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avrg: Illumina Body Map 2 (GSE30611)
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Results for UGUGCUU
Z-value: 3.58
Motif logo
miRNA associated with seed UGUGCUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-218-5p
|
MIMAT0000275 |
Activity profile of UGUGCUU motif
Sorted Z-values of UGUGCUU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of UGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.2 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 3.4 | 10.1 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 2.5 | 10.0 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 2.4 | 7.1 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 2.3 | 7.0 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
| 2.2 | 6.6 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) |
| 2.1 | 6.2 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 1.5 | 5.8 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 1.5 | 4.4 | GO:1900155 | regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) |
| 1.4 | 8.4 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.1 | 6.9 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 1.1 | 1.1 | GO:1990709 | presynaptic active zone organization(GO:1990709) |
| 1.0 | 10.2 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 1.0 | 6.9 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 1.0 | 12.8 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.9 | 4.7 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.9 | 12.0 | GO:0015820 | leucine transport(GO:0015820) |
| 0.9 | 3.6 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.9 | 0.9 | GO:1990770 | regulation of small intestine smooth muscle contraction(GO:1904347) positive regulation of small intestine smooth muscle contraction(GO:1904349) small intestine smooth muscle contraction(GO:1990770) |
| 0.9 | 7.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.8 | 6.5 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.8 | 4.9 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.8 | 5.5 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.8 | 2.3 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.7 | 5.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.7 | 11.4 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.7 | 4.9 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.6 | 1.9 | GO:0051463 | negative regulation of cortisol secretion(GO:0051463) |
| 0.6 | 7.1 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.6 | 1.2 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.6 | 1.9 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.6 | 4.2 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.6 | 2.4 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.6 | 7.6 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.6 | 1.7 | GO:0035668 | TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669) |
| 0.5 | 1.6 | GO:0043049 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.5 | 6.8 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.5 | 3.1 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.5 | 5.5 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.5 | 9.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.5 | 1.4 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.5 | 13.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.5 | 9.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.4 | 2.2 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.4 | 2.2 | GO:0009099 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.4 | 2.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.4 | 1.7 | GO:0009436 | glyoxylate catabolic process(GO:0009436) |
| 0.4 | 2.5 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.4 | 1.2 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.4 | 6.0 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.4 | 4.0 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.4 | 11.4 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 7.0 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.4 | 1.6 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 0.4 | 1.2 | GO:0015670 | carbon dioxide transport(GO:0015670) dipeptide transport(GO:0042938) |
| 0.4 | 4.2 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.4 | 3.2 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.3 | 4.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 2.8 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 0.3 | 1.7 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.3 | 26.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 4.0 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.3 | 2.0 | GO:0019075 | virus maturation(GO:0019075) |
| 0.3 | 1.3 | GO:0099542 | trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542) |
| 0.3 | 1.0 | GO:1903595 | positive regulation of histamine secretion by mast cell(GO:1903595) |
| 0.3 | 11.5 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.3 | 5.1 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.3 | 1.8 | GO:1903998 | response to isolation stress(GO:0035900) regulation of eating behavior(GO:1903998) |
| 0.3 | 2.0 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.3 | 1.9 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.3 | 12.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.3 | 3.7 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.3 | 7.6 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.3 | 1.0 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.3 | 4.7 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 0.3 | 1.3 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.3 | 2.8 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.2 | 7.3 | GO:0060973 | cell migration involved in heart development(GO:0060973) |
| 0.2 | 6.5 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.2 | 0.7 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.2 | 0.9 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.2 | 2.0 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.2 | 2.4 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.2 | 0.9 | GO:0072560 | type B pancreatic cell maturation(GO:0072560) |
| 0.2 | 6.9 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.2 | 1.3 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.2 | 5.9 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.2 | 2.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.2 | 2.5 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.2 | 11.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 1.2 | GO:0007497 | posterior midgut development(GO:0007497) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.2 | 2.9 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.2 | 1.0 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.2 | 2.3 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.2 | 15.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.2 | 1.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 3.3 | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471) |
| 0.2 | 9.8 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.2 | 13.2 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 9.5 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.2 | 5.4 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.2 | 1.6 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 6.7 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.2 | 1.6 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.2 | 5.0 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.2 | 1.6 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 0.6 | GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis(GO:0060979) |
| 0.2 | 1.1 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.2 | 0.6 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.1 | 1.4 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 1.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 1.8 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 0.4 | GO:1904908 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.1 | 0.6 | GO:1900247 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 24.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.7 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.7 | GO:0061290 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.1 | 0.8 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.1 | 9.9 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.1 | 1.2 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 7.5 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.1 | 2.0 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.1 | 2.2 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 8.2 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.1 | 1.3 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.1 | 3.4 | GO:0060292 | long term synaptic depression(GO:0060292) |
| 0.1 | 0.5 | GO:0051230 | mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) |
| 0.1 | 1.1 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.1 | 5.3 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.1 | 1.1 | GO:2000807 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) regulation of synaptic vesicle clustering(GO:2000807) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.1 | 1.1 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.1 | 1.3 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 7.6 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 1.9 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 0.9 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.1 | 0.7 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.1 | 1.5 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.1 | 2.6 | GO:0060384 | innervation(GO:0060384) |
| 0.1 | 3.6 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.1 | 0.9 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.1 | 4.7 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.1 | 0.4 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) |
| 0.1 | 1.8 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.1 | 5.6 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.1 | 2.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 0.2 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 0.1 | 1.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 2.3 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.7 | GO:1905146 | lysosomal protein catabolic process(GO:1905146) |
| 0.1 | 1.1 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 2.9 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.1 | 0.8 | GO:1990573 | membrane depolarization during SA node cell action potential(GO:0086046) potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 7.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 7.3 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 2.9 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.1 | 1.0 | GO:1903350 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
| 0.1 | 0.4 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 3.8 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 2.5 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.1 | 0.9 | GO:2000543 | positive regulation of gastrulation(GO:2000543) |
| 0.1 | 2.9 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 7.0 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.0 | 17.0 | GO:0043406 | positive regulation of MAP kinase activity(GO:0043406) |
| 0.0 | 0.9 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 1.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 6.0 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 4.5 | GO:0017156 | calcium ion regulated exocytosis(GO:0017156) |
| 0.0 | 0.5 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.0 | 1.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.6 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.0 | 0.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.3 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.0 | 0.7 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.0 | 2.1 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.4 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.0 | 1.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 2.5 | GO:0007040 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 5.8 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.5 | GO:0021794 | thalamus development(GO:0021794) |
| 0.0 | 2.8 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.0 | 2.9 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.0 | 3.0 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.4 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 0.2 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 0.2 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.0 | 0.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.1 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.0 | 0.6 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.0 | 0.5 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 0.2 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.0 | 2.9 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.1 | GO:1904481 | response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482) |
| 0.0 | 0.5 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.0 | 0.8 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.5 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 0.3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.2 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 0.6 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 2.9 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.5 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.0 | 0.5 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.0 | 0.1 | GO:0097698 | telomere maintenance via base-excision repair(GO:0097698) |
| 0.0 | 0.5 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.3 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.0 | 0.5 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 0.9 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.0 | 0.3 | GO:0043306 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.0 | 3.1 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433) |
| 0.0 | 1.0 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 0.3 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 2.9 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.6 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 1.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.0 | 0.2 | GO:0030828 | positive regulation of cGMP biosynthetic process(GO:0030828) |
| 0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.9 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.0 | 0.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.2 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 1.2 | 10.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 1.1 | 1.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 1.0 | 10.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.0 | 6.9 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.9 | 8.4 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.5 | 13.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.4 | 21.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.3 | 38.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 13.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.3 | 6.2 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.3 | 0.8 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.2 | 32.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 4.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 7.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 0.9 | GO:0000811 | GINS complex(GO:0000811) |
| 0.2 | 0.9 | GO:0039713 | viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517) |
| 0.2 | 8.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.2 | 6.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 3.4 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 2.9 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.2 | 0.8 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.2 | 15.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 10.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.2 | 0.7 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.2 | 1.0 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 1.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 1.8 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.2 | 3.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 0.6 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.1 | 2.2 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 0.1 | 1.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.6 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.1 | 3.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 0.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 1.0 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 21.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 2.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.0 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 19.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 1.4 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 16.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 3.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 11.6 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 0.3 | GO:1990844 | subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844) |
| 0.1 | 1.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 5.7 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 6.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 1.6 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 7.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.4 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 0.5 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 0.3 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.1 | 2.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 3.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 2.0 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 5.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 18.6 | GO:0098793 | presynapse(GO:0098793) |
| 0.1 | 6.8 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 5.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 7.8 | GO:0016234 | inclusion body(GO:0016234) |
| 0.1 | 8.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 3.9 | GO:0044309 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.1 | 1.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 4.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 2.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 16.6 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 12.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.5 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.1 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.0 | 1.8 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 1.1 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.0 | 0.3 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 5.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 3.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.5 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 3.7 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.2 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 6.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 8.7 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 3.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 19.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.7 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.2 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 26.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 69.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 2.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.8 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 11.5 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 1.7 | 6.8 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 1.7 | 8.4 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 1.1 | 10.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 1.0 | 10.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 1.0 | 4.9 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.8 | 8.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.8 | 2.5 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.8 | 8.1 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.8 | 2.3 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.7 | 7.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.7 | 7.1 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.7 | 2.8 | GO:0004605 | diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.7 | 9.8 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.6 | 3.1 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.6 | 2.5 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.5 | 13.0 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.5 | 3.1 | GO:0015137 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.5 | 16.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.5 | 2.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.5 | 2.3 | GO:0098988 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.5 | 3.2 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.4 | 2.2 | GO:0052655 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.4 | 6.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.4 | 12.0 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.4 | 5.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.4 | 3.6 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.4 | 5.1 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.4 | 1.5 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 0.4 | 1.1 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
| 0.3 | 5.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.3 | 3.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.3 | 4.4 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.3 | 1.3 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.3 | 10.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 5.3 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.3 | 7.9 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.3 | 1.8 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.3 | 1.7 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.3 | 5.7 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.3 | 6.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.3 | 1.7 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.3 | 4.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.3 | 3.3 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.3 | 12.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 1.8 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.3 | 1.5 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.3 | 1.3 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.2 | 1.0 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.2 | 2.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.2 | 6.6 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 1.7 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.2 | 12.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 4.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.2 | 3.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 1.0 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.2 | 9.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 1.0 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.2 | 2.0 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.2 | 2.0 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 0.9 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.2 | 1.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.2 | 7.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 1.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.2 | 2.5 | GO:0046790 | virion binding(GO:0046790) |
| 0.2 | 1.2 | GO:0004366 | glycerol-3-phosphate O-acyltransferase activity(GO:0004366) |
| 0.2 | 6.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.2 | 5.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 1.3 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.2 | 5.5 | GO:0015172 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.2 | 4.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 0.6 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.1 | 5.7 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 1.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 1.8 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 3.6 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 0.8 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.1 | 6.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 0.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 13.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 2.6 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 1.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 0.9 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.1 | 6.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.6 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 5.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 3.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.7 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 14.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 1.2 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.1 | 0.7 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.1 | 0.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 0.5 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 8.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 5.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 1.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 4.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.1 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.1 | 4.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 0.4 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 0.1 | 2.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 6.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 2.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.4 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 15.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.7 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 1.6 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 2.9 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 5.7 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 3.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 0.2 | GO:0005128 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 0.1 | 0.4 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 0.8 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 1.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.6 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 5.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 2.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.0 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 0.5 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.1 | 12.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 5.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.3 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 0.9 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.1 | 0.3 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.3 | GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) |
| 0.1 | 1.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 7.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 1.4 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.0 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 1.3 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 1.0 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 3.8 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 0.2 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.0 | 20.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.2 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 2.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.2 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 2.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.5 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 1.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 34.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 2.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 3.6 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 2.1 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 3.5 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.1 | GO:0015154 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.0 | 1.5 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 0.1 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 0.1 | GO:0070905 | serine binding(GO:0070905) |
| 0.0 | 0.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.1 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.0 | 0.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 6.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.1 | GO:0016426 | tRNA (adenine) methyltransferase activity(GO:0016426) |
| 0.0 | 0.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 1.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.1 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.0 | 0.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.3 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 0.6 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.1 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 0.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.8 | GO:0003774 | motor activity(GO:0003774) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 17.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 12.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 2.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 6.7 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 5.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 4.0 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 4.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.9 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 8.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.9 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 3.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 6.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.5 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 2.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 7.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.0 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.4 | 15.5 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.4 | 15.0 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.4 | 20.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.4 | 32.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 9.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 14.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 13.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 7.6 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.3 | 6.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 15.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 13.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 11.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 11.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 2.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 2.2 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 7.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 7.8 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 3.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 3.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 3.2 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.1 | 2.3 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 4.5 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 0.9 | REACTOME SHC MEDIATED SIGNALLING | Genes involved in SHC-mediated signalling |
| 0.1 | 2.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 0.6 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 5.0 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 2.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 3.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 1.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 0.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 0.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 5.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.6 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 1.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 2.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 3.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 6.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |