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avrg: Illumina Body Map 2 (GSE30611)
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Results for SP4_PML
Z-value: 3.29
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PML | hg38_v1_chr15_+_73994777_73994803 | -0.06 | 7.6e-01 | Click! |
| SP4 | hg38_v1_chr7_+_21428184_21428227 | 0.01 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 60.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.4 | 47.5 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.4 | 44.8 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.6 | 44.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.4 | 43.6 | GO:0014733 | regulation of skeletal muscle adaptation(GO:0014733) |
| 1.6 | 41.7 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.7 | 41.3 | GO:0008089 | anterograde axonal transport(GO:0008089) |
| 0.8 | 40.2 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 4.0 | 32.2 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 0.2 | 31.7 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 279.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.8 | 105.8 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.4 | 88.4 | GO:0098793 | presynapse(GO:0098793) |
| 0.2 | 85.6 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.5 | 74.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 54.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 51.6 | GO:0031674 | I band(GO:0031674) |
| 1.1 | 51.5 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.6 | 49.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.6 | 47.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 135.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 66.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 66.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 60.0 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.5 | 53.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.2 | 47.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.8 | 47.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.1 | 47.4 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.7 | 45.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.0 | 44.0 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 53.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.6 | 50.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.9 | 44.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.5 | 38.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 33.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.5 | 25.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 24.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 23.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.8 | 21.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 21.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 198.5 | REACTOME NEURONAL SYSTEM | Genes involved in Neuronal System |
| 1.2 | 72.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.5 | 64.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.8 | 62.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.7 | 50.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.5 | 47.5 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.7 | 46.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.0 | 44.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 32.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 31.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |