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avrg: Illumina Body Map 2 (GSE30611)

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Results for REST

Z-value: 5.93

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.19 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908894_56909016-0.476.9e-03Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_155070317 25.49 ENST00000287907.3
HTR5A
5-hydroxytryptamine receptor 5A
chr1_+_32886456 24.33 ENST00000373467.4
HPCA
hippocalcin
chr5_+_175871570 23.69 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr9_+_137139481 23.41 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr17_+_44308573 22.79 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUNDC3A
RUN domain containing 3A
chr20_+_46029165 22.77 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
SLC12A5
solute carrier family 12 member 5
chr18_-_43277482 22.18 ENST00000255224.8
ENST00000590752.5
ENST00000596867.1
SYT4
synaptotagmin 4
chrX_-_49200174 21.36 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr16_+_24256313 20.48 ENST00000005284.4
CACNG3
calcium voltage-gated channel auxiliary subunit gamma 3
chrX_-_47619850 20.44 ENST00000295987.13
ENST00000340666.5
SYN1
synapsin I
chr8_-_144336451 20.05 ENST00000569446.3
SCRT1
scratch family transcriptional repressor 1
chr12_+_112791933 19.49 ENST00000551052.5
ENST00000415485.7
RPH3A
rabphilin 3A
chr14_-_104604741 18.37 ENST00000615704.1
ENST00000415614.6
ENST00000556573.6
TMEM179
transmembrane protein 179
chr14_+_92923143 18.31 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr1_-_175743529 18.12 ENST00000367674.7
ENST00000263525.6
TNR
tenascin R
chr12_+_112791738 17.70 ENST00000389385.9
RPH3A
rabphilin 3A
chr14_-_51095091 17.59 ENST00000684578.1
TRIM9
tripartite motif containing 9
chr20_+_5911501 17.07 ENST00000378961.9
ENST00000455042.1
CHGB
chromogranin B
chr5_+_71719267 16.90 ENST00000296777.5
CARTPT
CART prepropeptide
chr10_+_59177161 16.47 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein like
chr4_+_157220691 16.04 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr1_+_65309517 16.01 ENST00000371069.5
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr10_+_97849824 16.00 ENST00000370602.6
GOLGA7B
golgin A7 family member B
chr19_-_40218339 15.90 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr14_-_51095066 15.37 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr2_-_51032091 15.35 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr9_+_137139139 15.22 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr17_+_32486975 15.21 ENST00000313401.4
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
chr1_-_101996919 15.16 ENST00000370103.9
OLFM3
olfactomedin 3
chr2_-_51032536 15.10 ENST00000626899.1
ENST00000406316.6
NRXN1
neurexin 1
chr10_+_26216766 14.99 ENST00000376261.8
GAD2
glutamate decarboxylase 2
chr10_+_26216665 14.88 ENST00000259271.7
GAD2
glutamate decarboxylase 2
chr20_+_46029206 14.65 ENST00000243964.7
SLC12A5
solute carrier family 12 member 5
chr4_+_157220654 14.51 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chrX_-_153875847 14.38 ENST00000361699.8
ENST00000361981.7
L1CAM
L1 cell adhesion molecule
chr2_+_114442616 14.23 ENST00000410059.6
DPP10
dipeptidyl peptidase like 10
chr12_+_118981531 13.84 ENST00000267260.5
SRRM4
serine/arginine repetitive matrix 4
chr1_+_154567770 13.84 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr9_-_133609325 13.82 ENST00000673969.1
FAM163B
family with sequence similarity 163 member B
chr16_+_4958289 13.54 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr15_-_82709859 13.39 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr5_+_175871670 13.08 ENST00000514150.5
CPLX2
complexin 2
chr2_-_51032390 12.85 ENST00000404971.5
NRXN1
neurexin 1
chr19_-_55180104 12.71 ENST00000537500.5
SYT5
synaptotagmin 5
chr5_-_176610104 12.36 ENST00000303991.5
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr1_-_241357085 11.98 ENST00000366564.5
RGS7
regulator of G protein signaling 7
chr14_-_51095314 11.95 ENST00000338969.9
TRIM9
tripartite motif containing 9
chr1_-_241357171 11.95 ENST00000440928.6
RGS7
regulator of G protein signaling 7
chr19_-_55180242 11.89 ENST00000592470.1
ENST00000354308.8
SYT5
synaptotagmin 5
chr8_-_90082871 11.84 ENST00000265431.7
CALB1
calbindin 1
chr3_+_9703826 11.78 ENST00000613455.4
ENST00000383831.7
ENST00000383832.8
CPNE9
copine family member 9
chr12_+_66755 11.46 ENST00000538872.6
IQSEC3
IQ motif and Sec7 domain ArfGEF 3
chr1_-_151716782 11.41 ENST00000420342.1
ENST00000290583.9
CELF3
CUGBP Elav-like family member 3
chr7_+_8433602 10.90 ENST00000405863.6
NXPH1
neurexophilin 1
chr15_-_82709823 10.79 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr15_-_82709886 10.48 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
AP3B2
adaptor related protein complex 3 subunit beta 2
chr11_+_125903320 10.38 ENST00000525943.1
DDX25
DEAD-box helicase 25
chr10_-_49762335 10.31 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr3_-_42701513 10.22 ENST00000310417.9
HHATL
hedgehog acyltransferase like
chr6_+_152750789 10.10 ENST00000367244.8
ENST00000367243.7
VIP
vasoactive intestinal peptide
chr3_-_132035004 10.09 ENST00000429747.6
CPNE4
copine 4
chr12_+_112791903 9.80 ENST00000550901.5
RPH3A
rabphilin 3A
chr18_-_43277364 9.33 ENST00000593720.1
SYT4
synaptotagmin 4
chr17_-_29005913 9.16 ENST00000442608.7
ENST00000317338.17
ENST00000335960.10
SEZ6
seizure related 6 homolog
chr20_-_62220267 8.95 ENST00000317393.10
ENST00000611492.1
ENST00000340177.10
HRH3
histamine receptor H3
chr19_-_55180010 8.73 ENST00000589172.5
SYT5
synaptotagmin 5
chr12_+_112791920 8.54 ENST00000551198.5
RPH3A
rabphilin 3A
chr7_-_101165558 8.42 ENST00000611537.1
ENST00000249330.3
VGF
VGF nerve growth factor inducible
chr16_+_2969307 8.39 ENST00000576565.1
ENST00000318782.9
PAQR4
progestin and adipoQ receptor family member 4
chr2_+_130756291 8.33 ENST00000458606.5
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr15_-_82709775 8.24 ENST00000535348.5
AP3B2
adaptor related protein complex 3 subunit beta 2
chr10_-_49762276 8.19 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr11_-_66347560 8.16 ENST00000311181.5
B4GAT1
beta-1,4-glucuronyltransferase 1
chr1_+_154567820 8.12 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr11_+_45885625 8.07 ENST00000241014.6
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_64505981 7.97 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr16_+_2969270 7.88 ENST00000293978.12
PAQR4
progestin and adipoQ receptor family member 4
chr3_+_62319037 7.69 ENST00000494481.5
C3orf14
chromosome 3 open reading frame 14
chr12_+_112791532 7.65 ENST00000552667.5
RPH3A
rabphilin 3A
chr3_+_62318983 7.62 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
C3orf14
chromosome 3 open reading frame 14
chr3_+_120908072 7.55 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
STXBP5L
syntaxin binding protein 5 like
chr16_+_285680 7.54 ENST00000435833.1
PDIA2
protein disulfide isomerase family A member 2
chr7_-_101165114 7.52 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr18_-_5197241 7.37 ENST00000434239.4
AKAIN1
A-kinase anchor inhibitor 1
chr1_+_209938169 7.04 ENST00000367019.5
ENST00000537238.5
ENST00000637265.1
SYT14
synaptotagmin 14
chr6_+_25652201 6.88 ENST00000612225.4
ENST00000377961.3
SCGN
secretagogin, EF-hand calcium binding protein
chr10_-_101031095 6.20 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chrX_-_153875979 6.20 ENST00000407935.6
ENST00000439496.5
L1CAM
L1 cell adhesion molecule
chr19_+_40530464 6.16 ENST00000392023.1
SPTBN4
spectrin beta, non-erythrocytic 4
chr15_-_26773737 5.96 ENST00000299267.8
GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
chr14_-_74426102 5.96 ENST00000554953.1
ENST00000331628.8
SYNDIG1L
synapse differentiation inducing 1 like
chr2_+_214411048 5.82 ENST00000312504.10
ENST00000427124.1
VWC2L
von Willebrand factor C domain containing 2 like
chr12_+_71439976 5.69 ENST00000536515.5
ENST00000540815.2
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr14_+_93430853 5.69 ENST00000553484.5
UNC79
unc-79 homolog, NALCN channel complex subunit
chr4_-_174829212 5.65 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr1_+_37793865 5.63 ENST00000397631.7
MANEAL
mannosidase endo-alpha like
chr20_+_46029009 5.36 ENST00000608944.5
SLC12A5
solute carrier family 12 member 5
chr15_-_31870651 5.32 ENST00000307050.6
ENST00000560598.2
OTUD7A
OTU deubiquitinase 7A
chr11_+_62613236 5.11 ENST00000278833.4
ROM1
retinal outer segment membrane protein 1
chr21_-_32728030 4.95 ENST00000382499.7
ENST00000433931.7
ENST00000382491.7
SYNJ1
synaptojanin 1
chr1_+_37793787 4.94 ENST00000373045.11
MANEAL
mannosidase endo-alpha like
chr14_+_93430927 4.90 ENST00000393151.6
UNC79
unc-79 homolog, NALCN channel complex subunit
chr17_+_74671096 4.74 ENST00000402449.8
RAB37
RAB37, member RAS oncogene family
chr17_-_29006145 4.69 ENST00000360295.13
SEZ6
seizure related 6 homolog
chr12_-_12684490 4.67 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr3_+_75906666 4.38 ENST00000487694.7
ENST00000602589.5
ROBO2
roundabout guidance receptor 2
chr9_+_114329869 4.27 ENST00000431067.4
ORM2
orosomucoid 2
chr2_+_206642487 4.25 ENST00000441223.4
FAM237A
family with sequence similarity 237 member A
chr12_+_71439789 4.23 ENST00000266674.10
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr8_-_56445941 4.20 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr9_+_135714582 4.06 ENST00000630792.2
KCNT1
potassium sodium-activated channel subfamily T member 1
chr2_+_114442299 4.05 ENST00000436732.5
DPP10
dipeptidyl peptidase like 10
chr3_-_48662877 3.93 ENST00000164024.5
CELSR3
cadherin EGF LAG seven-pass G-type receptor 3
chr9_+_135714425 3.88 ENST00000473941.5
ENST00000486577.6
KCNT1
potassium sodium-activated channel subfamily T member 1
chr2_-_51032151 3.79 ENST00000628515.2
NRXN1
neurexin 1
chr9_-_121050264 3.70 ENST00000223642.3
C5
complement C5
chr6_+_109978256 3.66 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr14_-_94293024 3.55 ENST00000393096.5
SERPINA10
serpin family A member 10
chr14_-_94293071 3.52 ENST00000554723.5
SERPINA10
serpin family A member 10
chr14_-_94293260 3.39 ENST00000261994.9
SERPINA10
serpin family A member 10
chr6_+_35805347 3.08 ENST00000360215.3
LHFPL5
LHFPL tetraspan subfamily member 5
chr4_+_95091462 3.02 ENST00000264568.8
BMPR1B
bone morphogenetic protein receptor type 1B
chr6_+_109978297 2.87 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr20_+_31968141 2.86 ENST00000562532.3
XKR7
XK related 7
chr9_-_71446835 2.82 ENST00000357533.6
TRPM3
transient receptor potential cation channel subfamily M member 3
chr20_-_63653413 2.68 ENST00000370053.3
STMN3
stathmin 3
chr6_+_35805392 2.56 ENST00000651676.1
LHFPL5
LHFPL tetraspan subfamily member 5
chr6_+_25652272 2.47 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr8_+_6708626 2.32 ENST00000285518.11
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr20_+_63696643 2.27 ENST00000369996.3
TNFRSF6B
TNF receptor superfamily member 6b
chr4_+_157220795 2.15 ENST00000506284.5
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr2_-_47570905 2.05 ENST00000327876.5
KCNK12
potassium two pore domain channel subfamily K member 12
chr8_+_6708685 1.94 ENST00000518327.1
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr19_+_39268394 1.93 ENST00000331982.6
IFNL2
interferon lambda 2
chr7_+_146115974 1.92 ENST00000625365.2
CNTNAP2
contactin associated protein 2
chr1_+_209938207 1.78 ENST00000472886.5
SYT14
synaptotagmin 14
chr11_-_93197932 1.62 ENST00000326402.9
SLC36A4
solute carrier family 36 member 4
chr18_-_5197502 1.62 ENST00000580650.1
AKAIN1
A-kinase anchor inhibitor 1
chr6_+_154039102 1.52 ENST00000360422.8
ENST00000330432.12
OPRM1
opioid receptor mu 1
chr12_-_57050102 1.47 ENST00000300119.8
MYO1A
myosin IA
chr8_-_92966129 1.47 ENST00000522925.5
ENST00000522903.5
ENST00000537541.1
ENST00000521988.6
ENST00000518748.5
ENST00000519069.5
TRIQK
triple QxxK/R motif containing
chr17_-_29006293 1.27 ENST00000585644.1
SEZ6
seizure related 6 homolog
chrX_+_7147675 1.05 ENST00000674429.1
STS
steroid sulfatase
chr3_+_149813806 0.97 ENST00000468648.5
ENST00000459632.5
RNF13
ring finger protein 13
chr19_-_11529116 0.82 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT
ECSIT signaling integrator
chrX_+_7147237 0.74 ENST00000666110.2
STS
steroid sulfatase
chr15_+_67825504 0.71 ENST00000380035.3
ENST00000554054.5
SKOR1
SKI family transcriptional corepressor 1
chr19_+_840991 0.71 ENST00000234347.10
PRTN3
proteinase 3
chr8_-_92966105 0.53 ENST00000524037.5
ENST00000520430.5
ENST00000521617.5
ENST00000523580.5
TRIQK
triple QxxK/R motif containing
chr8_-_92965988 0.53 ENST00000517751.5
ENST00000524107.5
TRIQK
triple QxxK/R motif containing
chr1_+_171781635 0.43 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr8_-_92966081 0.42 ENST00000517858.5
ENST00000378861.9
TRIQK
triple QxxK/R motif containing
chr10_-_77638369 0.42 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr16_+_31459950 0.41 ENST00000564900.1
ARMC5
armadillo repeat containing 5
chr11_+_92969651 0.24 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr19_-_11529094 0.20 ENST00000588998.5
ENST00000586149.1
ECSIT
ECSIT signaling integrator
chr19_-_38912177 0.16 ENST00000571838.2
CCER2
coiled-coil glutamate rich protein 2
chr1_+_212432891 0.15 ENST00000366988.5
NENF
neudesin neurotrophic factor
chr2_+_225399684 0.10 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_125903190 0.07 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
PUS3
pseudouridine synthase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 38.6 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
10.7 42.8 GO:0040040 thermosensory behavior(GO:0040040)
9.0 44.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
6.1 18.3 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
5.6 16.9 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
5.1 25.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
5.1 15.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
4.3 29.9 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
3.9 31.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
3.7 22.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
3.6 18.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
3.1 47.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
3.0 24.3 GO:1902075 cellular response to salt(GO:1902075)
2.6 10.2 GO:1903060 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
2.0 9.9 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
1.7 10.5 GO:0008218 bioluminescence(GO:0008218)
1.6 16.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.5 21.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.5 9.0 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
1.3 11.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.3 36.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
1.3 42.9 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.2 105.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.2 22.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
1.2 8.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.0 21.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.8 4.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.8 20.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.7 20.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.7 4.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.7 5.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.6 10.1 GO:0070459 prolactin secretion(GO:0070459)
0.6 7.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.6 3.7 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.6 11.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.6 3.9 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.5 32.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 8.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 15.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 6.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.4 15.9 GO:0002021 response to dietary excess(GO:0002021)
0.4 11.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.4 11.4 GO:0030575 nuclear body organization(GO:0030575)
0.4 18.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.4 3.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.3 2.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 4.3 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.3 20.3 GO:0001754 eye photoreceptor cell differentiation(GO:0001754)
0.3 11.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 6.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.2 6.7 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 4.2 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.2 1.9 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 18.3 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 2.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 20.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 9.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 4.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 7.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 10.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 11.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.7 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.1 6.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 7.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.8 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 4.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.9 GO:0002385 mucosal immune response(GO:0002385)
0.1 23.9 GO:0006457 protein folding(GO:0006457)
0.0 1.8 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.4 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 1.5 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.2 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 7.9 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 2.6 GO:0007631 feeding behavior(GO:0007631)
0.0 10.3 GO:0043687 post-translational protein modification(GO:0043687)
0.0 5.8 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 2.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 31.5 GO:0032127 dense core granule membrane(GO:0032127)
5.6 33.3 GO:1990769 proximal neuron projection(GO:1990769)
4.7 32.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
4.6 36.8 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
3.6 18.1 GO:0072534 perineuronal net(GO:0072534)
3.0 15.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.5 42.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
2.1 38.6 GO:0043083 synaptic cleft(GO:0043083)
2.1 6.2 GO:0002141 stereocilia ankle link(GO:0002141) USH2 complex(GO:1990696)
1.7 24.3 GO:0044327 dendritic spine head(GO:0044327)
1.7 18.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.7 40.1 GO:0060077 inhibitory synapse(GO:0060077)
0.9 21.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 16.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.8 10.4 GO:0070852 cell body fiber(GO:0070852)
0.8 18.3 GO:0042583 chromaffin granule(GO:0042583)
0.7 8.1 GO:0044294 dendritic growth cone(GO:0044294)
0.7 41.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 22.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.6 57.9 GO:0043198 dendritic shaft(GO:0043198)
0.6 20.6 GO:0044295 axonal growth cone(GO:0044295)
0.6 10.4 GO:0033391 chromatoid body(GO:0033391)
0.5 63.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 70.1 GO:0008021 synaptic vesicle(GO:0008021)
0.4 3.7 GO:0005579 membrane attack complex(GO:0005579)
0.3 47.1 GO:0042734 presynaptic membrane(GO:0042734)
0.3 5.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 23.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 16.8 GO:0043195 terminal bouton(GO:0043195)
0.2 5.6 GO:0032426 stereocilium tip(GO:0032426)
0.2 25.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 3.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 6.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.9 GO:0033010 paranodal junction(GO:0033010)
0.1 8.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 52.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 9.0 GO:0098793 presynapse(GO:0098793)
0.1 9.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 9.3 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 4.4 GO:0030673 axolemma(GO:0030673)
0.1 15.0 GO:0030426 growth cone(GO:0030426)
0.0 8.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 13.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.5 GO:0031941 basal plasma membrane(GO:0009925) filamentous actin(GO:0031941)
0.0 21.8 GO:0016604 nuclear body(GO:0016604)
0.0 116.3 GO:0016021 integral component of membrane(GO:0016021)
0.0 10.2 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
4.3 38.6 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
3.7 29.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.5 63.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
3.2 31.5 GO:0030348 syntaxin-3 binding(GO:0030348)
2.6 18.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
2.5 42.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.5 32.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.3 22.8 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
2.1 25.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
1.5 11.8 GO:0005499 vitamin D binding(GO:0005499)
1.5 47.1 GO:0097109 neuroligin family protein binding(GO:0097109)
1.2 8.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.1 45.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.0 20.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.9 11.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.9 4.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.8 36.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 9.0 GO:0004969 histamine receptor activity(GO:0004969)
0.7 22.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.6 5.0 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.5 94.4 GO:0000149 SNARE binding(GO:0000149)
0.5 18.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.5 6.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 8.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 1.8 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.4 1.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.4 7.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.4 4.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 16.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 6.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 20.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 9.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 11.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 18.5 GO:0042169 SH2 domain binding(GO:0042169)
0.2 3.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 8.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 17.1 GO:0005179 hormone activity(GO:0005179)
0.1 6.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 5.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 2.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 10.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 4.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 8.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 16.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 12.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 2.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 10.6 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 3.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 10.5 GO:0008201 heparin binding(GO:0008201)
0.0 13.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 25.8 GO:0003779 actin binding(GO:0003779)
0.0 50.6 GO:0005215 transporter activity(GO:0005215)
0.0 10.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 20.5 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 32.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.4 23.3 PID REELIN PATHWAY Reelin signaling pathway
0.2 20.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 18.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.0 PID BMP PATHWAY BMP receptor signaling
0.0 4.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 10.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 25.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
1.5 71.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.0 22.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.0 29.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.7 20.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.5 10.1 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.5 26.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 15.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 16.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 20.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 42.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 10.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 33.3 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 44.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 3.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 5.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 4.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 10.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events