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avrg: Illumina Body Map 2 (GSE30611)

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Results for PAX1_PAX9

Z-value: 0.97

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.14 PAX1
PAX9
ENSG00000198807.13 PAX9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX1hg38_v1_chr20_+_21705651_21705673-0.459.2e-03Click!
PAX9hg38_v1_chr14_+_36657664_366576770.067.5e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr22_+_22895368 3.01 ENST00000390321.2
IGLC1
immunoglobulin lambda constant 1
chr4_+_122826824 2.05 ENST00000608478.1
ENST00000644866.2
FGF2
fibroblast growth factor 2
chr8_-_23404076 2.02 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
LOXL2
lysyl oxidase like 2
chr2_+_118942290 2.00 ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr4_+_122826679 1.98 ENST00000264498.8
FGF2
fibroblast growth factor 2
chr8_-_23425282 1.63 ENST00000524144.5
LOXL2
lysyl oxidase like 2
chr10_+_71319249 1.37 ENST00000373189.6
ENST00000479577.2
SLC29A3
solute carrier family 29 member 3
chr8_-_23425307 1.37 ENST00000520871.1
LOXL2
lysyl oxidase like 2
chr14_-_68794597 1.35 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein like 1
chr18_-_50287570 1.17 ENST00000586837.1
ENST00000412036.6
ENST00000589940.5
ENST00000587396.1
ENST00000591474.5
ENST00000285106.11
CXXC1
CXXC finger protein 1
chr10_-_43409160 1.14 ENST00000337970.7
ENST00000682386.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr8_-_100952918 1.01 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr2_-_162074182 0.97 ENST00000360534.8
DPP4
dipeptidyl peptidase 4
chr2_-_162074394 0.95 ENST00000676810.1
DPP4
dipeptidyl peptidase 4
chr8_-_100953331 0.92 ENST00000353245.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr18_-_49492305 0.88 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr8_-_100952876 0.87 ENST00000437293.5
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_+_30434602 0.81 ENST00000413724.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr10_+_30434021 0.79 ENST00000542547.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr3_+_133805789 0.73 ENST00000678299.1
SRPRB
SRP receptor subunit beta
chr2_-_162074050 0.72 ENST00000676768.1
DPP4
dipeptidyl peptidase 4
chr10_+_30434176 0.64 ENST00000263056.6
ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr8_-_120811988 0.64 ENST00000517992.2
SNTB1
syntrophin beta 1
chr4_+_74365136 0.61 ENST00000244869.3
EREG
epiregulin
chr18_-_49491586 0.61 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr14_-_91417805 0.60 ENST00000389857.11
ENST00000553403.1
CCDC88C
coiled-coil domain containing 88C
chr17_+_39200275 0.58 ENST00000225430.9
RPL19
ribosomal protein L19
chr6_-_137173644 0.58 ENST00000296980.7
ENST00000349184.8
ENST00000339602.3
IL22RA2
interleukin 22 receptor subunit alpha 2
chr17_+_39200302 0.57 ENST00000579374.5
RPL19
ribosomal protein L19
chr17_+_39200334 0.56 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr10_+_30434116 0.54 ENST00000415139.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr17_+_39200507 0.52 ENST00000678573.1
RPL19
ribosomal protein L19
chr11_-_126268810 0.49 ENST00000332118.11
SRPRA
SRP receptor subunit alpha
chr14_+_64388296 0.39 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr2_-_174847765 0.36 ENST00000443238.6
CHN1
chimerin 1
chr12_+_57434778 0.33 ENST00000309668.3
INHBC
inhibin subunit beta C
chr3_+_195720974 0.33 ENST00000447234.7
ENST00000320736.10
MUC20
mucin 20, cell surface associated
chr9_-_122228845 0.32 ENST00000394319.8
ENST00000340587.7
LHX6
LIM homeobox 6
chr11_+_61755372 0.32 ENST00000265460.9
MYRF
myelin regulatory factor
chr3_-_57079287 0.30 ENST00000338458.8
ENST00000468727.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr11_-_126268913 0.28 ENST00000532259.1
SRPRA
SRP receptor subunit alpha
chr22_-_17773976 0.24 ENST00000317361.11
BID
BH3 interacting domain death agonist
chr6_+_132570322 0.24 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chrX_-_154479253 0.23 ENST00000357360.4
LAGE3
L antigen family member 3
chr17_+_78378633 0.23 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr17_+_41812974 0.21 ENST00000321562.9
FKBP10
FKBP prolyl isomerase 10
chr17_-_3557798 0.21 ENST00000301365.8
ENST00000572519.1
ENST00000576742.6
TRPV3
transient receptor potential cation channel subfamily V member 3
chr17_-_35487831 0.19 ENST00000260908.12
ENSG00000205045.11
schlafen family member 12 like
chr2_-_174847250 0.19 ENST00000409089.7
CHN1
chimerin 1
chr1_+_26432299 0.18 ENST00000427245.6
ENST00000236342.12
ENST00000525682.6
ENST00000526219.5
ENST00000374185.7
ENST00000360009.6
ENST00000533087.5
ENST00000531312.5
ENST00000525165.5
ENST00000525326.5
ENST00000525546.5
ENST00000436153.6
ENST00000530781.5
DHDDS
dehydrodolichyl diphosphate synthase subunit
chr17_-_35487739 0.17 ENST00000628453.3
ENSG00000205045.11
schlafen family member 12 like
chr12_+_57745017 0.16 ENST00000547992.5
ENST00000552816.5
ENST00000257910.8
ENST00000547472.5
TSPAN31
tetraspanin 31
chr12_+_131929219 0.15 ENST00000322060.9
PUS1
pseudouridine synthase 1
chr7_-_144835981 0.14 ENST00000360057.7
ENST00000378099.7
ENST00000639328.1
TPK1
thiamin pyrophosphokinase 1
chr2_+_68643579 0.14 ENST00000303786.5
PROKR1
prokineticin receptor 1
chr19_-_38847423 0.13 ENST00000647557.1
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr12_+_131929194 0.12 ENST00000443358.6
PUS1
pseudouridine synthase 1
chr1_-_1574824 0.11 ENST00000291386.4
SSU72
SSU72 homolog, RNA polymerase II CTD phosphatase
chr17_+_41812673 0.11 ENST00000585664.5
ENST00000585922.5
ENST00000429461.5
FKBP10
FKBP prolyl isomerase 10
chrX_-_149540900 0.10 ENST00000608355.1
ENST00000651111.1
LINC00893
ENSG00000241489.8
long intergenic non-protein coding RNA 893
novel protein
chr4_-_170090153 0.10 ENST00000509167.5
ENST00000353187.6
ENST00000507375.5
ENST00000515480.5
AADAT
aminoadipate aminotransferase
chr7_+_142770960 0.10 ENST00000632805.1
ENST00000633969.1
ENST00000539842.6
PRSS2
serine protease 2
chr6_+_34889228 0.09 ENST00000360359.5
ENST00000649117.1
ENST00000650178.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr3_-_57079253 0.09 ENST00000468466.1
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr1_+_26432803 0.08 ENST00000430232.5
DHDDS
dehydrodolichyl diphosphate synthase subunit
chr2_+_241809065 0.07 ENST00000415936.5
NEU4
neuraminidase 4
chr1_+_44674688 0.07 ENST00000418644.5
ENST00000458657.6
ENST00000535358.6
ENST00000441519.5
ENST00000445071.5
ARMH1
armadillo like helical domain containing 1
chr1_-_152115443 0.07 ENST00000614923.1
TCHH
trichohyalin
chr9_+_33750669 0.04 ENST00000361005.10
ENST00000342836.9
ENST00000429677.8
PRSS3
serine protease 3
chrX_-_132957245 0.04 ENST00000640529.1
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr6_-_170584581 0.03 ENST00000392090.6
ENST00000542896.5
ENST00000453163.6
ENST00000537445.5
ENST00000541970.6
PDCD2
programmed cell death 2
chr3_+_31532901 0.02 ENST00000295770.4
STT3B
STT3 oligosaccharyltransferase complex catalytic subunit B
chr3_+_195720867 0.02 ENST00000436408.6
MUC20
mucin 20, cell surface associated
chr2_-_39187707 0.01 ENST00000451199.5
CDKL4
cyclin dependent kinase like 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0042660 positive regulation of cell fate specification(GO:0042660)
1.3 5.0 GO:0018277 protein deamination(GO:0018277)
0.3 1.4 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.3 2.6 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
0.2 0.6 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 2.8 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.1 0.3 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.1 0.3 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 1.4 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 2.2 GO:0097421 liver regeneration(GO:0097421)
0.0 2.0 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 3.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 2.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.3 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 2.7 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 3.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 3.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.0 GO:0005604 basement membrane(GO:0005604)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.4 2.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 1.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 1.5 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 4.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.3 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 2.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.0 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 3.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 4.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 2.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 4.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)