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avrg: Illumina Body Map 2 (GSE30611)

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Results for ZFHX3

Z-value: 1.47

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.17 ZFHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg38_v1_chr16_-_73048104_73048136-0.757.4e-07Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_154590735 18.42 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr1_-_159714581 10.80 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr1_+_62597510 10.75 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr1_+_159587817 6.67 ENST00000255040.3
APCS
amyloid P component, serum
chr6_+_160702238 5.64 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
PLG
plasminogen
chr17_+_42900791 5.40 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
G6PC1
glucose-6-phosphatase catalytic subunit 1
chr14_+_94561435 4.71 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
SERPINA4
SERPINA5
serpin family A member 4
serpin family A member 5
chr9_-_121050264 3.96 ENST00000223642.3
C5
complement C5
chr4_+_73481737 3.42 ENST00000226355.5
AFM
afamin
chr19_-_58353482 3.41 ENST00000263100.8
A1BG
alpha-1-B glycoprotein
chr2_+_233712905 3.40 ENST00000373414.4
UGT1A5
UDP glucuronosyltransferase family 1 member A5
chr4_+_99574812 3.19 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr2_+_87748087 3.18 ENST00000359481.9
PLGLB2
plasminogen like B2
chr20_-_7940444 3.14 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr2_+_233718734 3.10 ENST00000373409.8
UGT1A4
UDP glucuronosyltransferase family 1 member A4
chr19_-_35812838 3.04 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr17_+_4788926 2.86 ENST00000331264.8
GLTPD2
glycolipid transfer protein domain containing 2
chr2_-_87021844 2.69 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr15_+_58431985 2.62 ENST00000433326.2
ENST00000299022.10
LIPC
lipase C, hepatic type
chr1_-_197067234 2.47 ENST00000367412.2
F13B
coagulation factor XIII B chain
chr2_+_233729042 2.20 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr6_-_160664270 1.86 ENST00000316300.10
LPA
lipoprotein(a)
chr7_-_44541262 1.85 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr11_+_22674769 1.84 ENST00000532398.1
GAS2
growth arrest specific 2
chr20_-_35147285 1.81 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr4_+_3441960 1.65 ENST00000382774.8
ENST00000511533.1
HGFAC
HGF activator
chr20_+_43558968 1.53 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr8_+_103819212 1.38 ENST00000515551.5
RIMS2
regulating synaptic membrane exocytosis 2
chr11_+_72223918 1.30 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase like 1
chr6_+_25754699 1.23 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr7_-_44541318 1.16 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr16_-_69351778 1.12 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr8_+_103819244 1.11 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chr11_+_72223688 1.11 ENST00000540973.1
INPPL1
inositol polyphosphate phosphatase like 1
chr12_-_130716264 1.10 ENST00000643940.1
RIMBP2
RIMS binding protein 2
chr16_+_56191476 0.95 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr3_-_114758940 0.93 ENST00000464560.5
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_39280021 0.89 ENST00000399220.3
CX3CR1
C-X3-C motif chemokine receptor 1
chr3_+_77039836 0.86 ENST00000461745.5
ROBO2
roundabout guidance receptor 2
chr2_-_2324642 0.84 ENST00000650485.1
ENST00000649207.1
MYT1L
myelin transcription factor 1 like
chr17_-_40999903 0.82 ENST00000391587.3
KRTAP3-2
keratin associated protein 3-2
chr2_-_2324323 0.79 ENST00000648339.1
ENST00000647694.1
MYT1L
myelin transcription factor 1 like
chrM_-_14669 0.79 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr6_-_116060859 0.78 ENST00000606080.2
FRK
fyn related Src family tyrosine kinase
chr14_+_39233908 0.77 ENST00000280082.4
MIA2
MIA SH3 domain ER export factor 2
chr2_+_184598520 0.76 ENST00000302277.7
ZNF804A
zinc finger protein 804A
chr7_+_151028422 0.76 ENST00000542328.5
ENST00000461373.5
ENST00000297504.10
ENST00000358849.9
ENST00000498578.5
ENST00000477719.5
ENST00000477092.5
ABCB8
ATP binding cassette subfamily B member 8
chr2_-_2324968 0.74 ENST00000649641.1
MYT1L
myelin transcription factor 1 like
chr12_+_54016879 0.70 ENST00000303406.4
HOXC4
homeobox C4
chr22_-_30246739 0.69 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr2_-_2324935 0.69 ENST00000649709.1
MYT1L
myelin transcription factor 1 like
chrM_+_10464 0.68 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L
chrM_+_8489 0.65 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase membrane subunit 6
chr15_+_76336755 0.64 ENST00000290759.9
ISL2
ISL LIM homeobox 2
chr1_-_160579439 0.59 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr3_-_108529322 0.59 ENST00000273353.4
MYH15
myosin heavy chain 15
chr2_-_60553474 0.57 ENST00000409351.5
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr14_-_100569780 0.57 ENST00000355173.7
BEGAIN
brain enriched guanylate kinase associated
chr8_-_18684033 0.56 ENST00000614430.3
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_18684093 0.54 ENST00000428502.6
PSD3
pleckstrin and Sec7 domain containing 3
chr10_-_72523936 0.53 ENST00000398763.8
ENST00000418483.6
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr1_-_247758680 0.51 ENST00000408896.4
OR1C1
olfactory receptor family 1 subfamily C member 1
chr3_-_167474026 0.48 ENST00000466903.1
ENST00000264677.8
SERPINI2
serpin family I member 2
chr2_-_60553409 0.48 ENST00000358510.6
ENST00000643004.1
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chrM_+_9207 0.45 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_-_116126120 0.44 ENST00000452729.1
ENST00000651968.1
ENST00000243222.8
COL10A1
collagen type X alpha 1 chain
chr4_-_99435134 0.43 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_+_116324440 0.42 ENST00000333254.4
CCDC172
coiled-coil domain containing 172
chr2_+_158533185 0.41 ENST00000629219.1
PKP4
plakophilin 4
chr4_-_99435336 0.41 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_+_70592253 0.41 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr5_-_116554858 0.40 ENST00000509665.1
SEMA6A
semaphorin 6A
chr8_-_144529048 0.40 ENST00000527462.1
ENST00000313465.5
ENST00000524821.6
C8orf82
chromosome 8 open reading frame 82
chr3_+_35680932 0.40 ENST00000396481.6
ARPP21
cAMP regulated phosphoprotein 21
chr12_-_7665897 0.39 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr17_-_41098084 0.38 ENST00000318329.6
ENST00000333822.5
KRTAP4-8
keratin associated protein 4-8
chr3_+_35680994 0.38 ENST00000441454.5
ARPP21
cAMP regulated phosphoprotein 21
chr11_+_5389377 0.37 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr12_+_53954870 0.36 ENST00000243103.4
HOXC12
homeobox C12
chr6_-_127918586 0.36 ENST00000626040.2
THEMIS
thymocyte selection associated
chr1_-_46551647 0.36 ENST00000481882.7
KNCN
kinocilin
chrM_+_14740 0.35 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chrX_+_85003863 0.33 ENST00000373173.7
APOOL
apolipoprotein O like
chr11_+_6199224 0.33 ENST00000311352.3
OR52W1
olfactory receptor family 52 subfamily W member 1
chr11_-_75089754 0.32 ENST00000305159.3
OR2AT4
olfactory receptor family 2 subfamily AT member 4
chrX_-_18672101 0.31 ENST00000379984.4
RS1
retinoschisin 1
chr12_+_55330746 0.29 ENST00000641740.2
OR6C3
olfactory receptor family 6 subfamily C member 3
chr7_+_36420163 0.28 ENST00000446635.5
ANLN
anillin actin binding protein
chr8_+_91101832 0.27 ENST00000518304.1
LRRC69
leucine rich repeat containing 69
chr6_-_127918604 0.24 ENST00000537166.5
THEMIS
thymocyte selection associated
chr15_+_47339059 0.21 ENST00000560636.5
SEMA6D
semaphorin 6D
chr20_+_43559060 0.21 ENST00000485914.2
SGK2
serum/glucocorticoid regulated kinase 2
chr15_-_42051190 0.20 ENST00000399518.3
PLA2G4E
phospholipase A2 group IVE
chr19_+_53962925 0.20 ENST00000270458.4
CACNG8
calcium voltage-gated channel auxiliary subunit gamma 8
chr6_-_127918540 0.16 ENST00000368250.5
THEMIS
thymocyte selection associated
chrY_+_18546691 0.14 ENST00000309834.8
ENST00000307393.3
ENST00000382856.2
HSFY1
heat shock transcription factor Y-linked 1
chr17_+_17782108 0.14 ENST00000395774.1
RAI1
retinoic acid induced 1
chr10_-_126521439 0.13 ENST00000284694.11
ENST00000432642.5
C10orf90
chromosome 10 open reading frame 90
chr12_-_56741535 0.13 ENST00000647707.1
ENSG00000285625.1
novel protein
chr7_+_33904911 0.13 ENST00000297161.6
BMPER
BMP binding endothelial regulator
chr14_-_20036038 0.12 ENST00000641664.1
ENST00000641904.1
OR4K13
olfactory receptor family 4 subfamily K member 13
chr12_-_10169155 0.12 ENST00000539518.5
OLR1
oxidized low density lipoprotein receptor 1
chr6_-_32407123 0.11 ENST00000374993.4
ENST00000544175.2
ENST00000454136.7
ENST00000446536.2
BTNL2
butyrophilin like 2
chr6_+_47781982 0.11 ENST00000489301.6
ENST00000638973.1
ENST00000371211.6
ENST00000393699.2
OPN5
opsin 5
chr12_+_64497968 0.10 ENST00000676593.1
ENST00000677093.1
TBK1
ENSG00000288665.1
TANK binding kinase 1
novel transcript
chr17_-_28406160 0.09 ENST00000618626.1
ENST00000612814.5
SLC46A1
solute carrier family 46 member 1
chr1_-_35554930 0.07 ENST00000440579.5
ENST00000494948.1
KIAA0319L
KIAA0319 like
chr2_-_60553558 0.07 ENST00000642439.1
ENST00000356842.9
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chr20_-_37178966 0.07 ENST00000422138.1
MROH8
maestro heat like repeat family member 8
chr4_-_22443110 0.06 ENST00000508133.5
ADGRA3
adhesion G protein-coupled receptor A3
chr8_-_69833338 0.04 ENST00000524945.5
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr18_+_34976928 0.03 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr11_-_559377 0.00 ENST00000486629.1
LMNTD2
lamin tail domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
1.4 5.6 GO:0052047 positive regulation of fibrinolysis(GO:0051919) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.3 18.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.9 10.8 GO:0051005 negative regulation of phospholipase activity(GO:0010519) negative regulation of lipoprotein lipase activity(GO:0051005)
0.8 4.7 GO:0061107 seminal vesicle development(GO:0061107)
0.8 3.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.7 8.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.7 4.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.6 1.8 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.5 10.8 GO:0008228 opsonization(GO:0008228)
0.4 3.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 2.6 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.3 3.2 GO:0034378 chylomicron assembly(GO:0034378)
0.2 0.9 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.2 0.6 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.2 0.8 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 0.6 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.2 2.5 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.2 0.7 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 3.0 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 0.9 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310) regulation of mRNA modification(GO:0090365)
0.1 1.9 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.1 0.7 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 0.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.3 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.3 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.1 3.1 GO:0048665 neuron fate specification(GO:0048665)
0.0 3.5 GO:0051180 vitamin transport(GO:0051180)
0.0 2.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.8 GO:0043383 negative T cell selection(GO:0043383)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.0 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0 3.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 18.4 GO:0005577 fibrinogen complex(GO:0005577)
1.2 4.7 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.8 5.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.5 4.0 GO:0005579 membrane attack complex(GO:0005579)
0.2 0.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.3 GO:0061617 MICOS complex(GO:0061617)
0.1 0.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 0.4 GO:0032437 cuticular plate(GO:0032437)
0.1 4.5 GO:1990777 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 13.5 GO:0072562 blood microparticle(GO:0072562)
0.0 1.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 3.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 12.2 GO:0030027 lamellipodium(GO:0030027)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.1 GO:0070469 respiratory chain(GO:0070469)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.8 GO:0033265 choline binding(GO:0033265)
1.9 5.6 GO:1904854 proteasome core complex binding(GO:1904854)
1.0 3.1 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.9 3.4 GO:0008431 vitamin E binding(GO:0008431)
0.8 6.7 GO:0001849 complement component C1q binding(GO:0001849)
0.5 4.7 GO:0032190 acrosin binding(GO:0032190)
0.3 10.8 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.2 0.9 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.2 0.8 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 1.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 8.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 4.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 2.4 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 3.0 GO:0031489 myosin V binding(GO:0031489)
0.1 3.0 GO:0071949 FAD binding(GO:0071949)
0.1 0.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 4.0 GO:0008009 chemokine activity(GO:0008009)
0.1 1.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 18.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 3.2 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 1.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 18.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 7.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 9.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 4.7 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 10.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.8 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 20.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.8 10.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 8.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 5.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 5.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 6.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 4.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.9 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 1.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 2.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor