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avrg: Illumina Body Map 2 (GSE30611)

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Results for PBX2

Z-value: 0.55

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.12 PBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg38_v1_chr6_-_32190170_321902140.057.7e-01Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_44978789 1.14 ENST00000448778.1
ENST00000298295.4
DEPP1
DEPP1 autophagy regulator
chr8_-_6563409 1.11 ENST00000325203.9
ANGPT2
angiopoietin 2
chr17_+_7855055 1.04 ENST00000574668.1
ENST00000301599.7
TMEM88
transmembrane protein 88
chr11_-_111923722 0.90 ENST00000527950.5
CRYAB
crystallin alpha B
chr5_+_55024250 0.69 ENST00000231009.3
GZMK
granzyme K
chr2_+_203867764 0.68 ENST00000648405.2
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr2_+_203867943 0.65 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr2_+_233692881 0.60 ENST00000305139.11
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr22_-_30246739 0.58 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr2_-_99301195 0.53 ENST00000308528.9
LYG1
lysozyme g1
chr7_+_142791635 0.52 ENST00000633705.1
TRBC1
T cell receptor beta constant 1
chr2_-_178794944 0.51 ENST00000436599.1
TTN
titin
chr2_+_233693659 0.46 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr1_+_101236860 0.46 ENST00000475821.2
S1PR1
sphingosine-1-phosphate receptor 1
chr14_-_23155302 0.46 ENST00000529705.6
SLC7A8
solute carrier family 7 member 8
chr1_+_101237009 0.44 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chr5_-_39462288 0.44 ENST00000511792.5
DAB2
DAB adaptor protein 2
chr2_+_33458043 0.41 ENST00000437184.5
RASGRP3
RAS guanyl releasing protein 3
chr11_-_104898670 0.39 ENST00000422698.6
CASP12
caspase 12 (gene/pseudogene)
chr7_+_134843884 0.35 ENST00000445569.6
CALD1
caldesmon 1
chr2_+_33436304 0.34 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr1_+_61952036 0.33 ENST00000646453.1
ENST00000635137.1
PATJ
PATJ crumbs cell polarity complex component
chr3_-_52830664 0.32 ENST00000266041.9
ENST00000406595.5
ENST00000485816.5
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
chr11_+_68460712 0.31 ENST00000528635.5
ENST00000533127.5
ENST00000529907.5
ENST00000529344.5
ENST00000534534.5
ENST00000524845.5
ENST00000393800.7
ENST00000265637.8
ENST00000524904.5
ENST00000393801.7
ENST00000265636.9
ENST00000529710.5
PPP6R3
protein phosphatase 6 regulatory subunit 3
chr16_+_1078781 0.31 ENST00000293897.5
SSTR5
somatostatin receptor 5
chr7_-_151519891 0.31 ENST00000262187.10
RHEB
Ras homolog, mTORC1 binding
chr13_-_106568107 0.30 ENST00000400198.8
ARGLU1
arginine and glutamate rich 1
chr14_+_64388296 0.28 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr7_-_151520080 0.27 ENST00000496004.5
RHEB
Ras homolog, mTORC1 binding
chr11_+_31816266 0.23 ENST00000644607.1
ENST00000646221.1
ENST00000643671.1
ENST00000643931.1
ENST00000642614.1
ENST00000642818.1
ENST00000645848.1
ENST00000506388.2
ENST00000645824.1
ENST00000532942.5
PAUPAR
ENSG00000285283.1
PAX6 upstream antisense RNA
novel protein
chr6_+_54111409 0.23 ENST00000503951.5
MLIP
muscular LMNA interacting protein
chr12_-_51814925 0.22 ENST00000642069.2
TMDD1
transmembrane and death domain 1
chr2_+_12716893 0.21 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr1_+_61952283 0.20 ENST00000307297.8
PATJ
PATJ crumbs cell polarity complex component
chr2_-_31217511 0.20 ENST00000403897.4
CAPN14
calpain 14
chr2_+_20447065 0.20 ENST00000272233.6
RHOB
ras homolog family member B
chr4_+_37960397 0.20 ENST00000504686.2
PTTG2
pituitary tumor-transforming 2
chr3_-_129440007 0.19 ENST00000503197.5
ENST00000249910.5
ENST00000507208.1
ENST00000393278.6
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chrX_+_120604084 0.18 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr11_+_62665305 0.17 ENST00000532971.2
CSKMT
citrate synthase lysine methyltransferase
chrM_+_12329 0.17 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr15_+_67125707 0.17 ENST00000540846.6
SMAD3
SMAD family member 3
chr12_+_53441641 0.17 ENST00000549924.5
PRR13
proline rich 13
chr9_-_104605627 0.16 ENST00000542196.2
OR13C2
olfactory receptor family 13 subfamily C member 2
chr9_+_104694518 0.15 ENST00000641530.1
OR13D1
olfactory receptor family 13 subfamily D member 1
chrX_+_56563569 0.13 ENST00000338222.7
UBQLN2
ubiquilin 2
chr3_-_129439925 0.13 ENST00000429544.7
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr18_-_75208417 0.13 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr12_-_27972725 0.12 ENST00000545234.6
PTHLH
parathyroid hormone like hormone
chrX_-_31178220 0.12 ENST00000681026.1
DMD
dystrophin
chrX_+_46837034 0.12 ENST00000218340.4
RP2
RP2 activator of ARL3 GTPase
chrX_-_31178149 0.10 ENST00000679437.1
DMD
dystrophin
chr8_+_109086585 0.10 ENST00000518632.2
TRHR
thyrotropin releasing hormone receptor
chr5_+_141392616 0.10 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr12_+_53441724 0.09 ENST00000551003.5
ENST00000429243.7
ENST00000549068.5
ENST00000549740.5
ENST00000546581.5
ENST00000549581.5
ENST00000547368.5
ENST00000379786.8
ENST00000551945.5
ENST00000547717.1
PRR13
ENSG00000257379.1
proline rich 13
novel transcript
chr1_-_114780624 0.09 ENST00000060969.6
ENST00000369528.9
SIKE1
suppressor of IKBKE 1
chr2_+_112275588 0.08 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr1_-_158399466 0.08 ENST00000334438.1
OR10T2
olfactory receptor family 10 subfamily T member 2
chr6_+_26045374 0.08 ENST00000612966.3
H3C3
H3 clustered histone 3
chr9_-_20382448 0.07 ENST00000491137.5
MLLT3
MLLT3 super elongation complex subunit
chr14_+_58298587 0.07 ENST00000445108.5
ARID4A
AT-rich interaction domain 4A
chr7_-_33100886 0.06 ENST00000448915.1
RP9
RP9 pre-mRNA splicing factor
chr13_+_108269629 0.05 ENST00000430559.5
ENST00000375887.9
TNFSF13B
TNF superfamily member 13b
chr7_-_32490361 0.05 ENST00000410044.5
ENST00000450169.7
ENST00000409987.5
ENST00000409782.5
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr14_+_58298497 0.04 ENST00000348476.7
ENST00000355431.8
ENST00000395168.7
ARID4A
AT-rich interaction domain 4A
chr18_-_75209126 0.04 ENST00000322342.4
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr10_+_68109433 0.03 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
MYPN
myopalladin
chr7_-_112939773 0.02 ENST00000297145.9
BMT2
base methyltransferase of 25S rRNA 2 homolog
chr6_+_159790448 0.01 ENST00000367034.5
MRPL18
mitochondrial ribosomal protein L18
chr7_-_112939618 0.01 ENST00000432572.1
BMT2
base methyltransferase of 25S rRNA 2 homolog
chr17_-_30824665 0.01 ENST00000324238.7
CRLF3
cytokine receptor like factor 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.2 1.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.2 0.9 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 1.1 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.4 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.5 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.3 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 0.5 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097169 IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
0.1 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 1.3 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.3 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0031433 telethonin binding(GO:0031433)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.1 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.4 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway