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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for SREBF2

Z-value: 1.28

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
ENSG00000198911.12 SREBF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg38_v1_chr22_+_41833079_418331420.086.7e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_-_32184287 6.70 ENST00000375069.7
ENST00000375070.7
ENST00000438221.6
ENST00000620802.4
ENST00000538695.2
advanced glycosylation end-product specific receptor
chr12_-_52949818 6.47 ENST00000546897.5
ENST00000552551.5
keratin 8
chr6_-_32184243 6.39 ENST00000375055.6
ENST00000375076.9
advanced glycosylation end-product specific receptor
chr2_-_55923775 6.35 ENST00000438672.5
ENST00000355426.8
ENST00000440439.5
ENST00000429909.5
ENST00000424207.5
ENST00000452337.5
ENST00000439193.5
ENST00000421664.1
EGF containing fibulin extracellular matrix protein 1
chr6_-_32184227 5.90 ENST00000450110.5
ENST00000375067.7
ENST00000375056.6
advanced glycosylation end-product specific receptor
chr12_-_52949776 4.69 ENST00000548998.5
keratin 8
chr12_-_52949849 4.62 ENST00000619952.2
ENST00000546826.5
keratin 8
chr6_+_151239951 4.36 ENST00000402676.7
A-kinase anchoring protein 12
chr12_-_91111460 4.35 ENST00000266718.5
lumican
chr5_-_150155828 4.09 ENST00000261799.9
platelet derived growth factor receptor beta
chr19_-_11197516 3.37 ENST00000592903.5
ENST00000586659.6
ENST00000589359.5
ENST00000588724.5
KN motif and ankyrin repeat domains 2
chr16_+_2033264 2.99 ENST00000565855.5
ENST00000566198.1
SLC9A3 regulator 2
chr5_-_150155627 2.83 ENST00000517488.1
platelet derived growth factor receptor beta
chr11_-_119340816 2.68 ENST00000528368.3
C1q and TNF related 5
chr17_-_15265230 2.59 ENST00000676161.1
ENST00000646419.2
ENST00000312280.9
ENST00000494511.7
ENST00000580584.3
ENST00000676221.1
peripheral myelin protein 22
chr19_+_55080363 2.53 ENST00000588359.5
ENST00000245618.5
EPS8 like 1
chr17_-_82098187 2.45 ENST00000634990.1
fatty acid synthase
chr5_+_160229499 2.43 ENST00000402432.4
fatty acid binding protein 6
chr3_+_50269140 2.38 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
semaphorin 3B
chr1_+_32753991 2.22 ENST00000373481.7
KIAA1522
chr6_-_52995170 2.21 ENST00000370959.1
ENST00000370963.9
glutathione S-transferase alpha 4
chr8_-_17722217 1.96 ENST00000381861.7
microtubule associated scaffold protein 1
chr19_+_11089446 1.91 ENST00000557933.5
ENST00000455727.6
ENST00000535915.5
ENST00000545707.5
ENST00000558518.6
ENST00000558013.5
low density lipoprotein receptor
chr15_+_47184076 1.69 ENST00000558014.5
semaphorin 6D
chr2_-_236503688 1.68 ENST00000418802.2
ENST00000431676.6
IQ motif containing with AAA domain 1
chr11_-_6655788 1.57 ENST00000299441.5
dachsous cadherin-related 1
chr5_-_43313403 1.42 ENST00000325110.11
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr5_-_43313473 1.38 ENST00000433297.2
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr3_-_16512895 1.38 ENST00000449415.5
ENST00000441460.5
raftlin, lipid raft linker 1
chr3_+_183253230 1.31 ENST00000326505.4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr16_+_66880503 1.22 ENST00000568869.1
ENST00000311765.4
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr16_+_22092532 1.19 ENST00000567131.5
ENST00000389398.10
ENST00000568328.5
von Willebrand factor A domain containing 3A
chr17_+_81103998 1.17 ENST00000572498.1
BAR/IMD domain containing adaptor protein 2
chr11_-_119340914 1.17 ENST00000634633.1
C1q and TNF related 5
chr6_+_41637005 1.16 ENST00000419164.6
ENST00000373051.6
MyoD family inhibitor
chr6_-_53348902 1.08 ENST00000370913.5
ENST00000304434.11
ELOVL fatty acid elongase 5
chr15_+_67067780 1.03 ENST00000679624.1
SMAD family member 3
chr3_+_183253795 0.97 ENST00000460419.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr14_+_32939243 0.91 ENST00000346562.6
ENST00000548645.5
ENST00000356141.8
ENST00000357798.9
neuronal PAS domain protein 3
chr3_+_183253546 0.84 ENST00000464191.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr17_-_17823593 0.79 ENST00000423161.3
sterol regulatory element binding transcription factor 1
chr19_-_45782479 0.76 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chr19_-_18281612 0.73 ENST00000252818.5
JunD proto-oncogene, AP-1 transcription factor subunit
chr15_+_78264552 0.73 ENST00000394852.8
ENST00000343789.7
DnaJ heat shock protein family (Hsp40) member A4
chr2_+_231707650 0.71 ENST00000409321.5
prothymosin alpha
chr14_-_74493291 0.70 ENST00000238633.6
ENST00000555619.6
ENST00000434013.6
NPC intracellular cholesterol transporter 2
chr3_-_160399512 0.67 ENST00000498409.5
ENST00000475677.5
ENST00000478536.1
intraflagellar transport 80
chr10_-_114684457 0.59 ENST00000392955.7
actin binding LIM protein 1
chr8_+_123416766 0.59 ENST00000287387.7
ENST00000650311.1
ENST00000523356.1
N-terminal glutamine amidase 1
chr2_-_219060914 0.58 ENST00000295731.7
Indian hedgehog signaling molecule
chr4_+_74365136 0.58 ENST00000244869.3
epiregulin
chr3_+_189171948 0.57 ENST00000345063.8
tumor protein p63 regulated 1
chr6_+_41636882 0.55 ENST00000432027.5
MyoD family inhibitor
chr8_+_22024731 0.53 ENST00000289820.10
ENST00000381530.9
nucleophosmin/nucleoplasmin 2
chrX_-_153971810 0.51 ENST00000310441.12
host cell factor C1
chr1_+_55039511 0.51 ENST00000302118.5
proprotein convertase subtilisin/kexin type 9
chr10_-_73096974 0.51 ENST00000440381.5
ENST00000263556.3
prolyl 4-hydroxylase subunit alpha 1
chr8_+_123416735 0.45 ENST00000524254.5
N-terminal glutamine amidase 1
chr8_+_123416718 0.43 ENST00000523984.5
N-terminal glutamine amidase 1
chr8_+_26577843 0.43 ENST00000311151.9
dihydropyrimidinase like 2
chr14_-_74493322 0.41 ENST00000553490.5
ENST00000557510.5
NPC intracellular cholesterol transporter 2
chr14_-_74493275 0.38 ENST00000541064.5
NPC intracellular cholesterol transporter 2
chr5_+_138439020 0.27 ENST00000378339.7
ENST00000254901.9
ENST00000506158.5
receptor accessory protein 2
chr10_-_73096850 0.26 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
prolyl 4-hydroxylase subunit alpha 1
chr4_+_725107 0.25 ENST00000433814.5
polycomb group ring finger 3
chr10_-_114684612 0.24 ENST00000533213.6
ENST00000369252.8
actin binding LIM protein 1
chr22_-_31140494 0.23 ENST00000215885.4
phospholipase A2 group III
chr16_+_31214111 0.22 ENST00000322122.8
tripartite motif containing 72
chr17_+_67044530 0.21 ENST00000226021.5
calcium voltage-gated channel auxiliary subunit gamma 1
chr19_-_45782388 0.19 ENST00000458663.6
DM1 protein kinase
chr11_+_65711991 0.16 ENST00000377046.7
ENST00000352980.8
lysine acetyltransferase 5
chr6_+_78867524 0.13 ENST00000369940.7
interleukin 1 receptor associated kinase 1 binding protein 1
chr16_+_31214088 0.12 ENST00000613872.1
tripartite motif containing 72
chr16_+_8642375 0.11 ENST00000562973.1
methyltransferase like 22
chr5_-_139904460 0.07 ENST00000340391.8
neuregulin 2
chr3_-_171810432 0.06 ENST00000356327.9
ENST00000351298.9
phospholipase D1
chr11_+_65712231 0.05 ENST00000530446.5
ENST00000534104.5
ENST00000341318.9
ENST00000530605.5
ENST00000528198.5
ENST00000531880.1
ENST00000534650.5
lysine acetyltransferase 5
chr9_+_128689201 0.05 ENST00000322030.13
SET nuclear proto-oncogene
chr6_+_117265550 0.04 ENST00000352536.7
ENST00000326274.6
vestigial like family member 2
chr19_-_55279690 0.01 ENST00000587959.1
ENST00000585927.1
ENST00000587922.5
ENST00000585698.1
HSPA (Hsp70) binding protein 1
chr3_+_160399630 0.00 ENST00000465903.5
ENST00000485645.5
ENST00000472991.5
ENST00000467468.5
ENST00000469762.5
ENST00000357388.8
ENST00000489573.5
ENST00000462787.5
ENST00000490207.5
ENST00000485867.5
structural maintenance of chromosomes 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
2.3 6.9 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
1.1 3.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.9 15.8 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.9 6.4 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.5 1.6 GO:0003192 mitral valve formation(GO:0003192)
0.4 1.9 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 4.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 4.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 1.5 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.2 0.6 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.2 0.6 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 0.5 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.2 2.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.4 GO:0019046 release from viral latency(GO:0019046)
0.1 2.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.0 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 1.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 1.7 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 2.6 GO:0032060 bleb assembly(GO:0032060)
0.1 1.1 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.9 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 0.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 2.2 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 1.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.8 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0 2.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 3.8 GO:0070206 protein trimerization(GO:0070206)
0.0 0.3 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 1.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 1.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 3.1 GO:0016266 glycolipid biosynthetic process(GO:0009247) O-glycan processing(GO:0016266)
0.0 2.4 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.5 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.0 0.7 GO:0002076 osteoblast development(GO:0002076)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.4 15.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 0.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 3.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 0.5 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.2 2.5 GO:0042587 glycogen granule(GO:0042587)
0.1 0.7 GO:0035976 AP1 complex(GO:0035976)
0.1 1.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 17.9 GO:0001650 fibrillar center(GO:0001650)
0.1 2.6 GO:0043218 compact myelin(GO:0043218)
0.0 8.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 3.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:1904599 advanced glycation end-product binding(GO:1904599)
1.7 6.9 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
1.3 6.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.9 2.8 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.8 2.5 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.6 3.1 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.5 0.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.2 1.9 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 1.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 4.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.5 GO:0042608 T cell receptor binding(GO:0042608)
0.1 17.0 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.0 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 2.4 GO:0032052 bile acid binding(GO:0032052)
0.1 0.8 GO:0032810 sterol response element binding(GO:0032810)
0.1 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 2.4 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.1 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0005113 patched binding(GO:0005113)
0.0 0.4 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 4.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.6 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.2 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 19.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.2 6.9 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 15.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 3.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 2.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 7.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 7.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 4.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 3.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 6.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG