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avrg: Illumina Body Map 2 (GSE30611)

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Results for TCF7L2

Z-value: 1.25

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
ENSG00000148737.17 TCF7L2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg38_v1_chr10_+_113125536_113125665-0.241.8e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr16_+_72063226 4.69 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
haptoglobin-related protein
chr11_+_114257800 4.53 ENST00000535401.5
nicotinamide N-methyltransferase
chr11_+_69641146 3.92 ENST00000227507.3
ENST00000536559.1
cyclin D1
chr16_+_72054477 3.55 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
haptoglobin
chr6_+_31946086 3.28 ENST00000425368.7
complement factor B
chr2_-_88128049 3.17 ENST00000393750.3
ENST00000295834.8
fatty acid binding protein 1
chr10_+_7703300 3.13 ENST00000358415.9
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_113553039 3.07 ENST00000351270.4
hyaluronan binding protein 2
chrX_-_32155462 3.01 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
dystrophin
chr2_+_233712905 2.99 ENST00000373414.4
UDP glucuronosyltransferase family 1 member A5
chr10_+_7703340 2.90 ENST00000429820.5
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr5_-_135954962 2.75 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
leukocyte cell derived chemotaxin 2
chr17_-_69141878 2.51 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr14_-_64942783 2.23 ENST00000612794.1
glutathione peroxidase 2
chr17_+_1771688 2.13 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr7_+_138076453 2.05 ENST00000242375.8
ENST00000411726.6
aldo-keto reductase family 1 member D1
chrX_+_153494970 2.02 ENST00000331595.9
ENST00000431891.1
biglycan
chrX_+_47078380 1.97 ENST00000352078.8
regucalcin
chrX_+_47078330 1.94 ENST00000457380.5
regucalcin
chr1_+_99646025 1.94 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
palmdelphin
chrX_+_47078434 1.86 ENST00000397180.6
regucalcin
chr4_-_108762964 1.84 ENST00000512646.5
ENST00000411864.6
ENST00000296486.8
ENST00000510706.5
ethanolamine-phosphate phospho-lyase
chr5_-_154478218 1.81 ENST00000231121.3
heart and neural crest derivatives expressed 1
chr12_+_107774704 1.72 ENST00000342331.5
achaete-scute family bHLH transcription factor 4
chr7_+_138076422 1.52 ENST00000432161.5
aldo-keto reductase family 1 member D1
chr10_+_99782628 1.46 ENST00000648689.1
ENST00000647814.1
ATP binding cassette subfamily C member 2
chr13_+_75760659 1.43 ENST00000526202.5
ENST00000465261.6
LIM domain 7
chr17_-_65561137 1.42 ENST00000580513.1
axin 2
chr2_+_167135901 1.41 ENST00000628543.2
xin actin binding repeat containing 2
chr4_-_74099187 1.39 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr14_-_93976719 1.34 ENST00000555287.1
ankyrin repeat and SOCS box containing 2
chr17_+_44004604 1.31 ENST00000293404.8
ENST00000589767.1
N-acetylglutamate synthase
chr17_+_81712236 1.29 ENST00000545862.5
ENST00000350690.10
ENST00000331531.9
solute carrier family 25 member 10
chr7_-_149028452 1.28 ENST00000413966.1
ENST00000652332.1
protein disulfide isomerase family A member 4
chr13_+_75760431 1.27 ENST00000321797.12
LIM domain 7
chr10_-_86957582 1.25 ENST00000372027.10
multimerin 2
chr1_+_162381703 1.22 ENST00000458626.4
chromosome 1 open reading frame 226
chr13_-_27969295 1.20 ENST00000381020.8
caudal type homeobox 2
chr6_-_25930678 1.19 ENST00000377850.8
solute carrier family 17 member 2
chr7_-_149028651 1.18 ENST00000286091.9
protein disulfide isomerase family A member 4
chr6_-_25930611 1.16 ENST00000360488.7
solute carrier family 17 member 2
chrX_+_106920393 1.15 ENST00000336803.2
claudin 2
chr18_+_48539017 1.14 ENST00000256413.8
cap binding complex dependent translation initiation factor
chr8_-_118951876 1.07 ENST00000297350.9
TNF receptor superfamily member 11b
chr9_-_4741176 1.06 ENST00000381809.8
adenylate kinase 3
chr2_-_71130214 1.04 ENST00000494660.6
ENST00000244217.6
ENST00000486135.1
methylmalonyl-CoA epimerase
chr17_-_47957824 1.03 ENST00000300557.3
proline rich 15 like
chr4_-_64409444 1.02 ENST00000381210.8
ENST00000507440.5
trans-2,3-enoyl-CoA reductase like
chr16_-_73048104 1.02 ENST00000268489.10
zinc finger homeobox 3
chr8_-_141002072 0.99 ENST00000517453.5
protein tyrosine kinase 2
chr14_-_93976550 0.95 ENST00000555019.6
ankyrin repeat and SOCS box containing 2
chr7_+_94394886 0.92 ENST00000297268.11
ENST00000620463.1
collagen type I alpha 2 chain
chr3_+_29281552 0.89 ENST00000452462.5
ENST00000456853.1
RNA binding motif single stranded interacting protein 3
chr5_-_176388563 0.89 ENST00000509257.1
ENST00000616685.1
ENST00000614830.5
NOP16 nucleolar protein
chr15_-_89751292 0.88 ENST00000300057.4
mesoderm posterior bHLH transcription factor 1
chr1_+_60865259 0.87 ENST00000371191.5
nuclear factor I A
chr20_-_57265738 0.87 ENST00000433911.1
bone morphogenetic protein 7
chr2_+_69013170 0.86 ENST00000303714.9
ANTXR cell adhesion molecule 1
chr18_+_48539198 0.85 ENST00000591412.5
cap binding complex dependent translation initiation factor
chr18_-_26865689 0.85 ENST00000675739.1
ENST00000383168.9
ENST00000672981.2
ENST00000578776.1
aquaporin 4
chr4_-_64409381 0.85 ENST00000509536.1
trans-2,3-enoyl-CoA reductase like
chr1_-_109392893 0.83 ENST00000633956.1
sortilin 1
chr14_+_32329341 0.83 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr5_-_59039454 0.80 ENST00000358923.10
phosphodiesterase 4D
chr18_+_48539112 0.79 ENST00000382998.8
cap binding complex dependent translation initiation factor
chr9_+_125748175 0.78 ENST00000491787.7
ENST00000447726.6
PBX homeobox 3
chr19_+_49581304 0.77 ENST00000246794.10
proline rich and Gla domain 2
chr4_+_86936386 0.76 ENST00000511442.1
AF4/FMR2 family member 1
chr16_+_19211157 0.75 ENST00000568433.1
synaptotagmin 17
chr5_-_176388629 0.75 ENST00000619979.4
ENST00000621444.4
NOP16 nucleolar protein
chr2_+_112911159 0.75 ENST00000263326.8
interleukin 37
chr14_+_32329256 0.74 ENST00000280979.9
A-kinase anchoring protein 6
chr10_-_73591330 0.74 ENST00000451492.5
ENST00000681793.1
ENST00000680396.1
ENST00000413442.5
ubiquitin specific peptidase 54
chr19_+_54983486 0.74 ENST00000540005.1
NLR family pyrin domain containing 2
chr6_+_63571702 0.73 ENST00000672924.1
protein tyrosine phosphatase 4A1
chr7_+_138076475 0.73 ENST00000438242.1
aldo-keto reductase family 1 member D1
chr1_+_77918128 0.72 ENST00000342754.5
nexilin F-actin binding protein
chr2_+_69013414 0.71 ENST00000681816.1
ENST00000482235.2
ANTXR cell adhesion molecule 1
chr1_-_11847772 0.70 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr7_+_120988683 0.69 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr18_-_26865732 0.69 ENST00000672188.1
aquaporin 4
chr10_-_102432565 0.68 ENST00000369937.5
CUE domain containing 2
chrX_-_47145035 0.68 ENST00000276062.8
NADH:ubiquinone oxidoreductase subunit B11
chrX_-_47144680 0.67 ENST00000377811.4
NADH:ubiquinone oxidoreductase subunit B11
chr14_-_52791597 0.66 ENST00000216410.8
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr5_+_171419635 0.66 ENST00000274625.6
fibroblast growth factor 18
chr15_+_43593601 0.65 ENST00000449946.5
ENST00000417289.1
creatine kinase, mitochondrial 1B
chr10_+_52128343 0.65 ENST00000672084.1
protein kinase cGMP-dependent 1
chr15_-_55588337 0.65 ENST00000563719.4
pygopus family PHD finger 1
chr2_-_55917699 0.65 ENST00000634374.1
EGF containing fibulin extracellular matrix protein 1
chr10_+_112374110 0.62 ENST00000354655.9
acyl-CoA synthetase long chain family member 5
chr3_-_134374439 0.60 ENST00000513145.1
ENST00000249883.10
ENST00000422605.6
angiomotin like 2
chr15_+_43593054 0.60 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr2_+_69013379 0.59 ENST00000409349.7
ANTXR cell adhesion molecule 1
chr19_-_40285251 0.58 ENST00000358335.9
AKT serine/threonine kinase 2
chr2_+_170715317 0.58 ENST00000375281.4
Sp5 transcription factor
chr10_-_99620401 0.56 ENST00000370495.6
solute carrier family 25 member 28
chr14_-_52791462 0.56 ENST00000650397.1
ENST00000554230.5
glucosamine-phosphate N-acetyltransferase 1
chr1_+_154272589 0.56 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HCLS1 associated protein X-1
chr17_-_81961837 0.56 ENST00000425009.1
notum, palmitoleoyl-protein carboxylesterase
chr1_-_93614091 0.56 ENST00000370247.7
BCAR3 adaptor protein, NSP family member
chr1_-_11848345 0.55 ENST00000376476.1
natriuretic peptide A
chr19_-_40285277 0.54 ENST00000579047.5
ENST00000392038.7
AKT serine/threonine kinase 2
chr6_-_11779606 0.52 ENST00000506810.1
androgen dependent TFPI regulating protein
chrX_+_2752024 0.52 ENST00000644266.2
ENST00000419513.7
ENST00000509484.3
ENST00000381174.10
Xg glycoprotein (Xg blood group)
chr20_-_675793 0.51 ENST00000488788.2
ENST00000246104.7
novel protein
scratch family transcriptional repressor 2
chr4_+_30720348 0.51 ENST00000361762.3
protocadherin 7
chr5_-_16936231 0.51 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
myosin X
chr2_+_69013337 0.51 ENST00000463335.2
ANTXR cell adhesion molecule 1
chr11_-_108552196 0.50 ENST00000526312.5
exophilin 5
chr19_-_18606779 0.50 ENST00000684169.1
ENST00000392386.8
cytokine receptor like factor 1
chr5_-_149551381 0.48 ENST00000670598.1
ENST00000657001.1
ENST00000515768.6
ENST00000261798.10
ENST00000377843.8
casein kinase 1 alpha 1
chr3_+_217535 0.48 ENST00000449294.6
cell adhesion molecule L1 like
chrX_+_17656082 0.48 ENST00000648929.1
NHS actin remodeling regulator
chr19_-_40285395 0.48 ENST00000424901.5
ENST00000578123.5
AKT serine/threonine kinase 2
chr19_-_43504711 0.47 ENST00000601646.1
pleckstrin homology like domain family B member 3
chrX_+_111511661 0.47 ENST00000569275.1
serine rich and transmembrane domain containing 2
chr11_-_70717994 0.47 ENST00000659264.1
SH3 and multiple ankyrin repeat domains 2
chr14_+_32934383 0.47 ENST00000551634.6
neuronal PAS domain protein 3
chr22_+_40951364 0.47 ENST00000216225.9
ring-box 1
chr11_+_111878926 0.46 ENST00000528125.5
chromosome 11 open reading frame 1
chr15_+_92904447 0.46 ENST00000626782.2
chromodomain helicase DNA binding protein 2
chr8_-_6926066 0.46 ENST00000297436.3
defensin alpha 6
chr7_+_80646305 0.43 ENST00000426978.5
ENST00000432207.5
CD36 molecule
chr5_+_102865737 0.42 ENST00000509523.2
peptidylglycine alpha-amidating monooxygenase
chr4_+_112860912 0.41 ENST00000671951.1
ankyrin 2
chr3_-_155293665 0.41 ENST00000489090.2
small transmembrane regulator of ion transport 1
chr17_-_41350824 0.41 ENST00000007735.4
keratin 33A
chr4_+_112861053 0.41 ENST00000672221.1
ankyrin 2
chr20_+_59300547 0.40 ENST00000644821.1
endothelin 3
chr11_+_124919244 0.39 ENST00000408930.6
hepatocellular carcinoma, down-regulated 1
chr7_+_80646347 0.39 ENST00000413265.5
CD36 molecule
chr15_-_93089192 0.39 ENST00000329082.11
repulsive guidance molecule BMP co-receptor a
chr7_+_27242700 0.38 ENST00000222761.7
even-skipped homeobox 1
chr6_-_112254555 0.38 ENST00000230538.12
ENST00000389463.9
ENST00000368638.5
ENST00000431543.6
ENST00000453937.2
laminin subunit alpha 4
chr5_+_140855882 0.38 ENST00000562220.2
ENST00000307360.6
ENST00000506939.6
protocadherin alpha 10
chr4_+_112860981 0.37 ENST00000671704.1
ankyrin 2
chr20_+_59300703 0.37 ENST00000395654.3
endothelin 3
chr2_+_69013282 0.37 ENST00000409829.7
ANTXR cell adhesion molecule 1
chr6_-_112254647 0.36 ENST00000455073.1
ENST00000522006.5
ENST00000519932.5
laminin subunit alpha 4
chr10_+_69801874 0.36 ENST00000357811.8
collagen type XIII alpha 1 chain
chr12_-_48570046 0.36 ENST00000301046.6
ENST00000549817.1
lactalbumin alpha
chr6_-_89217339 0.36 ENST00000454853.7
gamma-aminobutyric acid type A receptor subunit rho1
chr17_+_44846318 0.36 ENST00000591513.5
HIG1 hypoxia inducible domain family member 1B
chr12_-_23584600 0.35 ENST00000396007.6
SRY-box transcription factor 5
chr15_+_43692886 0.35 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr7_+_100015572 0.33 ENST00000535170.5
zinc finger with KRAB and SCAN domains 1
chr11_-_41459592 0.33 ENST00000528697.6
ENST00000530763.5
leucine rich repeat containing 4C
chr16_+_53208438 0.33 ENST00000565442.1
chromodomain helicase DNA binding protein 9
chr20_+_59300589 0.33 ENST00000337938.7
ENST00000371025.7
endothelin 3
chr6_+_155216959 0.32 ENST00000462408.2
TIAM Rac1 associated GEF 2
chr7_+_27242796 0.32 ENST00000496902.7
even-skipped homeobox 1
chr14_+_20768393 0.32 ENST00000326783.4
epididymal protein 3B
chr17_-_40966945 0.32 ENST00000355612.7
keratin 39
chr17_-_40100569 0.31 ENST00000246672.4
nuclear receptor subfamily 1 group D member 1
chr6_-_112254485 0.31 ENST00000521398.5
ENST00000424408.6
ENST00000243219.7
laminin subunit alpha 4
chr5_-_16742221 0.30 ENST00000505695.5
myosin X
chr3_+_137764296 0.30 ENST00000306087.3
SRY-box transcription factor 14
chr11_-_35360050 0.29 ENST00000644868.1
ENST00000643454.1
ENST00000646080.1
solute carrier family 1 member 2
chr1_-_230869564 0.29 ENST00000470540.5
chromosome 1 open reading frame 198
chr3_+_156120572 0.28 ENST00000389636.9
ENST00000490337.6
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr6_-_32178080 0.28 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr14_+_74348440 0.28 ENST00000256362.5
vertebrae development associated
chr5_+_55160161 0.28 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
glutathione peroxidase 8 (putative)
chr10_+_52314272 0.28 ENST00000373970.4
dickkopf WNT signaling pathway inhibitor 1
chr22_-_33572227 0.27 ENST00000674780.1
LARGE xylosyl- and glucuronyltransferase 1
chr5_-_161546671 0.27 ENST00000517547.5
gamma-aminobutyric acid type A receptor subunit beta2
chr11_-_76210736 0.26 ENST00000529461.1
Wnt family member 11
chr17_+_70104848 0.26 ENST00000392670.5
potassium inwardly rectifying channel subfamily J member 16
chr12_+_70366277 0.25 ENST00000258111.5
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr17_+_82860354 0.25 ENST00000576996.5
tubulin folding cofactor D
chr5_+_175861628 0.25 ENST00000509837.5
complexin 2
chr6_-_166167832 0.24 ENST00000366876.7
T-box transcription factor T
chr14_-_21034802 0.23 ENST00000382951.4
ribonuclease A family member 13 (inactive)
chr3_-_57165332 0.23 ENST00000296318.12
interleukin 17 receptor D
chr10_-_45307838 0.23 ENST00000536058.1
olfactory receptor family 13 subfamily A member 1
chr22_-_32464440 0.23 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPI fold containing family C
chr6_+_37170133 0.23 ENST00000373509.6
Pim-1 proto-oncogene, serine/threonine kinase
chr5_-_149551168 0.22 ENST00000515748.2
ENST00000606719.6
casein kinase 1 alpha 1
chr2_+_219444657 0.22 ENST00000451076.1
striated muscle enriched protein kinase
chr13_+_23570370 0.22 ENST00000403372.6
ENST00000248484.9
TNF receptor superfamily member 19
chr7_+_100015588 0.22 ENST00000324306.11
ENST00000426572.5
zinc finger with KRAB and SCAN domains 1
chr5_+_176388731 0.22 ENST00000274787.3
HIG1 hypoxia inducible domain family member 2A
chr17_+_70104991 0.22 ENST00000587698.5
ENST00000587892.1
potassium inwardly rectifying channel subfamily J member 16
chr5_+_102865805 0.21 ENST00000346918.7
peptidylglycine alpha-amidating monooxygenase
chr3_-_15797930 0.21 ENST00000683139.1
ankyrin repeat domain 28
chr8_-_71356653 0.21 ENST00000388742.8
ENST00000388740.4
EYA transcriptional coactivator and phosphatase 1
chr18_+_10454584 0.21 ENST00000355285.10
APC down-regulated 1
chr12_-_123149902 0.21 ENST00000542210.1
phosphatidylinositol transfer protein membrane associated 2
chr1_-_44141631 0.21 ENST00000634670.1
Kruppel like factor 18
chr4_-_108762535 0.20 ENST00000512320.1
ENST00000510723.1
ethanolamine-phosphate phospho-lyase
chr7_+_114416286 0.20 ENST00000635534.1
forkhead box P2
chr10_+_69801892 0.20 ENST00000398978.8
ENST00000645393.2
ENST00000354547.7
ENST00000674121.1
ENST00000673842.1
ENST00000520267.5
collagen type XIII alpha 1 chain
chrX_-_112679919 0.20 ENST00000371968.8
LHFPL tetraspan subfamily member 1
chr11_-_40294089 0.20 ENST00000278198.2
leucine rich repeat containing 4C
chr15_-_89221558 0.19 ENST00000268125.10
retinaldehyde binding protein 1
chr11_-_5234475 0.19 ENST00000292901.7
ENST00000650601.1
ENST00000417377.1
hemoglobin subunit delta
chr1_+_61952283 0.19 ENST00000307297.8
PATJ crumbs cell polarity complex component
chr4_-_138242325 0.18 ENST00000280612.9
solute carrier family 7 member 11
chr5_+_141417659 0.18 ENST00000398594.4
protocadherin gamma subfamily B, 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:1903631 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
1.2 3.5 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.9 4.3 GO:0030573 bile acid catabolic process(GO:0030573)
0.6 3.0 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.6 1.8 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.5 1.5 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.4 1.2 GO:0090381 regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.4 1.1 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.4 1.1 GO:0046041 ITP metabolic process(GO:0046041)
0.3 1.3 GO:0071422 succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422)
0.3 2.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 4.8 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 3.0 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 2.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.2 3.9 GO:0070141 Leydig cell differentiation(GO:0033327) positive regulation of mammary gland epithelial cell proliferation(GO:0033601) response to UV-A(GO:0070141)
0.2 0.9 GO:1905069 nephrogenic mesenchyme morphogenesis(GO:0072134) allantois development(GO:1905069)
0.2 1.0 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.2 1.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 3.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 0.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 0.6 GO:1990697 protein depalmitoleylation(GO:1990697)
0.2 4.6 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2 0.7 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 1.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.2 1.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 0.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 3.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 1.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.1 0.7 GO:0018032 protein amidation(GO:0018032)
0.1 0.7 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.7 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.3 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 6.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.7 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 1.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 2.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 1.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.7 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 1.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.2 GO:0021758 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
0.1 0.8 GO:2000332 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.9 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.5 GO:0010265 SCF complex assembly(GO:0010265)
0.0 1.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 1.5 GO:0006833 water transport(GO:0006833)
0.0 1.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.4 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.9 GO:0072189 ureter development(GO:0072189)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.0 2.5 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.2 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.7 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 0.7 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0 1.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 2.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 2.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 1.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 1.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.4 GO:0003281 ventricular septum development(GO:0003281)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.3 GO:0032196 transposition(GO:0032196)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.7 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0003190 atrioventricular valve formation(GO:0003190)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 0.9 GO:0005584 collagen type I trimer(GO:0005584)
0.2 4.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 2.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 0.6 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 3.0 GO:0016013 syntrophin complex(GO:0016013)
0.2 3.2 GO:0045179 apical cortex(GO:0045179)
0.2 2.1 GO:0043203 axon hillock(GO:0043203)
0.1 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 3.8 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 3.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 8.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.5 GO:0005883 neurofilament(GO:0005883)
0.0 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0005605 basal lamina(GO:0005605)
0.0 1.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.4 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0005816 spindle pole body(GO:0005816)
0.0 1.2 GO:0031430 M band(GO:0031430)
0.0 3.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:0004341 gluconolactonase activity(GO:0004341)
1.2 8.2 GO:0030492 hemoglobin binding(GO:0030492)
0.9 4.3 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.5 2.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.5 3.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.3 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.3 1.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.0 GO:0030379 neurotensin receptor activity, non-G-protein coupled(GO:0030379)
0.2 0.6 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.2 0.7 GO:0032090 Pyrin domain binding(GO:0032090)
0.2 1.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 2.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 2.5 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.7 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 3.0 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 3.9 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 3.3 GO:0001848 complement binding(GO:0001848)
0.1 1.5 GO:0015250 water channel activity(GO:0015250)
0.1 0.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.1 1.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 2.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.8 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0002046 opsin binding(GO:0002046)
0.1 0.2 GO:1990175 EH domain binding(GO:1990175)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.3 GO:0004803 transposase activity(GO:0004803)
0.1 2.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.5 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 8.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.0 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.6 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.9 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 3.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.0 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0 1.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 2.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0070402 NADPH binding(GO:0070402)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 3.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.6 ST GAQ PATHWAY G alpha q Pathway
0.0 1.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 5.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 8.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 3.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 3.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.0 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 3.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 4.1 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 2.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 4.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport