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avrg: Illumina Body Map 2 (GSE30611)
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Results for RFX7_RFX4_RFX1
Z-value: 7.60
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX4 | hg38_v1_chr12_+_106684696_106684755 | 0.72 | 3.4e-06 | Click! |
| RFX1 | hg38_v1_chr19_-_14006262_14006330 | 0.32 | 7.5e-02 | Click! |
| RFX7 | hg38_v1_chr15_-_56243829_56243891 | 0.19 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_109112733 Show fit | 34.64 |
ENST00000369948.8
ENST00000369945.7 |
chromosome 1 open reading frame 194 |
|
| chr1_+_36084079 Show fit | 25.37 |
ENST00000207457.8
|
tektin 2 |
|
| chr19_+_55376818 Show fit | 23.44 |
ENST00000291934.4
|
transmembrane protein 190 |
|
| chr10_+_22928030 Show fit | 22.67 |
ENST00000409983.7
ENST00000298032.10 ENST00000409049.7 |
armadillo repeat containing 3 |
|
| chr17_+_41930599 Show fit | 22.16 |
ENST00000377540.6
|
outer dynein arm docking complex subunit 4 |
|
| chr16_+_80540980 Show fit | 21.99 |
ENST00000568035.5
ENST00000305904.11 |
dynein light chain roadblock-type 2 |
|
| chr11_+_61481110 Show fit | 21.25 |
ENST00000338608.7
ENST00000432063.6 |
protein phosphatase 1 regulatory subunit 32 |
|
| chr5_-_7851146 Show fit | 20.88 |
ENST00000509627.1
|
chromosome 5 open reading frame 49 |
|
| chr5_-_7851111 Show fit | 20.70 |
ENST00000399810.7
|
chromosome 5 open reading frame 49 |
|
| chr2_-_169694367 Show fit | 19.96 |
ENST00000447353.6
|
coiled-coil domain containing 173 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 92.2 | GO:0042073 | intraciliary transport(GO:0042073) |
| 2.6 | 58.2 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 2.2 | 53.2 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 2.0 | 50.5 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) |
| 0.2 | 35.2 | GO:0007286 | spermatid development(GO:0007286) |
| 3.2 | 35.0 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 34.5 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.2 | 32.3 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 2.6 | 28.1 | GO:0003341 | cilium movement(GO:0003341) |
| 0.1 | 26.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 111.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.8 | 80.0 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 1.3 | 62.1 | GO:0030990 | intraciliary transport particle(GO:0030990) |
| 5.2 | 57.0 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.5 | 56.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 43.9 | GO:0005929 | cilium(GO:0005929) |
| 5.2 | 41.4 | GO:0002177 | manchette(GO:0002177) |
| 1.1 | 27.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 3.9 | 23.4 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 1.5 | 19.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 52.0 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 2.7 | 40.1 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.9 | 27.4 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 22.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 22.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.7 | 21.7 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 21.1 | GO:0019902 | phosphatase binding(GO:0019902) |
| 1.2 | 18.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.3 | 18.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 16.3 | GO:0043621 | protein self-association(GO:0043621) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.4 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 14.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.6 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 5.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 5.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 5.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.2 | 3.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 9.5 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.2 | 8.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 7.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 6.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 5.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 4.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 4.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 4.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 4.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |