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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for EVX2

Z-value: 1.22

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 EVX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EVX2hg38_v1_chr2_-_176083913_176083913-0.309.5e-02Click!

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EVX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_111998739 3.46 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr3_+_111999189 3.29 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111998915 3.13 ENST00000478951.6
TAGLN3
transgelin 3
chr5_-_97142579 2.77 ENST00000274382.9
LIX1
limb and CNS expressed 1
chr3_+_111999326 2.56 ENST00000494932.1
TAGLN3
transgelin 3
chr6_-_62286161 1.86 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr1_+_160190567 1.80 ENST00000368078.8
CASQ1
calsequestrin 1
chr5_-_97142753 1.50 ENST00000512378.1
LIX1
limb and CNS expressed 1
chr13_+_77741393 1.41 ENST00000496045.5
SLAIN1
SLAIN motif family member 1
chr13_+_77741331 1.31 ENST00000462234.5
SLAIN1
SLAIN motif family member 1
chr15_+_62758585 0.89 ENST00000472902.1
TLN2
talin 2
chr17_-_10026265 0.87 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr11_-_115504389 0.84 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr19_-_46634685 0.84 ENST00000300873.4
GNG8
G protein subunit gamma 8
chr12_+_15546344 0.79 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chrX_-_63755187 0.77 ENST00000635729.1
ENST00000623566.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr4_+_112860912 0.72 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_143391506 0.65 ENST00000509992.1
GAB1
GRB2 associated binding protein 1
chr4_+_112860981 0.64 ENST00000671704.1
ANK2
ankyrin 2
chr4_+_112861053 0.61 ENST00000672221.1
ANK2
ankyrin 2
chr4_+_143433491 0.60 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr2_+_71276553 0.45 ENST00000494621.5
ENST00000466975.5
ENST00000410075.5
ENST00000466330.5
ZNF638
zinc finger protein 638
chr21_-_31160904 0.41 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr4_-_145180496 0.38 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr4_+_94974984 0.38 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr6_+_39792298 0.36 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr8_+_91249307 0.31 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr12_-_53336342 0.30 ENST00000537210.2
ENST00000536324.4
SP7
Sp7 transcription factor
chr1_+_27934980 0.27 ENST00000373894.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr12_+_64405046 0.25 ENST00000540203.5
XPOT
exportin for tRNA
chr5_+_141484997 0.24 ENST00000617094.1
ENST00000306593.2
ENST00000610539.1
ENST00000618371.4
PCDHGC4
protocadherin gamma subfamily C, 4
chr1_+_27935110 0.20 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr6_-_111605859 0.19 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr18_+_13443720 0.13 ENST00000678309.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr8_+_7926337 0.13 ENST00000400120.3
ZNF705B
zinc finger protein 705B
chr17_+_39653080 0.11 ENST00000443521.1
STARD3
StAR related lipid transfer domain containing 3
chr6_-_111606260 0.11 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr17_+_18183052 0.10 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr12_+_119668109 0.09 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr15_+_101812202 0.08 ENST00000332238.5
OR4F15
olfactory receptor family 4 subfamily F member 15
chr1_-_159862648 0.06 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr1_+_27935022 0.05 ENST00000411604.5
ENST00000373888.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 2.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:1904266 positive regulation of Schwann cell migration(GO:1900149) regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.1 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.8 GO:0019236 response to pheromone(GO:0019236)
0.1 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 4.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 1.3 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 1.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0014802 terminal cisterna(GO:0014802)
0.0 12.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.0 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 12.9 GO:0051015 actin filament binding(GO:0051015)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.8 GO:0017147 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) Wnt-protein binding(GO:0017147) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions