Project
avrg: young vs old, Illumina Body Map 2 (GSE30611)
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Results for MLX_USF2_USF1_PAX2
Z-value: 2.11
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Transcription factors associated with MLX_USF2_USF1_PAX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF1 | hg38_v1_chr1_-_161045961_161045988 | 0.56 | 9.5e-04 | Click! |
| USF2 | hg38_v1_chr19_+_35269065_35269140 | 0.29 | 1.1e-01 | Click! |
| MLX | hg38_v1_chr17_+_42567072_42567083 | 0.06 | 7.6e-01 | Click! |
| PAX2 | hg38_v1_chr10_+_100735390_100735402 | 0.04 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.4 | GO:0010038 | response to metal ion(GO:0010038) |
| 0.5 | 20.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.3 | 17.5 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 15.7 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.7 | 12.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 10.3 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 1.0 | 9.9 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.7 | 9.5 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 0.7 | 8.8 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 8.2 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.8 | GO:1903561 | extracellular vesicle(GO:1903561) |
| 0.0 | 30.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 25.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 2.1 | 18.8 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 18.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 13.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 12.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.7 | 11.8 | GO:0071203 | WASH complex(GO:0071203) |
| 1.8 | 10.7 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 10.6 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 21.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.6 | 20.8 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 20.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 1.2 | 18.8 | GO:0016997 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.3 | 18.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 11.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 11.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.4 | 11.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.6 | 9.7 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 17.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 11.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 9.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 9.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 8.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 7.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 6.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 6.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 6.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.6 | 21.1 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 16.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 13.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 11.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 11.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 11.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 10.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.3 | 7.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 7.3 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |