Project
avrg: young vs old, Illumina Body Map 2 (GSE30611)
Navigation
Downloads
Results for FOSL2_SMARCC1
Z-value: 1.54
Motif logo
Transcription factors associated with FOSL2_SMARCC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL2 | hg38_v1_chr2_+_28392802_28392866 | 0.60 | 2.7e-04 | Click! |
| SMARCC1 | hg38_v1_chr3_-_47781837_47781908 | 0.34 | 5.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL2_SMARCC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_73830988 Show fit | 10.14 |
ENST00000340958.4
|
claudin 4 |
|
| chr22_+_22697789 Show fit | 9.60 |
ENST00000390306.2
|
immunoglobulin lambda variable 2-23 |
|
| chr22_+_22758698 Show fit | 9.21 |
ENST00000390312.2
|
immunoglobulin lambda variable 2-14 |
|
| chr22_+_22720615 Show fit | 8.88 |
ENST00000390309.2
|
immunoglobulin lambda variable 3-19 |
|
| chr8_-_81483226 Show fit | 8.81 |
ENST00000256104.5
|
fatty acid binding protein 4 |
|
| chr2_+_89862438 Show fit | 8.34 |
ENST00000448155.2
|
immunoglobulin kappa variable 1D-39 |
|
| chr22_+_22822658 Show fit | 7.62 |
ENST00000620395.2
|
immunoglobulin lambda variable 2-8 |
|
| chr2_+_89959979 Show fit | 7.22 |
ENST00000453166.2
|
immunoglobulin kappa variable 2D-28 |
|
| chr18_+_23873000 Show fit | 6.94 |
ENST00000269217.11
ENST00000587184.5 |
laminin subunit alpha 3 |
|
| chr5_+_150640652 Show fit | 6.07 |
ENST00000307662.5
|
synaptopodin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 98.9 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.2 | 49.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.3 | 13.7 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.4 | 13.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 12.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.6 | 12.3 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 1.5 | 8.9 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.5 | 8.8 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.3 | 8.4 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 7.1 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 54.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 52.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 26.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 16.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 14.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.2 | 13.7 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 9.6 | GO:0005811 | lipid particle(GO:0005811) |
| 3.1 | 9.2 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 9.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 8.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 152.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 25.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 18.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.8 | 14.3 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 12.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 10.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 8.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 8.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 7.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 7.0 | GO:0017160 | Ral GTPase binding(GO:0017160) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 26.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 13.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 12.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 8.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 6.2 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 6.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 14.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 11.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 11.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 9.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 9.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 7.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 6.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 6.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 6.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |