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avrg: Illumina Body Map 2 (GSE30611)
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Results for ZFX
Z-value: 3.85
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg38_v1_chrX_+_24149629_24149696 | 0.40 | 2.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50203607 Show fit | 7.32 |
ENST00000642316.2
ENST00000425460.6 ENST00000440075.6 ENST00000376970.6 ENST00000599920.5 |
myosin heavy chain 14 |
|
| chr11_+_1838970 Show fit | 7.10 |
ENST00000381911.6
|
troponin I2, fast skeletal type |
|
| chr19_-_45322867 Show fit | 5.93 |
ENST00000221476.4
|
creatine kinase, M-type |
|
| chr2_+_169479445 Show fit | 5.86 |
ENST00000513963.1
ENST00000392663.6 ENST00000295240.8 |
novel protein Bardet-Biedl syndrome 5 |
|
| chr15_+_84817346 Show fit | 5.84 |
ENST00000258888.6
|
alpha kinase 3 |
|
| chr2_-_127106961 Show fit | 5.40 |
ENST00000376113.6
|
bridging integrator 1 |
|
| chr9_-_111483657 Show fit | 5.08 |
ENST00000602447.5
|
Ecm29 proteasome adaptor and scaffold |
|
| chr22_-_35622521 Show fit | 4.76 |
ENST00000419229.1
ENST00000406324.5 |
myoglobin |
|
| chr22_+_19758749 Show fit | 4.73 |
ENST00000680333.1
|
T-box transcription factor 1 |
|
| chr1_+_15617415 Show fit | 4.72 |
ENST00000480945.6
|
DNA damage inducible 1 homolog 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.9 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 23.9 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 1.7 | 13.5 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 1.4 | 12.5 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.6 | 10.5 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.2 | 10.4 | GO:2000810 | regulation of bicellular tight junction assembly(GO:2000810) |
| 0.4 | 8.9 | GO:0031441 | negative regulation of mRNA 3'-end processing(GO:0031441) |
| 2.6 | 7.7 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.4 | 7.6 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.2 | 7.6 | GO:0006783 | heme biosynthetic process(GO:0006783) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 71.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 1.1 | 23.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 18.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 13.9 | GO:0016528 | sarcoplasm(GO:0016528) |
| 4.6 | 13.8 | GO:0060987 | lipid tube(GO:0060987) |
| 0.1 | 11.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.5 | 10.8 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 9.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 9.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 1.7 | 8.4 | GO:0016938 | kinesin I complex(GO:0016938) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 23.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.6 | 18.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.2 | 17.3 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 15.3 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 14.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.2 | 12.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 10.0 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 9.6 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 9.0 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.2 | 8.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 13.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 11.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 11.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.2 | 10.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 9.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 9.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.3 | 8.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 8.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 7.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 13.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.3 | 12.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 12.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 12.2 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.2 | 11.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 8.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 8.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 8.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 8.3 | REACTOME KINESINS | Genes involved in Kinesins |