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avrg: Illumina Body Map 2 (GSE30611)
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Results for TWIST1_SNAI1
Z-value: 2.77
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Transcription factors associated with TWIST1_SNAI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SNAI1 | hg38_v1_chr20_+_49982969_49982989 | 0.28 | 1.2e-01 | Click! |
| TWIST1 | hg38_v1_chr7_-_19117625_19117645 | 0.09 | 6.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.5 | 17.1 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 5.0 | 15.0 | GO:0043000 | Golgi to plasma membrane CFTR protein transport(GO:0043000) |
| 4.7 | 14.1 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 0.7 | 11.5 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.1 | 11.5 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 1.4 | 10.9 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) |
| 0.4 | 9.8 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 2.4 | 9.5 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.1 | 9.1 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 24.8 | GO:0070160 | occluding junction(GO:0070160) |
| 0.1 | 21.8 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.5 | 19.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.4 | 18.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 14.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 13.8 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.4 | 13.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 12.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 11.4 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 29.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 19.2 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.5 | 17.1 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.7 | 15.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.6 | 12.3 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.3 | 9.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.9 | 8.2 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.8 | 8.0 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 7.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 7.6 | GO:0000146 | microfilament motor activity(GO:0000146) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 12.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 11.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 10.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 10.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 9.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 8.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 7.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 4.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 32.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.5 | 13.1 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.5 | 12.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.7 | 10.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 10.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 9.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 9.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 7.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.3 | 7.3 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.2 | 7.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |