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avrg: Illumina Body Map 2 (GSE30611)

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Results for SIX1_SIX3_SIX2

Z-value: 1.40

Motif logo

Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
ENSG00000126778.12 SIX1
ENSG00000138083.5 SIX3
ENSG00000170577.8 SIX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX2hg38_v1_chr2_-_45009401_45009457-0.441.1e-02Click!
SIX1hg38_v1_chr14_-_60649449_60649490-0.421.6e-02Click!
SIX3hg38_v1_chr2_+_44941695_449417080.115.4e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_-_58731936 8.62 ENST00000344743.8
glycine-N-acyltransferase
chr11_-_58731968 8.10 ENST00000278400.3
glycine-N-acyltransferase
chr10_+_5196831 6.25 ENST00000263126.3
aldo-keto reductase family 1 member C4
chr13_-_46105009 5.25 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
carboxypeptidase B2
chr3_-_42875871 3.36 ENST00000316161.6
ENST00000437102.1
cytochrome P450 family 8 subfamily B member 1
chr19_-_50333504 3.31 ENST00000474951.1
potassium voltage-gated channel subfamily C member 3
chr2_+_233917371 3.04 ENST00000324695.9
ENST00000433712.6
transient receptor potential cation channel subfamily M member 8
chr19_+_44942230 2.72 ENST00000592954.2
ENST00000589057.5
apolipoprotein C4
APOC4-APOC2 readthrough (NMD candidate)
chr6_-_136526177 2.60 ENST00000617204.4
microtubule associated protein 7
chr4_+_154563003 2.47 ENST00000302068.9
ENST00000509493.1
fibrinogen beta chain
chr6_-_136525961 2.36 ENST00000438100.6
microtubule associated protein 7
chr2_+_210556590 2.33 ENST00000233072.10
ENST00000619804.1
carbamoyl-phosphate synthase 1
chr6_-_136526472 2.32 ENST00000454590.5
ENST00000432797.6
microtubule associated protein 7
chrX_+_139530730 2.31 ENST00000218099.7
coagulation factor IX
chr1_-_230745574 2.23 ENST00000681269.1
angiotensinogen
chr8_+_30638562 2.09 ENST00000517349.2
small integral membrane protein 18
chr11_-_128842467 2.02 ENST00000392664.2
potassium inwardly rectifying channel subfamily J member 1
chr6_-_136526654 2.02 ENST00000611373.1
microtubule associated protein 7
chrX_+_139530752 1.92 ENST00000394090.2
coagulation factor IX
chr1_+_241532370 1.89 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr17_+_4771878 1.78 ENST00000270560.4
transmembrane 4 L six family member 5
chr10_+_7703300 1.73 ENST00000358415.9
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7703340 1.71 ENST00000429820.5
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_241532121 1.67 ENST00000366558.7
kynurenine 3-monooxygenase
chr8_-_29263063 1.59 ENST00000524189.6
kinesin family member 13B
chr7_-_99971845 1.58 ENST00000419575.1
alpha-2-glycoprotein 1, zinc-binding
chr3_+_149474688 1.55 ENST00000305354.5
ENST00000465758.1
transmembrane 4 L six family member 4
chr1_+_209686173 1.45 ENST00000615289.4
ENST00000367028.6
ENST00000261465.5
hydroxysteroid 11-beta dehydrogenase 1
chr2_+_233693659 1.44 ENST00000406651.1
UDP glucuronosyltransferase family 1 member A6
chr8_-_29263087 1.44 ENST00000521515.1
kinesin family member 13B
chr9_-_27005659 1.43 ENST00000380055.6
leucine rich repeat containing 19
chr2_+_210477708 1.36 ENST00000673711.1
carbamoyl-phosphate synthase 1
chr14_-_94293024 1.32 ENST00000393096.5
serpin family A member 10
chr12_-_54984667 1.32 ENST00000524668.5
ENST00000533607.1
ENST00000449076.6
thymocyte expressed, positive selection associated 1
chr8_+_18391276 1.26 ENST00000286479.4
ENST00000520116.1
N-acetyltransferase 2
chr1_+_45500287 1.25 ENST00000401061.9
ENST00000616135.1
metabolism of cobalamin associated C
chr3_+_111999189 1.20 ENST00000455401.6
transgelin 3
chr17_-_7177564 1.19 ENST00000570576.1
asialoglycoprotein receptor 1
chr3_+_111998915 1.17 ENST00000478951.6
transgelin 3
chr2_+_234050679 1.12 ENST00000373368.5
ENST00000168148.8
secreted phosphoprotein 2
chr3_+_111998739 1.11 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr3_+_111999326 1.09 ENST00000494932.1
transgelin 3
chr1_+_196977550 1.07 ENST00000256785.5
complement factor H related 5
chr1_+_207104226 1.01 ENST00000367070.8
complement component 4 binding protein alpha
chr11_-_124935973 1.01 ENST00000298251.5
hepatic and glial cell adhesion molecule
chr11_-_34511710 1.00 ENST00000620316.4
ENST00000312319.6
E74 like ETS transcription factor 5
chr5_+_126423176 1.00 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr5_+_126423363 1.00 ENST00000285689.8
GRAM domain containing 2B
chr1_+_207104287 0.98 ENST00000421786.5
complement component 4 binding protein alpha
chr12_-_109021015 0.98 ENST00000546618.2
ENST00000610966.5
SV2 related protein
chr10_-_101843920 0.98 ENST00000358038.7
potassium voltage-gated channel interacting protein 2
chr11_-_49208589 0.97 ENST00000256999.7
folate hydrolase 1
chr14_+_94581388 0.96 ENST00000554866.5
ENST00000556775.5
serpin family A member 5
chr14_-_94293260 0.95 ENST00000261994.9
serpin family A member 10
chr19_+_44942268 0.90 ENST00000591600.1
apolipoprotein C4
chr1_-_167935987 0.89 ENST00000367846.8
mitochondrial pyruvate carrier 2
chr1_+_26410809 0.89 ENST00000254231.4
ENST00000326279.11
lin-28 homolog A
chr8_-_24956604 0.87 ENST00000610854.2
neurofilament light
chr15_+_62561361 0.85 ENST00000561311.5
talin 2
chr5_+_126423122 0.85 ENST00000515200.5
GRAM domain containing 2B
chr1_+_50106265 0.84 ENST00000357083.8
ELAV like RNA binding protein 4
chr17_-_46979240 0.84 ENST00000322329.5
reprimo like
chr14_+_58244821 0.83 ENST00000216455.9
ENST00000412908.6
ENST00000557508.5
proteasome 20S subunit alpha 3
chr5_-_35089620 0.80 ENST00000511486.5
ENST00000310101.9
ENST00000231423.7
ENST00000513753.5
ENST00000348262.7
prolactin receptor
chr14_+_50560125 0.80 ENST00000554886.1
atlastin GTPase 1
chr17_+_78187317 0.79 ENST00000409257.9
ENST00000591256.5
ENST00000589256.5
ENST00000588800.5
ENST00000591952.5
ENST00000327898.9
ENST00000586542.5
ENST00000586731.1
arylformamidase
chr1_+_186296267 0.76 ENST00000533951.5
ENST00000367482.8
ENST00000635041.1
ENST00000367483.8
ENST00000367485.4
ENST00000445192.7
proteoglycan 4
chr3_+_179148099 0.75 ENST00000477735.1
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr2_+_234050732 0.75 ENST00000425558.1
secreted phosphoprotein 2
chr3_+_42809439 0.74 ENST00000422265.6
ENST00000487368.4
atypical chemokine receptor 2
novel transcript
chr11_+_64555956 0.74 ENST00000377581.7
solute carrier family 22 member 11
chr2_-_208190001 0.74 ENST00000451346.5
ENST00000341287.9
chromosome 2 open reading frame 80
chr20_-_46684467 0.73 ENST00000372121.5
solute carrier family 13 member 3
chr6_-_43687774 0.73 ENST00000372133.8
ENST00000372116.5
ENST00000427312.1
mitochondrial ribosomal protein S18A
chr5_+_140821598 0.72 ENST00000614258.1
ENST00000529859.2
ENST00000529619.5
protocadherin alpha 5
chr16_+_27203480 0.71 ENST00000286096.9
lysine demethylase 8
chr12_+_57230086 0.70 ENST00000414700.7
ENST00000557703.5
serine hydroxymethyltransferase 2
chr2_+_127419686 0.69 ENST00000427769.5
protein C, inactivator of coagulation factors Va and VIIIa
chr1_+_161197372 0.69 ENST00000677550.1
ENST00000676600.1
ENST00000678507.1
ENST00000677579.1
ENST00000677231.1
ENST00000678911.1
ENST00000677846.1
NADH:ubiquinone oxidoreductase core subunit S2
chr4_+_2793077 0.67 ENST00000503393.8
SH3 domain binding protein 2
chr21_+_36069941 0.66 ENST00000530908.5
ENST00000439427.2
ENST00000290349.11
ENST00000399191.3
carbonyl reductase 1
chr2_-_60546162 0.66 ENST00000489183.1
ENST00000647469.1
ENST00000642180.1
BAF chromatin remodeling complex subunit BCL11A
chr10_+_5048748 0.66 ENST00000602997.5
ENST00000439082.7
aldo-keto reductase family 1 member C3
chr3_+_188239858 0.65 ENST00000457242.1
LIM domain containing preferred translocation partner in lipoma
chr20_+_38033719 0.65 ENST00000373433.9
regulation of nuclear pre-mRNA domain containing 1B
chr22_+_30409097 0.65 ENST00000439838.5
ENST00000439023.3
novel SEC14-like 2 (S. cerevisiae) (SEC14L2) and mitochondrial protein 18 kDa (MTP18) protein
chr4_+_88593251 0.63 ENST00000426683.5
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr10_+_4963406 0.63 ENST00000380872.9
ENST00000442997.5
aldo-keto reductase family 1 member C1
chr19_-_38229714 0.62 ENST00000416611.5
double PHD fingers 1
chr3_-_53846374 0.62 ENST00000315251.11
choline dehydrogenase
chr8_-_133060347 0.62 ENST00000427060.6
Src like adaptor
chr8_+_75539893 0.61 ENST00000674002.1
hepatocyte nuclear factor 4 gamma
chr11_+_61752603 0.60 ENST00000278836.10
myelin regulatory factor
chr7_+_29479712 0.60 ENST00000412711.6
chimerin 2
chr7_+_151062547 0.60 ENST00000392826.6
ENST00000461735.1
solute carrier family 4 member 2
chr8_+_75539862 0.58 ENST00000396423.4
hepatocyte nuclear factor 4 gamma
chr22_+_30425552 0.58 ENST00000629597.2
mitochondrial fission process 1
chr2_-_222320124 0.58 ENST00000678139.1
novel protein, ortholog of Gm2102 (M. musculus)
chr22_+_20967243 0.57 ENST00000683034.1
ENST00000440238.4
ENST00000405089.5
apoptosis inducing factor mitochondria associated 3
chrX_+_153642473 0.55 ENST00000370167.8
dual specificity phosphatase 9
chr6_-_35688907 0.55 ENST00000539068.5
ENST00000357266.9
FKBP prolyl isomerase 5
chr9_+_12693327 0.54 ENST00000388918.10
tyrosinase related protein 1
chr1_+_176463164 0.54 ENST00000367661.7
ENST00000367662.5
pappalysin 2
chr12_-_117968223 0.54 ENST00000425217.5
kinase suppressor of ras 2
chr7_-_72447061 0.53 ENST00000395276.6
ENST00000431984.5
calneuron 1
chr4_-_155376767 0.53 ENST00000450097.1
microtubule associated protein 9
chr19_+_18612848 0.52 ENST00000262817.8
transmembrane protein 59 like
chr2_-_55269038 0.51 ENST00000417363.5
ENST00000412530.1
ENST00000366137.6
ENST00000420637.5
mitochondrial translational initiation factor 2
chr11_+_1409753 0.51 ENST00000524702.5
BR serine/threonine kinase 2
chr12_+_81078035 0.51 ENST00000261206.7
ENST00000548058.6
acyl-CoA synthetase short chain family member 3
chr4_+_88593365 0.51 ENST00000452979.5
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr4_+_158210194 0.50 ENST00000508243.5
transmembrane protein 144
chr19_-_14062028 0.50 ENST00000669674.2
paralemmin 3
chr10_-_101843765 0.49 ENST00000370046.5
potassium voltage-gated channel interacting protein 2
chr15_+_90872862 0.48 ENST00000618099.4
furin, paired basic amino acid cleaving enzyme
chr17_+_7627963 0.48 ENST00000575729.5
ENST00000340624.9
sex hormone binding globulin
chr11_+_121576760 0.48 ENST00000532694.5
ENST00000534286.5
sortilin related receptor 1
chr19_-_11346486 0.47 ENST00000590482.5
transmembrane protein 205
chr2_-_55269207 0.47 ENST00000263629.9
ENST00000403721.5
mitochondrial translational initiation factor 2
chr2_-_2324323 0.47 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr2_-_55269335 0.45 ENST00000441307.5
mitochondrial translational initiation factor 2
chr10_-_101843777 0.45 ENST00000356640.7
potassium voltage-gated channel interacting protein 2
chr4_+_46993708 0.45 ENST00000513567.5
gamma-aminobutyric acid type A receptor subunit beta1
chr15_+_58138368 0.45 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr2_-_73269483 0.45 ENST00000295133.9
F-box protein 41
chr3_-_128052166 0.45 ENST00000648300.1
monoglyceride lipase
chr16_-_4474549 0.44 ENST00000404295.7
ENST00000283429.11
ENST00000574425.5
NmrA like redox sensor 1
chr14_+_73097027 0.44 ENST00000532192.1
RNA binding motif protein 25
chr7_-_142933723 0.43 ENST00000442623.1
ENST00000265310.6
transient receptor potential cation channel subfamily V member 5
chr1_-_13285154 0.43 ENST00000357367.6
ENST00000614831.1
PRAME family member 8
chr12_+_57230301 0.43 ENST00000553474.5
serine hydroxymethyltransferase 2
chr6_-_35688935 0.42 ENST00000542713.1
FKBP prolyl isomerase 5
chr3_+_11226005 0.42 ENST00000413416.1
histamine receptor H1
chr4_-_46993520 0.42 ENST00000264318.4
gamma-aminobutyric acid type A receptor subunit alpha4
chr8_-_18808837 0.42 ENST00000286485.12
pleckstrin and Sec7 domain containing 3
chr3_+_35680994 0.42 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr3_+_35681352 0.41 ENST00000436702.5
ENST00000438071.1
cAMP regulated phosphoprotein 21
chr12_+_20695469 0.41 ENST00000545604.5
solute carrier organic anion transporter family member 1C1
chr2_+_148947868 0.41 ENST00000679129.1
kinesin family member 5C
chr6_+_150368997 0.40 ENST00000392255.7
ENST00000500320.7
ENST00000344419.8
iodotyrosine deiodinase
chr11_-_67401560 0.40 ENST00000679175.1
protein phosphatase 1 catalytic subunit alpha
chr2_+_148978361 0.40 ENST00000678720.1
ENST00000678856.1
ENST00000677080.1
kinesin family member 5C
chr2_-_2324642 0.40 ENST00000650485.1
ENST00000649207.1
myelin transcription factor 1 like
chr22_+_40678750 0.40 ENST00000249016.4
melanin concentrating hormone receptor 1
chr5_-_161548124 0.39 ENST00000520240.5
ENST00000517901.5
ENST00000353437.10
gamma-aminobutyric acid type A receptor subunit beta2
chr16_-_66550142 0.39 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
thymidine kinase 2
chr4_+_158210479 0.39 ENST00000504569.5
ENST00000509278.5
ENST00000514558.5
ENST00000503200.5
ENST00000296529.11
transmembrane protein 144
chr3_+_25790076 0.39 ENST00000280701.8
ENST00000420173.2
3-oxoacyl-ACP synthase, mitochondrial
chr4_-_69787955 0.39 ENST00000512870.1
sulfotransferase family 1B member 1
chr19_-_5867741 0.39 ENST00000252675.6
fucosyltransferase 5
chr6_+_167999092 0.39 ENST00000443060.6
kinesin family member 25
chr20_-_32657362 0.39 ENST00000360785.6
chromosome 20 open reading frame 203
chr8_-_27605271 0.39 ENST00000522098.1
clusterin
chr12_+_20695442 0.39 ENST00000540354.5
solute carrier organic anion transporter family member 1C1
chr11_+_5422111 0.38 ENST00000300778.4
olfactory receptor family 51 subfamily Q member 1
chr9_+_74615582 0.38 ENST00000396204.2
RAR related orphan receptor B
chr11_+_64555924 0.38 ENST00000301891.9
solute carrier family 22 member 11
chr12_+_20695553 0.37 ENST00000545102.1
solute carrier organic anion transporter family member 1C1
chr6_-_138107412 0.37 ENST00000421351.4
p53 apoptosis effector related to PMP22
chr4_-_174522791 0.37 ENST00000541923.5
ENST00000542498.5
15-hydroxyprostaglandin dehydrogenase
chr10_-_112446932 0.37 ENST00000682195.1
ENST00000683505.1
ENST00000683895.1
ENST00000682839.1
ENST00000682055.1
zinc finger DHHC-type palmitoyltransferase 6
chr4_-_155376876 0.37 ENST00000433024.5
ENST00000379248.6
microtubule associated protein 9
chr12_+_57230336 0.36 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
serine hydroxymethyltransferase 2
chr4_+_2793056 0.36 ENST00000503219.5
SH3 domain binding protein 2
chr6_-_63319943 0.36 ENST00000622415.1
ENST00000370658.9
ENST00000485906.6
ENST00000370657.9
lengsin, lens protein with glutamine synthetase domain
chr19_+_34926892 0.36 ENST00000303586.11
ENST00000601142.2
ENST00000439785.5
ENST00000601540.5
ENST00000601957.5
zinc finger protein 30
chr22_+_20967212 0.36 ENST00000434714.6
apoptosis inducing factor mitochondria associated 3
chr16_+_31108294 0.36 ENST00000287507.7
ENST00000394950.7
ENST00000219794.11
ENST00000561755.1
branched chain keto acid dehydrogenase kinase
chr6_+_72366730 0.36 ENST00000414192.2
regulating synaptic membrane exocytosis 1
chr3_+_6861107 0.36 ENST00000357716.9
ENST00000486284.5
ENST00000389336.8
glutamate metabotropic receptor 7
chr17_+_7654096 0.36 ENST00000577113.1
ATPase Na+/K+ transporting subunit beta 2
chr10_-_112446734 0.36 ENST00000684507.1
zinc finger DHHC-type palmitoyltransferase 6
chr5_+_75337261 0.35 ENST00000680940.1
3-hydroxy-3-methylglutaryl-CoA reductase
chr1_+_14929734 0.35 ENST00000376028.8
ENST00000400798.6
kazrin, periplakin interacting protein
chr10_+_133394119 0.35 ENST00000317502.11
ENST00000432508.3
mitochondrial ribosome associated GTPase 1
chr1_+_13254212 0.35 ENST00000622421.2
PRAME family member 5
chr4_-_155376935 0.35 ENST00000311277.9
microtubule associated protein 9
chr12_-_57742120 0.35 ENST00000257897.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr22_+_35717872 0.34 ENST00000249044.2
apolipoprotein L5
chr10_+_133394094 0.34 ENST00000477902.6
mitochondrial ribosome associated GTPase 1
chr15_+_89088417 0.34 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr7_+_75882044 0.34 ENST00000428119.1
rhomboid domain containing 2
chr3_-_33097132 0.34 ENST00000307363.10
ENST00000307377.12
ENST00000440656.1
ENST00000436768.1
ENST00000342462.5
galactosidase beta 1
transmembrane protein with metallophosphoesterase domain
chr2_+_208359686 0.34 ENST00000617735.4
parathyroid hormone 2 receptor
chr1_-_13201409 0.33 ENST00000625019.3
PRAME family member 13
chr17_-_7627803 0.33 ENST00000573566.1
ENST00000269298.10
spermidine/spermine N1-acetyltransferase family member 2
chr12_+_57230124 0.33 ENST00000553529.5
ENST00000554310.5
serine hydroxymethyltransferase 2
chr10_-_5003850 0.33 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
aldo-keto reductase family 1 member C2
chr18_+_54828406 0.33 ENST00000262094.10
RAB27B, member RAS oncogene family
chr4_-_155376797 0.33 ENST00000650955.1
ENST00000515654.5
microtubule associated protein 9
chr20_+_18507520 0.33 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr7_-_101200912 0.32 ENST00000440203.6
ENST00000379423.3
ENST00000223114.9
monoacylglycerol O-acyltransferase 3
chr2_+_32063588 0.31 ENST00000646571.1
spastin
chr7_-_44159278 0.31 ENST00000345378.7
glucokinase
chr11_+_72189528 0.31 ENST00000312293.9
folate receptor alpha
chr11_+_925809 0.31 ENST00000332231.9
adaptor related protein complex 2 subunit alpha 2
chr9_-_110256466 0.31 ENST00000374515.9
ENST00000374517.6
thioredoxin
chr1_+_197268222 0.31 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chr6_+_101181254 0.30 ENST00000682090.1
ENST00000421544.6
glutamate ionotropic receptor kainate type subunit 2
chr21_+_43867215 0.30 ENST00000448287.5
1-acylglycerol-3-phosphate O-acyltransferase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
1.3 7.9 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.2 3.7 GO:1903717 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.7 3.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.6 18.8 GO:0006544 glycine metabolic process(GO:0006544)
0.4 4.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.4 3.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.4 3.0 GO:0050955 thermoception(GO:0050955)
0.4 2.3 GO:0008218 bioluminescence(GO:0008218)
0.4 1.4 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.3 0.9 GO:1903937 response to acrylamide(GO:1903937)
0.3 1.3 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.2 3.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.2 2.0 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.2 1.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.2 0.7 GO:0015744 succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422)
0.2 0.5 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.2 2.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.9 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 0.7 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.2 1.0 GO:0061107 seminal vesicle development(GO:0061107)
0.2 0.5 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.2 0.6 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.9 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.1 0.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 0.7 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 1.6 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.5 GO:0032903 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.1 1.4 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 1.0 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.3 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 0.7 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 1.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.3 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 0.4 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.1 0.4 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.1 1.3 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.8 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.3 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.1 0.3 GO:0051413 response to cortisone(GO:0051413)
0.1 0.7 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 1.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 1.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 1.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.6 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.2 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.3 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.1 0.4 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 1.7 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.4 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 3.4 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 8.3 GO:0006970 response to osmotic stress(GO:0006970)
0.1 0.3 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 0.3 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.4 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 0.4 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 0.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.3 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.7 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.4 GO:2001023 regulation of response to drug(GO:2001023)
0.0 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 1.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 1.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 2.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.5 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.3 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.0 0.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.2 GO:0035627 ceramide transport(GO:0035627)
0.0 2.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.4 GO:0000050 urea cycle(GO:0000050)
0.0 0.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.7 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.2 GO:0032445 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.4 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.4 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.4 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.3 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.3 GO:0006662 glycerol ether metabolic process(GO:0006662) protein repair(GO:0030091)
0.0 0.3 GO:0015866 ADP transport(GO:0015866)
0.0 0.1 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.0 0.6 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.4 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.5 GO:1904152 regulation of retrograde protein transport, ER to cytosol(GO:1904152)
0.0 0.3 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.0 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.5 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363)
0.0 0.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.9 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 1.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0046671 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.0 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.4 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.2 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 2.4 GO:0051262 protein tetramerization(GO:0051262)
0.0 0.1 GO:0002357 defense response to tumor cell(GO:0002357)
0.0 1.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.5 GO:0046849 bone remodeling(GO:0046849)
0.0 1.1 GO:0042246 tissue regeneration(GO:0042246)
0.0 1.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0036027 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.2 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 3.1 GO:0033270 paranode region of axon(GO:0033270)
0.1 2.7 GO:0042627 chylomicron(GO:0042627)
0.1 0.3 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.1 6.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.3 GO:1905103 integral component of lysosomal membrane(GO:1905103)
0.1 2.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.9 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0 0.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 3.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 9.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 0.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 1.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 19.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 3.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 4.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 4.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.3 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 3.3 GO:0043209 myelin sheath(GO:0043209)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
1.7 16.7 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.9 3.7 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 1.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.4 1.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.3 3.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 1.0 GO:1904492 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.2 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 2.1 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 0.7 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.2 0.4 GO:0070905 serine binding(GO:0070905)
0.2 2.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 0.3 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.2 0.6 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 1.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 5.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.7 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.7 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.1 0.7 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 1.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.1 0.4 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.1 0.3 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.1 1.0 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 2.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.3 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 0.4 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.3 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0042282 hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282)
0.1 3.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.4 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 1.6 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.3 GO:0001601 peptide YY receptor activity(GO:0001601)
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.5 GO:0005497 androgen binding(GO:0005497)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.4 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.4 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.2 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.0 0.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.3 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 6.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.3 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 3.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:0048038 quinone binding(GO:0048038)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.4 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 3.7 GO:0005319 lipid transporter activity(GO:0005319)
0.0 3.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 2.0 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 3.9 GO:0051015 actin filament binding(GO:0051015)
0.0 0.7 GO:0005549 odorant binding(GO:0005549)
0.0 1.3 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 3.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 3.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 2.0 PID CD40 PATHWAY CD40/CD40L signaling
0.0 8.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3 4.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 5.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 18.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 3.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.1 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.9 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 4.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)