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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for POU6F1

Z-value: 0.53

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.17 POU6F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg38_v1_chr12_-_51217671_51217827-0.134.8e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_50818857 1.22 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr14_+_94026314 1.21 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr6_+_42155399 1.20 ENST00000623004.2
ENST00000372963.4
ENST00000654459.1
GUCA1ANB
GUCA1A
GUCA1A neighbor
guanylate cyclase activator 1A
chrX_-_123622809 1.10 ENST00000441692.5
THOC2
THO complex 2
chr12_+_48904116 1.05 ENST00000552942.5
ENST00000320516.5
CCDC65
coiled-coil domain containing 65
chr2_-_216694794 1.04 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr2_-_99301195 1.02 ENST00000308528.9
LYG1
lysozyme g1
chr6_-_73521783 0.98 ENST00000331523.7
ENST00000356303.7
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr3_+_46354072 0.89 ENST00000445132.3
ENST00000421659.1
CCR2
C-C motif chemokine receptor 2
chr7_+_142313144 0.86 ENST00000390357.3
TRBV4-1
T cell receptor beta variable 4-1
chrX_-_123623155 0.84 ENST00000618150.4
THOC2
THO complex 2
chr19_-_35228699 0.82 ENST00000324675.3
FAM187B
family with sequence similarity 187 member B
chr19_+_10848366 0.81 ENST00000397820.5
C19orf38
chromosome 19 open reading frame 38
chr12_+_48904105 0.79 ENST00000266984.9
CCDC65
coiled-coil domain containing 65
chr16_-_87317364 0.77 ENST00000567970.2
C16orf95
chromosome 16 open reading frame 95
chr9_-_110337808 0.70 ENST00000374510.8
ENST00000374507.4
ENST00000423740.7
ENST00000374511.7
TXNDC8
thioredoxin domain containing 8
chr8_+_91249307 0.70 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr16_-_87317416 0.66 ENST00000253461.8
ENST00000618367.4
C16orf95
chromosome 16 open reading frame 95
chr9_-_86947496 0.66 ENST00000298743.9
GAS1
growth arrest specific 1
chr6_+_50818701 0.56 ENST00000344788.7
TFAP2B
transcription factor AP-2 beta
chr10_+_11823348 0.53 ENST00000277570.10
ENST00000622831.4
PROSER2
proline and serine rich 2
chr13_+_97960192 0.53 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
IPO5
importin 5
chr15_-_84716153 0.53 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr11_-_107858777 0.52 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr3_+_109136707 0.51 ENST00000622536.6
C3orf85
chromosome 3 open reading frame 85
chr4_-_168480477 0.50 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr19_+_51573171 0.50 ENST00000436511.2
ZNF175
zinc finger protein 175
chr15_-_84716129 0.50 ENST00000268220.12
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr7_-_77798359 0.49 ENST00000257663.4
TMEM60
transmembrane protein 60
chr22_-_28306645 0.49 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr3_-_48621760 0.48 ENST00000330862.4
TMEM89
transmembrane protein 89
chr11_-_107858561 0.47 ENST00000375682.8
SLC35F2
solute carrier family 35 member F2
chr6_-_132659178 0.47 ENST00000275216.3
TAAR1
trace amine associated receptor 1
chr1_+_224929648 0.45 ENST00000430092.5
ENST00000366850.7
ENST00000400952.7
ENST00000682510.1
ENST00000366849.5
DNAH14
dynein axonemal heavy chain 14
chr6_-_111483700 0.45 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr16_+_15650221 0.44 ENST00000396354.6
ENST00000570727.5
ENST00000674581.1
ENST00000674995.1
NDE1
nudE neurodevelopment protein 1
chr2_-_216695540 0.44 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr17_+_75543258 0.44 ENST00000581713.5
LLGL2
LLGL scribble cell polarity complex component 2
chr2_+_190180930 0.43 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr12_-_57050102 0.43 ENST00000300119.8
MYO1A
myosin IA
chr15_+_44736522 0.41 ENST00000329464.9
ENST00000558329.5
ENST00000560442.5
ENST00000561043.5
TRIM69
tripartite motif containing 69
chr13_+_30422487 0.41 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr12_+_15546344 0.40 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr12_-_30735014 0.39 ENST00000433722.6
CAPRIN2
caprin family member 2
chr1_-_153150884 0.39 ENST00000368748.5
SPRR2G
small proline rich protein 2G
chr4_+_105710809 0.37 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
GSTCD
glutathione S-transferase C-terminal domain containing
chr1_+_176463164 0.37 ENST00000367661.7
ENST00000367662.5
PAPPA2
pappalysin 2
chr12_+_102120172 0.36 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr11_-_4393650 0.36 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr8_-_89984609 0.35 ENST00000519426.5
ENST00000265433.8
NBN
nibrin
chr14_+_22515623 0.35 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr6_-_47042306 0.34 ENST00000371253.7
ADGRF1
adhesion G protein-coupled receptor F1
chr1_-_151459471 0.33 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr1_-_151459169 0.32 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr1_+_224952670 0.32 ENST00000366848.5
ENST00000439375.6
DNAH14
dynein axonemal heavy chain 14
chr20_-_59940289 0.31 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chr15_-_84716063 0.31 ENST00000558217.5
ENST00000558196.1
ENST00000558134.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr2_+_190180835 0.31 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr16_-_58684707 0.31 ENST00000564100.5
ENST00000570101.5
ENST00000562397.5
ENST00000219320.9
ENST00000564010.5
ENST00000570214.5
ENST00000563196.5
SLC38A7
solute carrier family 38 member 7
chr11_+_31650024 0.31 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr6_-_110815096 0.30 ENST00000457688.5
CDK19
cyclin dependent kinase 19
chr8_-_144950813 0.30 ENST00000532351.5
ENST00000394909.7
ENST00000276816.8
ENST00000611477.1
ZNF16
zinc finger protein 16
chr4_+_107824555 0.30 ENST00000394684.8
SGMS2
sphingomyelin synthase 2
chr15_+_44736556 0.29 ENST00000338264.8
TRIM69
tripartite motif containing 69
chr7_+_142345412 0.29 ENST00000390392.3
TRBV4-2
T cell receptor beta variable 4-2
chr5_+_163437569 0.28 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr15_-_84716099 0.26 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr11_-_89490715 0.25 ENST00000528341.5
NOX4
NADPH oxidase 4
chr21_-_31160904 0.25 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr3_-_114624921 0.25 ENST00000393785.6
ZBTB20
zinc finger and BTB domain containing 20
chr11_-_89491131 0.24 ENST00000343727.9
ENST00000531342.5
ENST00000375979.7
NOX4
NADPH oxidase 4
chr1_-_151459198 0.24 ENST00000531094.5
POGZ
pogo transposable element derived with ZNF domain
chr9_-_114806031 0.24 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr1_-_197146620 0.24 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr15_-_52191387 0.23 ENST00000261837.12
GNB5
G protein subunit beta 5
chr6_-_110815152 0.23 ENST00000413605.6
CDK19
cyclin dependent kinase 19
chr1_-_21050952 0.22 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr7_+_150322639 0.21 ENST00000343855.6
ZBED6CL
ZBED6 C-terminal like
chr2_+_102104563 0.21 ENST00000409589.5
ENST00000409329.5
IL1R1
interleukin 1 receptor type 1
chr8_+_32614361 0.20 ENST00000522569.1
NRG1
neuregulin 1
chr22_-_21952827 0.18 ENST00000397495.8
ENST00000263212.10
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr11_+_71833200 0.17 ENST00000328698.2
DEFB108B
defensin beta 108B
chr2_+_11539833 0.17 ENST00000263834.9
GREB1
growth regulating estrogen receptor binding 1
chr5_+_55851349 0.17 ENST00000652347.2
IL31RA
interleukin 31 receptor A
chr2_-_85601758 0.17 ENST00000425160.1
TMEM150A
transmembrane protein 150A
chr17_-_42185452 0.16 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr17_-_28645108 0.16 ENST00000528896.7
KIAA0100
KIAA0100
chr20_+_6007245 0.15 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr2_-_201698040 0.14 ENST00000396886.7
ENST00000409143.5
MPP4
membrane palmitoylated protein 4
chrX_-_100874332 0.14 ENST00000372960.8
NOX1
NADPH oxidase 1
chr12_-_108561157 0.14 ENST00000228284.8
ENST00000431469.6
ENST00000546815.6
SART3
spliceosome associated factor 3, U4/U6 recycling protein
chrX_-_100874209 0.14 ENST00000372964.5
ENST00000217885.5
NOX1
NADPH oxidase 1
chr20_-_51802509 0.13 ENST00000371539.7
ENST00000217086.9
SALL4
spalt like transcription factor 4
chr7_+_148590760 0.13 ENST00000307003.3
C7orf33
chromosome 7 open reading frame 33
chrX_-_100874351 0.13 ENST00000372966.8
NOX1
NADPH oxidase 1
chr20_+_59940362 0.13 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr6_+_25754699 0.13 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr3_-_114624979 0.12 ENST00000676079.1
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_161038907 0.12 ENST00000318289.14
ENST00000368023.7
ENST00000423014.3
ENST00000368024.5
TSTD1
thiosulfate sulfurtransferase like domain containing 1
chr2_+_241350087 0.11 ENST00000451310.1
SEPTIN2
septin 2
chr6_-_110815408 0.10 ENST00000368911.8
CDK19
cyclin dependent kinase 19
chr19_-_35563653 0.09 ENST00000262623.4
ATP4A
ATPase H+/K+ transporting subunit alpha
chr2_-_197675578 0.09 ENST00000295049.9
RFTN2
raftlin family member 2
chr22_-_28094135 0.09 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr4_+_122239965 0.09 ENST00000446180.5
KIAA1109
KIAA1109
chr2_-_201698692 0.09 ENST00000315506.11
ENST00000359962.9
ENST00000620095.4
MPP4
membrane palmitoylated protein 4
chr2_-_201698628 0.09 ENST00000602867.1
ENST00000409474.8
MPP4
membrane palmitoylated protein 4
chr5_-_144170607 0.08 ENST00000448443.6
ENST00000513112.5
ENST00000519064.5
ENST00000274496.10
ENST00000522203.5
YIPF5
Yip1 domain family member 5
chr20_-_51802433 0.08 ENST00000395997.3
SALL4
spalt like transcription factor 4
chr12_+_10307818 0.07 ENST00000350274.9
ENST00000336164.9
KLRD1
killer cell lectin like receptor D1
chr1_+_84164891 0.07 ENST00000413538.5
ENST00000417530.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr8_+_117134989 0.06 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr20_+_35542038 0.06 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC3
ERGIC and golgi 3
chr7_-_29969232 0.04 ENST00000409497.5
SCRN1
secernin 1
chr8_+_117135259 0.04 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr5_-_16916400 0.04 ENST00000513882.5
MYO10
myosin X
chr4_+_109827963 0.04 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr4_-_82891004 0.03 ENST00000513323.5
SEC31A
SEC31 homolog A, COPII coat complex component
chr2_-_201697993 0.03 ENST00000428900.6
MPP4
membrane palmitoylated protein 4
chr5_+_55851378 0.03 ENST00000396836.6
ENST00000359040.10
IL31RA
interleukin 31 receptor A
chr1_-_197146688 0.03 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr12_+_119668109 0.02 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr6_+_29306626 0.02 ENST00000377160.4
OR14J1
olfactory receptor family 14 subfamily J member 1
chr11_-_58423313 0.02 ENST00000302581.2
OR5B2
olfactory receptor family 5 subfamily B member 2
chr8_+_117135020 0.02 ENST00000518396.5
SLC30A8
solute carrier family 30 member 8
chr9_-_4666495 0.01 ENST00000475086.5
SPATA6L
spermatogenesis associated 6 like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0097272 ammonia homeostasis(GO:0097272) urea homeostasis(GO:0097274)
0.5 1.5 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 0.9 GO:0002436 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.1 0.4 GO:1990451 cellular stress response to acidic pH(GO:1990451)
0.1 1.0 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 1.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 0.3 GO:0006867 asparagine transport(GO:0006867)
0.1 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.4 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 1.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.3 GO:1904268 positive regulation of Schwann cell migration(GO:1900149) regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 1.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 0.7 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 1.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.7 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.7 GO:0019532 oxalate transport(GO:0019532)
0.0 0.9 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.0 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.4 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.2 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.5 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.8 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 1.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 1.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.3 GO:0015182 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
0.1 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.0 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 1.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.8 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication