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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for PRDM14

Z-value: 0.73

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.4 PRDM14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg38_v1_chr8_-_70071226_700712580.621.3e-04Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_43847142 1.75 ENST00000377203.8
ENST00000539718.5
ENST00000588884.1
ENST00000293396.12
ENST00000586233.5
CD300LG
CD300 molecule like family member g
chr17_+_43847168 1.69 ENST00000317310.5
CD300LG
CD300 molecule like family member g
chr12_+_54008961 1.07 ENST00000040584.6
HOXC8
homeobox C8
chr17_+_41837817 1.03 ENST00000438813.1
ENST00000293303.5
KLHL10
kelch like family member 10
chrX_-_120077690 0.96 ENST00000371402.5
RHOXF2B
Rhox homeobox family member 2B
chr5_-_168883333 0.87 ENST00000404867.7
SLIT3
slit guidance ligand 3
chr9_+_84668485 0.87 ENST00000359847.4
ENST00000395882.6
ENST00000376208.6
ENST00000376213.6
NTRK2
neurotrophic receptor tyrosine kinase 2
chrX_+_120158600 0.80 ENST00000371388.5
RHOXF2
Rhox homeobox family member 2
chr1_-_153113507 0.75 ENST00000468739.2
SPRR2F
small proline rich protein 2F
chr17_-_48615261 0.73 ENST00000239144.5
HOXB8
homeobox B8
chr17_+_49575828 0.70 ENST00000328741.6
NXPH3
neurexophilin 3
chr17_-_17582417 0.69 ENST00000395783.5
PEMT
phosphatidylethanolamine N-methyltransferase
chr1_+_155033824 0.67 ENST00000295542.6
ENST00000423025.6
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr1_+_145927105 0.64 ENST00000437797.5
ENST00000601726.3
ENST00000599626.5
ENST00000599147.5
ENST00000595494.5
ENST00000595518.5
ENST00000597144.5
ENST00000599469.5
ENST00000598354.5
ENST00000598103.5
ENST00000600340.5
ENST00000630257.2
ENST00000625258.1
LIX1L-AS1
ENSG00000280778.1
LIX1L antisense RNA 1
novel protein, lncRNA-POLR3GL readthrough
chr1_-_153094521 0.62 ENST00000368750.8
SPRR2E
small proline rich protein 2E
chr13_+_108629605 0.58 ENST00000457511.7
MYO16
myosin XVI
chr1_+_108560031 0.58 ENST00000405454.1
ENST00000370035.8
FAM102B
family with sequence similarity 102 member B
chr11_+_85855377 0.57 ENST00000342404.8
CCDC83
coiled-coil domain containing 83
chr11_+_65111845 0.52 ENST00000526809.5
ENST00000524986.5
ENST00000534371.5
ENST00000279263.14
ENST00000525385.5
ENST00000345348.9
ENST00000531321.5
ENST00000529414.5
ENST00000526085.5
ENST00000530750.5
TM7SF2
transmembrane 7 superfamily member 2
chr11_+_62707668 0.50 ENST00000294117.6
GNG3
G protein subunit gamma 3
chr1_-_155033778 0.46 ENST00000368424.4
DCST2
DC-STAMP domain containing 2
chr3_-_134373719 0.43 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr1_-_167914089 0.42 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr3_+_156120572 0.39 ENST00000389636.9
ENST00000490337.6
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr16_-_53703810 0.39 ENST00000569716.1
ENST00000562588.5
ENST00000621565.5
ENST00000562230.5
ENST00000563746.5
ENST00000568653.7
ENST00000647211.2
RPGRIP1L
RPGRIP1 like
chr11_-_62707413 0.36 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr11_-_62707581 0.36 ENST00000684475.1
ENST00000683296.1
ENST00000684067.1
ENST00000682223.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr3_-_143848442 0.35 ENST00000474151.1
ENST00000316549.11
SLC9A9
solute carrier family 9 member A9
chr1_+_26787926 0.33 ENST00000674202.1
ENST00000674222.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr7_-_30026617 0.32 ENST00000222803.10
FKBP14
FKBP prolyl isomerase 14
chrX_+_15507302 0.32 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr17_-_2214306 0.31 ENST00000572369.5
SMG6
SMG6 nonsense mediated mRNA decay factor
chr2_-_144520315 0.31 ENST00000465070.5
ENST00000465308.5
ENST00000636471.1
ENST00000629520.2
ENST00000675069.1
ENST00000636026.2
ENST00000444559.5
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_21570303 0.27 ENST00000374830.2
ALPL
alkaline phosphatase, biomineralization associated
chr5_-_160685379 0.26 ENST00000642502.1
ATP10B
ATPase phospholipid transporting 10B (putative)
chr1_+_26788166 0.25 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr7_-_124765753 0.22 ENST00000303921.3
GPR37
G protein-coupled receptor 37
chr17_-_48614628 0.22 ENST00000576562.1
HOXB8
homeobox B8
chr12_-_48957445 0.21 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ARF3
ADP ribosylation factor 3
chr22_+_31093358 0.21 ENST00000404574.5
SMTN
smoothelin
chr16_-_67483541 0.21 ENST00000290953.3
AGRP
agouti related neuropeptide
chr16_-_53703883 0.18 ENST00000262135.9
ENST00000564374.5
ENST00000566096.5
RPGRIP1L
RPGRIP1 like
chr17_-_19748355 0.17 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr19_+_42284483 0.17 ENST00000575354.6
CIC
capicua transcriptional repressor
chr15_+_74788542 0.16 ENST00000567571.5
CSK
C-terminal Src kinase
chr4_+_4859658 0.16 ENST00000382723.5
MSX1
msh homeobox 1
chr12_+_55932028 0.16 ENST00000394147.5
ENST00000551156.5
ENST00000553783.5
ENST00000557080.5
ENST00000432422.7
ENST00000556001.5
DGKA
diacylglycerol kinase alpha
chr9_+_129835442 0.16 ENST00000372429.8
ENST00000315480.9
ENST00000358355.5
USP20
ubiquitin specific peptidase 20
chr17_-_19748285 0.15 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_75779758 0.15 ENST00000592643.5
ENST00000591890.5
ENST00000587171.1
ENST00000254810.8
ENST00000589599.5
H3-3B
H3.3 histone B
chr9_+_97633845 0.15 ENST00000629069.1
NCBP1
nuclear cap binding protein subunit 1
chrX_+_51893533 0.14 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGED1
MAGE family member D1
chr17_-_17823593 0.13 ENST00000423161.3
SREBF1
sterol regulatory element binding transcription factor 1
chr8_+_109334317 0.13 ENST00000521662.5
ENST00000520147.5
ENST00000521688.6
ENY2
ENY2 transcription and export complex 2 subunit
chr11_-_106022209 0.13 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr11_-_62707331 0.13 ENST00000533982.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr4_-_10457385 0.12 ENST00000507515.1
ENST00000326756.4
ZNF518B
zinc finger protein 518B
chr10_+_88664439 0.12 ENST00000394375.7
ENST00000608620.5
ENST00000238983.9
ENST00000355843.2
LIPF
lipase F, gastric type
chr1_-_6261053 0.12 ENST00000377893.3
GPR153
G protein-coupled receptor 153
chr2_+_112275588 0.12 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr12_-_48957365 0.10 ENST00000398092.4
ENST00000539611.1
ENSG00000272822.2
ARF3
novel protein
ADP ribosylation factor 3
chr2_-_144521042 0.10 ENST00000637267.2
ZEB2
zinc finger E-box binding homeobox 2
chr1_-_40097216 0.09 ENST00000641083.1
ENST00000641471.1
ENST00000642050.2
ENST00000433473.8
ENST00000439754.6
ENST00000527311.7
ENST00000641319.1
ENST00000449045.7
PPT1
palmitoyl-protein thioesterase 1
chr19_+_3572777 0.09 ENST00000416526.5
HMG20B
high mobility group 20B
chr12_-_76348404 0.08 ENST00000650064.2
BBS10
Bardet-Biedl syndrome 10
chr1_+_65264694 0.08 ENST00000263441.11
ENST00000395325.7
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr11_-_62672255 0.08 ENST00000528862.2
LBHD1
LBH domain containing 1
chr2_-_227379297 0.07 ENST00000304568.4
TM4SF20
transmembrane 4 L six family member 20
chr17_+_38717424 0.07 ENST00000615858.1
MLLT6
MLLT6, PHD finger containing
chr1_+_23959109 0.06 ENST00000471915.5
PNRC2
proline rich nuclear receptor coactivator 2
chr5_+_32710630 0.05 ENST00000326958.5
NPR3
natriuretic peptide receptor 3
chr1_+_50105666 0.05 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr17_-_19748341 0.04 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr1_+_44808482 0.04 ENST00000450269.5
ENST00000409335.6
BTBD19
BTB domain containing 19
chr11_-_65856944 0.04 ENST00000524553.5
CFL1
cofilin 1
chr1_+_93079234 0.03 ENST00000540243.5
ENST00000545708.5
MTF2
metal response element binding transcription factor 2
chr7_+_39950187 0.03 ENST00000181839.10
CDK13
cyclin dependent kinase 13
chr18_+_59899988 0.03 ENST00000316660.7
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr17_+_77453993 0.03 ENST00000592951.5
SEPTIN9
septin 9
chr3_-_71132099 0.01 ENST00000650188.1
ENST00000648121.1
ENST00000648794.1
ENST00000649592.1
FOXP1
forkhead box P1
chr16_+_53703963 0.01 ENST00000636218.1
ENST00000637001.1
ENST00000471389.6
ENST00000637969.1
ENST00000640179.1
FTO
FTO alpha-ketoglutarate dependent dioxygenase
chr12_-_52573816 0.01 ENST00000549343.5
ENST00000305620.3
KRT74
keratin 74
chr14_-_53958757 0.01 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr1_-_26890237 0.01 ENST00000431781.2
ENST00000374135.9
GPN2
GPN-loop GTPase 2
chr3_+_36993798 0.01 ENST00000455445.6
ENST00000539477.6
ENST00000435176.5
ENST00000429117.5
ENST00000441265.6
MLH1
mutL homolog 1
chr3_-_155676363 0.00 ENST00000494598.5
PLCH1
phospholipase C eta 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.3 0.9 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.2 1.0 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.1 0.9 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.3 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.7 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 1.0 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.8 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.6 GO:0043584 nose development(GO:0043584)
0.0 0.3 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.6 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.6 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 1.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.2 0.7 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.2 0.6 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 0.6 GO:0031862 prostanoid receptor binding(GO:0031862)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 3.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.2 GO:0036505 prosaposin receptor activity(GO:0036505)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.4 GO:0070402 NADPH binding(GO:0070402)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane