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avrg: Illumina Body Map 2 (GSE30611)
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Results for REST
Z-value: 5.93
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Transcription factors associated with REST
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REST | hg38_v1_chr4_+_56908894_56909016 | -0.47 | 6.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of REST
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 105.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 3.1 | 47.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 9.0 | 44.9 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 1.3 | 42.9 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 10.7 | 42.8 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 12.9 | 38.6 | GO:0043449 | olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449) |
| 1.3 | 36.8 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.5 | 32.7 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 3.9 | 31.5 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 4.3 | 29.9 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 116.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 70.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.5 | 63.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.6 | 57.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 52.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 47.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 2.5 | 42.9 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.7 | 41.5 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.7 | 40.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 2.1 | 38.6 | GO:0043083 | synaptic cleft(GO:0043083) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 94.4 | GO:0000149 | SNARE binding(GO:0000149) |
| 3.5 | 63.2 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 50.6 | GO:0005215 | transporter activity(GO:0005215) |
| 1.5 | 47.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.1 | 45.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 2.5 | 42.8 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 4.3 | 38.6 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.8 | 36.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 2.5 | 32.7 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 3.2 | 31.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.4 | 23.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 20.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 18.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 10.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 4.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 3.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.3 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 71.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 44.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 42.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 33.3 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 1.0 | 29.9 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.5 | 26.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.7 | 25.5 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 1.0 | 22.0 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.3 | 20.5 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.7 | 20.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |