1 | 0.2 | GO:0000035 | acyl binding(GO:0000035) |
| 0.1 | 0.3 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.0 | 0.5 | GO:0019158 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.6 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 1.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 3.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 2.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.4 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.7 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.9 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 2.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.9 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 0.3 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 2.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 3.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.8 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 3.2 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 1.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.3 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 3.2 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.8 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 2.0 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 1.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 3.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.0 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.3 | GO:0022850 | serotonin-gated cation channel activity(GO:0022850) |
| 0.0 | 0.6 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 14.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 3.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.0 | 0.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 2.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 2.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.2 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 0.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.1 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.0 | 0.2 | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144) |
| 0.0 | 5.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 1.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.7 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 7.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 7.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 1.2 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 14.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 12.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 10.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.2 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 2.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 2.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 7.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 2.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.1 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 2.3 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 1.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 4.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 0.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.8 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.4 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.5 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 11.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.3 | 9.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.3 | 13.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 8.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 10.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 0.7 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.2 | 9.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 7.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 3.9 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.2 | 1.4 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 1.9 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 3.8 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 5.6 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 2.6 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.1 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.1 | 2.3 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 4.1 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 3.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 4.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.0 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 2.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 2.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 2.6 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.1 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 13.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 3.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 2.1 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.4 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 5.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.6 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.5 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 2.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 2.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 4.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 1.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.7 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 0.4 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |