Project
avrg: young vs old, Illumina Body Map 2 (GSE30611)
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Results for FOXO3_FOXD2
Z-value: 1.23
Motif logo
Transcription factors associated with FOXO3_FOXD2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FOXO3
|
ENSG00000118689.15 | FOXO3 |
|
FOXD2
|
ENSG00000186564.6 | FOXD2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO3 | hg38_v1_chr6_+_108656346_108656359 | 0.12 | 5.0e-01 | Click! |
| FOXD2 | hg38_v1_chr1_+_47438036_47438112 | -0.06 | 7.3e-01 | Click! |
Activity profile of FOXO3_FOXD2 motif
Sorted Z-values of FOXO3_FOXD2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO3_FOXD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 24.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 2.1 | 6.3 | GO:0045957 | regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) |
| 1.4 | 10.0 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 1.0 | 5.8 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.9 | 7.9 | GO:0035696 | monocyte extravasation(GO:0035696) |
| 0.8 | 4.7 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.7 | 2.2 | GO:2000547 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 0.7 | 2.1 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 0.6 | 1.8 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.5 | 1.6 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.5 | 2.0 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.5 | 3.4 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.5 | 2.8 | GO:0033082 | regulation of extrathymic T cell differentiation(GO:0033082) |
| 0.5 | 7.7 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.4 | 2.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.4 | 4.4 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.4 | 1.3 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.4 | 7.6 | GO:0072619 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.4 | 1.3 | GO:1990785 | response to water-immersion restraint stress(GO:1990785) |
| 0.4 | 2.1 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.4 | 1.7 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.4 | 1.2 | GO:1902523 | positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.4 | 1.2 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 0.4 | 1.1 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) |
| 0.4 | 1.1 | GO:0045175 | basal protein localization(GO:0045175) |
| 0.4 | 1.9 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.4 | 4.0 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.4 | 2.2 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 0.4 | 1.8 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.4 | 2.8 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.3 | 1.0 | GO:0006407 | rRNA export from nucleus(GO:0006407) |
| 0.3 | 1.4 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.3 | 2.4 | GO:0090095 | regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.3 | 3.4 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.3 | 0.7 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.3 | 1.3 | GO:1902868 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.3 | 1.3 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.3 | 2.0 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.3 | 1.3 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.3 | 1.9 | GO:2001153 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.3 | 4.2 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.3 | 2.2 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.3 | 1.2 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.3 | 1.8 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.3 | 0.9 | GO:0050717 | regulation of interleukin-1 alpha secretion(GO:0050705) positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.3 | 1.1 | GO:0002270 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) |
| 0.3 | 1.9 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.3 | 1.1 | GO:2000078 | type B pancreatic cell maturation(GO:0072560) positive regulation of type B pancreatic cell development(GO:2000078) |
| 0.3 | 0.8 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.3 | 2.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.3 | 2.6 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.3 | 5.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 1.0 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.2 | 0.5 | GO:0042322 | negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) |
| 0.2 | 1.5 | GO:0010897 | negative regulation of triglyceride catabolic process(GO:0010897) |
| 0.2 | 0.7 | GO:0098507 | polynucleotide 5' dephosphorylation(GO:0098507) |
| 0.2 | 1.9 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) |
| 0.2 | 1.2 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
| 0.2 | 1.2 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.2 | 1.4 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.2 | 3.6 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.2 | 1.1 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.2 | 2.4 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
| 0.2 | 2.9 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.2 | 1.3 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.2 | 1.5 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 0.2 | 1.7 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.2 | 1.7 | GO:0002911 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 0.2 | 0.9 | GO:0090214 | spongiotrophoblast layer developmental growth(GO:0090214) |
| 0.2 | 1.9 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.2 | 0.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.2 | 1.0 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.2 | 4.8 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.2 | 1.2 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.2 | 2.7 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.2 | 1.2 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.2 | 3.3 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 1.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.2 | 7.3 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.2 | 1.1 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.2 | 1.8 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.2 | 0.7 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 0.6 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.2 | 2.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.2 | 1.1 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.2 | 3.5 | GO:0070572 | positive regulation of neuron projection regeneration(GO:0070572) |
| 0.2 | 2.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.2 | 0.5 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.2 | 1.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 0.9 | GO:1903613 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.2 | 0.9 | GO:0043375 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) regulation of retinal cell programmed cell death(GO:0046668) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.2 | 4.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 1.0 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 1.7 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.2 | 2.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 3.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 2.0 | GO:0072564 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.2 | 3.1 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.2 | 1.5 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.2 | 0.5 | GO:0042938 | dipeptide transport(GO:0042938) |
| 0.2 | 2.1 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.2 | 0.9 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.2 | 2.5 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.2 | 2.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.2 | 0.6 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.2 | 0.5 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.2 | 2.4 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
| 0.2 | 2.6 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.1 | 0.7 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 1.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 0.4 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.1 | 3.0 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.1 | 1.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 2.8 | GO:0032740 | positive regulation of interleukin-17 production(GO:0032740) |
| 0.1 | 0.8 | GO:1904799 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 0.1 | 3.0 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 1.2 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.8 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 1.7 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.1 | 2.8 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 1.5 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.6 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 0.5 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.1 | 3.0 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.7 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 3.2 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 0.4 | GO:0008057 | eye pigment granule organization(GO:0008057) |
| 0.1 | 1.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.1 | 0.2 | GO:0061743 | motor learning(GO:0061743) |
| 0.1 | 1.5 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 2.0 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.1 | 0.5 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.1 | 2.9 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 0.6 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 0.7 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.1 | 0.4 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 1.1 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.1 | 0.9 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 0.1 | 1.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 2.3 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.1 | 3.0 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.1 | 1.1 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.1 | 1.0 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.1 | 1.4 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 1.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 1.4 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) |
| 0.1 | 0.5 | GO:0014062 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) regulation of serotonin secretion(GO:0014062) |
| 0.1 | 0.4 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 0.7 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 0.7 | GO:1902617 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) response to fluoride(GO:1902617) |
| 0.1 | 0.8 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.1 | 0.9 | GO:0097503 | sialylation(GO:0097503) |
| 0.1 | 1.0 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.1 | 2.5 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.1 | 0.8 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.1 | 1.7 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 0.5 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.1 | 0.3 | GO:0048867 | ganglion mother cell fate determination(GO:0007402) stem cell fate determination(GO:0048867) |
| 0.1 | 1.4 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 4.8 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.1 | 0.3 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.4 | GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340) |
| 0.1 | 0.9 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.1 | 1.5 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 0.3 | GO:0050883 | musculoskeletal movement, spinal reflex action(GO:0050883) |
| 0.1 | 0.9 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.1 | 2.9 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 0.6 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 0.4 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168) |
| 0.1 | 2.1 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.1 | 1.9 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 0.1 | 1.4 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 2.1 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.1 | 0.2 | GO:0060578 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578) |
| 0.1 | 2.2 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 0.3 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.1 | 1.9 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.1 | 0.6 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.1 | 2.0 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
| 0.1 | 0.2 | GO:0007210 | serotonin receptor signaling pathway(GO:0007210) |
| 0.1 | 1.1 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 3.2 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.1 | 0.9 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.1 | 0.2 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) positive regulation of meiosis I(GO:0060903) |
| 0.1 | 0.5 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 2.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 1.5 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 1.4 | GO:0030202 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.1 | 0.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 0.5 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.1 | 0.4 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.1 | 1.5 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 0.7 | GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.1 | 1.2 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 0.5 | GO:0021877 | forebrain neuron fate commitment(GO:0021877) |
| 0.1 | 0.3 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 1.9 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) |
| 0.1 | 0.3 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.1 | 0.9 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.1 | 0.7 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 0.1 | GO:0060300 | regulation of cytokine activity(GO:0060300) |
| 0.1 | 0.3 | GO:1903216 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.1 | 0.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 0.3 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.1 | 0.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.1 | 1.7 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 0.3 | GO:2000381 | growth plate cartilage chondrocyte proliferation(GO:0003419) negative regulation of nodal signaling pathway(GO:1900108) negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 0.3 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.1 | 0.8 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 3.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 0.6 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.1 | 1.0 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 0.3 | GO:0070982 | L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982) |
| 0.1 | 0.9 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 0.5 | GO:0000066 | mitochondrial ornithine transport(GO:0000066) |
| 0.1 | 0.6 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 1.0 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.1 | 0.3 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.1 | 2.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 1.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 0.3 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
| 0.1 | 0.7 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 1.0 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.1 | 5.0 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 0.2 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 0.5 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 1.0 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 4.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.6 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.0 | 0.6 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.0 | 0.8 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.0 | 0.6 | GO:0060125 | habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125) |
| 0.0 | 0.5 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.0 | 1.7 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 0.2 | GO:1903517 | regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824) |
| 0.0 | 0.2 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.0 | 1.5 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.0 | 1.1 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 0.6 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.5 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 1.0 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 0.4 | GO:0034139 | regulation of toll-like receptor 3 signaling pathway(GO:0034139) protein localization to plasma membrane raft(GO:0044860) regulation of establishment of T cell polarity(GO:1903903) |
| 0.0 | 0.6 | GO:0070141 | response to UV-A(GO:0070141) cellular response to UV-A(GO:0071492) |
| 0.0 | 4.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 3.7 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
| 0.0 | 1.1 | GO:0007039 | protein catabolic process in the vacuole(GO:0007039) |
| 0.0 | 0.5 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.3 | GO:1904721 | negative regulation of mRNA cleavage(GO:0031438) negative regulation of IRE1-mediated unfolded protein response(GO:1903895) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.0 | 0.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 4.7 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.0 | 2.3 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.2 | GO:1904479 | regulation of isoprenoid metabolic process(GO:0019747) negative regulation of intestinal absorption(GO:1904479) |
| 0.0 | 0.7 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 0.6 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 1.1 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 1.0 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 0.5 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 0.4 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.2 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.0 | 0.1 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.0 | 0.3 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.0 | 0.5 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 0.4 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.5 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.0 | 0.0 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.0 | 0.3 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.0 | 0.1 | GO:0090219 | negative regulation of lipid kinase activity(GO:0090219) |
| 0.0 | 0.5 | GO:0060992 | response to fungicide(GO:0060992) |
| 0.0 | 0.2 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.0 | 0.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.3 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.0 | 0.3 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.0 | 1.5 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.0 | 0.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 0.2 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.0 | 1.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.6 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 1.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 3.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.1 | GO:0019376 | galactolipid catabolic process(GO:0019376) |
| 0.0 | 1.3 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
| 0.0 | 2.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 1.5 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 0.4 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 2.6 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 0.4 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 2.1 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.0 | 0.3 | GO:0035965 | cardiolipin acyl-chain remodeling(GO:0035965) |
| 0.0 | 1.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 1.4 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 0.7 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.0 | 0.2 | GO:0051389 | inactivation of MAPKK activity(GO:0051389) |
| 0.0 | 0.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.6 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 1.1 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 0.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.4 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 1.9 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 1.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.3 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.0 | 0.2 | GO:2000543 | positive regulation of gastrulation(GO:2000543) |
| 0.0 | 0.1 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.0 | 2.4 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.3 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 0.1 | GO:1904504 | sphinganine metabolic process(GO:0006667) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504) |
| 0.0 | 0.0 | GO:0035565 | regulation of pronephros size(GO:0035565) |
| 0.0 | 2.2 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.0 | 0.9 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.9 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.2 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.0 | 0.5 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.8 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.4 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.4 | GO:0007625 | grooming behavior(GO:0007625) |
| 0.0 | 0.1 | GO:0072268 | pattern specification involved in metanephros development(GO:0072268) |
| 0.0 | 0.2 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 0.6 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.4 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770) |
| 0.0 | 0.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.4 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 11.4 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 0.6 | GO:0007628 | adult walking behavior(GO:0007628) |
| 0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.4 | GO:0031113 | regulation of microtubule polymerization(GO:0031113) |
| 0.0 | 0.2 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.5 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.3 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.0 | 0.1 | GO:0048537 | mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541) Peyer's patch morphogenesis(GO:0061146) |
| 0.0 | 0.3 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.0 | 0.1 | GO:0032264 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
| 0.0 | 1.1 | GO:0016445 | somatic diversification of immunoglobulins(GO:0016445) |
| 0.0 | 0.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.3 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.1 | GO:0060161 | positive regulation of dopamine receptor signaling pathway(GO:0060161) |
| 0.0 | 0.1 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.0 | 0.2 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 0.2 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 1.0 | GO:0007140 | male meiosis(GO:0007140) |
| 0.0 | 0.1 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.0 | 0.2 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.0 | 1.0 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.3 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.3 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.0 | 1.2 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.2 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.0 | 0.7 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.2 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.2 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.0 | 0.5 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.0 | 0.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.1 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.0 | 0.8 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) |
| 0.0 | 0.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.9 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 0.3 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.4 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.8 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 0.3 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.0 | 0.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.0 | 0.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 0.5 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.0 | 0.5 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.4 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.3 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 0.9 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.2 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.2 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.0 | 0.1 | GO:0097460 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.0 | 1.0 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.0 | 0.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.3 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.0 | 0.0 | GO:1904784 | NLRP1 inflammasome complex assembly(GO:1904784) |
| 0.0 | 1.7 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.1 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.0 | 0.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.5 | GO:0032456 | endocytic recycling(GO:0032456) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 25.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.6 | 3.5 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.5 | 1.6 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.5 | 5.8 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.5 | 5.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.4 | 1.3 | GO:0016590 | ACF complex(GO:0016590) |
| 0.4 | 1.5 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.3 | 5.5 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.3 | 2.7 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.2 | 1.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.2 | 0.9 | GO:0038038 | G-protein coupled receptor homodimeric complex(GO:0038038) |
| 0.2 | 1.5 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.2 | 1.0 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.2 | 0.6 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.2 | 0.8 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.2 | 2.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 1.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 0.5 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.2 | 0.5 | GO:0034657 | GID complex(GO:0034657) |
| 0.2 | 2.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.2 | 2.0 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 2.4 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 1.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 1.0 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 2.3 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 2.5 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 1.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.5 | GO:0070701 | mucus layer(GO:0070701) |
| 0.1 | 2.0 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 1.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 7.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 4.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.8 | GO:0033165 | interphotoreceptor matrix(GO:0033165) |
| 0.1 | 1.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 1.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 1.1 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 1.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.5 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.1 | 1.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 0.7 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 1.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 0.5 | GO:0035838 | growing cell tip(GO:0035838) |
| 0.1 | 3.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 0.7 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 0.3 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.1 | 0.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 2.1 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 3.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 0.4 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.1 | 1.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 0.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 0.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 1.0 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 0.5 | GO:1990745 | EARP complex(GO:1990745) |
| 0.1 | 0.5 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 1.3 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 1.7 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.1 | 0.6 | GO:0097651 | phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.0 | 2.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.7 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 1.0 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.0 | 0.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 2.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 2.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.9 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.8 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 3.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.3 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 0.6 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.4 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.2 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.4 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 1.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.2 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.0 | 0.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.4 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 5.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 1.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.4 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 0.2 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 1.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 1.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 4.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 17.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.6 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.1 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 1.2 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.6 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.6 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.8 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 0.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 1.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.2 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 0.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.5 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 2.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.4 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 6.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.2 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 2.1 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 2.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 4.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 1.3 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.4 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 3.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.2 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 0.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 2.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 1.8 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 2.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.3 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 0.0 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 6.9 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 1.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 5.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 3.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 0.1 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.3 | GO:0001861 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 1.1 | 3.2 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 1.0 | 25.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 1.0 | 3.0 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.9 | 2.8 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.8 | 5.8 | GO:0097108 | smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108) |
| 0.8 | 4.6 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.7 | 5.2 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.6 | 1.9 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.6 | 10.0 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.5 | 3.6 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.4 | 2.1 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.4 | 4.7 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.4 | 8.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.4 | 1.1 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.4 | 1.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.4 | 3.5 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 1.2 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.3 | 1.9 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.3 | 5.4 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.3 | 1.5 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
| 0.2 | 2.7 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.2 | 2.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.2 | 3.8 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.2 | 0.7 | GO:0004651 | polynucleotide 5'-phosphatase activity(GO:0004651) |
| 0.2 | 3.3 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.2 | 3.8 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.2 | 0.7 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 0.2 | 1.3 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.2 | 1.2 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.2 | 2.6 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.2 | 1.4 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.2 | 1.8 | GO:0042835 | BRE binding(GO:0042835) |
| 0.2 | 4.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 1.4 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 1.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.2 | 0.5 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.2 | 3.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 2.9 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.2 | 1.3 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.2 | 1.2 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 0.5 | GO:0016608 | growth hormone-releasing hormone activity(GO:0016608) |
| 0.2 | 0.6 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.2 | 2.1 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.2 | 2.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 1.4 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 0.5 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.2 | 0.8 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.1 | 0.7 | GO:0016823 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.1 | 0.7 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 3.4 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 2.0 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 0.8 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 1.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 1.5 | GO:0016433 | rRNA (adenine) methyltransferase activity(GO:0016433) |
| 0.1 | 3.6 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 2.5 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 0.5 | GO:0002046 | opsin binding(GO:0002046) |
| 0.1 | 0.8 | GO:1902444 | riboflavin binding(GO:1902444) |
| 0.1 | 0.9 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.1 | 0.6 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.7 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.1 | 0.5 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.1 | 1.0 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.1 | 2.8 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 1.6 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 1.0 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 1.1 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.1 | 1.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.7 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.1 | 0.5 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.1 | 0.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 0.9 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 1.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 2.2 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.1 | 0.4 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
| 0.1 | 0.4 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.1 | 0.8 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.1 | 1.1 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 1.1 | GO:0000405 | bubble DNA binding(GO:0000405) supercoiled DNA binding(GO:0097100) |
| 0.1 | 1.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 1.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.7 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 0.5 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.1 | 0.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 1.8 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 0.5 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 1.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 2.6 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.7 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.1 | 0.9 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.5 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 1.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.4 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 1.1 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 1.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 0.6 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 0.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 0.3 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.1 | 1.7 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 3.9 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.3 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 0.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 0.8 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 0.4 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.1 | 0.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 7.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 0.4 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 1.0 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.1 | 0.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 7.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.2 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.1 | 2.0 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 0.5 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 1.5 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 1.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 5.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 0.3 | GO:0004096 | catalase activity(GO:0004096) |
| 0.1 | 1.0 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 1.8 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 0.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.3 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.1 | 2.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.2 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 0.2 | GO:0052852 | (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
| 0.1 | 0.9 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 1.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 0.3 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 2.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 2.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.5 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 1.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.3 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.0 | 0.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.0 | 1.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 2.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 3.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 2.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.3 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.4 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.0 | 0.9 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
| 0.0 | 0.2 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307) |
| 0.0 | 1.5 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.3 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.0 | 5.5 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 1.1 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 1.0 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 0.3 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.0 | 0.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 1.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.6 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 2.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 1.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 3.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 1.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.2 | GO:0051500 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.0 | 1.4 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 2.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 1.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 22.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.2 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 8.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 0.5 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 0.3 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.0 | 0.2 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.0 | 2.4 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.2 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 1.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 1.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 1.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.6 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
| 0.0 | 1.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.8 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 4.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.1 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 2.4 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 1.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.3 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.2 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.0 | 0.3 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 4.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.3 | GO:0034979 | NAD-dependent protein deacetylase activity(GO:0034979) |
| 0.0 | 7.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.3 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.0 | 0.1 | GO:0033265 | choline binding(GO:0033265) |
| 0.0 | 0.2 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 1.0 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.9 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.9 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 1.3 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.0 | 0.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.1 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.0 | 0.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.6 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 0.1 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 1.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.1 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 1.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.9 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.1 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.0 | 0.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 2.7 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.2 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.4 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 2.6 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.6 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 2.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.3 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 3.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.0 | 0.1 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 1.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 3.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.0 | GO:0019237 | centromeric DNA binding(GO:0019237) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.3 | 8.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 4.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 6.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 10.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 7.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 7.8 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 1.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 8.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.9 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 4.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 9.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 6.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 1.6 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 2.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 2.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 4.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 6.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 1.9 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 4.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 7.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.9 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 2.3 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.4 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 4.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.1 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 3.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 3.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.1 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.6 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 24.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 1.9 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.3 | 4.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 1.7 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 8.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 3.4 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.2 | 5.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 7.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 7.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 3.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 7.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 4.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 3.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 2.5 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.1 | 5.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 6.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 0.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 4.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 7.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 1.2 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.1 | 4.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 2.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.2 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 3.3 | REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK |
| 0.1 | 1.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 0.5 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 0.8 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 2.5 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 2.0 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 1.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 4.5 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 0.9 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 1.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 5.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.7 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 1.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 1.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 19.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.1 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 1.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 1.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 0.8 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 1.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 3.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 1.0 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 9.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.4 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.0 | 0.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 1.7 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 4.4 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 4.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 5.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.7 | REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 0.0 | 1.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.4 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 1.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.7 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 7.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.3 | REACTOME GABA RECEPTOR ACTIVATION | Genes involved in GABA receptor activation |
| 0.0 | 1.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.8 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.6 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.3 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.7 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.0 | 0.2 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.0 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |