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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for NKX6-3

Z-value: 0.29

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.13 NKX6-3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg38_v1_chr8_-_41650808_41650822-0.261.6e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_13495984 1.62 ENST00000282091.6
PTH
parathyroid hormone
chr11_-_13496018 1.49 ENST00000529816.1
PTH
parathyroid hormone
chr9_+_122371014 1.44 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122370523 1.38 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371036 1.38 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr8_+_91249307 1.16 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr13_+_53028806 1.12 ENST00000219022.3
OLFM4
olfactomedin 4
chr6_+_130018565 0.92 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chrX_+_108045050 0.63 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr18_+_22914115 0.55 ENST00000579124.5
ENST00000577588.5
ENST00000582354.5
ENST00000581819.5
RBBP8
RB binding protein 8, endonuclease
chrX_+_108044967 0.54 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr6_+_113857333 0.49 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr1_+_160400543 0.48 ENST00000368061.3
VANGL2
VANGL planar cell polarity protein 2
chr3_+_138621207 0.43 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr19_+_49513353 0.43 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr7_+_130344810 0.39 ENST00000497503.5
ENST00000463587.5
ENST00000461828.5
ENST00000474905.6
ENST00000494311.1
ENST00000466363.6
CPA5
carboxypeptidase A5
chr5_-_143400716 0.37 ENST00000424646.6
ENST00000652686.1
NR3C1
nuclear receptor subfamily 3 group C member 1
chr20_-_35147285 0.36 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr3_+_136930469 0.35 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr17_-_40799939 0.34 ENST00000306658.8
KRT28
keratin 28
chr3_+_138621225 0.33 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr6_-_49964160 0.32 ENST00000322066.4
DEFB114
defensin beta 114
chr2_+_233917371 0.30 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr16_+_86566821 0.29 ENST00000649859.1
FOXC2
forkhead box C2
chr3_-_142029108 0.28 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr17_-_10469558 0.27 ENST00000255381.2
MYH4
myosin heavy chain 4
chr1_-_113871665 0.26 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr3_-_132684685 0.26 ENST00000512094.5
ENST00000632629.1
NPHP3
NPHP3-ACAD11
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr16_-_67483541 0.22 ENST00000290953.3
AGRP
agouti related neuropeptide
chr14_+_67364849 0.22 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2 subunit alpha
chr15_+_90191913 0.22 ENST00000559792.5
SEMA4B
semaphorin 4B
chr14_+_88385714 0.20 ENST00000045347.11
SPATA7
spermatogenesis associated 7
chr14_+_88385643 0.19 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chrX_+_43656289 0.16 ENST00000338702.4
MAOA
monoamine oxidase A
chr3_-_142000353 0.14 ENST00000499676.5
TFDP2
transcription factor Dp-2
chr20_-_31390483 0.13 ENST00000376315.2
DEFB119
defensin beta 119
chr15_+_92900189 0.11 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr1_-_151459169 0.11 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr4_-_106368772 0.10 ENST00000638719.4
GIMD1
GIMAP family P-loop NTPase domain containing 1
chr5_-_58999885 0.10 ENST00000317118.12
PDE4D
phosphodiesterase 4D
chr11_-_115256891 0.08 ENST00000545094.5
CADM1
cell adhesion molecule 1
chr19_+_4402615 0.07 ENST00000301280.10
CHAF1A
chromatin assembly factor 1 subunit A
chr4_-_122621011 0.04 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chrX_+_107777733 0.04 ENST00000509000.3
NCBP2L
nuclear cap binding protein subunit 2 like
chr1_-_151459471 0.04 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr1_-_151459198 0.01 ENST00000531094.5
POGZ
pogo transposable element derived with ZNF domain
chr15_+_92900338 0.01 ENST00000625990.3
CHD2
chromodomain helicase DNA binding protein 2
chr12_-_52367478 0.01 ENST00000257901.7
KRT85
keratin 85
chr8_+_76681208 0.01 ENST00000651372.2
ZFHX4
zinc finger homeobox 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 4.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.6 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.5 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1 0.4 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.1 0.3 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.3 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of vascular wound healing(GO:0035470) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 1.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 1.2 GO:0019532 oxalate transport(GO:0019532)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.3 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 1.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0050955 thermoception(GO:0050955)
0.0 0.4 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.2 GO:0033290 eukaryotic 48S preinitiation complex(GO:0033290) translation initiation ternary complex(GO:0044207)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 4.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 3.1 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.4 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 3.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac